Browsing Harvard Medical School by Title

Now showing items 1119-1138 of 18428

    • Assessing the acceptability and feasibility of encounter decision aids for early stage breast cancer targeted at underserved patients 

      Alam, Shama; Elwyn, Glyn; Percac-Lima, Sanja; Grande, Stuart; Durand, Marie-Anne (BioMed Central, 2016)
      Background: Women of low socioeconomic status (SES) diagnosed with early stage breast cancer are less likely to be involved in treatment decisions. They tend to report higher decisional regret and poorer communication. ...

    • Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses 

      Khawaja, Anthony P.; Cooke Bailey, Jessica N.; Kang, Jae Hee; Allingham, R. Rand; Hauser, Michael A.; Brilliant, Murray; Budenz, Donald L.; Christen, William G.; Fingert, John; Gaasterland, Douglas; Gaasterland, Terry; Kraft, Peter; Lee, Richard K.; Lichter, Paul R.; Liu, Yutao; Medeiros, Felipe; Moroi, Syoko E.; Richards, Julia E.; Realini, Tony; Ritch, Robert; Schuman, Joel S.; Scott, William K.; Singh, Kuldev; Sit, Arthur J.; Vollrath, Douglas; Wollstein, Gadi; Zack, Donald J.; Zhang, Kang; Pericak-Vance, Margaret; Weinreb, Robert N.; Haines, Jonathan L.; Pasquale, Louis R.; Wiggs, Janey L. (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose Recent studies indicate that mitochondrial proteins may contribute to the pathogenesis of primary open-angle glaucoma (POAG). In this study, we examined the association between POAG and common variations in ...

    • Assessing the Brazilian surgical system with six surgical indicators: a descriptive and modelling study 

      Massenburg, Benjamin B; Saluja, Saurabh; Jenny, Hillary; Raykar, Nakul Prakash; Ng-Kamstra, Josh; Guilloux, Aline G A; Scheffer, Mário C; Meara, John Gerard; Alonso, Nivaldo; Shrime, Mark George (BMJ, 2017)
      Background: Brazil boasts a health scheme that aspires to provide universal coverage, but its surgical system has rarely been analyzed. In an effort to strengthen surgical systems worldwide, the Lancet Commission on Global ...

    • Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead 

      Goodson, William H.; Lowe, Leroy; Carpenter, David O.; Gilbertson, Michael; Manaf Ali, Abdul; Lopez de Cerain Salsamendi, Adela; Lasfar, Ahmed; Carnero, Amancio; Azqueta, Amaya; Amedei, Amedeo; Charles, Amelia K.; Collins, Andrew R.; Ward, Andrew; Salzberg, Anna C.; Colacci, Annamaria; Olsen, Ann-Karin; Berg, Arthur; Barclay, Barry J.; Zhou, Binhua P.; Blanco-Aparicio, Carmen; Baglole, Carolyn J.; Dong, Chenfang; Mondello, Chiara; Hsu, Chia-Wen; Naus, Christian C.; Yedjou, Clement; Curran, Colleen S.; Laird, Dale W.; Koch, Daniel C.; Carlin, Danielle J.; Felsher, Dean W.; Roy, Debasish; Brown, Dustin G.; Ratovitski, Edward; Ryan, Elizabeth P.; Corsini, Emanuela; Rojas, Emilio; Moon, Eun-Yi; Laconi, Ezio; Marongiu, Fabio; Al-Mulla, Fahd; Chiaradonna, Ferdinando; Darroudi, Firouz; Martin, Francis L.; Van Schooten, Frederik J.; Goldberg, Gary S.; Wagemaker, Gerard; Nangami, Gladys; Calaf, Gloria M.; Williams, Graeme; Wolf, Gregory T.; Koppen, Gudrun; Brunborg, Gunnar; Kim Lyerly, H.; Krishnan, Harini; Ab Hamid, Hasiah; Yasaei, Hemad; Sone, Hideko; Kondoh, Hiroshi; Salem, Hosni K.; Hsu, Hsue-Yin; Park, Hyun Ho; Koturbash, Igor; Miousse, Isabelle R.; Scovassi, A.Ivana; Klaunig, James E.; Vondráček, Jan; Raju, Jayadev; Roman, Jesse; Wise, John Pierce; Whitfield, Jonathan R.; Woodrick, Jordan; Christopher, Joseph A.; Ochieng, Josiah; Martinez-Leal, Juan Fernando; Weisz, Judith; Kravchenko, Julia; Sun, Jun; Prudhomme, Kalan R.; Narayanan, Kannan Badri; Cohen-Solal, Karine A.; Moorwood, Kim; Gonzalez, Laetitia; Soucek, Laura; Jian, Le; D’Abronzo, Leandro S.; Lin, Liang-Tzung; Li, Lin; Gulliver, Linda; McCawley, Lisa J.; Memeo, Lorenzo; Vermeulen, Louis; Leyns, Luc; Zhang, Luoping; Valverde, Mahara; Khatami, Mahin; Romano, Maria Fiammetta; Chapellier, Marion; Williams, Marc A.; Wade, Mark; Manjili, Masoud H.; Lleonart, Matilde; Xia, Menghang; Gonzalez, Michael J.; Karamouzis, Michalis V.; Kirsch-Volders, Micheline; Vaccari, Monica; Kuemmerle, Nancy B.; Singh, Neetu; Cruickshanks, Nichola; Kleinstreuer, Nicole; van Larebeke, Nik; Ahmed, Nuzhat; Ogunkua, Olugbemiga; Krishnakumar, P.K.; Vadgama, Pankaj; Marignani, Paola A.; Ghosh, Paramita M.; Ostrosky-Wegman, Patricia; Thompson, Patricia; Dent, Paul; Heneberg, Petr; Darbre, Philippa; Sing Leung, Po; Nangia-Makker, Pratima; Cheng, Qiang (Shawn); Robey, R.Brooks; Al-Temaimi, Rabeah; Roy, Rabindra; Andrade-Vieira, Rafaela; Sinha, Ranjeet K.; Mehta, Rekha; Vento, Renza; Di Fiore, Riccardo; Ponce-Cusi, Richard; Dornetshuber-Fleiss, Rita; Nahta, Rita; Castellino, Robert C.; Palorini, Roberta; Abd Hamid, Roslida; Langie, Sabine A.S.; Eltom, Sakina; Brooks, Samira A.; Ryeom, Sandra; Wise, Sandra S.; Bay, Sarah N.; Harris, Shelley A.; Papagerakis, Silvana; Romano, Simona; Pavanello, Sofia; Eriksson, Staffan; Forte, Stefano; Casey, Stephanie C.; Luanpitpong, Sudjit; Lee, Tae-Jin; Otsuki, Takemi; Chen, Tao; Massfelder, Thierry; Sanderson, Thomas; Guarnieri, Tiziana; Hultman, Tove; Dormoy, Valérian; Odero-Marah, Valerie; Sabbisetti, Venkata; Maguer-Satta, Veronique; Rathmell, W.Kimryn; Engström, Wilhelm; Decker, William K.; Bisson, William H.; Rojanasakul, Yon; Luqmani, Yunus; Chen, Zhenbang; Hu, Zhiwei (Oxford University Press, 2015)
      Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that ...

    • Assessing the clinical utility of cancer genomic and proteomic data across tumor types 

      Yuan, Yuan; Van Allen, Eliezer M.; Omberg, Larsson; Wagle, Nikhil; Amin-Mansour, Ali; Sokolov, Artem; Byers, Lauren A.; Xu, Yanxun; Hess, Kenneth R.; Diao, Lixia; Han, Leng; Huang, Xuelin; Lawrence, Michael S.; Weinstein, John N.; Stuart, Josh M.; Mills, Gordon B.; Garraway, Levi A.; Margolin, Adam A.; Getz, Gad; Liang, Han (2014)
      Molecular profiling of tumors promises to advance the clinical management of cancer, but the benefits of integrating molecular data with traditional clinical variables have not been systematically studied. Here we ...

