Browsing Harvard Medical School by Title

Now showing items 13264-13283 of 18428

    • Polydopamine-Based Surface Modification of Novel Nanoparticle-Aptamer Bioconjugates for In Vivo Breast Cancer Targeting and Enhanced Therapeutic Effects 

      Tao, Wei; Zeng, Xiaowei; Wu, Jun; Zhu, Xi; Yu, Xinghua; Zhang, Xudong; Zhang, Jinxie; Liu, Gan; Mei, Lin (Ivyspring International Publisher, 2016)
      In this study, we reported a simple polydopamine (pD)-based surface modification method to prepare novel nanoparticle-aptamer bioconjugates (Apt-pD-DTX/NPs) for in vivo tumor targeting and enhanced therapeutic effects of ...

    • Polyethylene Glycol-Based Synthetic Hydrogel Sealant for Closing Vitrectomy Wounds: An In Vivo and Histological Study 

      Hoshi, Sujin; Okamoto, Fumiki; Arai, Mikki; Hirose, Tatsuo; Fukuda, Shinichi; Sugiura, Yoshimi; Oshika, Tetsuro (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose We conducted an in vivo study using Dutch pigmented rabbit eyes to test the usefulness of polyethylene glycol (PEG) sealant for the closure of sutureless sclerotomies in microincisional vitrectomy surgery (MIVS). ...

    • Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control 

      Ackerman, Margaret E.; Mikhailova, Anastassia; Brown, Eric P.; Dowell, Karen G.; Walker, Bruce D.; Bailey-Kellogg, Chris; Suscovich, Todd J.; Alter, Galit (Public Library of Science, 2016)
      Elite controllers (ECs) represent a unique model of a functional cure for HIV-1 infection as these individuals develop HIV-specific immunity able to persistently suppress viremia. Because accumulating evidence suggests ...

    • Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia 

      Ruderfer, Douglas M.; Fanous, Ayman H.; Ripke, Stephan; McQuillin, Andrew; Amdur, Richard L.; Gejman, Pablo V.; O’Donovan, Michael C.; Andreassen, Ole A.; Djurovic, Srdjan; Hultman, Christina M.; Kelsoe, John R.; Jamain, Stephane; Landén, Mikael; Leboyer, Marion; Nimgaonkar, Vishwajit; Nurnberger, John; Smoller, Jordan W.; Craddock, Nick; Corvin, Aiden; Sullivan, Patrick F.; Holmans, Peter; Sklar, Pamela; Kendler, Kenneth S. (2013)
      Bipolar disorder and schizophrenia are two often severe disorders with high heritabilities. Recent studies have demonstrated a large overlap of genetic risk loci between these disorders but diagnostic and molecular ...

    • Polygenic Inheritance of Paclitaxel-Induced Sensory Peripheral Neuropathy Driven by Axon Outgrowth Gene Sets in CALGB 40101 (Alliance) 

      Chhibber, Aparna; Mefford, Joel; Stahl, Eli A.; Pendergrass, Sarah A.; Baldwin, R. Michael; Owzar, Kouros; Li, Megan; Winer, Eric P.; Hudis, Clifford A.; Zembutsu, Hitoshi; Kubo, Michiaki; Nakamura, Yusuke; McLeod, Howard L.; Ratain, Mark J.; Shulman, Lawrence N.; Ritchie, Marylyn D.; Plenge, Robert M.; Witte, John S.; Kroetz, Deanna L. (2014)
      Peripheral neuropathy is a common dose-limiting toxicity for patients treated with paclitaxel. For most individuals there are no known risk factors that predispose patients to the adverse event, and pathogenesis for ...

    • Polymerase I and Transcript Release Factor Regulates Lipolysis via a Phosphorylation-Dependent Mechanism 

      Aboulaich, Nabila; Chui, Patricia C.; Asara, John M; Flier, Jeffrey S.; Maratos-Flier, Eleftheria (American Diabetes Association, 2011)
      OBJECTIVE: Polymerase I and transcript release factor (PTRF) is a protein highly expressed in adipose tissue and is an integral structural component of caveolae. Here, we report on a novel role of PTRF in lipid mobilization. ...

