Browsing Harvard Medical School by Title

Now showing items 12069-12088 of 18428

    • A Novel Hypoxia-Selective Epigenetic Agent RRx-001 Triggers Apoptosis and Overcomes Drug Resistance in Multiple Myeloma Cells 

      Das, Deepika Sharma; Ray, Arghya; Das, Abhishek; Song, Yan; Oronsky, Bryan; Richardson, Paul; Scicinski, Jan; Chauhan, Dharminder; Anderson, Kenneth C. (2016)
      The hypoxic bone-marrow (BM) microenvironment confers growth/survival and drug-resistance in multiple myeloma (MM) cells. Novel therapies targeting the MM cell in its hypoxic-BM milieu may overcome drug resistance. Recent ...

    • Novel Immunotherapeutic Approaches for Head and Neck Squamous Cell Carcinoma 

      Bann, Darrin V.; Deschler, Daniel G.; Goyal, Neerav (MDPI, 2016)
      The immune system plays a key role in preventing tumor formation by recognizing and destroying malignant cells. For over a century, researchers have attempted to harness the immune response as a cancer treatment, although ...

    • A Novel Implantable Glaucoma Valve Using Ferrofluid 

      Paschalis, Eleftherios I.; Chodosh, James; Sperling, Ralph A.; Salvador-Culla, Borja; Dohlman, Claes (Public Library of Science, 2013)
      Purpose To present a novel design of an implantable glaucoma valve based on ferrofluidic nanoparticles and to compare it with a well-established FDA approved valve. Setting: Massachusetts Eye & Ear Infirmary, Boston, USA. ...

    • A Novel Inhibitory Mechanism of Mitochondrion-Dependent Apoptosis by a Herpesviral Protein 

      Feng, Pinghui; Liang, Chengyu; Shin, Young Cheol; E, Xiaofei; Zhang, Weijun; Gravel, Robyn; Wu, Ting-ting; Sun, Ren; Usherwood, Edward; Jung, Jae Ung (Public Library of Science, 2007)
      Upon viral infection, cells undergo apoptosis as a defense against viral replication. Viruses, in turn, have evolved elaborate mechanisms to subvert apoptotic processes. Here, we report that a novel viral mitochondrial ...

    • Novel Insights into RNAi Off-Target Effects Using C. elegans Paralogs 

      Rual, Jean-Francois; Klitgord, Niels; Achaz, Guillaume (BioMed Central, 2007)
      Background: In the few years since its discovery, RNAi has turned into a very powerful tool for the study of gene function by allowing post-transcriptional gene silencing. The RNAi mechanism, which is based on the introduction ...

    • Novel Insights into the Molecular Mechanisms Governing Mdm2 Ubiquitination and Destruction 

      Inuzuka, Hiroyuki; Fukushima, Hidefumi; Shaik, Shavali; Wei, Wenyi (Impact Journals LLC, 2010)
      The Mdm2/p53 pathway is compromised in more than 50% of all human cancers, therefore it is an intensive area of research to understand the upstream regulatory pathways governing Mdm2/p53 activity. Mdm2 is frequently ...

    • A novel knee prosthesis model of implant-related osteo- myelitis in rats 

      Søe, Niels H; Jensen, Nina Vendel; Nürnberg, Birgit Meinecke; Jensen, Asger Lundorff; Koch, Janne; Poulsen, Steen Seier; Pier, Gerald B.; Johansen, Helle Krogh (Informa Healthcare, 2011)
      Background and purpose: There have been numerous reports of animal models of osteomyelitis. Very few of these have been prosthesis models that imitate human conditions. We have developed a new rat model of implant-related ...

    • A Novel Laser Vaccine Adjuvant Increases the Motility of Antigen Presenting Cells 

      Chen, Xinyuan; Kim, Pilhan; Farinelli, Bill; Doukas, Apostolos; Yun, Seok-Hyun; Gelfand, Jeffrey Alan; Anderson, Richard Rox; Wu, Mei X. (Public Library of Science, 2010)
      Background: Development of a potent vaccine adjuvant without introduction of any side effects remains an unmet challenge in the field of the vaccine research. Methodology/Principal Findings: We found that laser at a specific ...

    • Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease 

      Huertas-Vazquez, Adriana; Nelson, Christopher P.; Guo, Xiuqing; Reinier, Kyndaron; Uy-Evanado, Audrey; Teodorescu, Carmen; Ayala, Jo; Jerger, Katherine; Chugh, Harpriya; WTCCC+; Braund, Peter S.; Deloukas, Panos; Hall, Alistair S.; Balmforth, Anthony J.; Jones, Michelle; Taylor, Kent D.; Pulit, Sara L.; Newton-Cheh, Christopher Holmes; Gunson, Karen; Jui, Jonathan; Rotter, Jerome I.; Albert, Christine Marie; Samani, Nilesh J.; Chugh, Sumeet S. (Public Library of Science, 2013)
      Background: Recent genome-wide association studies (GWAS) have identified novel loci associated with sudden cardiac death (SCD). Despite this progress, identified DNA variants account for a relatively small portion of ...

    • Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals 

      Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John R. B.; Henneman, Peter; Heid, Iris M.; Kizer, Jorge R.; Lyytikäinen, Leo-Pekka; Fuchsberger, Christian; Tanaka, Toshiko; Morris, Andrew P.; Small, Kerrin; Isaacs, Aaron; Beekman, Marian; Coassin, Stefan; Lohman, Kurt; Kanoni, Stavroula; Pankow, James S.; Uh, Hae-Won; Bidulescu, Aurelian; Rasmussen-Torvik, Laura J.; Greenwood, Celia M. T.; Ladouceur, Martin; Grimsby, Jonna; Liu, Ching-Ti; Kooner, Jaspal; Mooser, Vincent E.; Vollenweider, Peter; Kapur, Karen A.; Chambers, John; Wareham, Nicholas J.; Langenberg, Claudia; Frants, Rune; Willems-vanDijk, Ko; Oostra, Ben A.; Willems, Sara M.; Lamina, Claudia; Winkler, Thomas W.; Psaty, Bruce M.; Tracy, Russell P.; Chen, Ida; Viikari, Jorma; Kähönen, Mika; Pramstaller, Peter P.; St. Pourcain, Beate; Sattar, Naveed; Wood, Andrew R.; Bandinelli, Stefania; Carlson, Olga D.; Egan, Josephine M.; Böhringer, Stefan; van Heemst, Diana; Kedenko, Lyudmyla; Kristiansson, Kati; Nuotio, Marja-Liisa; Loo, Britt-Marie; Harris, Tamara; Garcia, Melissa; Kanaya, Alka; Haun, Margot; Klopp, Norman; Wichmann, H.-Erich; Deloukas, Panos; Katsareli, Efi; Couper, David J.; Duncan, Bruce B.; Kloppenburg, Margreet; Adair, Linda S.; Borja, Judith B.; Wilson, James G.; Musani, Solomon; Guo, Xiuqing; Johnson, Toby; Semple, Robert; Teslovich, Tanya M.; Allison, Matthew A.; Buxbaum, Sarah G.; Mohlke, Karen L.; Meulenbelt, Ingrid; Ballantyne, Christie M.; Dedoussis, George V.; Liu, Yongmei; Paulweber, Bernhard; Spector, Timothy D.; Slagboom, P. Eline; Ferrucci, Luigi; Jula, Antti; Perola, Markus; Raitakari, Olli; Salomaa, Veikko; Eriksson, Johan G.; Frayling, Timothy M.; Hicks, Andrew A.; Lehtimäki, Terho; Siscovick, David S.; Kronenberg, Florian; van Duijn, Cornelia; Loos, Ruth J. F.; Waterworth, Dawn M.; Dupuis, Josee; Yuan, Xin; Scott, Robert A.; Qi, Lu; Wu, Ying; Manning, Alisa K; Brody, Jennifer Karen; Evans, David M.; Redline, Susan; Hu, Frank B.; Florez, Jose Carlos; Smith, George Davey; Meigs, James Benjamin; Richards, Jeremy B (Public Library of Science, 2012)
      Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis ...

    • Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis 

      Inouye, Michael; Ripatti, Samuli; Kettunen, Johannes; Lyytikäinen, Leo-Pekka; Oksala, Niku; Laurila, Pirkka-Pekka; Kangas, Antti J.; Soininen, Pasi; Savolainen, Markku J.; Viikari, Jorma; Kähönen, Mika; Perola, Markus; Salomaa, Veikko; Raitakari, Olli; Lehtimäki, Terho; Taskinen, Marja-Riitta; Järvelin, Marjo-Riitta; Ala-Korpela, Mika; Palotie, Aarno; de Bakker, Paul I Wen (Public Library of Science, 2012)
      Association testing of multiple correlated phenotypes offers better power than univariate analysis of single traits. We analyzed 6,600 individuals from two population-based cohorts with both genome-wide SNP data and serum ...

