Browsing Harvard Medical School by Title
Now showing items 11272-11291 of 18428
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Multi-Scale Motility Amplitude Associated with Suicidal Thoughts in Major Depression
(Public Library of Science, 2012)Major depression occurs at high prevalence in the general population, often starts in juvenile years, recurs over a lifetime, and is strongly associated with disability and suicide. Searches for biological markers in ... -
Multi-scale symbolic entropy analysis provides prognostic prediction in patients receiving extracorporeal life support
(BioMed Central, 2014)Introduction: Extracorporeal life support (ECLS) can temporarily support cardiopulmonary function, and is occasionally used in resuscitation. Multi-scale entropy (MSE) derived from heart rate variability (HRV) is a powerful ... -
Multi-scale thermal stability of a hard thermoplastic protein-based material
(Nature Pub. Group, 2015)Although thermoplastic materials are mostly derived from petro-chemicals, it would be highly desirable, from a sustainability perspective, to produce them instead from renewable biopolymers. Unfortunately, biopolymers ... -
A multi-site single-blind clinical study to compare the effects of STAIR Narrative Therapy to treatment as usual among women with PTSD in public sector mental health settings: study protocol for a randomized controlled trial
(BioMed Central, 2014)Background: This article provides a description of the rationale, design, and methods of a multisite clinical trial which evaluates the potential benefits of an evidence-based psychosocial treatment, STAIR Narrative Therapy, ... -
Multi-step control of muscle diversity by Hox proteins in the Drosophila embryo
(Company of Biologists, 2010)Hox transcription factors control many aspects of animal morphogenetic diversity. The segmental pattern of Drosophila larval muscles shows stereotyped variations along the anteroposterior body axis. Each muscle is seeded ... -
Multi-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomy
(Springer Science + Business Media, 2014)Subcaudate tractotomy (SCT) is a neurosurgical lesioning procedure that can reduce symptoms in medically intractable obsessive compulsive disorder (OCD). Due to the putative importance the orbitofrontal cortex (OFC) in ... -
Multi-Unit Activity in the Human Cortex as a Predictor of Seizure Onset
(2015-05-13)Epilepsy is a neurological disorder affecting 50 million people worldwide. It consists of a large number of syndromes, all of which are characterized by a predisposition to recurrent, unprovoked seizures, while differing ... -
Multibow: Digital Spectral Barcodes for Cell Tracing
(Public Library of Science, 2015)We introduce a multicolor labeling strategy (Multibow) for cell tracing experiments in developmental and regenerative processes. Building on Brainbow-based approaches that produce colors by differential expression levels ... -
A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus
(American Society for Microbiology, 2012)Thedisablingdisorderknownaschronicfatiguesyndromeormyalgicencephalomyelitis(CFS/ME)hasbeenlinkedin two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leu- ... -
Multicenter comparison of laboratory performance in cytomegalovirus and Epstein-Barr virus viral load testing using international standards
(Wiley-Blackwell, 2014)Background—Infections with cytomegalovirus (CMV) and Epstein Barr Virus (EBV) remain important in solid organ transplantation. Quantitative viral nucleic acid testing is a major advance to patient management. These assays ... -
Multicenter Evaluation of a Novel Surveillance Paradigm for Complications of Mechanical Ventilation
(Public Library of Science, 2011)Background: Ventilator-associated pneumonia (VAP) surveillance is time consuming, subjective, inaccurate, and inconsistently predicts outcomes. Shifting surveillance from pneumonia in particular to complications in general ... -
A multicenter evaluation of the efficacy and duration of action of alcaftadine 0.25% and olopatadine 0.2% in the conjunctival allergen challenge model
(Dove Medical Press, 2013)Background: The purpose of this study was to evaluate the efficacy and duration of action of once-daily dosing with alcaftadine 0.25% ophthalmic solution and olopatadine 0.2% ophthalmic solution as compared with placebo ... -
Multicenter Phase IB/II Study of AdV-Tk, a Gene-Mediated Cytotoxic Immunotherapy, Adjuvant to Surgical Resection for Patients With Newly Diagnosed High Grade Glioma
(2015-05-13)Purpose: The prognosis for malignant gliomas is poor, and overall survival remains less than 15 months despite improved diagnostic and treatment techniques, underscoring the need for novel therapeutic options. This ... -
A Multicenter Retrospective Study on Clinical Characteristics, Treatment Patterns, and Outcome in Elderly Patients with Hepatocellular Carcinoma
(AlphaMed Press, 2011)Background. There is a paucity of information on the clinical presentation and outcome of elderly hepatocellular carcinoma (HCC) patients. We performed a multicenter retrospective comparative study to assess the impact of ... -
Multicentre observational study of adults with asthma exacerbations: who are the frequent users of the emergency department in Japan?
(BMJ Publishing Group, 2015)Objectives: Emergency department (ED) visits for asthma exacerbation reflect a failure of longitudinal asthma management. However, little is known about the characteristics of patients with frequent ED visits (≥2 visits ... -
Multichannel vibrotactile display for sensory substitution during teleoperation
(SPIE, 2001)This paper presents the design and testing of a multi-channel vibrotactile display composed of cylindrical handle with four embedded vibrating elements driven by piezoelectric beams. The experimental goal of the paper is ... -
Multiclass Cancer Classification by Using Fuzzy Support Vector Machine and Binary Decision Tree With Gene Selection
(Hindawi Publishing Corporation, 2005)We investigate the problems of multiclass cancer classification with gene selection from gene expression data. Two different constructed multiclass classifiers with gene selection are proposed, which are fuzzy support ... -
Multicomponent Assembly of Proposed DNA Precursors in Water
(American Chemical Society, 2012)We propose a novel pathway for the prebiotic synthesis of 2′-deoxynucleotides. Consideration of the constitutional chemical relationships between glycolaldehyde and β-mercapto-acetaldehyde, and the corresponding proteinogenic ... -
A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
(New England Journal of Medicine (NEJM/MMS), 1999)BACKGROUND: Since in hospitalized older patients delirium is associated with poor outcomes, we evaluated the effectiveness of a multicomponent strategy for the prevention of delirium. METHODS: We studied 852 patients ... -
Multicomponent Targeted Intervention to Prevent Delirium in Hospitalized Older Patients
(Ovid Technologies (Wolters Kluwer Health), 2001)Introduction. Delirium, or acute confusional state, is a common and serious occurrence among hospitalized older persons. Current estimates suggest that delirium complicates hospital stays for more than 2.3 million older ...