    • Assessing the comparative effectiveness of Tai Chi versus physical therapy for knee osteoarthritis: design and rationale for a randomized trial 

      Wang, Chenchen; Iversen, Maura D; McAlindon, Timothy; Harvey, William F; Wong, John B; Fielding, Roger A; Driban, Jeffrey B; Price, Lori Lyn; Rones, Ramel; Gamache, Tressa; Schmid, Christopher H (BioMed Central, 2014)
      Background: Knee osteoarthritis (OA) causes pain and long-term disability with annual healthcare costs exceeding $185 billion in the United States. Few medical remedies effectively influence the course of the disease. ...

    • Assessing the Costs and Cost-Effectiveness of Genomic Sequencing 

      Christensen, Kurt D.; Dukhovny, Dmitry; Siebert, Uwe; Green, Robert C. (MDPI, 2015)
      Despite dramatic drops in DNA sequencing costs, concerns are great that the integration of genomic sequencing into clinical settings will drastically increase health care expenditures. This commentary presents an overview ...

    • Assessing the Effect of Epigenetic Dysregulation on Oncogenesis and Immunocompetence in a Mouse Model 

      Rosenthal, Joseph A. (2018-05-15)
      While there is a clear link between increasing mammalian age and alteration in baseline gene expression in somatic cells, the causality of these changes, how they affect the aging process itself, and their effect on ...

    • Assessing the Effect of Personalized Diabetes Risk Assessments During Ophthalmologic Visits on Glycemic Control 

      Aiello, Lloyd Paul; Ayala, Allison R.; Antoszyk, Andrew N.; Arnold-Bush, Bambi; Baker, Carl; Bressler, Neil M.; Elman, Michael J.; Glassman, Adam R.; Jampol, Lee M.; Melia, Michele; Nielsen, Jared; Wolpert, Howard Allan (American Medical Association (AMA), 2015)
      Importance: Optimization of glycemic control is critical to reduce diabetes related complications, but long-term success is challenging. Although vision loss is among the greatest fears of individuals with diabetes, ...

    • Assessing the effectiveness of gamified and non-gamified online clinical laboratory educational modules for medical students 

      Do, Marie Christine (2023-07-10)
      Collecting points. Earning rewards. These are features one would expect to find within an entertaining game. Gamification incorporates these design elements into non-game settings in the hopes of harnessing the engaging ...

    • Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome 

      Boyko, Adam R.; Indap, Amit R.; Degenhardt, Jeremiah D.; Hernandez, Ryan D.; Lohmueller, Kirk E.; Adams, Mark D.; Schmidt, Steffen; Sninsky, John J.; White, Thomas J.; Nielsen, Rasmus; Bustamante, Carlos D.; Williamson, Scott H.; Sunyaev, Shamil R.; Clark, Andrew G. (Public Library of Science, 2008)
      Quantifying the distribution of fitness effects among newly arising mutations in the human genome is key to resolving important debates in medical and evolutionary genetics. Here, we present a method for inferring this ...

    • Assessing the influence of scanner background noise on auditory processing. I. An fMRI study comparing three experimental designs with varying degrees of scanner noise 

      Gaab, Nadine; Gabrieli, John D.E.; Glover, Gary H. (Wiley-Blackwell, 2007)
      We compared two experimental designs aimed at minimizing the influence of scanner background noise (SBN) on functional MRI (fMRI) of auditory processes with one conventional fMRI design. Ten subjects listened to a series ...

    • Assessing the influence of scanner background noise on auditory processing. II. An fMRI study comparing auditory processing in the absence and presence of recorded scanner noise using a sparse design 

      Gaab, Nadine; Gabrieli, John D.E.; Glover, Gary H. (Wiley-Blackwell, 2007)
      Several studies reported decreased signal intensities within auditory areas for experimental designs employing continuous scanner background noise (SBN) in comparison to designs with less or no SBN. This study examined the ...