    • Polymeric nanoparticle drug delivery technologies for oral delivery applications 

      Pridgen, Eric M; Alexis, Frank; Farokhzad, Omid Cameron (Informa Healthcare, 2015)
      Introduction: Many therapeutics are limited to parenteral administration. Oral administration is a desirable alternative because of the convenience and increased compliance by patients, especially for chronic diseases ...

    • Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques 

      Majmudar, Maulik; Yoo, Jeongsoo; Keliher, Edmund; Truelove, Jessica; Iwamoto, Yoshiko; Sena, Brena; Dutta, Partha; Borodovsky, Anna; Fitzgerald, Kevin; Di Carli, Marcelo; Libby, Peter; Anderson, Daniel; Swirski, Filip; Weissleder, Ralph; Nahrendorf, Matthias (American Heart Association, 2013)
      Rationale: Myeloid cell content in atherosclerotic plaques associates with rupture and thrombosis. Thus, imaging of lesional monocytes and macrophages could serve as a biomarker of disease progression and therapeutic ...

    • Polymorphic Amplified Typing Sequences (PATS) Strain Typing System Accurately Discriminates a Set of Temporally and Spatially Disparate Escherichia coli O157 Isolates Associated with Human Infection 

      Kudva, Indira T.; Smole, Sandra; Griffin, Robert W.; Garren, Jeonifer; Kalia, Nimisha; Murray, Megan; John, Manohar; Timperi, Ralph; Calderwood, Stephen B. (Bentham Open, 2013)
      Polymorphic Amplified Typing Sequences (PATS) is a PCR-based Escherichia coli O157 (O157) strain typing system. Here, we show that PATS compares excellently with Pulsed-Field Gel Electrophoresis (PFGE) in that both methods ...

    • Polymorphic Amplified Typing Sequences and Pulsed-Field Gel Electrophoresis Yield Comparable Results in the Strain Typing of a Diverse Set of Bovine Escherichia coli O157:H7 Isolates 

      Kudva, Indira T.; Davis, Margaret A.; Griffin, Robert; Garren, Jeonifer; Murray, Megan Blanche; John, Manohar; Hovde, Carolyn J.; Calderwood, Stephen Beaven (Hindawi Publishing Corporation, 2012)
      Polymorphic amplified typing sequences (PATS), a PCR-based Escherichia coli O157:H7 (O157) strain typing system, targets insertions-deletions and single nucleotide polymorphisms at XbaI and AvrII restriction enzyme sites, ...

    • Polymorphic Amplified Typing Sequences Provide a Novel Approach to Escherichia coli O157:H7 Strain Typing 

      Kudva, Indira T.; Evans, Peter S.; Perna, Nicole T.; Barrett, Timothy J.; DeCastro, G. Joel; Ausubel, Frederick M.; Blattner, Frederick R.; Calderwood, Stephen B. (American Society for Microbiology, 2002)
      Escherichia coli O157:H7 (O157) strains are commonly typed by pulsed-field gel electrophoresis (PFGE) following digestion of genomic DNA with the restriction enzyme XbaI. We have shown that O157 strains differ from each ...

    • Polymorphic repeat in AIB1 does not alter breast cancer risk 

      Haiman, Christopher A; Hankinson, Susan Elizabeth; Spiegelman, Donna Lynn; Colditz, Graham A.; Willett, Walter C.; Speizer, Frank Erwin; Brown, Myles Avery; Hunter, David J. (BioMed Central, 2000)
      We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no association ...

