Browsing Harvard Medical School by Title

Now showing items 1063-1082 of 18428

    • Arterial versus venous endothelial cells 

      dela Paz, Nathaniel G.; D'Amore, Patricia Ann (Springer Nature, 2008)
      Vascular endothelial cells (ECs) form the inner lining of all blood vessels from the largest artery and veins, viz., the aorta and venae cavae, respectively, to the capillaries that connect the arterial and venous systems. ...

    • Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms 

      Stalmans, Ingeborg; Ng, Yin-Shan; Rohan, Richard; Fruttiger, Marcus; Bouché, Ann; Yuce, Ali; Fujisawa, Hajime; Hermans, Bart; Shani, Moshe; Jansen, Sandra; Hicklin, Dan; Anderson, David J.; Gardiner, Tom; Hammes, Hans-Peter; Moons, Lieve; Dewerchin, Mieke; Collen, Désiré; Carmeliet, Peter; D'Amore, Patricia Ann (American Society for Clinical Investigation, 2002)
      The murine VEGF gene is alternatively transcribed to yield the VEGF120, VEGF164, and VEGF188 isoforms, which differ in their potential to bind to heparan sulfate and neuropilin-1 and to stimulate endothelial growth. Here, ...

    • Arthritis Critically Dependent on Innate Immune System Players 

      Ji, Hong; Ohmura, Koichiro; Mahmood, Umar; Lee, David M.; Hofhuis, Frans M. A.; Boackle, Susan A.; Takahashi, Kazue; Holers, V.Michael; Walport, Mark; Gerard, Craig; Ezekowitz, Alan; Carroll, Michael C.; Brenner, Michael; Weissleder, Ralph; Verbeek, J.Sjef; Duchatelle, Veronique; Degott, Claude; Benoist, Christophe; Mathis, Diane (Elsevier, 2002)

    • Arthritis Imaging Using a Near-Infrared Fluorescence Folate-Targeted Probe 

      Chen, Wei-Tsung; Mahmood, Umar; Weissleder, Ralph; Tung, Ching-Hsuan (BioMed Central, 2005)
      A recently developed near-infrared fluorescence-labeled folate probe (NIR2-folate) was tested for in vivo imaging of arthritis using a lipopolysaccharide intra-articular injection model and a KRN transgenic mice serum ...

    • Article 1: Supervision, Performance Assessment, and Recognition Strategy (SPARS) - a multipronged intervention strategy for strengthening medicines management in Uganda: method presentation and facility performance at baseline 

      Trap, Birna; Ladwar, Denis Okidi; Oteba, Martin Olowo; Embrey, Martha; Khalid, Mohammed; Wagner, Anita Katharina (BioMed Central, 2016)
      Background: Uganda introduced a multipronged intervention, the supervision, performance assessment, and recognition strategy (SPARS), to improve medicines management (MM) in public and not-for-profit health facilities. ...

    • Articular cartilage generation applying PEG-LA-DM/PEGDM copolymer hydrogels 

      Zhao, Xing; Papadopoulos, Anestis; Ibusuki, Shinichi; Bichara, David A.; Saris, Daniel B.; Malda, Jos; Anseth, Kristi S.; Gill, Thomas J.; Randolph, Mark A. (BioMed Central, 2016)
      Background: Injuries to the human native cartilage tissue are particularly problematic because cartilage has little to no ability to heal or regenerate itself. Employing a tissue engineering strategy that combines suitable ...

    • Articular Cartilage Injury in Athletes 

      McAdams, Timothy R.; Mithoefer, Kai; Scopp, Jason M.; Mandelbaum, Bert R. (SAGE Publications, 2010)
      Articular cartilage lesions in the athletic population are observed with increasing frequency and, due to limited intrinsic healing capacity, can lead to progressive pain and functional limitation over time. If left ...

    • Articular cartilage of the knee 3 years after ACL reconstruction: A quantitative T2 relaxometry analysis of 10 knees 

      Bae, Ji-Hoon; Hosseini, Ali; Wang, Yang; Torriani, Martin; Gill, Thomas J; Grodzinsky, Alan J; Li, Guoan (Informa Healthcare, 2015)
      Background and purpose T1ρ or T2 relaxation imaging has been increasingly used to evaluate the cartilage of the knee. We investigated the cartilage of ACL-reconstructed knees 3 years after surgery using T2 relaxation times. ...

    • Artificial Arterial Blood Pressure Artifact Models and an Evaluation of a Robust Blood Pressure and Heart Rate Estimator 

      Li, Qiao; Mark, Roger Greenwood; Clifford, Gari D (BioMed Central, 2009)
      Background: Within the intensive care unit (ICU), arterial blood pressure (ABP) is typically recorded at different (and sometimes uneven) sampling frequencies, and from different sensors, and is often corrupted by different ...

    • Artificial Polymeric Scaffolds as Extracellular Matrix Substitutes for Autologous Conjunctival Goblet Cell Expansion 

      He, Min; Storr-Paulsen, Thomas; Wang, Annie L.; Ghezzi, Chiara E.; Wang, Siran; Fullana, Matthew; Karamichos, Dimitrios; Utheim, Tor P.; Islam, Rakibul; Griffith, May; Islam, M. Mirazul; Hodges, Robin R.; Wnek, Gary E.; Kaplan, David L.; Dartt, Darlene A. (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose We fabricated and investigated polymeric scaffolds that can substitute for the conjunctival extracellular matrix to provide a substrate for autologous expansion of human conjunctival goblet cells in culture. Methods: ...

