Browsing Harvard Medical School by Title

Now showing items 13020-13039 of 18428

    • Phenotype and prognostic correlations of the converter region mutations affecting the β myosin heavy chain 

      García-Giustiniani, Diego; Arad, Michael; Ortíz-Genga, Martín; Barriales-Villa, Roberto; Fernández, Xusto; Rodríguez-García, Isabel; Mazzanti, Andrea; Veira, Elena; Maneiro, Emilia; Rebolo, Paula; Lesende, Iván; Cazón, Laura; Freimark, Dov; Gimeno-Blanes, Juan Ramón; Seidman, Christine; Seidman, Jonathan; McKenna, William; Monserrat, Lorenzo (BMJ Publishing Group, 2015)
      Objectives: The prognostic value of genetic studies in cardiomyopathies is still controversial. Our objective was to evaluate the outcome of patients with cardiomyopathy with mutations in the converter domain of β myosin ...

    • Phenotype Matters: The Absence of a Positive Association Between Cortical Thinning and Chronic Low Back Pain When Controlling for Salient Clinical Variables 

      Dolman, Andrew J.; Loggia, Marco Luciano; Edwards, Robert R; Gollub, Randy Lyanne; Kong, Jian; Napadow, Vitaly J.; Wasan, Ajay D. (Ovid Technologies (Wolters Kluwer Health), 2014)
      Studies have associated chronic low back pain (cLBP) with grey matter thinning. But these studies have not controlled for important clinical variables (such as a comorbid affective disorder, pain medication, age, or pain ...

    • A Phenotype of Early Infancy Predicts Reactivity of the Amygdala in Male Adults 

      Schwartz, C. E.; Kunwar, P. S.; Greve, Douglas N.; Kagan, Jerome; Snidman, Nancy Claire; Bloch, R. B. (Nature Publishing Group, 2011)
      One of the central questions that has occupied those disciplines concerned with human development is the nature of continuities and discontinuities from birth to maturity. The amygdala plays a central role in the processing ...

    • Phenotype-Genotype Association Grid: A Convenient Method for Summarizing Multiple Association Analyses 

      Benjamin, Emelia J; Parise, Helen; Vasan, Ramachandran S; Izumo, Seigo; Larson, Martin G; Levy, Daniel; Depalma, Steven Robert; O'Donnell, Christopher Joseph; Hirschhorn, Joel Naom (BioMed Central, 2006)
      Background: High-throughput genotyping generates vast amounts of data for analysis; results can be difficult to summarize succinctly. A single project may involve genotyping many genes with multiple variants per gene and ...

    • Phenotypic lentivirus screens to identify functional single domain antibodies 

      Schmidt, Florian I.; Hanke, Leo; Morin, Benjamin; Brewer, Rebeccah; Brusic, Vesna; Whelan, Sean P.J.; Ploegh, Hidde L. (2016)
      Manipulation of proteins is key in assessing their in vivo function. While genetic ablation is straightforward, reversible and specific perturbation of protein function remains a challenge. Single domain antibody fragments, ...

    • Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart 

      Matsui, Takashi; Li, Ling; Wu, Justina C.; Cook, Stuart; Nagoshi, Tomohisa; Picard, Michael Howard; Liao, Ronglih; Rosenzweig, Anthony (American Society for Biochemistry & Molecular Biology (ASBMB), 2002)
      The serine-threonine kinase, Akt, inhibits cardiomyocyte apoptosis acutely both in vitro and in vivo. However, the effects of chronic Akt activation in the heart are unknown. To address this issue, we generated transgenic ...

    • Phenotypic Switching of Nonpeptidergic Cutaneous Sensory Neurons Following Peripheral Nerve Injury 

      Wang, Ting; Molliver, Derek C.; Jing, Xiaotang; Schwartz, Erica S.; Yang, Fu-Chia; Samad, Omar Abdel; Ma, Qiufu; Davis, Brian M. (Public Library of Science, 2011)
      In adult mammals, the phenotype of half of all pain-sensing (nociceptive) sensory neurons is tonically modulated by growth factors in the glial cell line-derived neurotrophic factor (GDNF) family that includes GDNF, artemin ...

