Now showing items 1544-1563 of 18423

    • Avoiding Symmetry-Breaking Spatial Non-Uniformity in Deformable Image Registration via a Quasi-Volume-Preserving Constraint 

      Aganj, Iman; Reuter, Martin; Sabuncu, Mert R.; Fischl, Bruce (Elsevier BV, 2015-02-01)
      The choice of a reference image typically influences the results of deformable image registration, thereby making it asymmetric. This is a consequence of a spatially non-uniform weighting in the cost function integral that ...
    • AVPV Neurons Containing Estrogen Receptor-Beta in Adult Male Rats Are Influenced by Soy Isoflavones 

      Bu, Lihong; Lephart, Edwin D (BioMed Central, 2007)
      Background: Isoflavones, the most abundant phytoestrogens in soy foods, are structurally similar to 17beta-estradiol. It is known that 17beta-estradiol induces apoptosis in anteroventral periventricular nucleus (AVPV) in ...
    • Awakening lineage potential by Ikaros-mediated transcriptional priming 

      Yoshida, Toshimi; Ng, Samuel Yao-Ming; Georgopoulos, Katia (Elsevier BV, 2010)
      Bioinformatic studies on a revised hierarchy of hematopoietic progenitors have provided a genome-wide view of lineage-affiliated transcriptional programs directing early hematopoiesis. Unexpectedly, lymphoid, myeloid, and ...
    • Awareness, Accuracy, and Predictive Validity of Self-reported Cholesterol in Women 

      Huang, Peng-yun A.; Buring, Julie Elizabeth; Ridker, Paul M.; Glynn, Robert J. (Springer-Verlag, 2007)
      Background: Although current guidelines emphasize the importance of cholesterol knowledge, little is known about accuracy of this knowledge, factors affecting accuracy, and the relationship of self-reported cholesterol ...
    • AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients 

      Batchelor, Tracy Todd; Sorensen, A; di Tomaso, Emmanuelle; Zhang, Wei-Ting; Duda, Dan Gabriel; Cohen, Kenneth S.; Kozak, Kevin R.; Cahill, Daniel P.; Chen, Poe-Jou; Zhu, Mingwang; Ancukiewicz, Marek; Mrugala, Maciej M.; Plotkin, Scott Randall; Drappatz, Jan; Louis, David N.; Ivy, Percy; Scadden, David Thomas; Benner, Thomas; Loeffler, Jay Steven; Wen, Patrick Yung Chih; Jain, Rakesh K. (Elsevier BV, 2007)
      Using MRI techniques, we show here that normalization of tumor vessels in recurrent glioblastoma patients by daily administration of AZD2171—an oral tyrosine kinase inhibitor of VEGF receptors—has rapid onset, is prolonged ...
    • Aβ Imaging: Feasible, Pertinent, and Vital to Progress in Alzheimer’s Disease 

      Villemagne, Victor L.; Klunk, William E.; Mathis, Chester A.; Rowe, Christopher C.; Ikonomovic, Milos D.; Ishii, Kenji; Jack, Clifford R.; Jagust, William J.; Koeppe, Robert A.; Lowe, Val J.; Masters, Colin L.; Montine, Thomas J.; Morris, John C.; Nordberg, Agneta; Petersen, Ronald C.; Reiman, Eric M.; Van Laere, Koen; Drzezga, Alexander; Brooks, David J.; Hyman, Bradley Theodore; Johnson, Keith Alan; Selkoe, Dennis J.; Sperling, Reisa Anne; Weiner, Michael W. (Springer-Verlag, 2012)
    • B Cell Antigen Receptor Signal Strength and Peripheral B Cell Development are Regulated by a 9-O-Acetyl Sialic Acid Esterase 

      Cariappa, Annaiah; Takematsu, Hiromu; Liu, Haoyuan; Diaz, Sandra; Haider, Khaleda; Kalloo, Geetika; Varki, Nissi; Varki, Ajit; Boboila, Cristian; Connole, Michelle Ann; Shi, Hai Ning; Pillai, Shiv Subramaniam (Rockefeller University Press, 2009)
      We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that ...
    • B cell homeostasis and follicle confines are governed by fibroblastic reticular cells 

      Cremasco, Viviana; Woodruff, Matthew C.; Onder, Lucas; Cupovic, Jovana; Nieves-Bonilla, Janice M.; Schildberg, Frank A.; Chang, Jonathan; Cremasco, Floriana; Harvey, Christopher J.; Wucherpfennig, Kai; Ludewig, Burkhard; Carroll, Michael C.; Turley, Shannon J. (2014)
      Fibroblastic reticular cells (FRCs) are known to inhabit T cell-rich areas of lymphoid organs where they function to coordinate T cell and dendritic cell interactions. However, in vivo manipulation of FRCs has been limited ...
    • B cell receptor pathway in chronic lymphocytic leukemia: specific role of CC-292 

      Arnason, Jon E; Brown, Jennifer R (Dove Medical Press, 2014)
      Chronic lymphocytic leukemia (CLL) is the most common adult leukemia. The current treatment paradigm involves the use of chemoimmunotherapy, when patients develop an indication for therapy. With this strategy, a majority ...
    • B Cells Populating the Multiple Sclerosis Brain Mature in the Draining Cervical Lymph Nodes 

