Browsing Harvard Medical School by Title
Now showing items 11646-11665 of 18427
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Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms
(Rockefeller University Press, 1990)Nerve growth factor (NGF), acidic fibroblast growth factor (aFGF), and basic fibroblast growth factor (bFGF) promote the survival and differentiation of a variety of peripheral and central neurons. The signal transduction ... -
Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction
(BioMed Central, 2014)Background: Assembly and disassembly of microtubules (MTs) is critical for neurite outgrowth and differentiation. Evidence suggests that nerve growth factor (NGF) induces neurite outgrowth from PC12 cells by activating the ... -
Nerve Wrapping of the Sciatic Nerve With Acellular Dermal Matrix in Chronic Complete Proximal Hamstring Ruptures and Ischial Apophyseal Avulsion Fractures
(SAGE Publications, 2016)Background: Patients with chronic injuries of the proximal hamstring can develop significant impairment because of weakness of the hamstring muscles, sciatic nerve compression from scar formation, or myositis ossificans. ... -
Nerves and Neovessels Inhibit Each Other in the Cornea
(Association for Research in Vision and Ophthalmology (ARVO), 2013)Purpose. To evaluate the regulatory cross-talk of the vascular and neural networks in the cornea. Methods. b-FGF micropellets (80 ng) were implanted in the temporal side of the cornea of healthy C57Bl/6 mice. On ... -
NEST 2014: Views from the Trainees—Talking About What Matters in Efforts to Diversify the STEM Workforce
(American Society for Cell Biology, 2014)This paper summarizes the outcomes of a retreat designed to cultivate interactions between trainees at various training levels and provide them opportunities to share their training perspectives and expectations. Retreat ... -
Nest Making and Oxytocin Comparably Promote Wound Healing in Isolation Reared Rats
(Public Library of Science, 2009)Background: Environmental enrichment (EE) fosters attachment behavior through its effect on brain oxytocin levels in the hippocampus and other brain regions, which in turn modulate the hypothalamic-pituitary axis (HPA). ... -
Nestin depletion induces melanoma matrix metalloproteinases and invasion
(2015)Matrix metalloproteinases (MMPs) are key biological mediators of processes as diverse as wound healing, embryogenesis, and cancer progression. Although MMPs may be induced through multiple signaling pathways, the precise ... -
Net Clinical Benefit of Oral Anticoagulants: A Multiple Criteria Decision Analysis
(Public Library of Science, 2015)Background: This study quantitatively evaluated the comparative efficacy and safety of new oral anticoagulants (dabigatran, rivaroxaban, and apizaban) and warfarin for treatment of nonvalvular atrial fibrillation. We also ... -
Net −1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA
(National Academy of Sciences, 2012)Ribosomal frameshifting entails slippage of the translational machinery during elongation. Frameshifting permits expression of more than one polypeptide from an otherwise monocistronic mRNA, and can restore expression of ... -
Netrin-1 – DCC Signaling Systems and Age-Related Macular Degeneration
(Public Library of Science, 2015)We conducted a nested candidate gene study and pathway-based enrichment analysis on data from a multi-national 77,000-person project on the molecular genetics of age-related macular degeneration (AMD) to identify AMD-associated ... -
Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord
(BioMed Central, 2016)Background: Newborn neurons often migrate before undergoing final differentiation, extending neurites, and forming synaptic connections. Therefore, neuronal migration is crucial for establishing neural circuitry during ... -
Network Analyses Reveal Novel Aspects of ALS Pathogenesis
(Public Library of Science, 2015)Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective loss of motor neurons, muscle atrophy and paralysis. Mutations in the human VAMP-associated protein B (hVAPB) cause a ... -
Network Analysis Identifies SOD2 mRNA as a Potential Biomarker for Parkinson's Disease
(Public Library of Science, 2014)Increasing evidence indicates that Parkinson's disease (PD) and type 2 diabetes (T2DM) share dysregulated molecular networks. We identified 84 genes shared between PD and T2DM from curated disease-gene databases. Nitric ... -
Network analysis of gene essentiality in functional genomics experiments
(BioMed Central, 2015)Many genomic techniques have been developed to study gene essentiality genome-wide, such as CRISPR and shRNA screens. Our analyses of public CRISPR screens suggest protein interaction networks, when integrated with gene ... -
Network Analysis of Genome-Wide Selective Constraint Reveals a Gene Network Active in Early Fetal Brain Intolerant of Mutation
(Public Library of Science, 2016)Using robust, integrated analysis of multiple genomic datasets, we show that genes depleted for non-synonymous de novo mutations form a subnetwork of 72 members under strong selective constraint. We further show this ... -
Network Analysis: Applications for the Developing Brain
(SAGE Publications, 2011)Development of the human brain follows a complex trajectory of age-specific anatomical and physiological changes. The application of network analysis provides an illuminating perspective on the dynamic interregional and ... -
Network Dynamics Underlying Speed-Accuracy Trade-Offs in Response to Errors
(Public Library of Science, 2013)The ability to dynamically and rapidly adjust task performance based on its outcome is fundamental to adaptive, flexible behavior. Over trials of a task, responses speed up until an error is committed and after the error ... -
Network link prediction by global silencing of indirect correlations
(2013)Predicting physical and functional links between cellular components is a fundamental challenge of biology and network science. Yet, correlations, a ubiquitous input for biological link prediction, are affected by both ... -
Network meta-analysis incorporating randomized controlled trials and non-randomized comparative cohort studies for assessing the safety and effectiveness of medical treatments: challenges and opportunities
(BioMed Central, 2015)Network meta-analysis is increasingly used to allow comparison of multiple treatment alternatives simultaneously, some of which may not have been compared directly in primary research studies. The majority of network ... -
A network model for angiogenesis in ovarian cancer
(BioMed Central, 2015)Background: We recently identified two robust ovarian cancer subtypes, defined by the expression of genes involved in angiogenesis, with significant differences in clinical outcome. To identify potential regulatory mechanisms ...