Now showing items 10711-10730 of 18424

    • METAmplification Identifies a Small and Aggressive Subgroup of Esophagogastric Adenocarcinoma With Evidence of Responsiveness to Crizotinib 

      Lennerz, J. K.; Kwak, E. L.; Ackerman, Allison Kalben; Michael, M.; Fox, S. B.; Bergethon, K.; Lauwers, Gregory Y.; Christensen, J. G.; Wilner, K. D.; Haber, Daniel Arie; Salgia, R.; Bang, Y.-J.; Clark, Jeffrey William; Solomon, B. J.; Iafrate, Anthony John (American Society of Clinical Oncology (ASCO), 2011)
      Purpose: Amplification of the MET proto-oncogene in gastroesophageal cancer (GEC) may constitute a molecular marker for targeted therapy. We examined a GEC cohort with follow-up and reported the clinical response of four ...
    • MetaRanker 2.0: a web server for prioritization of genetic variation data 

      Pers, Tune H.; Dworzyński, Piotr; Thomas, Cecilia Engel; Lage, Kasper; Brunak, Søren (Oxford University Press, 2013)
      MetaRanker 2.0 is a web server for prioritization of common and rare frequency genetic variation data. Based on heterogeneous data sets including genetic association data, protein–protein interactions, large-scale text-mining ...
    • Metastasis is an Early Event in Mouse Mammary Carcinomas and is Associated with Cells Bearing Stem Cell Markers 

      Weng, Desheng; Penzner, Jeffrey H; Song, Baizheng; Koido, Shigeo; Calderwood, Stuart K.; Gong, Jianlin (BioMed Central, 2012)
      Introduction: It is still uncertain whether metastasis is predominantly an early or late event in tumor progression. The detection of early metastases and cells responsible for the dissemination may therefore have significant ...
    • A metastasis map of human cancer cell lines 

      Jin, Xin; Demere, Zelalem; Nair, Karthik; Ali, Ahmed; Ferraro, Gino; Natoli, Ted; Deik, Amy; Petronio, Lia; Tang, Andrew A.; Zhu, Cong; Wang, Li; Rosenberg, Danny; Mangena, Vamsi; Roth, Jennifer; Chung, Kwanghun; Jain, Rakesh; Clish, Clary B.; Vander Heiden, Matthew G.; Golub, Todd R. (Springer Science and Business Media LLC, 2020-12-09)
      Most deaths from cancer are explained by metastasis, and yet large-scale metastasis research has been impractical due to the complexity of in vivo models. Here, we introduce an in vivo barcoding strategy capable of determining ...
    • Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model 

      Duquette, Mark; Sadow, Peter M.; Husain, Amjad; Sims, Jennifer N.; Antonello, Zeus A.; Fischer, Andrew H.; Song, Chen; Castellanos-Rizaldos, Elena; Makrigiorgos, G. Mike; Kurebayashi, Junichi; Nose, Vania; Van Hummelen, Paul; Bronson, Roderick T.; Vinco, Michelle; Giordano, Thomas J.; Dias-Santagata, Dora; Pandolfi, Pier Paolo; Nucera, Carmelo (Impact Journals LLC, 2015)
      BRAFV600E mutation exerts an essential oncogenic function in many tumors, including papillary thyroid carcinoma (PTC). Although BRAFV600E inhibitors are available, lack of response has been frequently observed. To study ...
    • Metastatic Breast Cancer With ESR1 Mutation: Clinical Management Considerations From the Molecular and Precision Medicine (MAP) Tumor Board at Massachusetts General Hospital 

      Bardia, Aditya; Iafrate, John A.; Sundaresan, Tilak; Younger, Jerry; Nardi, Valentina (AlphaMed Press, 2016)
      The last decade in oncology has witnessed impressive response rates with targeted therapies, largely because of collaborative efforts at understanding tumor biology and careful patient selection based on molecular ...
    • Metastatic pattern of uterine leiomyosarcoma: retrospective analysis of the predictors and outcome in 113 patients 

      Tirumani, Sree Harsha; Deaver, Pamela; Shinagare, Atul B.; Tirumani, Harika; Hornick, Jason L.; George, Suzanne; Ramaiya, Nikhil H. (Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology, 2014)
      Objective: To describe metastatic pattern of uterine leiomyosarcomas (ULMS) and correlate it with clinical and histopathologic parameters. Methods: We included 113 women (mean age, 53 years; range, 29 to 72 years) with ...
    • Metastatic Renal Cell Carcinoma to the Sinonasal Cavity: A Case Series 

      Remenschneider, Aaron K.; Sadow, Peter M.; Lin, Derrick T.; Gray, Stacey T. (Georg Thieme Verlag KG, 2013)
      Objectives: To describe the presentation, work-up, and management of patients with metastatic renal cell carcinoma (RCC) to the sinonasal cavity and skull base, and to describe our current treatment algorithm of endoscopic ...
    • Metasurface-based bijective illumination collection imaging provides high-resolution tomography in three dimensions 

      Pahlevaninezhad, Masoud; Huang, Yao-Wei; Pahlevani, Majid; Bouma, Brett; Suter, Melissa J.; Capasso, Federico; Pahlevaninezhad, Hamid (Springer Science and Business Media LLC, 2022-02-14)
    • Metformin and Hepatocellular Carcinoma 

      Kilaru, Saikiran Mayi; Baffy, Gyorgy (2015)
      There is ample evidence that type 2 diabetes is an independent risk factor for the development of various cancers including hepatocellular carcinoma (HCC). Metformin, a widely used antidiabetic agent, has been shown to ...
    • Metformin improves healthspan and lifespan in mice 

