Browsing Harvard Medical School by Title

Now showing items 13418-13437 of 18428

    • The Practice of Privacy 

      Gustainis, Emily R.; Letocha, Phoebe Evans (Council on Library and Information Resource., 2015)
      Drawing on our experiences managing CLIR-funded processing initiatives for public health collections containing protected health information as part of the grant “Private Practices, Public Health: Privacy-Aware Processing ...

    • Practice Patterns of Naturopathic Physicians: Results from a Random Survey of Licensed Practitioners in Two US States 

      Boon, Heather S; Cherkin, Daniel C; Erro, Janet; Sherman, Karen J; Milliman, Bruce; Booker, Jennifer; Cramer, Elaine H; Smith, Michael J.; Deyo, Richard A; Eisenberg, David Miles (BioMed Central, 2004)
      Background: Despite the growing use of complementary and alternative medicine (CAM) by consumers in the U.S., little is known about the practice of CAM providers. The objective of this study was to describe and compare the ...

    • The PRC2-associated factor C17orf96 is a novel CpG island regulator in mouse ES cells 

      Liefke, Robert; Shi, Yang (Nature Publishing Group, 2015)
      CpG islands (CGIs) are key DNA regulatory elements in the vertebrate genome and are often found at gene promoters. In mammalian embryonic stem (ES) cells, CGIs are decorated by either the active or repressive histone marks, ...

    • A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation 

      Yi, Yang; Li, Yanqiang; Meng, Qingshu; Li, Qiaqia; Li, Fuxi; Lu, Bing; Shen, Jiangchuan; Fazli, Ladan; Zhao, Dongyu; Li, Chao; Jiang, Weihua; Wang, Rui; Liu, Qipeng; Szczepanski, Aileen; Li, Qianru; Qin, Wei; Weiner, Adam B.; Lotan, Tamara L.; Ji, Zhe; Kalantry, Sundeep; Wang, Lu; Schaeffer, Edward M.; Niu, Hengyao; Dong, Xuesen; Zhao, Wei; Chen, Kaifu; Cao, Qi (Springer Science and Business Media LLC, 2021-04)
      Uncontrolled translation is a common feature of cancer. Uncovering its governing factors and underlying mechanism are important for cancer therapy. Herein, we report that enhancer of zeste homolog 2 (EZH2), previously known ...

    • Prdx1 Inhibits Tumorigenesis via Regulating PTEN/AKT Activity 

      Cao, Juxiang; Schulte, Jennifer; Knight, Alexander; Leslie, Nicholas R; Zagozdzon, Agnieszka; Bronson, Roderick Terry; Manevich, Yefim; Beeson, Craig; Neumann, Carola A (Nature Publishing Group, 2009)
      It is widely accepted that reactive oxygen species (ROS) promote tumorigenesis. However, the exact mechanisms are still unclear. As mice lacking the peroxidase peroxiredoxin1 (Prdx1) produce more cellular ROS and die ...

    • Pre-Adult MRI of Brain Cancer and Neurological Injury: Multivariate Analyses 

      Levman, Jacob; Takahashi, Emi (Frontiers Media S.A., 2016)
      Brain cancer and neurological injuries, such as stroke, are life-threatening conditions for which further research is needed to overcome the many challenges associated with providing optimal patient care. Multivariate ...

    • Pre-amyloid oligomers budding: A metastatic mechanism of proteotoxicity 

      Bernini, Fabrizio; Malferrari, Daniele; Pignataro, Marcello; Bortolotti, Carlo Augusto; Di Rocco, Giulia; Lancellotti, Lidia; Brigatti, Maria Franca; Kayed, Rakez; Borsari, Marco; Del Monte, Federica; Castellini, Elena (Springer Nature, 2016)
      The pathological hallmark of misfolded protein diseases and aging is the accumulation of proteotoxic aggregates. However, the mechanisms of proteotoxicity and the dynamic changes in fiber formation and dissemination remain ...

    • Pre-Clinical Drug Prioritization via Prognosis-Guided Genetic Interaction Networks 

      Xiong, Jianghui; Liu, Juan; Rayner, Simon; Tian, Ze; Li, Yinghui; Chen, Shanguang (Public Library of Science, 2010)
      The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs. Patient population heterogeneity and unpredictable physiology complicate ...

    • Pre-Diagnostic Leukocyte Genomic DNA Methylation and the Risk of Colorectal Cancer in Women 

      Nan, Hongmei; Giovannucci, Edward L.; Wu, Kana; Selhub, Jacob; Paul, Ligi; Rosner, Bernard Alfred; Fuchs, Charles Stewart; Cho, Eunyoung (Public Library of Science, 2013)
      Background: Abnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia. Methods: We evaluated the association between ...

    • Pre-diagnostic leukocyte mitochondrial DNA copy number and risk of lung cancer 

      Meng, Shasha; De Vivo, Immaculata; Liang, Liming; Hu, Zhibin; Christiani, David C.; Giovannucci, Edward; Han, Jiali (Impact Journals LLC, 2016)
      We prospectively investigated the relationship between mtCN and the risk of lung cancer in 463 case-control pairs from two prospective cohort studies, the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up ...