    • Phenotypical and Functional Characterization of Meningeal Localized Regulatory T cells 

      Chen, Yin (2021-07-19)
      The regulatory T cells (Treg) population is characterized by their unique immunoregulatory functions. Recently, more and more evidence has elucidated Tregs’ roles beyond immune suppression, such as its ability to facilitate ...

    • Pheromonal and Behavioral Cues Trigger Male-to-Female Aggression in Drosophila 

      la Paz Fernández, María de; Yew, Joanne Y.; Billeter, Jean-Christophe; Dreisewerd, Klaus; Levine, Joel D.; Waddell, Scott; Chan, Yick-Bun; Kravitz, Edward A. (Public Library of Science, 2010)
      Appropriate displays of aggression rely on the ability to recognize potential competitors. As in most species, Drosophila males fight with other males and do not attack females. In insects, sex recognition is strongly ...

    • Pheromone killing of multidrug-resistant Enterococcus faecalis V583 by native commensal strains 

      Gilmore, Michael S.; Rauch, Marcus; Ramsey, Matthew Mark; Himes, Paul R.; Varahan, Sriram; Manson, Janet M.; Lebreton, Francois Herve; Hancock, Lynn Ernest (Proceedings of the National Academy of Sciences, 2015)
      Multidrug-resistant Enterococcus faecalis possess numerous mobile elements that encode virulence and antibiotic resistance traits as well as new metabolic pathways, often constituting over one-quarter of the genome. It was ...

    • A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate 

      Pacold, Michael E.; Brimacombe, Kyle R.; Chan, Sze Ham; Rohde, Jason M.; Lewis, Caroline A.; Swier, Lotteke J.Y.M.; Possemato, Richard; Chen, Walter W.; Sullivan, Lucas B.; Fiske, Brian P.; Cho, Sung Won; Freinkman, Elizaveta; Birsoy, Kıvanç; Abu-Remaileh, Monther; Shaul, Yoav D.; Liu, Chieh Min; Zhou, Minerva; Koh, Min Jung; Chung, Haeyoon; Davidson, Shawn M.; Luengo, Alba; Wang, Amy Q.; Xu, Xin; Yasgar, Adam; Liu, Li; Rai, Ganesha; Westover, Kenneth D.; Vander Heiden, Matthew G.; Shen, Min; Gray, Nathanael S.; Boxer, Matthew B.; Sabatini, David M. (2016)
      Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate ...

    • A Philosophy for CNS Radiotracer Design 

      Van de Bittner, Genevieve C.; Ricq, Emily L.; Hooker, Jacob M. (American Chemical Society, 2014)
      Conspectus Decades after its discovery, positron emission tomography (PET) remains the premier tool for imaging neurochemistry in living humans. Technological improvements in radiolabeling methods, camera design, and image ...

    • PhIP-Seq Characterization of Autoantibodies From Patients With Multiple Sclerosis, Type 1 Diabetes and Rheumatoid Arthritis 

      Larman, H. Benjamin; Laserson, Uri; Querol, Luis; Verhaeghen, Katrijn; Solimini, Nicole L.; Xu, George; Klarenbeek, Paul L.; Church, George; Hafler, David A.; Plenge, Robert M.; Nigrovic, Peter; De Jager, Philip; Weets, Ilse; Martens, Geert A.; O'Connor, Kevin C.; Elledge, Stephen (Elsevier BV, 2013-06)
      Autoimmune disease results from a loss of tolerance to self-antigens in genetically susceptible individuals. Completely understanding this process requires that targeted antigens be identified, and so a number of techniques ...

