Browsing Harvard Medical School by Title
Now showing items 11563-11582 of 18428
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Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors
(Public Library of Science, 2016)Deficiency of mitochondrial complex I is encountered in both rare and common diseases, but we have limited therapeutic options to treat this lesion to the oxidative phosphorylation system (OXPHOS). Idebenone and menadione ... -
Natural Products in Epilepsy—the Present Situation and Perspectives for the Future
(MDPI, 2010)More efficacious and better tolerated treatments for epilepsy are clearly needed. Complementary and alternative medicine (CAM) has a long history of use in certain parts of the world and has gained increasing interest over ... -
Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria
(Oxford University Press, 2013)The discovery of diverse codon reassignment events has demonstrated that the canonical genetic code is not universal. Studying coding reassignment at the molecular level is critical for understanding genetic code evolution, ... -
Natural Variation in Preparation for Nutrient Depletion Reveals a Cost–Benefit Tradeoff
(Public Library of Science, 2015)Maximizing growth and survival in the face of a complex, time-varying environment is a common problem for single-celled organisms in the wild. When offered two different sugars as carbon sources, microorganisms first consume ... -
Natural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa
(BioMed Central, 2013)Background: Transmission of drug susceptible and drug resistant TB occurs in health care facilities, and community and households settings, particularly in highly prevalent TB and HIV areas. There is a paucity of data ... -
Naturally Occurring Mutations in the Human 5-Lipoxygenase Gene Promoter That Modify Transcription Factor Binding and Reporter Gene Transcription
(American Society for Clinical Investigation, 1997-03-01)Five lipoxygenase (5-LO) is the first committed enzyme in the metabolic pathway leading to the synthesis of the leukotrienes. We examined genomic DNA isolated from 25 normal subjects and 31 patients with asthma (6 of whom ... -
The ‘Natural’ History of Cancer in Africa: Tracking Malignancy, Oncology, and Its Ideologies (1957-1984), With a Comparative View to the 21st Century in Rwanda
(2017-05-12)While it is widely accepted that cancer incidence is on the rise in Africa, and global oncology has burgeoned, the history of cancer and cancer research on the continent is generally not discussed. This thesis reviews ... -
The nature of sleep examined via the science of sleep
(Dove Medical Press, 2011) -
Nature of the quantum metal in a two-dimensional crystalline superconductor
(Nature Publishing Group, 2015)Two-dimensional (2D) materials are not expected to be metals at low temperature owing to electron localization. Consistent with this, pioneering studies on thin films reported only superconducting and insulating ground ... -
The nature of white matter abnormalities in blast-related mild traumatic brain injury
(Elsevier, 2015)Blast-related traumatic brain injury (TBI) has been a common injury among returning troops due to the widespread use of improvised explosive devices in the Iraq and Afghanistan Wars. As most of the TBIs sustained are in ... -
Nature Versus Nurture: The Impact of Nativity and Site of Treatment on Survival for Gastric Cancer
(2018-05-15)Purpose: The prognosis of gastric cancer patients is substantially better in Asia than in the West. Genetic, environmental, and treatment factors have all been implicated. We sought to explore the extent to which the place ... -
Nature, Niche, and Nurture: The Role of Social Experience in Transforming Genotype Into Phenotype
(Springer Nature, 1998-12)Nature and nurture stand in reciprocity, not opposition. Offspring inherit, along with their parents' genes, their parents, their peers, and the places they inhabit. The ontogenetic niche is a crucial link between parents ... -
Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome
(Oxford University Press, 2013)Dravet syndrome is a severe epileptic encephalopathy mainly caused by heterozygous mutations in the SCN1A gene encoding a voltage-gated sodium channel Nav1.1. We previously reported dense localization of Nav1.1 in parvalbumin ... -
Near Infrared Fluorescence (NIRF) Molecular Imaging of Oxidized LDL with an Autoantibody in Experimental Atherosclerosis
(Nature Publishing Group, 2016)We aimed to develop a quantitative antibody-based near infrared fluorescence (NIRF) approach for the imaging of oxidized LDL in atherosclerosis. LO1, a well- characterized monoclonal autoantibody that reacts with ... -
Near Infrared Fluorescent Probe for Imaging of Pancreatic Beta Cells
(American Chemical Society, 2010)The ability to image and ultimately quantitate beta-cell mass in vivo will likely have far reaching implications in the study of diabetes biology, in the monitoring of disease progression or response to treatment, and for ... -
Near Normalization of Metabolic and Functional Features of the Central Nervous System in Type 1 Diabetic Patients With End-Stage Renal Disease After Kidney-Pancreas Transplantation
(American Diabetes Association, 2012)OBJECTIVE The pathogenesis of brain disorders in type 1 diabetes (T1D) is multifactorial and involves the adverse effects of chronic hyperglycemia and of recurrent hypoglycemia. Kidney-pancreas (KP), but not kidney alone ... -
A Near-Infrared Cell Tracker Reagent for Multiscopic In Vivo Imaging and Quantification of Leukocyte Immune Responses
(Public Library of Science, 2007)The complexity of the tumor microenvironment necessitates that cell behavior is studied in a broad, multi-scale context. Although tomographic and microscopy-based far and near infrared fluorescence (NIRF, >650 nm) imaging ... -
Near-Infrared Fluorescence Imaging for Noninvasive Trafficking of Scaffold Degradation
(Nature Publishing Group, 2013)Biodegradable scaffolds could revolutionize tissue engineering and regenerative medicine; however, in vivo matrix degradation and tissue ingrowth processes are not fully understood. Currently a large number of samples and ... -
Near-infrared fluorescence imaging platform for quantifying in vivo nanoparticle diffusion from drug loaded implants
(Dove Medical Press, 2016)Drug loaded implants are a new, versatile technology platform to deliver a localized payload of drugs for various disease models. One example is the implantable nanoplatform for chemo-radiation therapy where inert brachytherapy ... -
Near-infrared fluorescent imaging of matrix metalloproteinase activity following myocardial infarction
(American Heart Association, 2005)