    • A polymorphism in HLA-G modifies statin benefit in asthma 

      Naidoo, Devesh; Wu, Ann C; Brilliant, Murray H; Denny, Joshua; Ingram, Christie; Kitchner, Terrie E; Linneman, James G; McGeachie, Michael J; Roden, Dan M; Shaffer, Christian M; Shah, Anushi; Weeke, Peter; Weiss, Scott T; Xu, Hua; Medina, Marisa W (2014)
      Several reports have shown that statin treatment benefits patients with asthma, however inconsistent effects have been observed. The mir-152 family (148a, 148b and 152) has been implicated in asthma. These microRNAs suppress ...

    • A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies 

      Terry, Kathryn Lynne; Vitonis, Allison F.; Hernandez, Dena; Lurie, Galina; Song, Honglin; Ramus, Susan J.; Titus-Ernstoff, Linda; Carney, Michael E.; Wilkins, Lynne R.; Gentry-Maharaj, Aleksandra; Menon, Usha; Gayther, Simon A.; Pharaoh, Paul D.; Goodman, Marc T.; Cramer, Daniel William; Birrer, Michael James (e-Century Publishing, 2010)
      Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer ...

    • Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women 

      McGrath, Monica; Michaud, Dominique; De Vivo, Immaculata (BioMed Central, 2006)
      Background: Cigarette smoking is an established risk factor for bladder cancer. Epidemiological and biological data suggest that genetic polymorphisms in activating and detoxifying enzymes may play a role in determining ...

    • Polymorphisms in IL12A and Cockroach Allergy in Children with Asthma 

      Pistiner, Michael; Hunninghake, Gary Matthew; Soto-Quiros, Manuel E; Avila, Lydiana; Murphy, Amy; Su, Jessica Ann Lasky; Schuemann, Brooke; Klanderman, Barbara Jordan; Raby, Benjamin Alexander; Celedón, Juan C (BioMed Central, 2008)
      Background: IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases. Methods: We tested for association between four linkage disequilibrium (LD)-tagging SNPs ...

    • Polymorphisms in Nucleotide Excision Repair Genes, Arsenic Exposure, and Non-melanoma Skin Cancer in New Hampshire 

      Applebaum, Katie Lyn; Karagas, Margaret R.; Hunter, David J.; Catalano, Paul J.; Byler, Steven H.; Morris, Steve; Nelson, Heather H. (National Institute of Environmental Health Sciences, 2007)
      Background: Arsenic exposure may alter the efficiency of DNA repair. UV damage is specifically repaired by nucleotide excision repair (NER), and common genetic variants in NER may increase risk for non-melanoma skin cancer ...

    • Polymorphisms in Signal Transducer and Activator of Transcription 3 and Lung Function in Asthma 

      Litonjua, Augusto Ampil; Tantisira, Kelan; Lake, Stephen; Lazarus, Ross; Richter, Brent G; Gabriel, Stacey; Silverman, Eric S; Weiss, Scott Tillman (BioMed Central, 2005)
      Background: Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in ...

    • POLYMORPHISMS IN THE SERUM- AND GLUCOCORTICOID-INDUCIBLE KINASE 1 GENE ARE ASSOCIATED WITH BLOOD PRESSURE AND RENIN RESPONSE TO DIETARY SALT INTAKE 

      Rao, Ajay D; Sun, Bei; Saxena, Aditi; Hopkins, Paul N; Jeunemaitre, Xavier; Brown, Nancy J; Adler, Gail K; Williams, Jonathan S (2012)
      Serum- and glucocorticoid-inducible kinase 1 (SGK1) plays a central role in epithelial sodium channel (ENaC)-dependent Na+ transport in the distal nephron. We hypothesized that SGK1 gene variants may contribute to the ...

    • Polymorphisms in the Vitamin D Receptor and Risk of Ovarian Cancer in Four Studies 

      Tworoger, Shelley Slate; Gate, M. A.; Lee, I-Min; Buring, Julie Elizabeth; Titus-Ernstoff, L.; Cramer, Daniel William; Hankinson, Susan Elizabeth (American Association for Cancer Research (AACR), 2009)
      Prior studies have suggested that vitamin D may reduce ovarian cancer risk. Thus, we examined whether three single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene (Fok1, Bsm1, Cdx2) were associated ...