Browsing Harvard Medical School by Title

Now showing items 12965-12984 of 18428

    • PGC1α-dependent NAD biosynthesis links oxidative metabolism to renal protection 

      Tran, Mei T.; Zsengeller, Zsuzsanna K.; Berg, Anders H.; Khankin, Eliyahu V.; Bhasin, Manoj K.; Kim, Wondong; Clish, Clary B.; Stillman, Isaac E.; Karumanchi, S. Ananth; Rhee, Eugene P.; Parikh, Samir M. (2016)
      The energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischemia. Indeed, acute kidney injury (AKI) affects 3% of all hospitalized ...

    • PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury 

      North, Trista E.; Babu, I. Ramesh; Vedder, Lea M.; Lord, Allegra M.; Wishnok, John S.; Tannenbaum, Steven R.; Zon, Leonard I.; Goessling, Wolfram (National Academy of Sciences, 2010)
      Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver failure in the United States. The only available treatment, N-acetylcysteine (NAC), has a limited time window of efficacy, indicating a ...

    • pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices 

      Zhang, Shiyi; Bellinger, Andrew M.; Glettig, Dean L.; Barman, Ross; Lee, Young-Ah Lucy; Zhu, Jiahua; Cleveland, Cody; Montgomery, Veronica A; Gu, Li; Nash, Landon D.; Maitland, Duncan J.; Langer, Robert; Traverso, Giovanni (2015)
      Devices resident in the stomach -- which are used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric retentive dosage ...

    • PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance 

      Kiando, Soto Romuald; Tucker, Nathan R.; Castro-Vega, Luis-Jaime; Katz, Alexander; D’Escamard, Valentina; Tréard, Cyrielle; Fraher, Daniel; Albuisson, Juliette; Kadian-Dodov, Daniella; Ye, Zi; Austin, Erin; Yang, Min-Lee; Hunker, Kristina; Barlassina, Cristina; Cusi, Daniele; Galan, Pilar; Empana, Jean-Philippe; Jouven, Xavier; Gimenez-Roqueplo, Anne-Paule; Bruneval, Patrick; Hyun Kim, Esther Soo; Olin, Jeffrey W.; Gornik, Heather L.; Azizi, Michel; Plouin, Pierre-François; Ellinor, Patrick T.; Kullo, Iftikhar J.; Milan, David J.; Ganesh, Santhi K.; Boutouyrie, Pierre; Kovacic, Jason C.; Jeunemaitre, Xavier; Bouatia-Naji, Nabila (Public Library of Science, 2016)
      Fibromuscular dysplasia (FMD) is a nonatherosclerotic vascular disease leading to stenosis, dissection and aneurysm affecting mainly the renal and cerebrovascular arteries. FMD is often an underdiagnosed cause of hypertension ...

    • Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity 

      Hobbs, Samuel; Wein, Tanita; Lu, Allen; Morehouse, Benjamin R.; Schnabel, Julia; Leavitt, Azita; Yirmiya, Erez; Sorek, Rotem; Kranzusch, Philip J. (Springer Science and Business Media LLC, 2022-04-08)
      The cyclic oligonucleotide-based antiphage signalling system (CBASS) and the pyrimidine cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse bacteria that use cyclic nucleotide signals ...

    • Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity 

      Richter, Michelle F.; Zhao, Kevin T.; Eton, Elliot; Lapinaite, Audrone; Newby, Gregory A.; Thuronyi, B W.; Wilson, Christopher; Koblan, Luke W.; Zeng, Jing; Bauer, Daniel E.; Doudna, Jennifer A.; Liu, David (Springer Science and Business Media LLC, 2020-03-16)

    • Phage-Encoded Inhibitor of Staphylococcus aureus Transcription Exerts Context-Dependent Effects on Promoter Function in a Modified Escherichia coli-Based Transcription System 

      Montero-Diez, Cristina; Deighan, Padraig; Osmundson, Joseph; Darst, Seth A.; Hochschild, Ann (American Society for Microbiology, 2013)
      Promoter recognition in bacteria is mediated primarily by the sigma subunit of RNA polymerase (RNAP), which makes sequence-specific contacts with the promoter -10 and -35 elements in the context of the RNAP holoenzyme. ...

    • Phantom Acupuncture: Dissociating Somatosensory and Cognitive/Affective Components of Acupuncture Stimulation with a Novel Form of Placebo Acupuncture 

      Lee, Jeungchan; Napadow, Vitaly; Kim, Jieun; Lee, Seunggi; Choi, Woojin; Kaptchuk, Ted J.; Park, Kyungmo (Public Library of Science, 2014)
      In a clinical setting, acupuncture treatment consists of multiple components including somatosensory stimulation, treatment context, and attention to needle-based procedures. In order to dissociate somatosensory versus ...

