Browsing Harvard Medical School by Title
Now showing items 1492-1511 of 18424
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Automated Modelling of Signal Transduction Networks
(BioMed Central, 2002)Background: Intracellular signal transduction is achieved by networks of proteins and small molecules that transmit information from the cell surface to the nucleus, where they ultimately effect transcriptional changes. ... -
Automated motion artifact removal for intravital microscopy, without a priori information
(Nature Publishing Group, 2014)Intravital fluorescence microscopy, through extended penetration depth and imaging resolution, provides the ability to image at cellular and subcellular resolution in live animals, presenting an opportunity for new insights ... -
Automated neuron tracking inside moving and deforming C. elegans using deep learning and targeted augmentation
(Springer Science and Business Media LLC, 2023-12-05)Recent advances allow sustained rapid 3D functional imaging of large numbers of neurons inside behaving animals. To decode neural activity, individual neurons must be segmented and tracked. This can be challenging inside ... -
Automated real time constant-specificity surveillance for disease outbreaks
(BioMed Central, 2007)Background: For real time surveillance, detection of abnormal disease patterns is based on a difference between patterns observed, and those predicted by models of historical data. The usefulness of outbreak detection ... -
Automated Screening of Microtubule Growth Dynamics Identifies MARK2 as a Regulator of Leading Edge Microtubules Downstream of Rac1 in Migrating Cells
(Public Library of Science, 2012)Polarized microtubule (MT) growth in the leading edge is critical to directed cell migration, and is mediated by Rac1 GTPase. To find downstream targets of Rac1 that affect MT assembly dynamics, we performed an RNAi screen ... -
Automated Sulcal Depth Measurement on Cortical Surface Reflecting Geometrical Properties of Sulci
(Public Library of Science, 2013)Sulcal depth that is one of the quantitative measures of cerebral cortex has been widely used as an important marker for brain morphological studies. Several studies have employed Euclidean (EUD) or geodesic (GED) algorithms ... -
Automated Synthesis and Visualization of a Chemotherapy Treatment Regimen Network
(2013)Cytotoxic treatments for cancer remain highly toxic, expensive, and variably efficacious. Many chemotherapy regimens are never directly compared in randomized clinical trials (RCTs); as a result, the vast majority of ... -
Automated System for Gathering and Reporting Clinical Outcomes to Providers
(2015-09-29)BACKGROUND: Automated communication systems can help healthcare providers learn about their patients’ outcomes to detect patients who haven’t improved as expected. OBJECTIVE: To provide feedback to healthcare providers on ... -
Automated Validation Of Genetic Variants From Large Databases: Ensuring That Variant References Refer To The Same Genomic Locations
(Oxford University Press, 2011)Accurate annotations of genomic variants are necessary to achieve full-genome clinical interpretations that are scientifically sound and medically relevant. Many disease associations, especially those reported before the ... -
Automated Vocabulary Discovery for Geo-Parsing Online Epidemic Intelligence
(BioMed Central, 2009)Background Automated surveillance of the Internet provides a timely and sensitive method for alerting on global emerging infectious disease threats. HealthMap is part of a new generation of online systems designed to monitor ... -
Automated white matter fiber tract identification in patients with brain tumors
(Elsevier, 2016)We propose a method for the automated identification of key white matter fiber tracts for neurosurgical planning, and we apply the method in a retrospective study of 18 consecutive neurosurgical patients with brain tumors. ... -
Automatic clustering and population analysis of white matter tracts using maximum density paths
(Elsevier BV, 2014-08)We introduce a framework for population analysis of white matter tracts based on diffusion-weighted images of the brain. The framework enables extraction of fibers from high angular resolution diffusion images (HARDI); ... -
Automatic detection of ventilatory modes during invasive mechanical ventilation
(BioMed Central, 2016)Background: Expert systems can help alleviate problems related to the shortage of human resources in critical care, offering expert advice in complex situations. Expert systems use contextual information to provide advice ... -
Automatic Identification of Environment Haptic Properties
(MIT Press - Journals, 1999)Many applications can be imagined for a system that processes sensory information collected during telemanipulation tasks in order to automatically identify properties of the remote environment. These applications include ... -
Automatic Prediction of Rheumatoid Arthritis Disease Activity from the Electronic Medical Records
(Public Library of Science, 2013)Objective: We aimed to mine the data in the Electronic Medical Record to automatically discover patients' Rheumatoid Arthritis disease activity at discrete rheumatology clinic visits. We cast the problem as a document ... -
Automatic Verification of the Gradient Table in Diffusion-Weighted MRI Based on Fiber Continuity
(Springer Science and Business Media LLC, 2018-11-08)In diffusion-weighted magnetic resonance imaging (dMRI), the coordinate systems where the image and the diffusion gradients are represented may be inconsistent, thus impacting the quality of subsequent fiber tracking and ... -
The Autonomic Brain: An Activation Likelihood Estimation Meta-Analysis for Central Processing of Autonomic Function
(Society for Neuroscience, 2013)The autonomic nervous system (ANS) is of paramount importance for daily life. Its regulatory action on respiratory, cardiovascular, digestive, endocrine, and many other systems is controlled by a number of structures in ... -
Autonomic Dysregulation in Multiple Sclerosis
(MDPI, 2015)Multiple sclerosis (MS) is a chronic, progressive central neurological disease characterized by inflammation and demyelination. In patients with MS, dysregulation of the autonomic nervous system may present with various ... -
Autonomic Effects of Controlled Fine Particulate Exposure in Young Healthy Adults: Effect Modification by Ozone
(National Institute of Environmental Health Sciences, 2009)Background: Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by ... -
The autonomic nervous system and renal physiology
(Dove Medical Press, 2013)Research in resistant hypertension has again focused on autonomic nervous system denervation – 50 years after it had been stopped due to postural hypotension and availability of newer drugs. These (ganglionic blockers) ...