Browsing Harvard Medical School by Title
Now showing items 14911-14930 of 18428
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Retinopathy of prematurity
(Elsevier BV, 2013)The immature retinas of preterm neonates are susceptible to insults that disrupt neurovascular growth, leading to retinopathy of prematurity. Suppression of growth factors due to hyperoxia and loss of the maternal-fetal ... -
Retinopathy of prematurity: the need for prevention
(Dove Medical Press Ltd., 2016)More than 450,000 babies are born prematurely in the USA every year. The improved survival of even the most vulnerable low body weight preterm infants has, despite improving health outcomes, led to the resurgence in preterm ... -
Retraction of the Drosophila Germ Band Requires Cell-Matrix Interaction
(Cold Spring Harbor Laboratory, 2003-03-01)Integrins and laminins are important mediators of cell–matrix interactions in both vertebrates and invertebrates. Here, we show that germ-band retraction in the Drosophila embryo, during which the tail end of the embryo ... -
Retraction: Fatty Acid Synthase is a Novel Therapeutic Target in Multiple Myeloma
(Blackwell Publishing Ltd, 2008)This study investigated the biological significance of the inhibition of fatty acid synthase (FAS) in multiple myeloma (MM) using the small molecule inhibitor Cerulenin. Cerulenin triggered growth inhibition in both MM ... -
Retrievable stent thrombectomy in the treatment of acute ischemic stroke: Analysis of a revolutionizing treatment technique
(Elsevier BV, 2013)Acute ischemic stroke resulting from intracranial vessel occlusion is associated with high morbidity and mortality. The mainstays of therapy are fibrinolytics and mechanical thrombectomy in properly selected patients. A ... -
Retrieval of Radiology Reports Citing Critical Findings with Disease-Specific Customization
(Bentham Open, 2012)Background: Communication of critical results from diagnostic procedures between caregivers is a Joint Commission national patient safety goal. Evaluating critical result communication often requires manual analysis of ... -
Retrieval-induced forgetting in schizophrenia
(Elsevier BV, 2005)Retrieving category associates (e.g., FRUIT-ORANGE) may induce forgetting other category members (e.g., FRUIT-BANANA), a phenomenon known as retrieval-induced forgetting (RIF). We designed 2 experiments to examine the role ... -
Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
(eLife Sciences Publications, Ltd, 2016)Communication between pre- and postsynaptic cells promotes the initial organization of synaptic specializations, but subsequent synaptic stabilization requires transcriptional regulation. Here we show that fibroblast growth ... -
Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons
(Company of Biologists, 2010)Mammalian limb and trunk skeletal muscles are composed of muscle fibers that differ in contractile and molecular properties. They are commonly divided into four categories according to the myosin heavy chain that they ... -
Retroperitoneal Laparoscopic Management of Paraganglioma: A Single Institute Experience
(Public Library of Science, 2016)Objectives: To explore the feasibility and safety of retroperitoneal laparoscopic resection of paraganglioma (RLPG) in a large study population. Methods: In a six-year period, 49 patients with primary retroperitoneal ... -
A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments
(BioMed Central, 2015)Background: Limited clinical data on real-world practice patterns are available for patients with metastatic/relapsed soft tissue sarcomas (STS). The primary objective of this study was to evaluate treatment patterns in ... -
A Retrospective Cohort Study of U.S. Service Members Returning from Afghanistan and Iraq: Is Physical Health Worsening Over time?
(BioMed Central, 2012)Background: High rates of mental health disorders have been reported in veterans returning from deployment to Afghanistan (Operation Enduring Freedom: OEF) and Iraq (Operation Iraqi Freedom: OIF); however, less is known ... -
Retrospective cohort study of usage patterns of epidural injections for spinal pain in the US fee-for-service Medicare population from 2000 to 2014
(BMJ Publishing Group, 2016)Objective: To assess the usage patterns of epidural injections for chronic spinal pain in the fee-for-service (FFS) Medicare population from 2000 to 2014 in the USA. Design: A retrospective cohort. Methods: The descriptive ... -
Retrospective Evaluation of Elastic Stain in the Assessment of Serosal Invasion of pT3N0 Colorectal Cancers
(Ovid Technologies (Wolters Kluwer Health), 2013)Peritoneal involvement is an important adverse prognostic factor in colorectal cancer (CRC) and determines a shift in the pathologic tumor node metastasis stage. Because peritoneal involvement is difficult to identify, use ... -
Retroviral DNA Integration
(American Chemical Society, 2016)The integration of a DNA copy of the viral RNA genome into host chromatin is the defining step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded integrase protein, which is conserved among ... -
Retroviral Integrase Proteins and HIV-1 DNA Integration
(American Society for Biochemistry and Molecular Biology, 2012)Retroviral integrases catalyze two reactions, 3'-processing of viral DNA ends, followed by integration of the processed ends into chromosomal DNA. X-ray crystal structures of integrase-DNA complexes from prototype foamy ... -
Retrovirus-Delivered siRNA
(BioMed Central, 2002)Background: The ability of transfected synthetic small interfering (si) RNAs to suppress the expression of specific transcripts has proved a useful technique to probe gene function in mammalian cells. However, high production ... -
Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice
(eLife Sciences Publications, Ltd, 2014)Loss of function of the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2) causes the progressive neurological disorder Rett syndrome (RTT). Conversely, duplication or triplication of Xq28 causes an equally ... -
Return to play after thigh muscle injury in elite football players: implementation and validation of the Munich muscle injury classification
(BMJ Publishing Group, 2013)Background: Owing to the complexity and heterogeneity of muscle injuries, a generally accepted classification system is still lacking. Aims To prospectively implement and validate a novel muscle injury classification and ... -
Returners and explorers dichotomy in human mobility
(Nature Pub. Group, 2015)The availability of massive digital traces of human whereabouts has offered a series of novel insights on the quantitative patterns characterizing human mobility. In particular, numerous recent studies have lead to an ...