Browsing Harvard Medical School by Title
Now showing items 13387-13406 of 18426
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Potential Savings From Redetermining Disability Among Children Receiving Supplemental Security Income Benefits
(Elsevier BV, 2012)Objective: To compare costs of redetermining disability to direct savings in SSI payments associated with different strategies for implementing Continuing Disability Reviews (CDRs) among children potentially enrolled in ... -
Potential self-regulatory mechanisms of yoga for psychological health
(Frontiers Media S.A., 2014)Research suggesting the beneficial effects of yoga on myriad aspects of psychological health has proliferated in recent years, yet there is currently no overarching framework by which to understand yoga’s potential beneficial ... -
Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers
(Impact Journals LLC, 2011)Recent clinical trials with selective inhibitors of the BRAF and MEK kinases have shown promising results in patients with tumors harboring BRAF V600 mutations. However, as has been observed previously with similarly ... -
Potentially disruptive life events: what are the immediate impacts on chronic disease management? A case-crossover analysis
(BMJ Publishing Group, 2016)Objective: To explore the association between unexpected potentially disruptive life events in a patient or family member that may challenge an individual's ability to take medications as prescribed and the discontinuation ... -
Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production
(2012)The ever-increasing incidence of antibiotic-resistant infections combined with a weak pipeline of new antibiotics has created a global public health crisis1. Accordingly, novel strategies for enhancing our antibiotic arsenal ... -
Poverty and common mental disorders in developing countries
(World Health Organization, 2003)A review of English-language journals published since 1990 and three global mental health reports identified 11 community studies on the association between poverty and common mental disorders in six low- and middle-income ... -
Poverty, Disease, and the Ecology of Complex Systems
(Public Library of Science, 2014)Understanding why some human populations remain persistently poor remains a significant challenge for both the social and natural sciences. The extremely poor are generally reliant on their immediate natural resource base ... -
Power Enhancement Via Multivariate Outlier Testing With Gene Expression Arrays
(Oxford University Press, 2008)Motivation: As the use of microarrays in human studies continues to increase, stringent quality assurance is necessary to ensure accurate experimental interpretation. We present a formal approach for microarray quality ... -
Power Evaluation of Disease Clustering Tests
(BioMed Central, 2003)Background: Many different test statistics have been proposed to test for spatial clustering. Some of these statistics have been widely used in various applications. In this paper, we use an existing collection of 1,220,000 ... -
The Power of Gene-Based Rare Variant Methods to Detect Disease-Associated Variation and Test Hypotheses About Complex Disease
(Public Library of Science, 2015)Genome and exome sequencing in large cohorts enables characterization of the role of rare variation in complex diseases. Success in this endeavor, however, requires investigators to test a diverse array of genetic hypotheses ... -
Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies
(Springer Science and Business Media LLC, 2022-12-23)Meta-analysis of whole-genome/exome sequencing (WGS/WES) studies provides an attractive solution to obtain large sample sizes from multiple studies for discovering rare variants associated with complex phenotypes. Existing ... -
PP2A Regulates BCL-2 Phosphorylation and Proteasome-mediated Degradation at the Endoplasmic Reticulum
(American Society for Biochemistry and Molecular Biology, 2006)Anti-apoptotic activity of BCL-2 is mediated by phosphorylation at the endoplasmic reticulum (ER), but how this phosphorylation is regulated and the mechanism(s) by which it regulates apoptosis are unknown. We purified ... -
PP2ARts1 is a master regulator of pathways that control cell size
(The Rockefeller University Press, 2014)Cell size checkpoints ensure that passage through G1 and mitosis occurs only when sufficient growth has occurred. The mechanisms by which these checkpoints work are largely unknown. PP2A associated with the Rts1 regulatory ... -
PPAR\(\alpha\) Deficiency in Inflammatory Cells Suppresses Tumor Growth
(Public Library of Science, 2007)Inflammation in the tumor bed can either promote or inhibit tumor growth. Peroxisome proliferator-activated receptor (PPAR)\(\alpha\) is a central transcriptional suppressor of inflammation, and may therefore modulate tumor ... -
PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns
(BioMed Central, 2016)Background: Children exposed to gestational diabetes mellitus (GDM) are at a higher risk of developing obesity and type 2 diabetes. This susceptibility might involve brown adipose tissue (BAT), which is suspected to protect ... -
PPARβ/δ Regulates Glucocorticoid- and Sepsis-Induced FOXO1 Activation and Muscle Wasting
(Public Library of Science, 2013)FOXO1 is involved in glucocorticoid- and sepsis-induced muscle wasting, in part reflecting regulation of atrogin-1 and MuRF1. Mechanisms influencing FOXO1 expression in muscle wasting are poorly understood. We hypothesized ... -
PPARγ Deficiency Results in Reduced Lung Elastic Recoil and Abnormalities in Airspace Distribution
(BioMed Central, 2010)Background: Peroxisome proliferator-activated receptor (PPAR)-γ is a nuclear hormone receptor that regulates gene expression, cell proliferation and differentiation. We previously described airway epithelial cell PPARγ ... -
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
(BMJ Publishing Group, 2015)Objectives: We have previously shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is essential for the normal growth and development of cartilage. In the present study, we created ... -
PPARγ is a Major Driver of the Accumulation and Phenotype of Adipose-Tissue \(T_{reg}\) Cells
(Nature Publishing Group, 2012)Obesity and type-2 diabetes have increased markedly over the past few decades, in parallel. One of the major links between these two disorders is chronic, low-grade inflammation. Prolonged nutrient excess promotes the ... -
PPIRank - an advanced method for ranking protein-protein interations in TAP/MS data
(BioMed Central, 2013)Background: Tandem affinity purification coupled with mass-spectrometry (TAP/MS) analysis is a popular method for the identification of novel endogenous protein-protein interactions (PPIs) in large-scale. Computational ...