Browsing Harvard Medical School by Title

Now showing items 11872-11891 of 18428

    • NFATc1 in Mice Represses Osteoprotegerin During Osteoclastogenesis and Dissociates Systemic Osteopenia From Inflammation in Cherubism 

      Aliprantis, Antonios O.; Ueki, Yasuyoshi; Sulyanto, Rosalyn; Park, Arnold; Sigrist, Kirsten S.; Sharma, Sudarshana M.; Ostrowski, Michael C.; Olsen, Bjorn; Glimcher, Laurie (American Society for Clinical Investigation, 2008-11-03)
      Osteoporosis results from an imbalance in skeletal remodeling that favors bone resorption over bone formation. Bone matrix is degraded by osteoclasts, which differentiate from myeloid precursors in response to the cytokine ...

    • NGF – the TrkA to successful pain treatment 

      Kumar, Vinayak; Mahal, Brandon (Dove Medical Press, 2012)
      Chronic pain arising from various pathological conditions such as osteoarthritis, low back or spinal injuries, cancer, and urological chronic pelvic pain syndromes presents significant challenges in diagnosis and treatment. ...

    • NgR1 and NgR3 are Receptors for Chondroitin Sulfate Proteoglycans 

      Dickendesher, Travis L.; Baldwin, Katherine T.; Mironova, Yevgeniya A.; Koriyama, Yoshiki; Raiker, Stephen J; Askew, Kim L.; Wood, Andrew; Geoffroy, Cédric G.; Zheng, Binhai; Liepmann, Claire D.; Katagiri, Yasuhiro; Benowitz, Larry Ira; Geller, Herbert M.; Giger, Roman J. (Nature, 2012)
      In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin–associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting following injury. The Nogo receptor family ...

    • NICE to HELP: Operationalizing National Institute for Health and Clinical Excellence Guidelines to Improve Clinical Practice 

      Yue, Jirong; Tabloski, Patricia; Dowal, Sarah L.; Puelle, Margaret R.; Nandan, Rakesh; Inouye, Sharon (Wiley-Blackwell, 2014)
      The National Institute for Health and Clinical Excellence (NICE) in the United Kingdom developed guidelines for the diagnosis, prevention, and management of delirium in July 2010 that included 10 recommendations for delirium ...

    • Niche induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool 

      Mesa, Kailin R.; Rompolas, Panteleimon; Zito, Giovanni; Myung, Peggy; Sun, Thomas Yang; Brown, Samara; Gonzalez, David; Blagoev, Krastan B.; Haberman, Ann M.; Greco, Valentina (2015)
      Summary Tissue homeostasis is achieved through a balance of cell production (growth) and elimination (regression)1,2. Contrary to tissue growth, the cells and molecular signals required for tissue regression remain unknown. ...

    • Niche Recycling through Division-Independent Egress of Hematopoietic Stem Cells 

      Bhattacharya, Deepta; Czechowicz, Agnieszka; Ooi, A.G. Lisa; Rossi, Derrick J; Bryder, David; Weissman, Irving L. (The Rockefeller University Press, 2009)
      Hematopoietic stem cells (HSCs) are thought to reside in discrete niches through stable adhesion, yet previous studies have suggested that host HSCs can be replaced by transplanted donor HSCs, even in the absence of ...

    • Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors 

      Chattopadhyay, Shrikanta; Stewart, Alison L.; Mukherjee, Siddhartha; Huang, Cherrie; Hartwell, Kimberly A.; Miller, Peter Grant; Subramanian, Radhika; Carmody, Leigh C.; Yusuf, Rushdia Zareen; Sykes, David Brian; Paulk, Joshiawa; Vetere, Amedeo; Vallet, Sonia; Santo, Loredana; Cirstea, Diana D.; Hideshima, Teru; Dan?ík, Vlado; Majireck, Max M.; Hussain, Mahmud M.; Singh, Shambhavi; Quiroz, Ryan; Iaconelli, Jonathan; Karmacharya, Rakesh; Tolliday, Nicola J.; Clemons, Paul A.; Moore, Malcolm A.S.; Stern, Andrew M.; Shamji, Alykhan Farid; Ebert, Benjamin L.; Golub, Todd Robert; Raje, Noopur; Scadden, David Thomas; Schreiber, Stuart L. (Elsevier BV, 2015)
      Novel therapeutic approaches are urgently required for multiple myeloma (MM). We used a phenotypic screening approach using co-cultures of MM cells with bone marrow stromal cells to identify compounds that overcome stromal ...

    • Nicorandil Attenuates Monocrotaline-Induced Vascular Endothelial Damage and Pulmonary Arterial Hypertension 

      Sahara, Makoto; Sata, Masataka; Morita, Toshihiro; Hirata, Yasunobu; Nagai, Ryozo (Public Library of Science, 2012)
      Background: An antianginal KATP channel opener nicorandil has various beneficial effects on cardiovascular systems; however, its effects on pulmonary vasculature under pulmonary arterial hypertension (PAH) have not yet ...

    • Nicotinamide Impairs Entry into and Exit from Meiosis I in Mouse Oocytes 

      Riepsamen, Angelique; Wu, Lindsay; Lau, Laurin; Listijono, Dave; Ledger, William; Sinclair, David; Homer, Hayden (Public Library of Science, 2015)
      Following exit from meiosis I, mammalian oocytes immediately enter meiosis II without an intervening interphase, accompanied by rapid reassembly of a bipolar spindle that maintains condensed chromosomes in a metaphase ...

