Browsing Harvard Medical School by Author "Baffy, Gyorgy"
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Complexity and network dynamics in physiological adaptation: An integrated view
Baffy, Gyorgy; Loscalzo, Joseph (Elsevier BV, 2014)Living organisms constantly interact with their surroundings and sustain internal stability against perturbations. This dynamic process follows three fundamental strategies (restore, explore, and abandon) articulated in ... -
Decoding multifocal hepatocellular carcinoma: an opportune pursuit
Baffy, Gyorgy (AME, 2015)Hepatocellular carcinoma (HCC) is a malignancy with major worldwide prevalence and a poor overall prognosis. About 75% of all HCC cases are initially diagnosed as multiple tumors, presenting a particular challenge for ... -
Disordered Purinergic Signaling and Abnormal Cellular Metabolism are Associated with Development of Liver Cancer in Cd39/Entpd1 Null Mice
Sun, Xiaofeng; Han, Lihui; Seth, Pankaj; Bian, Shu; Li, Linglin; Csizmadia, Eva; Junger, Wolfgang; Schmelzle, Moritz; Usheva, Anny; Tapper, Elliot B.; Baffy, Gyorgy; Sukhatme, Vikas; Wu, Yan; Robson, Simon (Wiley, 2013-01)Liver cancer is associated with chronic inflammation, which is linked to immune dysregulation, disordered metabolism and aberrant cell proliferation. CD39/ENTPD1 is an ectonucleotidase that regulates extracellular ... -
Eosinophilic Colitis
Okpara, Nnenna; Aswad, Bassam; Baffy, Gyorgy (Baishideng Publishing Group Inc., 2009-06-28)Eosinophilic colitis (EC) is a rare form of primary eosinophilic gastrointestinal disease with a bimodal peak of prevalence in neonates and young adults. EC remains a little understood condition in contrast to the increasingly ... -
Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention
Baffy, György (XIA & HE Publishing Ltd, 2013)Hepatocellular cancer (HCC) is the fifth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Non-alcoholic fatty liver disease (NAFLD), a spectrum of hepatic disorders associated with ... -
The Impact of Network Medicine in Gastroenterology and Hepatology
Baffy, Gyorgy (Elsevier BV, 2013)In the footsteps of groundbreaking achievements made by biomedical research, another scientific revolution is unfolding. Systems biology draws from the chaos and complexity theory and applies computational models to predict ... -
Metformin and Hepatocellular Carcinoma
Kilaru, Saikiran Mayi; Baffy, Gyorgy (2015)There is ample evidence that type 2 diabetes is an independent risk factor for the development of various cancers including hepatocellular carcinoma (HCC). Metformin, a widely used antidiabetic agent, has been shown to ... -
MicroRNAs in Nonalcoholic Fatty Liver Disease
Baffy, Gyorgy (2015)Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disorder. Strongly linked to obesity and diabetes, NAFLD has the characteristics of complex diseases with substantial heterogeneity. Accordingly, ... -
Mitochondrial recoupling: a novel therapeutic strategy for cancer?
Baffy, Gyorgy; Derdak, Z; Robson, Simon Christopher (Nature Publishing Group, 2011)Recent findings link metabolic transformation of cancer cells to aberrant functions of mitochondrial uncoupling proteins (UCPs). By inducing proton leak, UCPs interfere with mitochondrial synthesis of adenosine 5′-triphosphate, ... -
Mitochondrial uncoupling in cancer cells: Liabilities and opportunities
Baffy, Gyorgy (Elsevier BV, 2017)Acquisition of the endosymbiotic ancestor of mitochondria was a critical event in eukaryote evolution. Mitochon- dria offered an unparalleled source of metabolic energy through oxidative phosphorylation and allowed the de- ... -
The Mitochondrial Uncoupling Protein-2 Promotes Chemoresistance in Cancer Cells
Derdak, Zoltan; Mark, Nicholas M.; Beldi, Guido; Robson, Simon; Wands, Jack R.; Baffy, Gyorgy (American Association for Cancer Research (AACR), 2008-04-15)Cancer cells acquire drug resistance as a result of selection pressure dictated by unfavorable microenvironments. This survival process is facilitated through efficient control of oxidative stress originating from mitochondria ... -
Novel strategies in the pharmacotherapy of nonalcoholic fatty liver disease
Baffy, Gyorgy (Promenade Publishing House, 2016)Nonalcoholic fatty liver disease (NAFLD) affects an estimated one billion people in the world. NAFLD is a spectrum of disease ranging from steatosis to steatohepatitis with variable outcomes that include cirrhosis and ... -
Origins of Portal Hypertension in Nonalcoholic Fatty Liver Disease
Baffy, Gyorgy (Springer Nature, 2018)Nonalcoholic fatty liver disease (NAFLD) advanced to cirrhosis is often complicated by clinically significant portal hypertension, which is primarily caused by increased intrahepatic vascular resistance. Liver fibrosis ... -
Scientific Authors in a Changing World of Scholarly Communication: What Does the Future Hold?
Baffy, Gyorgy; Burns, Michele; Hoffmann, Beatrice; Ramani, Subha; Sabharwal, Sunil; Borus, Jonathan; Pories, Susan; Quan, Stuart; Ingelfinger, Julie (Elsevier BV, 2020-01)Scholarly communication in science, technology and medicine has been organized around journal-based scientific publishing for the past 350 years. Scientific publishing has unique business models and includes stakeholders ... -
Uncoupling protein-2 and non-alcoholic fatty liver disease
Baffy, Gyorgy (Frontiers in Bioscience, 2005)Non-alcoholic fatty liver disease (NAFLD) has become the most common form of hepatic disorders in the developed world. NAFLD is part of the metabolic syndrome with insulin resistance as a primary underlying derangement. ... -
Uncoupling Protein-2 Modulates the Lipid Metabolic Response to Fasting in Mice
Sheets, Anthony; Fülöp, Péter; Derdák, Zoltán; Kassai, Andrea; Sabo, Edmond; Mark, Nicholas M.; Paragh, György; Wands, Jack R.; Baffy, Gyorgy (American Physiological Society, 2008-04)Uncoupling protein-2 (UCP2) regulates insulin secretion by controlling ATP levels in β cells. While UCP2 deficiency improves glycemic control in mice, increased expression of UCP2 interferes with glucose-stimulated insulin ...