Browsing Harvard Medical School by Title

Now showing items 12832-12851 of 18428

    • Pediatric forearm fractures with in situ intramedullary implants 

      Kelly, Brian A.; Shore, Benjamin J.; Bae, Donald S.; Hedequist, Daniel J.; Glotzbecker, Michael P. (Springer Berlin Heidelberg, 2016)
      Purpose The purpose of this investigation is to present our institutional experience with fractures of the pediatric forearm with in situ intramedullary nails. Methods: Six patients treated at our institution for forearm ...

    • Pediatric Health-Related Quality of Life: A Structural Equation Modeling Approach 

      Villalonga-Olives, Ester; Kawachi, Ichiro; Almansa, Josué; Witte, Claudia; Lange, Benjamin; Kiese-Himmel, Christiane; von Steinbüchel, Nicole (Public Library of Science, 2014)
      Objectives: One of the most referenced theoretical frameworks to measure Health Related Quality of Life (HRQoL) is the Wilson and Cleary framework. With some adaptions this framework has been validated in the adult population, ...

    • Pediatric hereditary angioedema 

      MacGinnitie, Andrew J (BlackWell Publishing Ltd, 2013)
      Hereditary angioedema (HAE) is a lifelong illness characterized by recurrent swelling of the skin, intestinal tract, and, ominously, the upper airway. It is caused by inadequate activity of the protein C1-inhibitor, with ...

    • Pediatric neuroimaging in early childhood and infancy: challenges and practical guidelines 

      Raschle, Nora; Zuk, Jennifer Margaret; Ortiz-Mantilla, Silvia; Sliva, Danielle D.; Franceschi, Angela; Grant, P. Ellen; Benasich, April A.; Gaab, Nadine (Wiley-Blackwell, 2012)
      Structural and functional magnetic resonance imaging (fMRI) has been used increasingly to investigate typical and atypical brain development. However, in contrast to studies in school-aged children and adults, MRI research ...

    • Pediatric pain management: the multidisciplinary approach 

      Odell, Shannon; Logan, Deirdre E (Dove Medical Press, 2013)
      Chronic pain in children and adolescents is a growing problem and one that is increasingly being addressed with multidisciplinary treatment teams. This review summarizes different multidisciplinary clinics, focusing ...

    • The Pediatric Research Equity Act Moves Into Adolescence 

      Bourgeois, Florence Tanya; Hwang, Thomas J (American Medical Association (AMA), 2017)

    • Pediatric Response to Court-Mandated Medicaid Behavioral Screening in Massachusetts 

      Van Cleave, Jeanne; Morales, Dianali Rivera; Perrin, James Marc (Ovid Technologies (Wolters Kluwer Health), 2013)
      Objective: In 2007 in Massachusetts, a settlement of a class-action lawsuit on behalf of Medicaid beneficiaries mandated that primary care practices perform developmental, behavioral and mental health screening using formal ...

    • Pediatric Response to Second-Line Antiretroviral Therapy in South Africa 

      Zanoni, Brian C; Sunpath, Henry; Feeney, Margaret E. (Public Library of Science, 2012)
      Background: With improved access to pediatric antiretroviral therapy (ART) in resource-limited settings, more children could experience first-line ART treatment failure. Methods: We performed a retrospective cohort analysis ...

    • Pediatric sepsis: Important considerations for diagnosing and managing severe infections in infants, children, and adolescents 

      Randolph, Adrienne G; McCulloh, Russell J (Landes Bioscience, 2014)
      Sepsis is the leading cause of death in children worldwide. Although the diagnosis and management of sepsis in infants and children is largely influenced by studies done in adults, there are important considerations relevant ...

    • Pediatricians’ Practice Location Choice—Evaluating the Effect of Japan’s 2004 Postgraduate Training Program on the Spatial Distribution of Pediatricians 

      Sakai, Rie; Fink, Günther; Kawachi, Ichiro (Japan Epidemiological Association, 2014)
      Objectives: To explore determinants of change in pediatrician supply in Japan, and examine impacts of a 2004 reform of postgraduate medical education on pediatricians’ practice location choice. Methods: Data were compiled ...

    • PEDSnet: a National Pediatric Learning Health System 

      Forrest, Christopher B; Margolis, Peter A; Bailey, L Charles; Marsolo, Keith; Del Beccaro, Mark A; Finkelstein, Jonathan A; Milov, David E; Vieland, Veronica J; Wolf, Bryan A; Yu, Feliciano B; Kahn, Michael G (BMJ Publishing Group, 2014)
      A learning health system (LHS) integrates research done in routine care settings, structured data capture during every encounter, and quality improvement processes to rapidly implement advances in new knowledge, all with ...

