Browsing Harvard Medical School by Title
Now showing items 11071-11090 of 18428
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Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival
(American Society for Microbiology, 2002) -
Molecular basis of caspase-1 polymerization and its inhibition by a novel capping mechanism
(2016)Inflammasomes are cytosolic caspase-1 activation complexes that sense intrinsic and extrinsic danger signals to trigger inflammatory responses and pyroptotic cell death. Homotypic interactions by Pyrin domains (PYD) and ... -
Molecular basis of ion permeability in a voltage‐gated sodium channel
(John Wiley and Sons Inc., 2016)Abstract Voltage‐gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events ... -
Molecular Biomarkers of Vascular Dysfunction in Obstructive Sleep Apnea
(Public Library of Science, 2013)Untreated and long-lasting obstructive sleep apnea (OSA) may lead to important vascular abnormalities, including endothelial cell (EC) dysfunction, hypertension, and atherosclerosis. We observed a correlation between ... -
Molecular characterization and quantification using state of the art solid-state adiabatic TOBSY NMR in burn trauma
(D.A. Spandidos, 2009)We describe a novel solid-state nuclear magnetic resonance (NMR) method that maximizes the advantages of high-resolution magic-angle-spinning (HRMAS), relative conventional liquid-state NMR approaches, when applied to ... -
Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance
(Elsevier, 2014)Advances in nanotechnology and microfluidics are enabling the analysis of small amounts of human cells. We tested whether recently developed micro-nuclear magnetic resonance (mu NMR) technology could be leveraged for ... -
The Molecular Characterization of the Mitochondrial Calcium Uniporter
(2014-07-07)By buffering cytosolic calcium, mitochondria can shape the magnitude and duration of intracellular calcium transients, which in turn govern key physiological events. Although controlled uptake of calcium into the matrix ... -
Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala
(Nature Publishing Group, 2016)Molecular characterization of neuron populations, particularly those controlling threat responses, is essential for understanding the cellular basis of behaviour and identifying pharmacological agents acting selectively ... -
Molecular Cochaperones: Tumor Growth and Cancer Treatment
(Hindawi Publishing Corporation, 2013)Molecular chaperones play important roles in all cellular organisms by maintaining the proteome in an optimally folded state. They appear to be at a premium in cancer cells whose evolution along the malignant pathways ... -
Molecular Dissection of the Essential Features of the Origin of Replication of the Second Vibrio cholerae Chromosome
(American Society of Microbiology, 2015)ABSTRACT Vibrionaceae family members are interesting models for studying DNA replication initiation, as they contain two circular chromosomes. Chromosome II (chrII) replication is governed by two evolutionarily unique yet ... -
Molecular driver alterations and their clinical relevance in cancer of unknown primary site
(Impact Journals LLC, 2016)Cancer of unknown primary (CUP) is defined as metastatic solid malignancy where no primary tumor is detected despite appropriate staging. About 90% of CUP represent adenocarcinoma or undifferentiated carcinoma. Since therapy ... -
Molecular Etiology of Hearing Impairment in Inner Mongolia: Mutations in SLC26A4 Gene and Relevant Phenotype Analysis
(BioMed Central, 2008)Background: The molecular etiology of hearing impairment in Chinese has not been thoroughly investigated. Study of GJB2 gene revealed that 30.4% of the patients with hearing loss in Inner Mongolia carried GJB2 mutations. ... -
Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1
(Public Library of Science, 2014)To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been ... -
Molecular evolution of human adenoviruses
(Nature Publishing Group, 2013)The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the ... -
Molecular Genetic Analysis of Revertants from a Poliovirus Mutant That Is Specifically Adapted to the Mouse Spinal Cord
(American Society for Microbiology, 2001)SA virus, a mutant of the Mahoney strain of type 1 poliovirus (PV1/Mahoney), replicates specifically in the spinal cords of mice and causes paralysis, although the PV1/Mahoney strain does not show any mouse neurovirulence ... -
Molecular Genetics of FAM161A in North American Patients with Early-Onset Retinitis Pigmentosa
(Public Library of Science, 2014)Retinitis pigmentosa (RP) is a hereditary disease that leads to the progressive degeneration of retinal photoreceptor cells and to blindness. It is caused by mutations in several distinct genes, including the ciliary gene ... -
The Molecular Genetics of Head Development in Drosophila melanogaster
(The Company of Biologists, 1991-08-01) -
Molecular Identification and Epidemiological Features of Human Adenoviruses Associated with Acute Respiratory Infections in Hospitalized Children in Southern China, 2012-2013
(Public Library of Science, 2016)Background: Acute respiratory infections (ARI) are the major worldwide health problem associated with high morbidity and mortality rates. Human adenovirus (HAdV) is one of the most common pathogens associated with viral ... -
Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging
(Nature Publishing Group, 2013)Drug transit through the blood-brain barrier (BBB) is essential for therapeutic responses in malignant glioma. Conventional methods for assessment of BBB penetrance require synthesis of isotopically labeled drug derivatives. ... -
Molecular Imaging of Inflammation in Atherosclerosis
(Ivyspring International Publisher, 2013)Acute rupture of vulnerable plaques frequently leads to myocardial infarction and stroke. Within the last decades, several cellular and molecular players have been identified that promote atherosclerotic lesion formation, ...