    • A Pharmacodynamic Comparison of Prasugrel vs. High-Dose Clopidogrel in Patients with Type 2 Diabetes Mellitus and Coronary Artery Disease: Results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 Trial 

      Angiolillo, Dominick J.; Badimon, Juan Jose; Saucedo, Jorge F.; Frelinger, Andrew Lawrence; Michelson, Alan D; Jakubowski, Joseph A.; Zhu, Baojin; Ojeh, Clement K.; Baker, Brian A.; Effron, Mark B. (Oxford University Press, 2011)
      Aims: Patients with diabetes mellitus (DM) have increased platelet reactivity and reduced platelet response to clopidogrel compared with patients without DM. Prasugrel, a more potent antiplatelet agent, is associated with ...

    • Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins 

      Postmus, Iris; Trompet, Stella; Deshmukh, Harshal A.; Barnes, Michael R.; Li, Xiaohui; Warren, Helen R.; Chasman, Daniel I.; Zhou, Kaixin; Arsenault, Benoit J.; Donnelly, Louise A.; Wiggins, Kerri L.; Avery, Christy L.; Griffin, Paula; Feng, QiPing; Taylor, Kent D.; Li, Guo; Evans, Daniel S.; Smith, Albert V.; de Keyser, Catherine E.; Johnson, Andrew D.; de Craen, Anton J. M.; Stott, David J.; Buckley, Brendan M.; Ford, Ian; Westendorp, Rudi G. J.; Eline Slagboom, P.; Sattar, Naveed; Munroe, Patricia B.; Sever, Peter; Poulter, Neil; Stanton, Alice; Shields, Denis C.; O’Brien, Eoin; Shaw-Hawkins, Sue; Ida Chen, Y.-D.; Nickerson, Deborah A.; Smith, Joshua D.; Pierre Dubé, Marie; Matthijs Boekholdt, S.; Kees Hovingh, G.; Kastelein, John J. P.; McKeigue, Paul M.; Betteridge, John; Neil, Andrew; Durrington, Paul N.; Doney, Alex; Carr, Fiona; Morris, Andrew; McCarthy, Mark I.; Groop, Leif; Ahlqvist, Emma; Bis, Joshua C.; Rice, Kenneth; Smith, Nicholas L.; Lumley, Thomas; Whitsel, Eric A.; Stürmer, Til; Boerwinkle, Eric; Ngwa, Julius S.; O’Donnell, Christopher J.; Vasan, Ramachandran S.; Wei, Wei-Qi; Wilke, Russell A.; Liu, Ching-Ti; Sun, Fangui; Guo, Xiuqing; Heckbert, Susan R; Post, Wendy; Sotoodehnia, Nona; Arnold, Alice M.; Stafford, Jeanette M.; Ding, Jingzhong; Herrington, David M.; Kritchevsky, Stephen B.; Eiriksdottir, Gudny; Launer, Leonore J.; Harris, Tamara B.; Chu, Audrey Y.; Giulianini, Franco; MacFadyen, Jean G.; Barratt, Bryan J.; Nyberg, Fredrik; Stricker, Bruno H.; Uitterlinden, André G.; Hofman, Albert; Rivadeneira, Fernando; Emilsson, Valur; Franco, Oscar H.; Ridker, Paul M.; Gudnason, Vilmundur; Liu, Yongmei; Denny, Joshua C.; Ballantyne, Christie M.; Rotter, Jerome I.; Adrienne Cupples, L.; Psaty, Bruce M.; Palmer, Colin N. A.; Tardif, Jean-Claude; Colhoun, Helen M.; Hitman, Graham; Krauss, Ronald M.; Wouter Jukema, J; Caulfield, Mark J.; Donnelly, Peter; Barroso, Ines; Blackwell, Jenefer M.; Bramon, Elvira; Brown, Matthew A.; Casas, Juan P.; Corvin, Aiden; Deloukas, Panos; Duncanson, Audrey; Jankowski, Janusz; Markus, Hugh S.; Mathew, Christopher G.; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J.; Trembath, Richard C.; Viswanathan, Ananth C.; Wood, Nicholas W.; Spencer, Chris C. A.; Band, Gavin; Bellenguez, Céline; Freeman, Colin; Hellenthal, Garrett; Giannoulatou, Eleni; Pirinen, Matti; Pearson, Richard; Strange, Amy; Su, Zhan; Vukcevic, Damjan; Langford, Cordelia; Hunt, Sarah E.; Edkins, Sarah; Gwilliam, Rhian; Blackburn, Hannah; Bumpstead, Suzannah J.; Dronov, Serge; Gillman, Matthew; Gray, Emma; Hammond, Naomi; Jayakumar, Alagurevathi; McCann, Owen T.; Liddle, Jennifer; Potter, Simon C.; Ravindrarajah, Radhi; Ricketts, Michelle; Waller, Matthew; Weston, Paul; Widaa, Sara; Whittaker, Pamela (Nature Pub. Group, 2014)
      Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of ...