    • PEG-Like Nanoprobes: Multimodal, Pharmacokinetically and Optically Tunable Nanomaterials 

      Guo, Yanyan; Yuan, Hushan; Claudio, Natalie M.; Kura, Sreekanth; Shakerdge, Naomi; Mempel, Thorsten R.; Bacskai, Brian J.; Josephson, Lee (Public Library of Science, 2014)
      “PEG-like Nanoprobes” (PN’s) are pharmacokinetically and optically tunable nanomaterials whose disposition in biological systems can be determined by fluorescence or radioactivity. PN’s feature a unique design where a ...

    • Pelvic and breast examination skills curricula in United States medical schools: a survey of obstetrics and gynecology clerkship directors 

      Dugoff, Lorraine; Pradhan, Archana; Casey, Petra; Dalrymple, John L.; Abbott, Jodi F.; Buery-Joyner, Samantha D.; Chuang, Alice; Cullimore, Amie J.; Forstein, David A.; Hampton, Brittany S.; Kaczmarczyk, Joseph M.; Katz, Nadine T.; Nuthalapaty, Francis S.; Page-Ramsey, Sarah M.; Wolf, Abigail; Hueppchen, Nancy A. (BioMed Central, 2016)
      Background: Learning to perform pelvic and breast examinations produces anxiety for many medical students. Clerkship directors have long sought strategies to help students become comfortable with the sensitive nature of ...

    • Pelvic Insufficiency Fractures after Chemoradiation for Gynecologic Malignancies: A Review of Seven Cases 

      Aviki, Emeline; Cowan, Sophie; Young, Laura; del Carmen, Marcela; Growdon, Whitfield; Russell, Anthony; Goodman, Annekathryn (Scientific Research Publishing, Inc,, 2013-12)
      Background: Radiation-induced pelvic insufficiency fracture (PIF) is an important complication associated with pelvic radiation therapy (RT) for patients with gynecologic malignancies. Despite known risk factors and recent ...

    • Pelvic trauma: WSES classification and guidelines 

      Coccolini, Federico; Stahel, Philip F.; Montori, Giulia; Biffl, Walter; Horer, Tal M; Catena, Fausto; Kluger, Yoram; Moore, Ernest E.; Peitzman, Andrew B.; Ivatury, Rao; Coimbra, Raul; Fraga, Gustavo Pereira; Pereira, Bruno; Rizoli, Sandro; Kirkpatrick, Andrew; Leppaniemi, Ari; Manfredi, Roberto; Magnone, Stefano; Chiara, Osvaldo; Solaini, Leonardo; Ceresoli, Marco; Allievi, Niccolò; Arvieux, Catherine; Velmahos, George; Balogh, Zsolt; Naidoo, Noel; Weber, Dieter; Abu-Zidan, Fikri; Sartelli, Massimo; Ansaloni, Luca (BioMed Central, 2017)
      Complex pelvic injuries are among the most dangerous and deadly trauma related lesions. Different classification systems exist, some are based on the mechanism of injury, some on anatomic patterns and some are focusing on ...

    • Pen-2 Is Essential for γ-Secretase Complex Stability and Trafficking but Partially Dispensable for Endoproteolysis 

      Holmes, Oliver; Paturi, Swetha; Selkoe, Dennis J.; Wolfe, Michael S. (American Chemical Society, 2014)
      The 19-transmembrane γ-secretase complex generates the amyloid β-peptide of Alzheimer’s disease by intramembrane proteolysis of the β-amyloid precursor protein. This complex is comprised of presenilin, Aph1, nicastrin, and ...

    • Penetrating Abdominal Injuries: Management Controversies 

      Butt, Muhammad Umar; Zacharias, Nikolaos; Velmahos, George (BioMed Central, 2009)
      Penetrating abdominal injuries have been traditionally managed by routine laparotomy. New understanding of trajectories, potential for organ injury, and correlation with advanced radiographic imaging has allowed a shift ...

    • Penetrating Blast Injury to the Knee of a United States Soldier Treated with Allograft Mosaicplasty 

      Eichinger, Maj. Josef K.; Bluman, Eric M.; Arrington, Col. Edward D. (SAGE Publications, 2011)
      Objective: This is the first report of successful allograft mosaicplasty treatment of a large osteochondral lesion of the knee caused by a blast fragment sustained during combat operations. The patient was able to return ...

    • Penetration of Endothelial Cell Coated Multicellular Tumor Spheroids by Iron Oxide Nanoparticles 

      Ho, Don N.; Kohler, Nathan; Sigdel, Aruna; Kalluri, Raghu; Morgan, Jeffrey R.; Xu, Chenjie; Sun, Shouheng (Ivyspring International Publisher, 2012)
      Iron oxide nanoparticles are a useful diagnostic contrast agent and have great potential for therapeutic applications. Multiple emerging diagnostic and therapeutic applications and the numerous versatile parameters of the ...

    • Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding 

      Vistnes, Maria; Aronsen, Jan Magnus; Lunde, Ida G.; Sjaastad, Ivar; Carlson, Cathrine R.; Christensen, Geir (Public Library of Science, 2014)
      Background: We hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to ...