    • ARTIST: High-Resolution Genome-Wide Assessment of Fitness Using Transposon-Insertion Sequencing 

      Pritchard, Justin R.; Chao, Michael C.; Abel, Sören; Davis, Brigid M.; Baranowski, Catherine; Zhang, Yanjia J.; Rubin, Eric J.; Waldor, Matthew K. (Public Library of Science, 2014)
      Transposon-insertion sequencing (TIS) is a powerful approach for deciphering genetic requirements for bacterial growth in different conditions, as it enables simultaneous genome-wide analysis of the fitness of thousands ...

    • The “ART” of Linkage: Pre-Treatment Loss to Care after HIV Diagnosis at Two PEPFAR Sites in Durban, South Africa 

      Losina, Elena; Bassett, Ingrid; Giddy, Janet; Chetty, Senica; Regan, Susan; Walensky, Rochelle; Ross, Douglas; Scott, Callie A.; Uhler, Lauren M.; Katz, Jeffrey; Holst, Helga; Freedberg, Kenneth (Public Library of Science (PLoS), 2010-03-04)
      Background Although loss to follow-up after antiretroviral therapy (ART) initiation is increasingly recognized, little is known about pre-treatment losses to care (PTLC) after an initial positive HIV test. Our objective ...

    • Arylbenzazepines Are Potent Modulators for the Delayed Rectifier K+ Channel: A Potential Mechanism for Their Neuroprotective Effects 

      Chen, Xue-Qin; Jin, Guo-Zhang; Hu, Guo-Yuan; Zhang, Ao; Zhen, Xuechu; Bernhard, Eric J.; Zhang, Jing; Neumeyer, John Leopold (Public Library of Science, 2009)
      (±) SKF83959, like many other arylbenzazepines, elicits powerful neuroprotection in vitro and in vivo. The neuroprotective action of the compound was found to partially depend on its D1-like dopamine receptor agonistic ...

    • as-PSOCT: Volumetric microscopic imaging of human brain architecture and connectivity 

      Wang, Hui; Magnain, Caroline; Wang, Ruopeng; Dubb, Jay; Varjabedian, Ani; Tirrell, Lee; Stevens, Allison; Augustinack, Jean; Konukoglu, Ender; Aganj, Iman; Frosch, Matthew; Schmahmann, Jeremy; Fischl, Bruce; Boas, David (Elsevier BV, 2018-01)
      Polarization sensitive optical coherence tomography (PSOCT) with serial sectioning has enabled the investigation of 3D structures in mouse and human brain tissue samples. By using intrinsic optical properties of back-scattering ...

    • AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin 

      Cheng, Ye; Zhao, Gang; Zhang, Siwen; Nigim, Fares; Zhou, Guangtong; Yu, Zhiyun; Song, Yang; Chen, Yong; Li, Yunqian (Public Library of Science, 2016)
      AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I and II clinical trials for the treatment of several cancers. However, the mechanisms by which AS1411 targets and kills glioma cells ...

    • Asbestos and shipbuilding: fatal consequences 

      Hedley-Whyte, John; Milamed, Debra (The Ulster Medical Society, 2008)
      The severe bombing of Belfast in 1941 had far-reaching consequences. Harland and Wolff was crippled. The British Merchant Ship Building Mission to the USA was being constrained by the UK treasury. On being told of the ...

    • Asbestos Burden Predicts Survival in Pleural Mesothelioma 

      Christensen, Brock C.; Godleski, John Joseph; Roelofs, Cora R.; Longacker, Jennifer L.; Bueno, Raphael; Sugarbaker, David John; Marsit, Carmen J.; Nelson, Heather H.; Kelsey, Karl T. (National Institute of Environmental Health Sciences, 2008)
      Background: Malignant pleural mesothelioma (MPM) is a rapidly fatal asbestos-associated malignancy with a median survival time of < 1 year following diagnosis. Treatment strategy is determined in part using known ...

    • Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma 

      Christensen, Brock C.; Godleski, John Joseph; Marsit, Carmen J.; Houseman, Eugene Andres; Lopez-Fagundo, Cristina Y.; Longacker, Jennifer L.; Bueno, Raphael; Sugarbaker, David John; Nelson, Heather H.; Kelsey, Karl T. (Oxford University Press, 2008)
      Malignant pleural mesothelioma (MPM) is a rapidly fatal tumor with increasing incidence worldwide responsible for many thousands of deaths annually. Although there is a clear link between exposure to asbestos and mesothelioma, ...

    • Ascites analysis by a microfluidic chip allows tumor-cell profiling 

      Peterson, Vanessa M.; Castro, Cesar M.; Chung, Jaehoon; Miller, Nathan C.; Ullal, Adeeti V.; Castano, Maria D.; Penson, Richard T.; Lee, Hakho; Birrer, Michael J.; Weissleder, Ralph (National Academy of Sciences, 2013)
      Ascites tumor cells (ATCs) represent a potentially valuable source of cells for monitoring treatment of ovarian cancer as it would obviate the need for more invasive surgical biopsies. The ability to perform longitudinal ...

    • Ascorbic Acid Prevents Loss of Dlk1-Dio3 Imprinting and Facilitates Generation of All-iPS Cell Mice from Terminally Differentiated B Cells 

      Stadtfeld, Matthias; Apostolou, Effie; Chen, Taiping; Oi, Steen; Bestor, Tim; Ferrari, Francesco; Choi, Jiho; Walsh, Ryan Michael; Kim, Sang Yong; Shioda, Toshi; Park, Peter J.; Hochedlinger, Konrad (Nature Publishing Group, 2012)
      The generation of induced pluripotent stem cells (iPSCs) often results in aberrant epigenetic silencing of the imprinted Dlk1-Dio3 gene cluster, compromising the ability to generate entirely iPSC-derived adult mice ('all-iPSC ...