Browsing Harvard Medical School by Author "Tabas, Ira"

Now showing items 1-5 of 5

    • Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress 

      Senokuchi, Takafumi; Liang, Chien-Ping; Seimon, Tracie A.; Han, Seongah; Matsumoto, Michihiro; Accili, Domenico; Tabas, Ira; Tall, Alan R.; Banks, Alexander; Paik, Ji-Hye; DePinho, Ronald A. (American Diabetes Association, 2008)
      OBJECTIVE—Endoplasmic reticulum stress increases macrophage apoptosis, contributing to the complications of atherosclerosis. Insulin-resistant macrophages are more susceptible to endoplasmic reticulum stress–associated ...

    • An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques 

      Fredman, Gabrielle; Hellmann, Jason; Proto, Jonathan D.; Kuriakose, George; Colas, Romain A.; Dorweiler, Bernhard; Connolly, E. Sander; Solomon, Robert; Jones, David M.; Heyer, Eric J.; Spite, Matthew; Tabas, Ira (Nature Publishing Group, 2016)
      Chronic unresolved inflammation plays a causal role in the development of advanced atherosclerosis, but the mechanisms that prevent resolution in atherosclerosis remain unclear. Here, we use targeted mass spectrometry to ...

    • Inflammation and plaque vulnerability 

      Hansson, Goran; Libby, Peter; Tabas, Ira (Wiley-Blackwell, 2015)
      Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs at sites of blood flow disturbance. The disease usually remains silent until a breakdown of integrity at the arterial surface triggers ...

    • Recent insights into the cellular biology of atherosclerosis 

      Tabas, Ira; García-Cardeña, Guillermo; Owens, Gary K. (The Rockefeller University Press, 2015)
      Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at regions of disturbed blood flow and is triggered by an interplay between endothelial dysfunction and subendothelial lipoprotein ...

    • A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins 

      Choi, Won Il; Kamaly, Nazila; Riol-Blanco, Lorena; Lee, In-Hyun; Wu, Jun; Swami, Archana; Vilos, Cristian; Yameen, Basit; Yu, Mikyung; Shi, Jinjun; Tabas, Ira; von Andrian, Ulrich H.; Jon, Sangyong; Farokhzad, Omid C. (American Chemical Society, 2014)
      Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge ...