Browsing Harvard Medical School by Issue Date
Now showing items 1-20 of 18209
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Myelin: Dynamic or Stable?
(Rockefeller University Press, 1968) -
Electron Microscopy of Protocollagen Proline Hydroxylase from Chick Embryos
(Elsevier BV, 1970-05-25)Protocollagen proline hydroxylase was purified from chick embryos, and it was examined by electron microscopy with negative staining techniques. Enzyme prepared in Helsinki consisted almost entirely of single ring structures. ... -
Titration and Melting Curves of the Collagen-like Triple Helices Formed from (Pro-Pro-Gly)10 in Aqueous Solution
(Elsevier BV, 1970-11-10)Previous reports demonstrated that synthetic polytripeptides of the structure (Pro-Pro-Gly)10, prepared with a specific modification of the Merrifield technique, formed triple helical structures in aqueous solution which ... -
The Process of Janusian Thinking in Creativity
(American Medical Association (AMA), 1971)"Janusian thinking"—the capacity to conceive and utilize two or more opposite or contradictory ideas, concepts, or images simultaneously—is discussed in relation to its role in the creative process in art, literature, ... -
Regional Medical Programs in Search of a Mission
(Massachusetts Medical Society, 1971-04-08)Created five years ago, the Regional Medical Programs now have established organizations that cover the entire country. Private medicine is involved to a degree unparalleled in any other federal health program. In many ... -
Fine Structural Localization of Cholesterol-1,2-3h in Degenerating and Regenerating Mouse Sciatic Nerve
(Rockefeller University Press, 1972)The localization of 3H-labeled cholesterol in nerves undergoing degeneration and regeneration was studied by radioautography at the electron microscope level. Two types of experiments were carried out: (a) Cholesterol-1,2-3H ... -
Coronary Artery Reperfusion
(American Society for Clinical Investigation, 1972)The effects of coronary artery reperfusion 3 hr after coronary occlusion on contractile function and the development of myocardial damage at 24 hr was studied experimentally. In 14 control and 6 reperfused dogs, relationships ... -
Precordial S-T segment elevation mapping: An atraumatic method for assessing alterations in the extent of myocardial ischemic injury
(Elsevier BV, 1972)A noninvasive technique for evaluating the extent of myocardial ischemic injury after experimental coronary artery occlusion was devised and applied to study alterations in the extent of injury produced by hemodynamic and ... -
Reduction of Experimental Myocardial Infarct Size by Corticosteroid Administration
(American Society for Clinical Investigation, 1973)The influence of the administration of pharmacologic doses of hydrocortisone on the extent and severity of acute myocardial ischemic injury and on subsequent necrosis after acute coronary occlusion was investigated in 28 ... -
Effect of pharmacologic agents on the function of the ischemic heart
(Elsevier BV, 1973)Since isoproterenol, tachycardia induced by atrial pacing, propranolol and Hyaluronidase alter the extent and severity of cardiac damage after coronary occlusion, their effects on the function of the severely ischemic heart ... -
Intracellular Collagen and Protocollagen from Embryonic Tendon Cells
(Elsevier BV, 1973-01) -
Protocols for Physician Assistants — Management of Diabetes and Hypertension
(Massachusetts Medical Society, 1974-02-07)Physician assistants used problem-oriented protocols in management of patients with diabetes and hypertension. The protocols directed the physician assistant in determining what data to collect, and whether the patients ... -
Distribution of [1,2-3H]cholesterol in mouse brain after injection in the suckling period
(Rockefeller University Press, 1975)Glutaraldehyde-carbohydrazide polymer (GACH) was used to embed olfactory tracts, trapezoid body, and sciatic nerves of 9-, 10-, and 49- day old mice 2 h, 24 h, and 6 wk (respectively) after the intraperitoneal administration ... -
Two Improved Methods for Preparing Ferritin-Protein Conjugates for Electron Microscopy
(Rockefeller University Press, 1975-02-01)Two improved procedures were developed for activating ferritin so that the ferritin could be covalently linked to antibodies. One procedure involved use of a water-soluble carbodiimide and N-hydroxysuccinimide to prepare ... -
Further characterization of embryonic tendon fibroblasts and the use of immunoferritin techniques to study collagen biosynthesis.
(Rockefeller University Press, 1975-02-01)Morphological studies were carried out on fibroblasts from chick embryo tendons, cells which have been used in a number of recent studies on collagen biosynthesis. The cells were relatively rich in endoplasmic reticulum ... -
Location of Procollagen in Chick Corneal and Tendon Fibroblasts With Ferritin-Conjugated Antibodies
(Rockefeller University Press, 1975-04-01)Three distinct antiprocollagen preparations were characterized and used in immunocytochemical staining of chick embryo corneal and tendon cells. The several ferritin-conjugated antibody preparations permitted similar ... -
Homospatial Thinking in Creativity
(1976) -
Alternatives to Metronidazole
(American Medical Association (AMA), 1976-05-10)To the Editor.— The recent warning in The Medical Letter1 regarding the mutagenicity and possible carcinogenicity of metronidazole (Flagyl) raises the question of whether there is an alternative treatment of equal efficacy ... -
Neighborhood Health Centers as Providers of Primary Mental-Health Care
(Massachusetts Medical Society, 1976-07-15)The 19 Boston neighborhood health centers with mental-health programs were studied to investigate the delivery of mental-health services as part of a primary health-care system. Staff-time utilization data show these ... -
Ultrastructural localization of glial fibrillary acidic protein in mouse cerebellum by immunoperoxidase labeling
(Rockefeller University Press, 1977)Glial fibrillary acidic protein was localized at the electron microscope level in the cerebellum of adult mice by indirect immunoperoxidase histology. In confirmation of previous studies at the light microscope level, the ...