Browsing Harvard Medical School by Title

Now showing items 12124-12143 of 18428

    • A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis 

      Zhang, Lin; Orban, Martin; Lorenz, Michael; Barocke, Verena; Braun, Daniela Anne; Urtz, Nicole; Schulz, Christian; von Brühl, Marie-Luise; Tirniceriu, Anca; Gaertner, Florian; Proia, Richard L.; Graf, Thomas; Bolz, Steffen-Sebastian; Montanez, Eloi; Prinz, Marco; Müller, Alexandra; von Baumgarten, Louisa; Billich, Andreas; Sixt, Michael; Fässler, Reinhard; Von Andrian, Ulrich H.; Junt, Tobias; Massberg, Steffen (The Rockefeller University Press, 2012)
      Millions of platelets are produced each hour by bone marrow (BM) megakaryocytes (MKs). MKs extend transendothelial proplatelet (PP) extensions into BM sinusoids and shed new platelets into the blood. The mechanisms that ...

    • Novel Roles for MLH3 Deficiency and TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression 

      Chen, Peng-Chieh; Kuraguchi, Mari; Velasquez, John; Wang, Yuxun; Yang, Kan; Edwards, Robert R; Gillen, Dan; Edelmann, Winfried; Kucherlapati, Raju; Lipkin, Steven M. (Public Library of Science, 2008)
      DNA mismatch repair suppresses gastrointestinal tumorgenesis. Four mammalian E. coli MutL homologues heterodimerize to form three distinct complexes: MLH1/PMS2, MLH1/MLH3, and MLH1/PMS1. To understand the mechanistic ...

    • A Novel SALL4/OCT4 Transcriptional Feedback Network for Pluripotency of Embryonic Stem Cells 

      Yang, Jianchang; Ma, Yupo; Bridger, Joanna Mary; Gao, Chong; Chai, Li (Public Library of Science, 2010)
      Background: SALL4 is a member of the SALL gene family that encodes a group of putative developmental transcription factors. Murine Sall4 plays a critical role in maintaining embryonic stem cell (ES cell) pluripotency and ...

    • Novel Secretion Apparatus Maintains Spore Integrity and Developmental Gene Expression in Bacillus subtilis 

      Doan, Thierry; Morlot, Cecile; Meisner, Jeffrey; Serrano, Monica; Henriques, Adriano O.; Moran, Charles P. Jr.; Rudner, David Z. (Public Library of Science, 2009)
      Sporulation in Bacillus subtilis involves two cells that follow separate but coordinately regulated developmental programs. Late in sporulation, the developing spore (the forespore) resides within a mother cell. The ...

    • A Novel Service-Oriented Professional Development Program for Research Assistants at an Academic Hospital: A Web-Based Survey 

      Kitts, Robert Li; Koleoglou, Kyle John; Holland, Jennifer Elysia; Hutchinson, Eliza Haapaniemi; Nang, Quincy Georgdie; Mehta, Clare Marie; Tran, Chau Minh; Fishman, Laurie Newman (JMIR Publications Inc., 2015)
      Background: Research assistants (RAs) are hired at academic centers to staff the research and quality improvement projects that advance evidence-based medical practice. Considered a transient population, these young ...

    • A Novel Small-Molecule Tumor Necrosis Factor \(\alpha\) Inhibitor Attenuates Inflammation in a Hepatitis Mouse Model 

      Ma, Li; Gong, Haiyan; Zhu, Haiyan; Ji, Qing; Su, Pei; Liu, Peng; Cao, Shannan; Yao, Jianfeng; Jiang, Linlin; Han, Mingzhe; Ma, Xiaotong; Xiong, Dongsheng; Luo, Hongbo; Wang, Fei; Zhou, Jiaxi; Xu, Yuanfu (American Society for Biochemistry & Molecular Biology (ASBMB), 2014)
      Over-expression of tumor necrosis factor α (TNFα) is a hallmark of many inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease and septic shock and hepatitis, making it a potential therapeutic ...

    • Novel Strategies for Drug Discovery Based on Intrinsically Disordered Proteins (IDPs) 

      Wang, Jihua; Cao, Zanxia; Zhao, Liling; Li, Shuqiang (Molecular Diversity Preservation International, 2011)
      Intrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions. Numerous IDPs have close relationships with human ...

    • Novel strategies in the pharmacotherapy of nonalcoholic fatty liver disease 

      Baffy, Gyorgy (Promenade Publishing House, 2016)
      Nonalcoholic fatty liver disease (NAFLD) affects an estimated one billion people in the world. NAFLD is a spectrum of disease ranging from steatosis to steatohepatitis with variable outcomes that include cirrhosis and ...

    • A Novel T55A Variant of Gsα Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis 

      Wentworth, Kelly; Hsing, Alyssa; Urrutia, Ashley; Zhu, Yan; Horvai, Andrew E.; Bastepe, Murat; Hsiao, Edward C. (Hindawi Publishing Corporation, 2016)
      G-protein coupled receptors (GPCRs) mediate a wide spectrum of biological activities. The GNAS complex locus encodes the stimulatory alpha subunit of the guanine nucleotide binding protein (Gsα) and regulates production ...

    • Novel therapeutic and diagnostic management of heart transplant patients 

      D'Addio, Francesca; Margonato, Davide; Pensato, Umberto; Borgese, Laura; Potena, Luciano; Fiorina, Paolo (EDIMES Edizioni Internazionali Srl, 2015)
      Heart transplantation was performed for the first time 40 years ago and it is now universally considered the “gold standard” treatment for individuals suffering from end-stage heart failure. The increased understanding of ...