    • Assessing the Online Social Environment for Surveillance of Obesity Prevalence 

      Chunara, Rumi; Bouton, Lindsay Legault; Ayers, John W.; Brownstein, John Samuel (Public Library of Science, 2013)
      Background: Understanding the social environmental around obesity has been limited by available data. One promising approach used to bridge similar gaps elsewhere is to use passively generated digital data. Purpose This ...

    • Assessing the Performance of a Computer-Based Policy Model of HIV and AIDS 

      Rydzak, Chara Elaine; Cotich, Kara L.; Sax, Paul Edward; Hsu, Heather Emery Smith; Wang, Bingxia; Losina, Elena; Freedberg, Kenneth Alan; Weinstein, Milton C.; Goldie, Sue J. (2010)
      Background: Model-based analyses, conducted within a decision analytic framework, provide a systematic way to combine information about the natural history of disease and effectiveness of clinical management strategies ...

    • Assessing the Quality of Annotations in Asthma Gene Expression Experiments 

      Lacson, Ronilda C.; Mbagwu, Michael; Yousif, Hisham; Ohno-Machado, Lucila (BioMed Central, 2010)
      Background: The amount of data deposited in the Gene Expression Omnibus (GEO) has expanded significantly. It is important to ensure that these data are properly annotated with clinical data and descriptions of experimental ...

    • Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis 

      Mantha, S; Karp, Rebecca Sara; Raghavan, V; Terrin, N; Bauer, Kenneth Alan; Zwicker, Jeffrey Isaac (BMJ Publishing Group Ltd., 2012)
      Objectives: To evaluate the risk of venous thromboembolic events associated with the use of progestin-only contraception and whether that risk differs with the mode of drug delivery (oral, intrauterine, or depot injection). ...

    • Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma 

      Beroukhim, Rameen; Getz, Gad; Nghiemphu, Leia; Barretina, Jordi; Hsueh, Teli; Linhart, David; Vivanco, Igor; Lee, Jeffrey C.; Huang, Julie H.; Alexander, Sethu; Du, Jinyan; Kau, Tweeny; Thomas, Roman K.; Shah, Kinjal; Soto, Horacio; Perner, Sven; Prensner, John; Debiasi, Ralph M.; Demichelis, Francesca; Hatton, Charlie; Rubin, Mark A.; Garraway, Levi A.; Nelson, Stan F.; Liau, Linda; Mischel, Paul S.; Cloughesy, Tim F.; Meyerson, Matthew; Golub, Todd A.; Lander, Eric S.; Mellinghoff, Ingo K.; Sellers, William R. (National Academy of Sciences, 2007)
      Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to analyze cancer genomes are underway, but the ...

    • Assessment of abdominal fat compartments using DXA in premenopausal women from anorexia nervosa to morbid obesity 

      Bredella, Miriam A.; Gill, Corey M.; Keating, Leigh K.; Torriani, Martin; Anderson, Ellen J.; Punyanitya, Mark; Wilson, Kevin E.; Kelly, Thomas L.; Miller, Karen K. (2013)
      Objective: The purpose of this study was to test a newly developed DXA method for abdominal fat depot quantification in subjects with AN, normal weight, and obesity using CT as a gold standard. Design and Methods 135 ...

    • Assessment of Acute Myocardial Infarction: Current Status and Recommendations From the North American Society for Cardiovascular Imaging and the European Society of Cardiac Radiology 

      Stillman, Arthur E.; Oudkerk, Matthijs; Bluemke, David; Bremerich, Jens; Esteves, Fabio P.; Garcia, Ernest V.; Gutberlet, Matthias; Hundley, W. Gregory; Kuijpers, Dirkjan; Nagel, Eike; Lerakis, Stamatios; Oshinski, John; Underwood, Richard; Wintersperger, Bernd J.; Jerosch-Herold, Michael; Kwong, Raymond Yan-Kit; Rees, Michael R.; Paul, Jean-François (Springer Netherlands, 2010)
      There are a number of imaging tests that are used in the setting of acute myocardial infarction and acute coronary syndrome. Each has their strengths and limitations. Experts from the European Society of Cardiac Radiology ...