      Martin-Montalvo, Alejandro; Mercken, Evi M.; Mitchell, Sarah J.; Palacios, Hector H.; Mote, Patricia L.; Scheibye-Knudsen, Morten; Gomes, Ana P.; Ward, Theresa M.; Minor, Robin K.; Blouin, Marie-José; Schwab, Matthias; Pollak, Michael; Zhang, Yongqing; Yu, Yinbing; Becker, Kevin G.; Bohr, Vilhelm A.; Ingram, Donald K.; Sinclair, David A.; Wolf, Norman S.; Spindler, Stephen R.; Bernier, Michel; de Cabo, Rafael (2013)
      Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan and lifespan in male mice, ...
    • Metformin Inhibits Proinflammatory Responses and Nuclear Factor-\(\kappa\)B in Human Vascular Wall Cells 

      Isoda, Kikuo; Young, James Leroy; Zirlik, Andreas; MacFarlane, Lindsey Adair; Tsuboi, Naotake; Gerdes, Norbert; Schönbeck, Uwe; Libby, Peter (American Heart Association, 2006)
      Objective. Metformin may benefit the macrovascular complications of diabetes independently of its conventional hypoglycemic effects. Accumulating evidence suggests that inflammatory processes participate in type 2 diabetes ...
    • Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages 

      Incio, Joao; Suboj, Priya; Chin, Shan M.; Vardam-Kaur, Trupti; Liu, Hao; Hato, Tai; Babykutty, Suboj; Chen, Ivy; Deshpande, Vikram; Jain, Rakesh K.; Fukumura, Dai (Public Library of Science, 2015)
      Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with a dismal prognosis for most patients. Fibrosis and inflammation are hallmarks of tumor desmoplasia. We have previously demonstrated ...
    • Metformin represses cancer cells via alternate pathways in N-cadherin expressing vs. N-cadherin deficient cells 

      Ge, Rongbin; Wang, Zongwei; Wu, Shulin; Zhuo, Yangjia; Otsetov, Aleksandar G.; Cai, Chao; Zhong, Weide; Wu, Chin-Lee; Olumi, Aria F. (Impact Journals LLC, 2015)
      Metformin has emerged as a potential anticancer agent. Here, we demonstrate that metformin plays an anti-tumor role via repressing N-cadherin, independent of AMPK, in wild-type N-cadherin cancer cells. Ectopic-expression ...
    • Metformin Therapy in a Hyperandrogenic Anovulatory Mutant Murine Model with Polycystic Ovarian Syndrome Characteristics Improves Oocyte Maturity during Superovulation 

      Sabatini, Mary Elizabeth; Guo, Lankai; Lynch, Maureen Patricia; Doyle, Joseph O'Brien; Lee, HoJoon; Rueda, Bo Ruben; Styer, Aaron Kyle (BioMed Central, 2011)
      Background: Metformin, an oral biguanide traditionally used for the treatment of type 2 diabetes, is widely used for the management of polycystic ovary syndrome (PCOS)-related anovulation. Because of the significant ...
    • Metformin versus Placebo in Obese Pregnant Women without Diabetes 

      Stanford, Fatima Cody; Alfaris, Nasreen; Misra, Madhusmita (Massachusetts Medical Society, 2016)
      Syngelaki et al. (Feb. 4 issue)1 describe the efficacy of metformin in reducing gestational weight gain in women with a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of more ...
    • Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice 

      Li, Mingchang; Wang, Wei; Mai, Haojian; Zhang, Xinmu; Wang, Jian; Gao, Yufeng; Wang, Yuefei; Deng, Gang; Gao, Ling; Zhou, Shuanhu; Chen, Qianxue; Wang, Xin (Nature Publishing Group, 2016)
      Subarachnoid hemorrhage (SAH) results in significant nerve dysfunction, such as hemiplegia, mood disorders, cognitive and memory impairment. Currently, no clear measures can reduce brain nerve damage. The study of brain ...
    • Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections 

      Waters, Elaine M.; Rudkin, Justine K.; Schaeffer, Carolyn R.; Lohan, Amanda J.; Tong, Pin; Loftus, Brendan J.; Fey, Paul D.; Massey, Ruth C.; O'Gara, James P.; Pozzi, Clarissa; Pier, Gerald B. (Public Library of Science, 2012)
      Clinical isolates of Staphylococcus aureus can express biofilm phenotypes promoted by the major cell wall autolysin and the fibronectin-binding proteins or the icaADBC-encoded polysaccharide intercellular adhesin/poly-N- ...
    • Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino acid status 

      Lee, Byung Cheon; Kaya, Alaattin; Ma, Siming; Kim, Gwansu; Gerashchenko, Maxim V.; Yim, Sun Hee; Hu, Zhen; Harshman, Lawrence G.; Gladyshev, Vadim N. (2014)
      Reduced methionine (Met) intake can extend lifespan of rodents, but whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in ...
    • A Method for Clustering White Matter Fiber Tracts 

      O'Donnell, Lauren Jean; Kubicki, Marek R.; Shenton, Martha Elizabeth; Dreusicke, M.H.; Grimson, W.E.L.; Westin, Carl-Fredrik (American Society of Neuroradiology, 2006)
      BACKGROUND/PURPOSE: Despite its potential for visualizing white matter fiber tracts in vivo, diffusion tensor tractography has found only limited applications in clinical research in which specific anatomic connections ...