    • The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-γ Inhibitor AS605240 in Autoimmune Diabetes 

      Azzi, Jamil; Moore, Robert F.; Elyaman, Wassim; Mounayar, Marwan; El Haddad, Najib; Yang, Sunmi; Jurewicz, Mollie; Takakura, Ayumi; Petrelli, Alessandra; Fiorina, Paolo; Ruckle, Thomas; Abdi, Reza (American Diabetes Association, 2012)
      Type 1 diabetes (T1D) remains a major health problem worldwide, with a steadily rising incidence yet no cure. Phosphoinositide 3-kinase-γ (PI3Kγ), a member of a family of lipid kinases expressed primarily in leukocytes, ...

    • Novel Therapy for Primary Canaliculitis: A Pilot Study of Intracanalicular Ophthalmic Corticosteroid/Antibiotic Combination Ointment Infiltration 

      Xu, Jianjiang; Liu, Zuguo; Mashaghi, Alireza; Sun, Xinghuai; Lu, Yi; Li, Yimin; Wu, Dan; Yang, Yujing; Wei, Anji; Zhao, Yujin; Lu, Chun; Hong, Jiaxu (Wolters Kluwer Health, 2015)
      Abstract In patients with primary canaliculitis, conservative medical therapy is associated with a high recurrence rate. Surgical treatments carry a great resolution rate but sometimes can result in the lacrimal pump ...

    • A Novel Totivirus and Piscine Reovirus (PRV) in Atlantic Salmon (Salmo salar) with Cardiomyopathy Syndrome (CMS) 

      Løvoll, Marie; Wiik-Nielsen, Jannicke; Grove, Søren; Wiik-Nielsen, Christer R; Kristoffersen, Anja B; Faller, Randi; Poppe, Trygve; Jung, Joonil; Pedamallu, Chandra S; Nederbragt, Alexander J; Rimstad, Espen; Tengs, Torstein; Meyerson, Matthew Langer (BioMed Central, 2010)
      Background: Cardiomyopathy syndrome (CMS) is a severe disease affecting large farmed Atlantic salmon. Mortality often appears without prior clinical signs, typically shortly prior to slaughter. We recently reported the ...

    • Novel treatment options for ulcerative colitis 

      Vaughn, Byron P; Moss, Alan C (OMICS Publishing Group, 2013)
      The approved treatment options for patients with ulcerative colitis (UC) are currently limited to mesalamine or immunosuppressants. Patients who do not respond to mesalamine-based therapy can be treated with immunomodulators ...

    • Novel Treatments for Airway Disease 

      Cahill, Catherine; Boyce, Joshua; Israel, Elliot (Massachusetts Medical Society, 2017-08-10)

    • Novel Tumor Suppressor Function of Glucocorticoid-Induced TNF Receptor GITR in Multiple Myeloma 

      Liu, Yang; Quang, Phong; Braggio, Esteban; Ngo, Hai; Badalian-Very, Gayane; Flores, Ludmila; Zhang, Yong; Sacco, Antonio; Maiso, Patricia; Azab, Abdel Kareem; Azab, Feda; Carrasco, Ruben; Rollins, Barrett J.; Roccaro, Aldo M.; Ghobrial, Irene M. (Public Library of Science, 2013)
      Glucocorticoid-induced TNF receptor (GITR) plays a crucial role in modulating immune response and inflammation, however the role of GITR in human cancers is poorly understood. In this study, we demonstrated that GITR is ...

    • Novel Use of Natural Language Processing (NLP) to Predict Suicidal Ideation and Psychiatric Symptoms in a Text-Based Mental Health Intervention in Madrid 

      Cook, Benjamin L.; Progovac, Ana M.; Chen, Pei; Mullin, Brian; Hou, Sherry; Baca-Garcia, Enrique (Hindawi Publishing Corporation, 2016)
      Natural language processing (NLP) and machine learning were used to predict suicidal ideation and heightened psychiatric symptoms among adults recently discharged from psychiatric inpatient or emergency room settings in ...

    • A Novel Whole-Cell Lysate Kinase Assay Identifies Substrates of the p38 MAPK in Differentiating Myoblasts 

      Knight, James DR; Tian, Ruijun; Wang, Fangjun; Beauvais, Ariane; Zou, Hanfa; Megeney, Lynn A; Gingras, Anne-Claude; Pawson, Tony; Figeys, Daniel; Kothary, Rashmi; Lee, Robin (BioMed Central, 2012)
      Background: The p38\(\alpha\) mitogen-activated protein kinase (MAPK) is a critical mediator of myoblast differentiation, and does so in part through the phosphorylation and regulation of several transcription factors and ...

    • A Novel, Highly Sensitive Antibody Allows for the Routine Detection of ALK-rearranged Lung Adenocarcinomas by Standard Immunohistochemistry 

      Mino-Kenudson, Mari; Chirieac, Lucian; Law, Kenny; Hornick, Jason; Lindeman, Neal; Mark, Eugene; Cohen, David W.; Johnson, Bruce; Janne, Pasi; Iafrate, Anthony; Rodig, Scott (American Association for Cancer Research, 2010-03)
      Purpose Approximately 5% of lung adenocarcinomas harbor an EML4-ALK gene fusion and define a unique tumor group that may be responsive to targeted therapy. However ALK-rearranged lung adenocarcinomas are difficult to ...

    • De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds 

      Dudchenko, Olga; Batra, Sanjit S.; Omer, Arina D.; Nyquist, Sarah K.; Hoeger, Marie; Durand, Neva C.; Shamim, Muhammad S.; Machol, Ido; Lander, Eric Steven; Aiden, Aviva; Aiden, Erez Lieberman (American Association for the Advancement of Science (AAAS), 2017)
      The Zika outbreak, spread by the Aedes aegypti mosquito, highlights the need to create high-quality assemblies of large genomes in a rapid and cost-effective fashion. Here, we combine Hi-C data with existing draft ...