Browsing Harvard Medical School by Title

Now showing items 157-176 of 18428

    • A20 deficiency causes spontaneous neuroinflammation in mice 

      Guedes, Renata Padilha; Csizmadia, Eva; Moll, Herwig P; Ma, Averil; Ferran, Christiane; da Silva, Cleide Gonçalves (BioMed Central, 2014)
      Background: A20 (TNFAIP3) is a pleiotropic NFκB-dependent gene that terminates NFκB activation in response to inflammatory stimuli. The potent anti-inflammatory properties of A20 are well characterized in several organs. ...

    • A20 Modulates Lipid Metabolism and Energy Production to Promote Liver Regeneration 

      Studer, Peter; Longo, Christopher R.; Csizmadia, Eva; Shrikhande, Gautam V.; Scali, Salvatore T.; Bhasin, Manoj K.; Selvarajoo, Kumar; Damrauer, Scott Michael; Da Silva, Cleide Gonsalves; Ramsey, Haley Elizabeth; Libermann, Towia Aron; Ferran, Christiane (Public Library of Science, 2011)
      Background: Liver Regeneration is clinically of major importance in the setting of liver injury, resection or transplantation. We have demonstrated that the NF-\(\kappa\)B inhibitory protein A20 significantly improves ...

    • The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer 

      Cotter, Kristina; Liberman, Rachel; Sun-Wada, GeHong; Wada, Yoh; Sgroi, Dennis; Naber, Stephen; Brown, Dennis; Breton, Sylvie; Forgac, Michael (Impact Journals LLC, 2016)
      The vacuolar (H+)-ATPases (V-ATPases) are a family of ATP-driven proton pumps that acidify intracellular compartments and transport protons across the plasma membrane. Previous work has demonstrated that plasma membrane ...

    • \(A\beta\) alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo 

      Cao, Luxiang; Schrank, Benjamin R.; Rodriguez, Steven; Benz, Eric G.; Moulia, Thomas W.; Rickenbacher, Gregory T.; Gomez, Alexis C.; Levites, Yona; Edwards, Sarah R.; Golde, Todd E.; Hyman, Bradley Theodore; Barnea, Gilad; Albers, Mark W (Nature Publishing Group, 2012)
      The amyloid beta peptide aggregates into amyloid plaques at presymptomatic stages of Alzheimer's disease, but the temporal relationship between plaque formation and neuronal dysfunction is poorly understood. Here we ...

    • Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1 

      Calvo, Jennifer A.; Moroski-Erkul, Catherine A.; Lake, Annabelle; Eichinger, Lindsey W.; Shah, Dharini; Jhun, Iny; Limsirichai, Prajit; Bronson, Roderick Terry; Christiani, David C.; Meira, Lisiane B.; Samson, Leona D. (Public Library of Science, 2013)
      Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential ...

    • AAV TRANSDUCTION TRACING IN HEMATOPOIETIC CELLS BY TARGETED SCARRING OF GENOMIC SAFE HARBORS 

      Kim, Rebekah (2023-05-10)
      AAV is a potent and broadly used gene delivery platform with potential applications to treat many genetic diseases, including incurable diseases of hematopoietic cells and the immune system. As this viral vector becomes ...

    • AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges 

      Gardner, Matthew R.; Kattenhorn, Lisa M.; Kondur, Hema R.; von Schaewen, Markus; Dorfman, Tatyana; Chiang, Jessica J.; Haworth, Kevin G.; Decker, Julie M.; Alpert, Michael D.; Bailey, Charles C.; Neale, Ernest S.; Fellinger, Christoph H.; Joshi, Vinita R.; Fuchs, Sebastian P.; Martinez-Navio, Jose M.; Quinlan, Brian D.; Yao, Annie Y.; Mouquet, Hugo; Gorman, Jason; Zhang, Baoshan; Poignard, Pascal; Nussenzweig, Michel C.; Burton, Dennis R.; Kwong, Peter D.; Piatak, Michael; Lifson, Jeffrey D.; Gao, Guangping; Desrosiers, Ronald C.; Evans, David T.; Hahn, Beatrice H.; Ploss, Alexander; Cannon, Paula M.; Seaman, Michael S.; Farzan, Michael (2015)
      Long-term in vivo expression of a broad and potent entry inhibitor could circumvent the need for a conventional vaccine for HIV-1. Adeno-associated virus (AAV) vectors can stably express HIV-1 broadly neutralizing antibodies ...