    • Novel Locus FER Is Associated With Serum HMW Adiponectin Levels 

      Qi, Lu; Menzaghi, Claudia; Salvemini, Lucia; De Bonis, Concetta; Trischitta, Vincenzo; Hu, Frank B. (American Diabetes Association, 2011)
      OBJECTIVE High molecular weight (HMW) adiponectin is a predominant isoform of circulating adiponectin and has been related to type 2 diabetes. Previous linkage studies suggest that different genetic components might be ...

    • Novel Marmoset (Callithrix jacchus) Model of Human Herpesvirus 6A and 6B Infections: Immunologic, Virologic and Radiologic Characterization 

      Leibovitch, Emily; Wohler, Jillian E.; Macri, Sheila; Motanic, Kelsey; Harberts, Erin; Gaitán, María I.; Maggi, Pietro; Ellis, Mary E; Westmoreland, Susan V.; Silva, Afonso; Reich, Daniel S.; Jacobson, Steven (Public Library of Science, 2013)
      Human Herpesvirus 6 (HHV-6) is a ubiquitous virus with an estimated seroprevalence of 95% in the adult population. HHV-6 is associated with several neurologic disorders, including multiple sclerosis, an inflammatory ...

    • A novel mechanism for glycoconjugate vaccine activation of the adaptive immune system 

      Avci, Fikri Yavuz; Li, Xiangming; Tsuji, Moriya; Kasper, Dennis Lee (2012)
      Although glycoconjugate vaccines have provided enormous health benefits globally, they have been less successful in significant high-risk populations. Exploring novel approaches to the enhancement of glycoconjugate ...

    • Novel Mechanisms by Which Fat Cells Regulate Systemic Insulin Sensitivity and Diabetes Risk 

      Kahn, Barbara; Herman, Mark Andrew; Peroni, Odile Daniele (BioMed Central, 2012)

    • A novel mentorship programme for residents integrating academic development, clinical teaching and graduate medical education assessment 

      Bhatia, Kriti; Takayesu, James Kimo; Nadel, Eric S. (Bohn Stafleu van Loghum, 2016)
      Introduction: Mentorship fosters career development and growth. During residency training, mentorship should support clinical development along with intellectual and academic interests. Reported resident mentoring programmes ...

    • Novel Method for Automated Analysis of Retinal Images: Results in Subjects with Hypertensive Retinopathy and CADASIL 

      Cavallari, Michele; Stamile, Claudio; Umeton, Renato; Calimeri, Francesco; Orzi, Francesco (Hindawi Publishing Corporation, 2015)
      Morphological analysis of the retinal vessels by fundoscopy provides noninvasive means for detecting and staging systemic microvascular damage. However, full exploitation of fundoscopy in clinical settings is limited by ...

    • Novel Method for Quantifying Radiation-Induced Single-Strand-Break Yields in Plasmid DNA Highlights 10-Fold Discrepancy 

      Balagurumoorthy, Pichumani; Adelstein, Stanley; Kassis, Amin (Elsevier BV, 2011-10)
      The widely used agarose gel electrophoresis method for assessing radiation-induced single-strand-break (SSB) yield in plasmid DNA involves measurement of the fraction of relaxed-circular (C) form that migrates independently ...

    • A Novel Method to Capture the Onset of Dynamic Electrocardiographic Ischemic Changes and its Implications to Arrhythmia Susceptibility 

      Sayadi, Omid; Puppala, Dheeraj; Ishaque, Nosheen; Doddamani, Rajiv; Merchant, Faisal M.; Barrett, Conor; Singh, Jagmeet P.; Heist, E. Kevin; Mela, Theofanie; Martínez, Juan Pablo; Laguna, Pablo; Armoundas, Antonis A. (Blackwell Publishing Ltd, 2014)
      Background: This study investigates the hypothesis that morphologic analysis of intracardiac electrograms provides a sensitive approach to detect acute myocardial infarction or myocardial infarction‐induced arrhythmia ...

    • Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production 

      Wu, Connie; Arora, Pankaj; Agha, Obiajulu; Hurst, Liam A.; Allen, Kaitlin; Nathan, Daniel I.; Hu, Dongjian; Jiramongkolchai, Pawina; Smith, J. Gustav; Melander, Olle; Trenson, Sander; Janssens, Stefan P.; Domian, Ibrahim J.; Wang, Thomas J.; Bloch, Kenneth; Buys, Emmanuel; Bloch, Donald Bendit; Newton-Cheh, Christopher Holmes (American Society for Microbiology, 2016)
      Atrial natriuretic peptide (ANP) has a central role in regulating blood pressure in humans. Recently, microRNA 425 (miR-425) was found to regulate ANP production by binding to the mRNA of NPPA, the gene encoding ANP. mRNAs ...