Browsing Harvard Medical School by Title
Now showing items 11840-11859 of 18428
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A new statistical method for testing hypotheses of neuropsychological/MRI relationships in schizophrenia: partial least squares analysis
(Elsevier BV, 2002)We applied partial least squares (PLS) as a novel multivariate statistical technique to examine neuropsychological correlates of magnetic resonance imaging (MRI) measures of brain volumes in a well studied sample of 15 ... -
New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes
(Public Library of Science, 2012)Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to ... -
New targeted molecular therapies for cancer: radiological response in intrathoracic malignancies and cardiopulmonary toxicity: what the radiologist needs to know
(BioMed Central, 2014)The emergence of new novel therapeutic agents which directly target molecules that are uniquely or abnormally expressed in cancer cells (molecular targeted therapy, MTT) has changed dramatically the treatment of cancer in ... -
New techniques for motion-artifact-free in vivo cardiac microscopy
(Frontiers Media S.A., 2015)Intravital imaging microscopy (i.e., imaging in live animals at microscopic resolution) has become an indispensable tool for studying the cellular micro-dynamics in cancer, immunology and neurobiology. High spatial and ... -
New Techniques of Recording and Interpretation of Dynamic Coronary Angiography
(Tan Tao University, 2023-08-15)In the study of coronary artery disease (CAD), the mechanism of plaque formation and development was still the subject of continuing debate. The limitation of the current coronary angiogram (CAG) is that it can only show ... -
New Tools for Comparing Microscopy Images: Quantitative Analysis of Cell Types in Bacillus subtilis
(American Society for Microbiology, 2015)Fluorescence microscopy is a method commonly used to examine individual differences between bacterial cells, yet many studies still lack a quantitative analysis of fluorescence microscopy data. Here we introduce some simple ... -
New Treatments Addressing the Pathophysiology of Hereditary Angioedema
(BioMed Central, 2008)Hereditary angioedema is a serious medical condition caused by a deficiency of C1-inhibitor. The condition is the result of a defect in the gene controlling the synthesis of C1-inhibitor, which regulates the activity of a ... -
New Treatments for Chronic Hepatitis C
(The Korean Association for the Study of the Liver, 2010)Treatments for chronic hepatitis C has evolved significantly in the past 15 years. The standard of care (SOC) is peginterferon alfa-2a/-2b with ribavirin for 48 weeks or 24 weeks in patients infected with HCV genotype 1 ... -
The New Zealand 1986 very low birth weight cohort as young adults: mapping the road ahead
(BioMed Central, 2015)Background: Very low birth weight (less than 1500 g) is associated with increased morbidity and costs of health care in childhood. Emerging evidence suggests these infants face a range of health and social problems as young ... -
The Newborn Behavioral Observations (NBO) System as a Form of Intervention and Support for New Parents
(2015)The period covering the first 3 months of life consists of a series of pivotal, life-changing transitions for the infant, for the parents, and for the emerging parent-child relationship. The Newborn Behavioral Observations ... -
Newborn-Care Training in Developing Countries
(Massachusetts Medical Society, 2010) -
Next Generation Gene Synthesis by targeted retrieval of bead-immobilized, sequence verified DNA clones from a high throughput pyrosequencing device
(2012)The setup of synthetic biological systems involving millions of bases is still limited by the required high quality of synthetic DNA. Important drivers to further open up the field are the accuracy and scale of chemical ... -
The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions
(National Institute of Environmental Health Sciences, 2016)Background: The Next Generation (NexGen) of Risk Assessment effort is a multi-year collaboration among several organizations evaluating new, potentially more efficient molecular, computational, and systems biology approaches ... -
Next generation sequencing with copy number variant detection expands the phenotypic spectrum of HSD17B4-deficiency
(BioMed Central, 2014)Background: D-bifunctional protein deficiency, caused by recessive mutations in HSD17B4, is a severe, infantile-onset disorder of peroxisomal fatty acid oxidation. Few affected patients survive past two years of age. ... -
Next generation sequencing‐based copy number analysis reveals low prevalence of deletions and duplications in 46 genes associated with genetic cardiomyopathies
(John Wiley and Sons Inc., 2015)Abstract Background: Diagnostic testing for genetic cardiomyopathies has undergone dramatic changes in the last decade with next generation sequencing (NGS) expanding the number of genes that can be interrogated simultaneously. ... -
The next new target in leukemia: The embryonic stem cell gene SALL4
(2015)The embryonic stem (ES) cell gene SALL4 has recently been identified as a new target for cancer therapy, including leukemia. SALL4 is expressed in ES cells and during embryonic development, but is absent in most adult ... -
Next-generation carrier screening
(Nature Publishing Group, 2014)Purpose: Carrier screening for recessive Mendelian disorders traditionally employs focused genotyping to interrogate limited sets of mutations most prevalent in specific ethnic groups. We sought to develop a next-generation ... -
Next-Generation cDNA Screening for Oncogene and Resistance Phenotypes
(Public Library of Science, 2012)There is a pressing need for methods to define the functional relevance of genetic alterations identified by next-generation sequencing of cancer specimens. We developed new approaches to efficiently construct full-length ... -
Next-Generation High-Throughput Functional Annotation of Microbial Genomes
(American Society for Microbiology, 2016)ABSTRACT Host infection by microbial pathogens cues global changes in microbial and host cell biology that facilitate microbial replication and disease. The complete maps of thousands of bacterial and viral genomes have ... -
Next-generation in vivo optical imaging with short-wave infrared quantum dots
(Springer Nature, 2017)The short-wavelength infrared region (SWIR; 1000—2000 nm) provides several advantages over the visible and near-infrared regions for in vivo imaging. The general lack of autofluorescence, low light absorption by blood and ...