Browsing Harvard Medical School by Title

Now showing items 12694-12713 of 18428

    • Particulate matter and risk of parkinson disease in a large prospective study of women 

      Palacios, Natalia; Fitzgerald, Kathryn C; Hart, Jaime E; Weisskopf, Marc G; Schwarzschild, Michael A; Ascherio, Alberto; Laden, Francine (BioMed Central, 2014)
      Background: Exposure to air pollution has been implicated in a number of adverse health outcomes and the effect of particulate matter (PM) on the brain is beginning to be recognized. Yet, no prospective study has examined ...

    • Partitioning heritability by functional annotation using genome-wide association summary statistics 

      Finucane, Hilary K.; Bulik-Sullivan, Brendan; Gusev, Alexander; Trynka, Gosia; Reshef, Yakir; Loh, Po-Ru; Anttila, Verneri; Xu, Han; Zang, Chongzhi; Farh, Kyle; Ripke, Stephan; Day, Felix R.; Consortium, ReproGen; Purcell, Shaun; Stahl, Eli; Lindstrom, Sara; Perry, John R. B.; Okada, Yukinori; Raychaudhuri, Soumya; Daly, Mark; Patterson, Nick; Neale, Benjamin M.; Price, Alkes L. (2015)
      Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here, we analyze a broad set of functional elements, including cell-type-specific ...

    • Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture 

      Davis, Lea K.; Yu, Dongmei; Keenan, Clare L.; Gamazon, Eric R.; Konkashbaev, Anuar I.; Derks, Eske M.; Neale, Benjamin M.; Yang, Jian; Lee, S. Hong; Evans, Patrick; Barr, Cathy L.; Bellodi, Laura; Benarroch, Fortu; Berrio, Gabriel Bedoya; Bienvenu, Oscar J.; Bloch, Michael H.; Blom, Rianne M.; Bruun, Ruth D.; Budman, Cathy L.; Camarena, Beatriz; Campbell, Desmond; Cappi, Carolina; Cardona Silgado, Julio C.; Cath, Danielle C.; Cavallini, Maria C.; Chavira, Denise A.; Chouinard, Sylvain; Conti, David V.; Cook, Edwin H.; Coric, Vladimir; Cullen, Bernadette A.; Deforce, Dieter; Delorme, Richard; Dion, Yves; Edlund, Christopher K.; Egberts, Karin; Falkai, Peter; Fernandez, Thomas V.; Gallagher, Patience J.; Garrido, Helena; Geller, Daniel; Girard, Simon L.; Grabe, Hans J.; Grados, Marco A.; Greenberg, Benjamin D.; Gross-Tsur, Varda; Haddad, Stephen; Heiman, Gary A.; Hemmings, Sian M. J.; Hounie, Ana G.; Illmann, Cornelia; Jankovic, Joseph; Jenike, Michael A.; Kennedy, James L.; King, Robert A.; Kremeyer, Barbara; Kurlan, Roger; Lanzagorta, Nuria; Leboyer, Marion; Leckman, James F.; Lennertz, Leonhard; Liu, Chunyu; Lochner, Christine; Lowe, Thomas L.; Macciardi, Fabio; McCracken, James T.; McGrath, Lauren M.; Mesa Restrepo, Sandra C.; Moessner, Rainald; Morgan, Jubel; Muller, Heike; Murphy, Dennis L.; Naarden, Allan L.; Ochoa, William Cornejo; Ophoff, Roel A.; Osiecki, Lisa; Pakstis, Andrew J.; Pato, Michele T.; Pato, Carlos N.; Piacentini, John; Pittenger, Christopher; Pollak, Yehuda; Rauch, Scott L.; Renner, Tobias J.; Reus, Victor I.; Richter, Margaret A.; Riddle, Mark A.; Robertson, Mary M.; Romero, Roxana; Rosàrio, Maria C.; Rosenberg, David; Rouleau, Guy A.; Ruhrmann, Stephan; Ruiz-Linares, Andres; Sampaio, Aline S.; Samuels, Jack; Sandor, Paul; Sheppard, Brooke; Singer, Harvey S.; Smit, Jan H.; Stein, Dan J.; Strengman, E.; Tischfield, Jay A.; Valencia Duarte, Ana V.; Vallada, Homero; Van Nieuwerburgh, Filip; Veenstra-VanderWeele, Jeremy; Walitza, Susanne; Wang, Ying; Wendland, Jens R.; Westenberg, Herman G. M.; Shugart, Yin Yao; Miguel, Euripedes C.; McMahon, William; Wagner, Michael; Nicolini, Humberto; Posthuma, Danielle; Hanna, Gregory L.; Heutink, Peter; Denys, Damiaan; Arnold, Paul D.; Oostra, Ben A.; Nestadt, Gerald; Freimer, Nelson B.; Pauls, David L.; Wray, Naomi R.; Stewart, S. Evelyn; Mathews, Carol A.; Knowles, James A.; Cox, Nancy J.; Scharf, Jeremiah M. (Public Library of Science, 2013)
      The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated ...

