Browsing Harvard Medical School by Title
Now showing items 14413-14432 of 18428
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Recent advances in understanding schizophrenia
(Faculty of 1000 Ltd, 2014)Schizophrenia is a highly disabling disorder whose causes remain to be better understood, and treatments have to be improved. However, several recent advances have been made in diagnosis, etiopathology, and treatment. ... -
Recent advances in understanding the extracellular calcium-sensing receptor
(F1000Research, 2016)The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca ... -
Recent Developments in Home Sleep-Monitoring Devices
(International Scholarly Research Network, 2012)Improving our understanding of sleep physiology and pathophysiology is an important goal for both medical and general wellness reasons. Although the gold standard for assessing sleep remains the laboratory polysomnogram, ... -
Recent Developments in Novel Antidepressants Targeting α4β2-Nicotinic Acetylcholine Receptors: Miniperspective
(American Chemical Society, 2014)Nicotinic acetylcholine receptors (nAChRs) have been investigated for developing drugs that can potentially treat various central nervous system disorders. Considerable evidence supports the hypothesis that modulation of ... -
Recent insights into the cellular biology of atherosclerosis
(The Rockefeller University Press, 2015)Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at regions of disturbed blood flow and is triggered by an interplay between endothelial dysfunction and subendothelial lipoprotein ... -
Recent Trends in Imaging for Atrial Fibrillation Ablation
(Indian Heart Rhythm Society, 2010)Catheter ablation provides an important treatment option for patients with both paroxysmal and persistent atrial fibrillation. It mainly involves pulmonary vein isolation and additional ablations in the left atrium in ... -
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection
(2013)NOD2 receptor and the cytosolic protein kinase RIPK2 regulate NF-κB and MAP kinase signaling during bacterial infections, but the role of this immune axis during viral infections has not been addressed. We demonstrate that ... -
Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration
(Proceedings of the National Academy of Sciences, 2012)Retinitis pigmentosa comprises a group of inherited retinal photoreceptor degenerations that lead to progressive loss of vision. Although in most cases rods, but not cones, harbor the deleterious gene mutations, cones do ... -
Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis
(Proceedings of the National Academy of Sciences, 2010)Apoptosis has been shown to be a significant form of cell loss in many diseases. Detachment of photoreceptors from the retinal pigment epithelium, as seen in various retinal disorders, causes photoreceptor loss and subsequent ... -
The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi
(Public Library of Science, 2012)Trypanosoma cruzi, the protozoan parasite responsible for Chagas' disease, causes severe myocarditis often resulting in death. Here, we report that Slamf1−/− mice, which lack the hematopoietic cell surface receptor Slamf1, ... -
Receptor Specificity and Transmission of H2N2 Subtype Viruses Isolated from the Pandemic of 1957
(Public Library of Science, 2010)Influenza viruses of the H2N2 subtype have not circulated among humans in over 40 years. The occasional isolation of avian H2 strains from swine and avian species coupled with waning population immunity to H2 hemagglutinin ... -
Receptor Tyrosine Kinases in Drosophila Development
(2013)Tyrosine phosphorylation plays a significant role in a wide range of cellular processes. The Drosophila genome encodes more than 20 receptor tyrosine kinases and extensive studies in the past 20 years have illustrated their ... -
Receptor-Binding and Oncogenic Properties of Polyoma Viruses Isolated from Feral Mice
(Public Library of Science, 2007)Laboratory strains of the mouse polyoma virus differ markedly in their abilities to replicate and induce tumors in newborn mice. Major determinants of pathogenicity lie in the sialic binding pocket of the major capsid ... -
Receptor-mediated Immunoglobulin G Transport Across Mucosal Barriers in Adult Life Functional Expression of FcRn in the Mammalian Lung
(Rockefeller University Press, 2002)Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain the immunoglobulins (Ig)G and secretory IgA (sIgA) that function together in host defense. Exactly how IgG crosses epithelia barriers ... -
Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73
(Oxford University Press, 2015)We describe a novel nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum among 30 children (ages 1.0 to 28 years) from diverse Amish demes. Children with nephrocerebellar syndrome had progressive microcephaly, ... -
Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma
(Impact Journals LLC, 2015)Crk is the prototypical member of a class of Src homology 2 (SH2) and Src homology 3 (SH3) domain-containing adaptor proteins that positively regulate cell motility via the activation of Rac1 and, in certain tumor types ... -
Reciprocal Regulation of C-Maf Tyrosine Phosphorylation by Tec and Ptpn22
(Public Library of Science, 2015)C-Maf plays an important role in regulating cytokine production in TH cells. Its transactivation of IL-4 is optimized by phosphorylation at Tyr21, Tyr92, and Tyr131. However, the molecular mechanism regulating its tyrosine ... -
Reclassification of genetic-based risk predictions as GWAS data accumulate
(BioMed Central, 2016)Background: Disease risk assessments based on common genetic variation have gained widespread attention and use in recent years. The clinical utility of genetic risk profiles depends on the number and effect size of ... -
Recoding of the Vesicular Stomatitis Virus L Gene by Computer-Aided Design Provides a Live, Attenuated Vaccine Candidate
(American Society of Microbiology, 2015)ABSTRACT Codon pair bias (CPB), which has been observed in all organisms, is a neglected genomic phenomenon that affects gene expression. CPB results from synonymous codons that are paired more or less frequently in ORFeomes ... -
The recognition and categorization of upright and inverted emotional expressions by 7-month-old infants
(Elsevier BV, 1990)Upright and inverted faces were used to determine whether 7-month-old infants discriminate emotional expressions on the basis of affectively relevant information. In Experiment 1, infants recognized the similarity of happy ...