Browsing Harvard Medical School by Title
Now showing items 11111-11130 of 18428
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Molecular Sampling of Prostate Cancer: A Dilemma for Predicting Disease Progression
(BioMed Central, 2010)Background: Current prostate cancer prognostic models are based on pre-treatment prostate specific antigen (PSA) levels, biopsy Gleason score, and clinical staging but in practice are inadequate to accurately predict disease ... -
Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses
(Public Library of Science, 2014)Recent studies have shown high usage of the IGHV1-69 germline immunoglobulin gene for influenza hemagglutinin stem-directed broadly-neutralizing antibodies (HV1-69-sBnAbs). Here we show that a major structural solution for ... -
Molecular stratification of metastatic melanoma using gene expression profiling : Prediction of survival outcome and benefit from molecular targeted therapy
(Impact Journals LLC, 2015)Melanoma is currently divided on a genetic level according to mutational status. However, this classification does not optimally predict prognosis. In prior studies, we have defined gene expression phenotypes (high-immune, ... -
Molecular Structure and Dimeric Organization of the Notch Extracellular Domain as Revealed by Electron Microscopy
(Public Library of Science, 2010)Background: The Notch receptor links cell fate decisions of one cell to that of the immediate cellular neighbor. In humans, malfunction of Notch signaling results in diseases and congenital disorders. Structural information ... -
Molecular Subgroups of Medulloblastoma: an International Meta-Analysis of Transcriptome, Genetic Aberrations, and Clinical Data of WNT, SHH, Group 3, and Group 4 Medulloblastomas
(Springer-Verlag, 2012)Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies from several groups around the world demonstrated that medulloblastoma is not one disease but comprises a collection of distinct ... -
Molecular Subgroups of Medulloblastoma: The Current Consensus
(Springer-Verlag, 2011)Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of morbidity and mortality in pediatric oncology. Current mechanisms for clinical prognostication and stratification include clinical factors ... -
Molecular T Cell Biology – Basic and Translational Challenges in the Twenty-First Century
(Frontiers Research Foundation, 2011) -
Molecular Threading: Mechanical Extraction, Stretching and Placement of DNA Molecules from a Liquid-Air Interface
(Public Library of Science, 2013)We present “molecular threading”, a surface independent tip-based method for stretching and depositing single and double-stranded DNA molecules. DNA is stretched into air at a liquid-air interface, and can be subsequently ... -
Molecular Weight Assessment of Proteins in Total Proteome Profiles Using 1D-PAGE and LC/MS/MS
(BioMed Central, 2005)Background: The observed molecular weight of a protein on a 1D polyacrylamide gel can provide meaningful insight into its biological function. Differences between a protein's observed molecular weight and that predicted ... -
Molecular, Spatial, and Functional Single-Cell Profiling of the Hypothalamic Preoptic Region
(American Association for the Advancement of Science (AAAS), 2018-11-16)The hypothalamus controls essential social behaviors and homeostatic functions. However, the cellular architecture of hypothalamic nuclei, including the molecular identity, spatial organization, and function of distinct ... -
Molecularly Self-Assembled Nucleic Acid Nanoparticles for Targeted In Vivo siRNA Delivery
(2013)Nanoparticles are employed for delivering therapeutics into cells1,2. However, size, shape, surface chemistry and the presentation of targeting ligands on the surface of nanoparticles can affect circulation half-life and ... -
Monitoring and visualization techniques for MR-guided laser ablations in an open MR system
(Wiley-Blackwell, 1998)Our purpose was to develop temperature sensitive MR sequences and image-processing techniques to asses their potential of monitoring interstitial laser therapy (ILT) in brain tumors (n = 3) and liver tumors (n = 7). ILT ... -
Monitoring Disease Trends using Hospital Traffic Data from High Resolution Satellite Imagery: A Feasibility Study
(Nature Publishing Group, 2015)Challenges with alternative data sources for disease surveillance include differentiating the signal from the noise, and obtaining information from data constrained settings. For the latter, events such as increases in ... -
Monitoring iCCM referral systems: Bugoye Integrated Community Case Management Initiative (BIMI) in Uganda
(BioMed Central, 2016)Background: In Uganda, over half of under-five child mortality is attributed to three infectious diseases: malaria, pneumonia and diarrhoea. Integrated community case management (iCCM) trains village health workers (VHWs) ... -
Monitoring Influenza Epidemics in China with Search Query from Baidu
(Public Library of Science, 2013)Several approaches have been proposed for near real-time detection and prediction of the spread of influenza. These include search query data for influenza-related terms, which has been explored as a tool for augmenting ... -
Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors
(2015)Methionine can be reversibly oxidized to methionine sulfoxide (MetO) under physiological and pathophysiological conditions, but its use as a redox marker suffers from the lack of tools to detect and quantify MetO within ... -
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging
(Nature Publishing Group, 2016)The study of amyotrophic lateral sclerosis (ALS) and potential interventions would be facilitated if motor axon degeneration could be more readily visualized. Here we demonstrate that stimulated Raman scattering (SRS) ... -
Monitoring Processed, Mature Human Immunodeficiency Virus Type 1 Particles Immediately Following Treatment with a Protease Inhibitor-containing Treatment Regimen
(BioMed Central, 2005)Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor ... -
Monkeypox Virus Infection of Rhesus Macaques Induces Massive Expansion of Natural Killer Cells but Suppresses Natural Killer Cell Functions
(Public Library of Science, 2013)Natural killer (NK) cells play critical roles in innate immunity and in bridging innate and adaptive immune responses against viral infection. However, the response of NK cells to monkeypox virus (MPXV) infection is not ... -
Mono- and Biallelic Variant Effects on Disease at Biobank Scale
(Springer Science and Business Media LLC, 2023-01-18)Identifying causal factors for Mendelian and common diseases is an ongoing challenge in medical genetics 1 . Population bottleneck events, such as in the Finnish population history, enrich some homozygous variants to ...