    • Phobic Anxiety is Associated with Higher Serum Concentrations of Adipokines and Cytokines in Women with Diabetes 

      Brennan, Aoife M.; Fargnoli, Jessica L.; Williams, Catherine J.; Li, Tricia; Willett, Walter C.; Kawachi, Ichiro; Qi, Lu; Hu, Frank B.; Mantzoros, Christos S. (American Diabetes Association, 2009)
      OBJECTIVE: Phobic anxiety has been associated with increased risk of cardiovascular disease (CVD), but the underlying mechanisms are poorly understood. We aimed to determine whether associations of phobic anxiety with ...

    • The phosphatase PTEN-mediated control of PI-3 kinase in Tregs cells maintains homeostasis and lineage stability 

      Huynh, Alexandria; DuPage, Michel; Priyadharshini, Bhavana; Sage, Peter T.; Quiros, Jason; Borges, Christopher M.; Townamchai, Natavudh; Gerriets, Valerie A.; Rathmell, Jeffrey C.; Sharpe, Arlene H.; Bluestone, Jeffrey A.; Turka, Laurence A. (2014)
      Foxp3+ regulatory T cells (Tregs) are required for immune homeostasis. One notable distinction between conventional T cells (Tconv) and Tregs is differential phosphatidylinositol 3-kinase (PI3K) activity: only Tconv ...

    • Phosphatases in Mouse Mast Cell Rapid IgE Desensitization: The Role of SHIP-1 

      AlEnazy, Leila Askar (2017-06-07)
      Rapid Drug Desensitization (RDD) is a widely used and effective clinical approach to enable allergic individuals to temporary tolerate various drugs to which they have an IgE-mediated hypersensitivity reaction. Latest ...

    • Phosphatidylinositol 3-Kinase Mediates Bronchioalveolar Stem Cell Expansion in Mouse Models of Oncogenic K-ras-Induced Lung Cancer 

      Yang, Yanan; Iwanaga, Kentaro; Raso, Maria Gabriela; Wislez, Marie; Hanna, Amy E.; Wieder, Eric D.; Molldrem, Jeffrey J.; Wistuba, Ignacio I.; Powis, Garth; Demayo, Francesco J.; Kurie, Jonathan M.; Kim, Carla (Public Library of Science, 2008)
      Background: Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related death in Western countries. Developing more effective NSCLC therapeutics will require the elucidation of the genetic and biochemical ...

    • Phosphatidylserine exposing-platelets and microparticles promote procoagulant activity in colon cancer patients 

      Zhao, Liangliang; Bi, Yayan; Kou, Junjie; Shi, Jialan; Piao, Daxun (BioMed Central, 2016)
      Background: Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear. We explored ...

    • Phosphoantigen/IL2 Expansion and Differentiation of Vγ2Vδ2 T Cells Increase Resistance to Tuberculosis in Nonhuman Primates 

      Chen, Crystal Y.; Yao, Shuyu; Huang, Dan; Wei, Huiyong; Sicard, Helene; Zeng, Gucheng; Jomaa, Hassan; Larsen, Michelle H.; Jacobs, William R.; Wang, Richard; Letvin, Norman; Shen, Yun; Qiu, Liyou; Shen, Ling; Chen, Zheng W. (Public Library of Science, 2013)
      Dominant Vγ2Vδ2 T-cell subset exist only in primates, and recognize phosphoantigen from selected pathogens including M. tuberculosis(Mtb). In vivo function of Vγ2Vδ2 T cells in tuberculosis remains unknown. We conducted ...

    • Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid 

      Maki, Takakuni; Okamoto, Yoko; Carare, Roxana O; Hase, Yoshiki; Hattori, Yorito; Hawkes, Cheryl A; Saito, Satoshi; Yamamoto, Yumi; Terasaki, Yasukazu; Ishibashi-Ueda, Hatsue; Taguchi, Akihiko; Takahashi, Ryosuke; Miyakawa, Taihei; Kalaria, Raj N; Lo, Eng H; Arai, Ken; Ihara, Masafumi (Blackwell Publishing Ltd, 2014)
      Objective: Brain amyloidosis is a key feature of Alzheimer's disease (AD). It also incorporates cerebrovascular amyloid β (Aβ) in the form of cerebral amyloid angiopathy (CAA) involving neurovascular dysfunction. We have ...