    • Partner testing, linkage to care, and HIV-free survival in a program to prevent parent-to-child transmission of HIV in the Highlands of Papua New Guinea 

      Carmone, Andy; Bomai, Korai; Bongi, Wayaki; Frank, Tarua Dale; Dalepa, Huleve; Loifa, Betty; Kiromat, Mobumo; Das, Sarthak; Franke, Molly F. (Co-Action Publishing, 2014)
      Background: To eliminate new pediatric HIV infections, interventions that facilitate adherence, including those that minimize stigma, enhance social support, and mitigate the influence of poverty, will likely be required ...

    • Partnering with health system operations leadership to develop a controlled implementation trial 

      Bauer, Mark S.; Miller, Christopher; Kim, Bo; Lew, Robert; Weaver, Kendra; Coldwell, Craig; Henderson, Kathy; Holmes, Sally; Seibert, Marjorie Nealon; Stolzmann, Kelly; Elwy, A. Rani; Kirchner, JoAnn (BioMed Central, 2016)
      Background: Outcome for mental health conditions is suboptimal, and care is fragmented. Evidence from controlled trials indicates that collaborative chronic care models (CCMs) can improve outcomes in a broad array of mental ...

    • Partnerships in mental healthcare service delivery in low-resource settings: developing an innovative network in rural Nepal 

      Acharya, Bibhav; Maru, Duncan; Schwarz, Ryan; Citrin, David; Tenpa, Jasmine; Hirachan, Soniya; Basnet, Madhur; Thapa, Poshan; Swar, Sikhar; Halliday, Scott; Kohrt, Brandon; Luitel, Nagendra P.; Hung, Erick; Gauchan, Bikash; Pokharel, Rajeev; Ekstrand, Maria (BioMed Central, 2017)
      Background: Mental illnesses are the largest contributors to the global burden of non-communicable diseases. However, there is extremely limited access to high quality, culturally-sensitive, and contextually-appropriate ...

    • Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study 

      Frost, Jeffrey L.; Liu, Bin; Kleinschmidt, Martin; Schilling, Stephan; Demuth, Hans-Ulrich; Lemere, Cynthia A. (S. Karger AG, 2012)
      Background: N-terminally truncated and modified pyroglutamate-3 amyloid-β protein (pE3-Aβ) is present in most, if not all, cerebral plaque and vascular amyloid deposits in human Alzheimer's disease (AD). pE3-Aβ deposition ...

    • Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose 

      Sholukh, Anton M; Byrareddy, Siddappa N; Shanmuganathan, Vivekanandan; Hemashettar, Girish; Lakhashe, Samir K; Rasmussen, Robert A; Watkins, Jennifer D; Vyas, Hemant K; Thorat, Swati; Brandstoetter, Tania; Mukhtar, Muhammad M; Yoon, John K; Novembre, Francis J; Villinger, Francois; Landucci, Gary; Forthal, Donald N; Ratcliffe, Sarah; Tuero, Iskra; Robert-Guroff, Marjorie; Polonis, Victoria R; Bilska, Miroslawa; Montefiori, David C; Johnson, Welkin E; Ertl, Hildegund C; Ruprecht, Ruth M (BioMed Central, 2014)
      Background: A key goal for HIV-1 envelope immunogen design is the induction of cross-reactive neutralizing antibodies (nAbs). As AIDS vaccine recipients will not be exposed to strains exactly matching any immunogens due ...

    • Passive immunization with polyclonal anti-SHIV IgG: partial protection or increased acquisition of heterologous tier 2 SHIV – depending on IgG dose 

      Sholukh, Anton M; Siddappa, NB; Shanmuganathan, V; Lakhashe, Samir; Rasmussen, Robert Anthony; Watkins, Jennifer D; Vyas, Hemant Kumar; Mukhtar, Muhammad Mahmood; Hemashettar, G; Thorat, Swati; Yoon, JK; Villinger, F; Novembre, FJ; Landucci, G; Forthal, DN; Ratcliffe, S; Robert-Guroff, M; Polonis, V; Montefiori, DC; Ertl, HC; Ruprecht, Ruth Margrit (BioMed Central, 2012)

    • Passive Markers for Tracking Surgical Instruments in Real-Time 3-D Ultrasound Imaging 

      Stoll, J.; Ren, H.; Dupont, Pierre E (Institute of Electrical and Electronics Engineers (IEEE), 2012)
      A family of passive echogenic markers is presented by which the position and orientation of a surgical instrument can be determined in a 3-D ultrasound volume, using simple image processing. Markers are attached near the ...

    • Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques 

      Shingai, Masashi; Donau, Olivia K.; Plishka, Ronald J.; Buckler-White, Alicia; Mascola, John R.; Nabel, Gary J.; Nason, Martha C.; Montefiori, David; Moldt, Brian; Poignard, Pascal; Diskin, Ron; Bjorkman, Pamela J.; Eckhaus, Michael A.; Klein, Florian; Mouquet, Hugo; Cetrulo Lorenzi, Julio Cesar; Gazumyan, Anna; Burton, Dennis R.; Nussenzweig, Michel C.; Martin, Malcolm A.; Nishimura, Yoshiaki (The Rockefeller University Press, 2014)
      It is widely appreciated that effective human vaccines directed against viral pathogens elicit neutralizing antibodies (NAbs). The passive transfer of anti–HIV-1 NAbs conferring sterilizing immunity to macaques has been ...

    • Past and Future Spread of the Arbovirus Vectors Aedes Aegypti and Aedes Albopictus 

      Yi, Dingdong; Johnson, Kimberly; Jones, Peter; Bengtsson, Linus; Wetter, Erik; Lambrechts, Louis; Cauchemez, Simon; Linardos, Catherine; Yu, Hongjie; Wint, G. R. William; Kraemer, Moritz; Reiner, Robert; Brady, Oliver; Messina, Jane; Gilbert, Marius; Pigott, David; Earl, Lucas; Marczak, Laurie; Shirude, Shreya; Davis Weaver, Nicole; Bisanzio, Donal; Perkins, T. Alex; Lai, Shengjie; Lu, Xin; Coelho, Giovanini; Carvalho, Roberta; Van Bortel, Wim; Marsboom, Cedric; Hendrickx, Guy; Schaffner, Francis; Moore, Chester; Nax, Heinrich; Tatem, Andrew; Brownstein, John; Smith, David; Faria, Nuno; Pybus, Oliver; Scott, Thomas; Liu, Qiyong; Hay, Simon; Golding, Nick (Springer Science and Business Media LLC, 2019-03-04)
      The global population at risk from mosquito-borne diseases – including dengue, yellow fever, chikungunya, and Zika – is expanding in concert with changes in the distribution of two key vectors, Aedes aegypti and Ae. ...

