Browsing Harvard Medical School by Title
Now showing items 10219-10238 of 18424
-
Lung Biopsy in ARDS: Is It Worth the Risk?
(BioMed Central, 2006)Progress in the treatment of acute respiratory distress syndrome (ARDS) has been slow, perhaps in part due to the heterogeneity in the biology underlying this syndrome. Open lung biopsy is a feasible approach to define ... -
Lung Cancer and Elemental Carbon Exposure in Trucking Industry Workers
(National Institute of Environmental Health Sciences, 2012)Background: Diesel exhaust has been considered to be a probable lung carcinogen based on studies of occupationally exposed workers. Efforts to define lung cancer risk in these studies have been limited in part by lack of ... -
Lung Cancer and Exposure to Nitrogen Dioxide and Traffic: A Systematic Review and Meta-Analysis
(National Institute of Environmental Health Sciences, 2015)Background and objective Exposure to traffic-related air pollutants is an important public health issue. Here, we present a systematic review and meta-analysis of research examining the relationship of measures of nitrogen ... -
Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies
(Public Library of Science, 2008)Background: Better information on lung cancer occurrence in lifelong nonsmokers is needed to understand gender and racial disparities and to examine how factors other than active smoking influence risk in different time ... -
Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4
(The Rockefeller University Press, 2013)T cell trafficking into the lung is critical for lung immunity, but the mechanisms that mediate T cell lung homing are not well understood. Here, we show that lung dendritic cells (DCs) imprint T cell lung homing, as lung ... -
Lung Hyperinflation and Cardiac Impairment in Chronic Obstructive Pulmonary Disease
(2016-05-18)Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity worldwide. Significantly, COPD carries a 2-5 fold increased risk of cardiovascular disease (CVD). This association persists even ... -
Lung Injury Prediction Score for the Emergency Department: First Step Towards Prevention in Patients at Risk
(Springer, 2012)Background: Early identification of patients at risk of developing acute lung injury (ALI) is critical for potential preventive strategies. We aimed to derive and validate an acute lung injury prediction score (EDLIPS) in ... -
Lung Injury Prevention with Aspirin (LIPS-A): a Protocol for a Multicentre Randomised Clinical Trial in Medical Patients at High Risk of Acute Lung Injury
(BMJ Publishing Group, 2012)Introduction: Acute lung injury (ALI) is a devastating condition that places a heavy burden on public health resources. Although the need for effective ALI prevention strategies is increasingly recognised, no effective ... -
Lung MRI and impairment of diaphragmatic function in Pompe disease
(BioMed Central, 2015)Background: Pompe disease is a progressive metabolic myopathy. Involvement of respiratory muscles leads to progressive pulmonary dysfunction, particularly in supine position. Diaphragmatic weakness is considered to be the ... -
The LUNG SAFE: a biased presentation of the prevalence of ARDS!
(BioMed Central, 2016)The recent Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) challenges current data on the prevalence of acute respiratory distress syndrome (ARDS). The LUNG SAFE ... -
Lung Stem and Progenitor Cells in Tissue Homeostasis and Disease
(Elsevier, 2014)The mammalian lung is a complex organ containing numerous putative stem/progenitor cell populations that contribute to region-specific tissue homeostasis and repair. In this review, we discuss recent advances in identifying ... -
Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis
(Elsevier BV, 2014-01-30)Lung stem cells are instructed to produce lineage-specific progeny through unknown factors in their microenvironment. We used clonal three-dimensional (3D) co-cultures of endothelial cells and distal lung stem cells, ... -
Lung Stem Cell Self-Renewal Relies on BMI1-Dependent Control of Expression at Imprinted Loci
(Elsevier BV, 2011-09-02)Bmi1 is required for the self-renewal of stem cells in many tissues including the lung epithelial stem cells, Bronchioalveolar Stem Cells (BASCs). Imprinted genes, which exhibit expression from only the maternally- or ... -
Lupus-Prone Mice Fail to Raise Antigen-Specific T Cell Responses to Intracellular Infection
(Public Library of Science, 2014)Systemic lupus erythematosus (SLE) is characterized by multiple cellular abnormalities culminating in the production of autoantibodies and immune complexes, resulting in tissue inflammation and organ damage. Besides active ... -
Lurasidone for the treatment of bipolar depression: an evidence-based review
(Dove Medical Press, 2015)Bipolar disorder (BD) is a debilitating and difficult-to-treat psychiatric disease that presents a serious burden to patients’ lives as well as health care systems around the world. The essential diagnostic criterion for ... -
Lutein Protects against Methotrexate-Induced and Reactive Oxygen Species-Mediated Apoptotic Cell Injury of IEC-6 Cells
(Public Library of Science, 2013)Purpose High-dose chemotherapy using methotrexate (MTX) frequently induces side effects such as mucositis that leads to intestinal damage and diarrhea. Several natural compounds have been demonstrated of their effectiveness ... -
Lüer’s Lure: From an International Standards Perspective
(Ovid Technologies (Wolters Kluwer Health), 2012-12-01) -
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
(American Society for Clinical Investigation, 2007)Macrophage accumulation participates decisively in the development and exacerbation of atherosclerosis. Circulating monocytes, the precursors of macrophages, display heterogeneity in mice and humans, but their relative ... -
Ly-6Chigh Monocytes Depend on Nr4a1 to Balance both Inflammatory and Reparative Phases in the Infarcted Myocardium
(American Heart Association, 2014)Rationale: Healing after myocardial infarction involves the biphasic accumulation of inflammatory lymphocyte antigen 6C (Ly-6C)(high) and reparative Ly-6C(low) monocytes/macrophages (Mo/M). According to 1 model, Mo/M ... -
Lyapunov Exponents and Phase Diagrams Reveal Multi-Factorial Control over TRAIL-Induced Apoptosis
(Nature Publishing Group, 2011)Receptor-mediated apoptosis proceeds via two pathways: one requiring only a cascade of initiator and effector caspases (type I behavior) and the second requiring an initiator–effector caspase cascade and mitochondrial outer ...