      Stern, Joel N. H.; Yaari, Gur; Vander Heiden, Jason A.; Church, George; Donahue, William F.; Hintzen, Rogier Q.; Huttner, Anita J.; Laman, Jon D.; Nagra, Rashed M.; Nylander, Alyssa; Pitt, David; Ramanan, Sriram; Siddiqui, Bilal A.; Vigneault, Francois; Kleinstein, Steven H.; Hafler, David A.; O’Connor, Kevin C. (American Association for the Advancement of Science (AAAS), 2014-08-06)
      Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) characterized by autoimmune mediated demyelination and neurodegeneration. The CNS of patients with MS harbors expanded clones of ...
    •  B-Crystallin Protects Retinal Tissue during Staphylococcus aureus- Induced Endophthalmitis 

      Whiston, E. A.; Sugi, N.; Kamradt, M. C.; Sack, C.; Heimer, S. R.; Engelbert, M.; Wawrousek, E. F.; Gilmore, Michael S.; Ksander, Bruce R.; Gregory, M. S. (American Society for Microbiology, 2008)
      Bacterial infections of the eye highlight a dilemma that is central to all immune-privileged sites. On the one hand, immune privilege limits inflammation to prevent bystander destruction of normal tissue and loss of vision. ...
    • b-FGF Induces Corneal Blood and Lymphatic Vessel Growth in a Spatially Distinct Pattern 

      Hajrasouliha, Amir R.; Sadrai, Zahra; Chauhan, Sunil Kumar; Dana, Reza (Ovid Technologies (Wolters Kluwer Health), 2012)
      Purpose To study the spatial variances in ligand expression and angiogenic effect in response to the inflammatory response induced by b-FGF. Methods b-FGF micropellets (80ng) were implanted in the temporal side ...
    • B-MYB Is Essential for Normal Cell Cycle Progression and Chromosomal Stability of Embryonic Stem Cells 

      Tarasov, Kirill V.; Tarasova, Yelena S.; Tam, Wai Leong; Riordon, Daniel R.; Elliott, Steven T.; Kania, Gabriela; Li, Jinliang; Yamanaka, Satoshi; Crider, David G.; Testa, Gianluca; Li, Ronald A.; Stewart, Colin L.; Liu, Yie; Van Eyk, Jennifer E.; Wersto, Robert P.; Wobus, Anna M.; Boheler, Kenneth R.; Lim, Bing (Public Library of Science, 2008)
      Background: The transcription factor B-Myb is present in all proliferating cells, and in mice engineered to remove this gene, embryos die in utero just after implantation due to inner cell mass defects. This lethal phenotype ...
    • B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS 

      O’Donovan, Kevin J.; Ma, Kaijie; Guo, Hengchang; Wang, Chen; Sun, Fang; Han, Seung Baek; Kim, Hyukmin; Wong, Jamie K.; Charron, Jean; Zou, Hongyan; Son, Young-Jin; He, Zhigang; Zhong, Jian (The Rockefeller University Press, 2014)
      Activation of intrinsic growth programs that promote developmental axon growth may also facilitate axon regeneration in injured adult neurons. Here, we demonstrate that conditional activation of B-RAF kinase alone in mouse ...
    • BACE1 activity regulates cell surface contactin-2 levels 

      Gautam, Vivek; D’Avanzo, Carla; Hebisch, Matthias; Kovacs, Dora M; Kim, Doo Yeon (BioMed Central, 2014)
      Background: Although BACE1 is a major therapeutic target for Alzheimer’s disease (AD), potential side effects of BACE1 inhibition are not well characterized. BACE1 cleaves over 60 putative substrates, however the majority ...
    • Bachelors, Divorcees, and Widowers: Does Marriage Protect Men from Type 2 Diabetes? 

      Cornelis, Marilyn C.; Chiuve, Stephanie E.; Glymour, M. Maria; Chang, Shun-Chiao; Tchetgen Tchetgen, Eric J.; Liang, Liming; Koenen, Karestan C.; Rimm, Eric B.; Kawachi, Ichiro; Kubzansky, Laura D. (Public Library of Science, 2014)
      While research has suggested that being married may confer a health advantage, few studies to date have investigated the role of marital status in the development of type 2 diabetes. We examined whether men who are not ...
    • Bacillus subtilis cell diameter is determined by the opposing actions of two distinct cell wall synthetic systems 

      Dion, Michael; Kapoor, Mrinal; Sun, Yingjie; Wilson, Sean; Ryan, Joel; Vigouroux, Antoine; van Teeffelen, Sven; Oldenbourg, Rudolf; Garner, Ethan (Springer Science and Business Media LLC, 2019-05-13)
      Rod shaped bacteria grow by adding material into their cell wall via the action of two spatially distinct enzymatic systems: The Rod system moves around the cell circumference, while the class A penicillin-binding proteins ...
    • Bacillus subtilis Genome Diversity 

      Earl, Ashlee M.; Losick, Richard; Kolter, Roberto (American Society for Microbiology, 2007)
      Microarray-based comparative genomic hybridization (M-CGH) is a powerful method for rapidly identifying regions of genome diversity among closely related organisms. We used M-CGH to examine the genome diversity of 17 strains ...
    • Back to the family: a renewed approach to rare variant studies 

      Zielinski, Dina; Gymrek, Melissa; Erlich, Yaniv (BioMed Central, 2012)
      A report on the 62nd Annual Meeting of the American Society of Human Genetics, San Francisco, California, USA, 6-10 November 2012.
    • Back to the Future: Reclaiming Aphasia from Cognitive Neurolinguistics 

      Milberg, William; Blumstein, Sheila (Elsevier BV, 2000-01)