    • Past, Current, and Future Trends in Infant Face Perception Research 

      Nelson, Charles A.; Ludemann, Pamela M. (American Psychological Association (APA), 1989)
      Our review of infant face perception research had three purposes. First, we briefly attempted to describe a number of themes prevalent in the literature before 1979. Although the themes were broad and difficult to identify ...

    • PASTA: splice junction identification from RNA-Sequencing data 

      Tang, Shaojun; Riva, Alberto (BioMed Central, 2013)
      Background: Next generation transcriptome sequencing (RNA-Seq) is emerging as a powerful experimental tool for the study of alternative splicing and its regulation, but requires ad-hoc analysis methods and tools. PASTA ...

    • Patents on Technologies of Human Tissue and Organ Regeneration from Pluripotent Human Embryonic Stem Cells 

      Parsons, Xuejun H; Teng, Yang D; Moore, Dennis A; Snyder, Evan Y (Bentham Science Publishers Ltd, 2011)
      Human embryonic stem cells (hESCs) are genetically stable with unlimited expansion ability and unrestricted plasticity, proffering a pluripotent reservoir for in vitro derivation of a large supply of disease-targeted human ...

    • Paternal age increases the risk for autism in an Iranian population sample 

      Sasanfar, Roksana; Haddad, Stephen A; Tolouei, Ala; Ghadami, Majid; Yu, Dongmei; Santangelo, Susan L. (BioMed Central, 2010)
      Background: Autism is a neurodevelopmental disorder which is known to have a strong genetic component and is most likely oligogenic. However, the necessary role of environmental factors has been well documented. Prior ...

    • Paternal Urinary Concentrations of Parabens and Other Phenols in Relation to Reproductive Outcomes among Couples from a Fertility Clinic 

      Dodge, Laura E.; Williams, Paige L.; Williams, Michelle A.; Missmer, Stacey A.; Toth, Thomas L.; Calafat, Antonia M.; Hauser, Russ (NLM-Export, 2015)
      Background: Human exposure to phenols, including bisphenol A and parabens, is widespread. Evidence suggests that paternal exposure to environmental chemicals may adversely affect reproductive outcomes. Objectives: We ...

    • Pathobiology of Experimental Acute Pancreatitis 

      Steer, Michael Lewis (Yale Journal of Biology and Medicine, 1992)
      Pancreatic duct obstruction, even in the absence of biliary obstruction and/or bile reflux into the pancreatic duct, can trigger acute hemorrhagic necrotizing pancreatitis. The earliest changes are seen within acinar cells. ...

    • Pathogen-Secreted Proteases Activate a Novel Plant Immune Pathway 

      Cheng, Zhenyu; Li, Jian-Feng; Niu, Yajie; Zhang, Xue-Cheng; Woody, Owen Z.; Xiong, Yan; Djonović, Slavica; Millet, Yves; Bush, Jenifer; McConkey, Brendan J.; Sheen, Jen; Ausubel, Frederick M. (2015)
      Mitogen-Activated Protein Kinase (MAPK) cascades play central roles in innate immune signaling networks in plants and animals1,2. In plants, however, the molecular mechanisms of how signal perception is transduced to MAPK ...

    • Pathogenic E. coli Exploits SslE Mucinase Activity to Translocate through the Mucosal Barrier and Get Access to Host Cells 

      Valeri, Maria; Rossi Paccani, Silvia; Kasendra, Magdalena; Nesta, Barbara; Serino, Laura; Pizza, Mariagrazia; Soriani, Marco (Public Library of Science, 2015)
      SslE is a zinc-metalloprotease involved in the degradation of mucin substrates and recently proposed as a potential vaccine candidate against pathogenic E. coli. In this paper, by exploiting a human in vitro model of ...