    • Pre-Diagnostic Plasma 25-Hydroxyvitamin D Levels and Risk of Non-Melanoma Skin Cancer in Women 

      Liang, Geyu; Nan, Hongmei; Qureshi, Abrar A.; Han, Jiali (Public Library of Science, 2012)
      Background: Recent reports have shown that vitamin D status was inversely associated with the risk of various cancers. However, few studies examined the association between vitamin D levels and risk of skin cancer. Methods: ...

    • Pre-eclampsia, Soluble fms-like Tyrosine Kinase 1, and the Risk of Reduced Thyroid Function: Nested Case-Control and Population Based Study 

      Levine, Richard J; Vatten, Lars Johan; Horowitz, Gary Leigh; Qian, Cong; Romundstad, Pal R; Yu, Kai F; Hollenberg, Anthony Neil; Hellevik, Alf I; Asvold, Bjorn O; Karumanchi, Subbian Ananth (BMJ Publishing Group, 2009)
      Objective: To determine if pre-eclampsia is associated with reduced thyroid function during and after pregnancy. Design: Nested case-control study during pregnancy and population based follow-up study after pregnancy. ...

    • Pre-mRNA Splicing and Gene Density are Significant Determinants of Lentiviral Integration 

      Singh, Parmit; Chivukula, Vidya; Cherepanov, Peter; Engelman, Alan (2021-05)
      Nuclear speckles harbor proteins important for transcription and pre-mRNA splicing. HIV-1 preintegration complexes localize to speckles in a capsid (CA)-CPSF6 dependent manner and preferentially target speckle-associated ...

    • Pre-operative glucose as a screening tool in patients without diabetes 

      Wang, Rui (2015-06-08)
      Background: Although hyperglycemia has been associated with poor post-operative outcomes, pre-operative hyperglycemia is not used as a screening tool in patients without diabetes. We evaluated pre-operative glucose as a ...

    • Pre-Operative Status and Quality of Life Following Total Joint Replacement in a Developing Country: A Prospective Pilot Study 

      Niu, Nina; Collins, Jamie E; Thornhill, Thomas Stone; Alcantara Abreu, Luis; Ghazinouri, Roya; Okike, Kanu; Katz, Jeffrey Neil (Bentham Science Publishers Ltd., 2011)
      Background: An increasing number of medical relief organizations have launched programs to perform total joint replacements in the developing world. There is a paucity of data on the clinical outcomes of these procedures. ...

    • Pre-Travel Health Care of Immigrants Returning Home to Visit Friends and Relatives 

      Larocque, Regina Celes; Deshpande, Bhushan R.; Rao, Sowmya R.; Brunette, Gary W.; Sotir, Mark J.; Jentes, Emily S.; Ryan, Edward Thomas (The American Society of Tropical Medicine and Hygiene, 2013)
      Immigrants returning home to visit friends and relatives (VFR travelers) are at higher risk of travel-associated illness than other international travelers. We evaluated 3,707 VFR and 17,507 non-VFR travelers seen for ...

    • Pre-Travel Medical Preparation of Business and Occupational Travelers: An Analysis of the Global TravEpiNet Consortium, 2009 to 2012 

      Khan, Nomana M.; Jentes, Emily S.; Brown, Clive; Han, Pauline; Rao, Sowmya R.; Kozarsky, Phyllis; Hagmann, Stefan H.F.; LaRocque, Regina C.; Ryan, Edward T. (Lippincott Williams & Wilkins, 2015)
      Objectives: The aim of the study was to understand more about pre-travel preparations and itineraries of business and occupational travelers. Methods: De-identified data from 18 Global TravEpiNet clinics from January 2009 ...

    • Pre-Travel Preparation of US Travelers Going Abroad to Provide Humanitarian Service, Global TravEpiNet 2009–2011 

      Stoney, Rhett J.; Jentes, Emily S.; Sotir, Mark J.; Kozarsky, Phyllis; Rao, Sowmya R.; LaRocque, Regina C.; Ryan, Edward T. (The American Society of Tropical Medicine and Hygiene, 2014)
      We analyzed characteristics of humanitarian service workers (HSWs) seen pre-travel at Global TravEpiNet (GTEN) practices during 2009–2011. Of 23,264 travelers, 3,663 (16%) travelers were classified as HSWs. Among HSWs, ...

    • Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells 

      Rhee, Marie; Lee, Seung-Hwan; Kim, Ji-Won; Ham, Dong-Sik; Park, Heon-Seok; Yang, Hae Kyung; Shin, Ju-Young; Cho, Jae-Hyoung; Kim, Young-Bum; Youn, Byung-Soo; Sul, Hei Sook; Yoon, Kun-Ho (Nature Publishing Group, 2016)
      The preadipocyte factor 1 (Pref-1) is involved in the proliferation and differentiation of various precursor cells. However, the intracellular signaling pathways that control these processes and the role of Pref-1 in the ...

    • Precipitating Factors for Delirium in Hospitalized Elderly Persons 

      Inouye, Sharon; Charpentier, Peter A. (American Medical Association (AMA), 1996)
      OBJECTIVES: To prospectively develop and validate a predictive model for delirium based on precipitating factors during hospitalization, and to examine the interrelationship of precipitating factors and baseline vulnerability. ...