Browsing Harvard Medical School by Author "Carroll, Michael"

Now showing items 1-7 of 7

    • B cell homeostasis and follicle confines are governed by fibroblastic reticular cells 

      Cremasco, Viviana; Woodruff, Matthew C.; Onder, Lucas; Cupovic, Jovana; Nieves-Bonilla, Janice M.; Schildberg, Frank A.; Chang, Jonathan; Cremasco, Floriana; Harvey, Christopher J.; Wucherpfennig, Kai; Ludewig, Burkhard; Carroll, Michael C.; Turley, Shannon J. (2014)
      Fibroblastic reticular cells (FRCs) are known to inhabit T cell-rich areas of lymphoid organs where they function to coordinate T cell and dendritic cell interactions. However, in vivo manipulation of FRCs has been limited ...

    • Bacteria activate sensory neurons that modulate pain and inflammation 

      Chiu, Isaac M.; Heesters, Balthasar A.; Ghasemlou, Nader; Von Hehn, Christian A.; Zhao, Fan; Tran, Johnathan; Wainger, Brian; Strominger, Amanda; Muralidharan, Sriya; Horswill, Alexander R.; Wardenburg, Juliane Bubeck; Hwang, Sun Wook; Carroll, Michael C.; Woolf, Clifford J. (2013)
      Summary Nociceptor sensory neurons are specialized to detect potentially damaging stimuli, protecting the organism by initiating the sensation of pain and eliciting defensive behaviors. Bacterial infections produce pain ...

    • The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture 

      Astarita, Jillian L.; Cremasco, Viviana; Fu, Jianxin; Darnell, Max C.; Peck, James R.; Nieves-Bonilla, Janice M.; Song, Kai; Woodruff, Matthew C.; Gogineni, Alvin; Onder, Lucas; Ludewig, Burkhard; Weimer, Robby M.; Carroll, Michael C.; Mooney, David J.; Xia, Lijun; Turley, Shannon J. (2014)
      In lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of FRCs is their propensity to contract ...

    • Corneal Transplantation in Antibody-Deficient Hosts 

      Goslings, Willem R.O.; Yamada, Jun; Dana, Reza; Streilein, J. Wayne; van Beelen, Els; Prodeus, Andrey P.; Carroll, Michael; Jager, Martine J. (Association for Research in Vision and Ophthalmology, 1999-01)
      Purpose: To examine the role of donor-specific antibodies, with or without complement, in rejection of orthotopic corneal transplants by using mice as recipients in which the genes for the heavy chain of immunoglobulin or ...

    • Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes 

      Heesters, Balthasar A.; Lindqvist, Madelene; Vagefi, Parsia A.; Scully, Eileen P.; Schildberg, Frank A.; Altfeld, Marcus; Walker, Bruce D.; Kaufmann, Daniel E.; Carroll, Michael C. (Public Library of Science, 2015)
      Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound. Follicular dendritic cells (FDC) are in direct contact with CD4+ T cells ...

    • Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine 

      Woodruff, Matthew C.; Heesters, Balthasar A.; Herndon, Caroline N.; Groom, Joanna R.; Thomas, Paul G.; Luster, Andrew D.; Turley, Shannon J.; Carroll, Michael C. (The Rockefeller University Press, 2014)
      Dendritic cells (DCs) are well established as potent antigen-presenting cells critical to adaptive immunity. In vaccination approaches, appropriately stimulating lymph node–resident DCs (LNDCs) is highly relevant to effective ...

    • Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks 

      Malhotra, Deepali; Fletcher, Anne; Astarita, Jillian Leigh; Lukacs-Kornek, Veronika; Tayalia, Prakriti; Gonzalez, Santiago F.; Elpek, Kutlu G.; Chang, Sook Kyung; Knoblich, Konstantin; Hemler, Martin Edward; Brenner, Michael Barry; Carroll, Michael C.; Mooney, David J.; Turley, Shannon J. (Nature Publishing Group, 2012)
      Lymph node stromal cells (LNSCs) closely regulate immunity and self-tolerance, yet key aspects of their biology remain poorly illuminated. Comparative transcriptomic analyses of murine LNSC subsets revealed expression of ...