    • AAV-Mediated Administration of Myostatin Pro-Peptide Mutant in Adult Ldlr Null Mice Reduces Diet-Induced Hepatosteatosis and Arteriosclerosis 

      Guo, Wen; Wong, Siu; Bhasin, Shalender (Public Library of Science, 2013)
      Genetic disruption of myostatin or its related signaling is known to cause strong protection against diet-induced metabolic disorders. The translational value of these prior findings, however, is dependent on whether such ...

    • AAV-Mediated Gene Delivery in Adult GM1-Gangliosidosis Mice Corrects Lysosomal Storage in CNS and Improves Survival 

      Baek, Rena C.; Broekman, Marike L. D.; Leroy, Stanley G.; Tierney, Laryssa A.; Sandberg, Michael Arthur; d'Azzo, Alessandra; Seyfried, Thomas N.; Sena-Esteves, Miguel (Public Library of Science, 2010)
      Background: GM1-gangliosidosis is a glycosphingolipid (GSL) lysosomal storage disease caused by a genetic deficiency of acid β-galactosidase (βgal), which results in the accumulation of GM1-ganglioside and its asialo-form ...

    • AAV-Mediated Intramuscular Delivery of Myotubularin Corrects the Myotubular Myopathy Phenotype in Targeted Murine Muscle and Suggests a Function in Plasma Membrane Homeostasis 

      Buj-Bello, Anna; Fougerousse, Françoise; Schwab, Yannick; Messaddeq, Nadia; Spehner, Danièle; Pierson, Christopher R.; Durand, Muriel; Kretz, Christine; Danos, Olivier; Douar, Anne-Marie; Schultz, Patrick; Montus, Marie; Denèfle, Patrice; Mandel, Jean-Louis; Beggs, Alan Hendrie (Oxford University Press, 2008)
      Myotubular myopathy (XLMTM, OMIM 310400) is a severe congenital muscular disease due to mutations in the myotubularin gene (MTM1) and characterized by the presence of small myofibers with frequent occurrence of central ...

    • Ab initiostudies of the phase transitions inK2SeO4 

      Lu, Hsiao-ming; Hardy, J. R. (American Physical Society (APS), 1990)
      An ab initio model is developed for the potentials in ionic molecular solids in which the electron covalency within the molecular ions substantially affects the interionic interactions. By treating the intermolecular and ...

    • An ABC Transporter Is Required for Secretion of Peptide Sex Pheromones in Enterococcus faecalis 

      Varahan, Sriram; Harms, Nathan; Gilmore, Michael S.; Tomich, John M.; Hancock, Lynn E. (American Society of Microbiology, 2014)
      ABSTRACT Enterococci are leading causes of hospital-acquired infection in the United States and continue to develop resistances to new antibiotics. Many Enterococcus faecalis isolates harbor pheromone-responsive plasmids ...

    • ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas 

      Johnatty, Sharon E.; Beesley, Jonathan; Gao, Bo; Chen, Xiaoqing; Lu, Yi; Law, Matthew H.; Henderson, Michelle J.; Russell, Amanda J.; Hedditch, Ellen L.; Emmanuel, Catherine; Fereday, Sian; Webb, Penelope M.; Goode, Ellen L.; Vierkant, Robert A.; Fridley, Brooke L.; Cunningham, Julie M; Fasching, Peter A.; Beckmann, Matthias W.; Ekici, Arif B.; Hogdall, Estrid; Kjaer, Susanne K.; Jensen, Allan; Hogdall, Claus; Brown, Robert; Paul, Jim; Lambrechts, Sandrina; Despierre, Evelyn; Vergote, Ignace; Lester, Jenny; Karlan, Beth Y.; Heitz, Florian; du Bois, Andreas; Harter, Philipp; Schwaab, Ira; Bean, Yukie; Pejovic, Tanja; Levine, Douglas A.; Goodman, Marc T.; Camey, Michael E.; Thompson, Pamela J.; Lurie, Galina; Shildkraut, Joellen; Berchuck, Andrew; Terry, Kathryn Lynne; Cramer, Daniel William; Norris, Murray D.; Haber, Michelle; MacGregor, Stuart; deFazio, Anna; Chenevix-Trench, Georgia (Elsevier BV, 2013)
      Objective ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical ...

    • Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria 

      Chen, Wen; Paradkar, P. N.; Li, L.; Pierce, E. L.; Langer, N. B.; Takahashi-Makise, N.; Hyde, B. B.; Shirihai, O. S.; Ward, D. M.; Kaplan, J.; Paw, Barry Htin (Proceedings of the National Academy of Sciences, 2009)
      Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the mitochondrial inner membrane, functions as an essential iron importer for the synthesis of mitochondrial heme and iron–sulfur clusters ...

    • abd-A Regulation by the iab-8 Noncoding RNA 

      Gummalla, Maheshwar; Maeda, Robert K.; Castro Alvarez, Javier J.; Gyurkovics, Henrik; Singari, Swetha; Edwards, Kevin A.; Karch, François; Bender, Welcome W. (Public Library of Science, 2012)
      The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior ...

    • Abdominal Cross-sectional Imaging for Inpatients With Abnormal Liver Function Test Results 

      Rothschild, Jeffrey Mark; Khorasani, Ramin; Silverman, Stuart George; Hanson, Richard; Fiskio, Julie M.; Bates, David Westfall (American Medical Association (AMA), 2001)
      Background: Abdominal cross-sectional imaging is often performed to evaluate abnormal liver function test (LFT) results in hospitalized patients. However, few data are available regarding the yield and usefulness of imaging ...

    • Abdominal obesity and hyperglycemia mask the effect of a common APOC3 haplotype on the risk of myocardial infarction 

      Ruiz-Narváez, Edward; Sacks, Frank Martin; Campos, Hannia (American Society for Nutrition, 2008)
      Background Plasma apolipoprotein (apo) C-III strongly predicts myocardial infarction (MI) and directly activates atherogenic processes invascularcells.Geneticvariationintheinsulinresponseelementofthe APOC3 promoter is ...

    • Abdominal Pain, the Adolescent and Altered Brain Structure and Function 

      Hubbard, Catherine S.; Becerra, Lino; Heinz, Nicole; Ludwick, Allison; Rasooly, Tali; Wu, Rina; Johnson, Adriana; Schechter, Neil L.; Borsook, David; Nurko, Samuel (Public Library of Science, 2016)
      Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder of unknown etiology. Although relatively common in children, how this condition affects brain structure and function in a pediatric population ...

    • Abdominal Subcutaneous Adipose Tissue: A Protective Fat Depot? 

      Porter, Stacy Ann; Massaro, Joseph M.; Hoffmann, Udo; Vasan, Ramachandran S.; O'Donnel, Christopher J.; Fox, Caroline (American Diabetes Association, 2009)
      OBJECTIVE: Obesity is associated with increased metabolic and cardiovascular risk. The ectopic fat hypothesis suggests that subcutaneous fat may be protective, but this theory has yet to be fully explored. RESEARCH DESIGN ...

    • Abdominal Superficial Subcutaneous Fat 

      Golan, Rachel; Shelef, Ilan; Rudich, Assaf; Gepner, Yftach; Shemesh, Elad; Chassidim, Yoash; Harman-Boehm, Ilana; Henkin, Yaakov; Schwarzfuchs, Dan; Ben Avraham, Sivan; Witkow, Shula; Liberty, Idit F.; Tangi-Rosental, Osnat; Sarusi, Benjamin; Stampfer, Meir; Shai, Iris (American Diabetes Association, 2012)
      OBJECTIVE: Unlike visceral adipose tissue (VAT), the association between subcutaneous adipose tissue (SAT) and obesity-related morbidity is controversial. In patients with type 2 diabetes, we assessed whether this variability ...