    • Pharmacogenetics in Type 2 Diabetes: Potential Implications for Clinical Practice 

      Huang, Chunmei; Florez, Jose Carlos (BioMed Central, 2011)
      Pharmacogenetic research aims to study how genetic variation may influence drug efficacy and/or toxicity; pharmacogenomics expands this quest to the entire genome. Pharmacogenetic findings may help to uncover new drug ...

    • Pharmacointeraction Network Models Predict Unknown Drug-Drug Interactions 

      Cami, Aurel; Manzi, Shannon; Arnold, Alana; Reis, Ben Y. (Public Library of Science, 2013)
      Drug-drug interactions (DDIs) can lead to serious and potentially lethal adverse events. In recent years, several drugs have been withdrawn from the market due to interaction-related adverse events (AEs). Current methods ...

    • Pharmacokinetic modeling of [18F]fluorodeoxyglucose (FDG) for premature infants, and newborns through 5-year-olds 

      Khamwan, Kitiwat; Plyku, Donika; O’Reilly, Shannon E.; Goodkind, Alison; Cao, Xinhua; Fahey, Frederic H.; Treves, S. Ted; Bolch, Wesley E.; Sgouros, George (Springer Berlin Heidelberg, 2016)
      Background: Absorbed dose estimates for pediatric patients require pharmacokinetics that are, to the extent possible, age-specific. Such age-specific pharmacokinetic data are lacking for many of the diagnostic agents ...

    • Pharmacokinetics and tolerability of NSC23925b, a novel P-glycoprotein inhibitor: preclinical study in mice and rats 

      Gao, Yan; Shen, Jacson K.; Choy, Edwin; Zhang, Zhan; Mankin, Henry J.; Hornicek, Francis J.; Duan, Zhenfeng (Nature Publishing Group, 2016)
      Overexpression of P-glycoprotein (Pgp) increases multidrug resistance (MDR) in cancer, which greatly impedes satisfactory clinical treatment and outcomes of cancer patients. Due to unknown pharmacokinetics, the use of Pgp ...

    • Pharmacokinetics of High-dose Oral Thiamine Hydrochloride in Healthy Subjects 

      Smithline, Howard A.; Donnino, Michael William; Greenblatt, David J. (BioMed Central, 2012)
      Background: High dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at ...

    • Pharmacokinetics of Natural and Engineered Secreted Factors Delivered by Mesenchymal Stromal Cells 

      Elman, Jessica S.; Murray, Ryan M.; Wang, Fangjing; Shen, Keyue; Gao, Shan; Conway, Kevin E.; Yarmush, Martin L.; Tannous, Bakhos A.; Weissleder, Ralph; Parekkadan, Biju (Public Library of Science, 2014)
      Transient cell therapy is an emerging drug class that requires new approaches for pharmacological monitoring during use. Human mesenchymal stem cells (MSCs) are a clinically-tested transient cell therapeutic that naturally ...

    • Pharmacokinetics of the Potent Hallucinogen, Salvinorin A in Primates Parallels the Rapid Onset and Short Duration of Effects in Humans 

      Hooker, Jacob M; Xu, Youwen; Schiffer, Wynne; Shea, Colleen; Carter, Pauline; Fowler, Joanna S. (Elsevier BV, 2008)
      Salvia divinorum, a mint plant originally used by the Mazatecs of Oaxaca, Mexico in spiritual rituals has gained popularity, in smoked form, as a legal hallucinogen in the United States and Europe. Abuse results in rapid ...

    • Pharmacological and Combined Interventions for the Acute Depressive Episode: Focus on Efficacy and Tolerability 

      Brunoni, Andre R; Fraguas, Renerio; Fregni, Felipe (Dove Medical Press, 2009)
      Background: Use of antidepressants is the gold standard therapy for major depression. However, despite the large number of commercially available antidepressant drugs there are several differences among them in efficacy, ...

    • Pharmacological Approaches for Treatment-resistant Bipolar Disorder 

      Poon, Shi Hui; Sim, Kang; Baldessarini, Ross J. (Bentham Science Publishers, 2015)
      Bipolar disorder is prevalent, with high risks of disability, substance abuse and premature mortality. Treatment responses typically are incomplete, especially for depressive components, so that many cases can be considered ...

    • Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry 

      Santos-Martinez, Maria J; Tomaszewski, Krzysztof A; Medina, Carlos; Bazou, Despina; Gilmer, John F; Radomski, Marek W (Dove Medical Press, 2015)
      Background: Engineered nanoparticles (NPs) can induce platelet activation and aggregation, but the mechanisms underlying these interactions are not well understood. This could be due in part to use of devices that study ...