    • Nicotine Overrides DNA Damage-Induced G1/S Restriction in Lung Cells 

      Nishioka, Takashi; Yamamoto, Daisuke; Zhu, Tongbo; Guo, Jianjun; Kim, Sung-Hoon; Chen, Chang-Yan (Public Library of Science, 2011)
      As an addictive substance, nicotine has been suggested to facilitate pro-survival activities (such as anchorage-independent growth or angiogenesis) and the establishment of drug resistance to anticancer therapy. Tobacco ...

    • NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restriction 

      Als, Heidelise; Duffy, Frank Hopkins; McAnulty, Gloria; Butler, Samantha C.; Lightbody, L; Kosta, S; Weisenfeld, Neil I; Robertson, Richard Lee; Parad, Richard Barry; Ringer, Steven Alan; Blickman, J G; Zurakowski, David; Warfield, Simon Keith (Nature Publishing Group, 2012)
      Objective: The effect of NIDCAP (Newborn Individualized Developmental Care and Assessment Program) was examined on the neurobehavioral, electrophysiological and neurostructural development of preterm infants with severe ...

    • Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor 

      Krishnan, Anuja; Miller, Emily Happy; Herbert, Andrew S.; Ng, Melinda; Ndungo, Esther; Whelan, Sean P.J.; Dye, John M.; Chandran, Kartik (MDPI, 2012)
      We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses. Here we show that Niemann-Pick ...

    • Niemann-Pick C1 Affects the Gene Delivery Efficacy of Degradable Polymeric Nanoparticles 

      Eltoukhy, Ahmed A.; Sahay, Gaurav; Cunningham, James M.; Anderson, Daniel G. (American Chemical Society, 2014)
      Despite intensive research effort, the rational design of improved nanoparticulate drug carriers remains challenging, in part due to a limited understanding of the determinants of nanoparticle entry and transport in target ...

    • Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo 

      Herbert, Andrew S.; Davidson, Cristin; Kuehne, Ana I.; Bakken, Russell; Braigen, Stephen Z.; Gunn, Kathryn E.; Whelan, Sean P.; Brummelkamp, Thijn R.; Twenhafel, Nancy A.; Chandran, Kartik; Walkley, Steven U.; Dye, John M. (American Society of Microbiology, 2015)
      ABSTRACT Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus entry requirements of NPC1 in vitro, its roles in filovirus ...

    • Nifedipine Treatment Reduces Resting Calcium Concentration, Oxidative and Apoptotic Gene Expression, and Improves Muscle Function in Dystrophic mdx Mice 

      Altamirano, Francisco; Valladares, Denisse; Henríquez-Olguín, Carlos; Casas, Mariana; López, Jose R.; Allen, Paul D.; Jaimovich, Enrique (Public Library of Science, 2013)
      Duchenne Muscular Dystrophy (DMD) is a recessive X-linked genetic disease, caused by mutations in the gene encoding dystrophin. DMD is characterized in humans and in mdx mice by a severe and progressive destruction of ...

    • Night heart rate variability and particulate exposures among boilermaker construction workers 

      Cavallari, Jennifer Margaret; Eisen, Ellen A.; Chen, Jiu-Chiuan; Fang, Shona C.; Dobson, Christine; Schwartz, Joel David; Christiani, David C. (National Institute of Environmental Health Sciences, 2007)
      Background: Although studies have documented the association between heart rate variability (HRV) and ambient particulate exposures, the association between HRV, especially at night, and metal-rich, occupational particulate ...

    • NIH working group report—using genomic information to guide weight management: From universal to precision treatment 

      Bray, Molly S; Loos, Ruth JF; McCaffery, Jeanne M; Ling, Charlotte; Franks, Paul W; Weinstock, George M; Snyder, Michael P; Vassy, Jason L; Agurs-Collins, Tanya (John Wiley & Sons, Ltd, 2015)
      Objective: Precision medicine utilizes genomic and other data to optimize and personalize treatment. Although more than 2,500 genetic tests are currently available, largely for extreme and/or rare phenotypes, the question ...

    • Nine Criteria for a Measure of Scientific Output 

      Kreiman, Gabriel; Maunsell, John (Frontiers Media SA, 2011)
      Scientific research produces new knowledge, technologies, and clinical treatments that can lead to enormous returns. Often, the path from basic research to new paradigms and direct impact on society takes time. Precise ...

    • Nipple-areolar Complex Reconstruction following Postmastectomy Breast Reconstruction: A Comparative Utility Assessment Study 

      Ibrahim, Ahmed M. S.; Sinno, Hani H.; Izadpanah, Ali; Vorstenbosch, Joshua; Dionisopoulos, Tassos; Mureau, Marc A. M.; Tobias, Adam M.; Lee, Bernard T.; Lin, Samuel J. (Wolters Kluwer Health, 2015)
      Background: Nipple-areola complex (NAC) reconstruction occurs toward the final stage of breast reconstruction; however, not all women follow through with these procedures. The goal of this study was to determine the impact ...

    • Nitric Oxide Activates Intradomain Disulfide Bond Formation in the Kinase Loop of Akt1/PKBα after Burn Injury 

      Lu, Xiaoming; Tompkins, Ronald Gary; FISCHMAN, A.J. (D.A. Spandidos, 2013)
      Severe burn injury is an acute inflammatory state with massive alterations in gene expression and levels of growth factors, cytokines and free radicals. During the catabolic processes, changes in insulin sensitivity and ...