Browsing Harvard Medical School by Title

Now showing items 15726-15745 of 18428

    • Simple, Inexpensive Technique for High-Quality Smartphone Fundus Photography in Human and Animal Eyes 

      Haddock, Luis J.; Kim, David Y.; Mukai, Shizuo (Hindawi Publishing Corporation, 2013)
      Purpose. We describe in detail a relatively simple technique of fundus photography in human and rabbit eyes using a smartphone, an inexpensive app for the smartphone, and instruments that are readily available in an ...

    • A Simple, Rapid Method for the Preparation of [11 C]Formaldehyde 

      Hooker, Jacob M; Schönberger, Matthias; Schieferstein, Hanno; Fowler, Joanna S. (Wiley-Blackwell, 2008)
      A PET project: A powerful reagent for the synthesis of positron-emitting imaging molecules—[11C]formaldehyde—is accessible from [11C]methyl iodide and trimethylamine N-oxide (TMAO) in high yields and under mild conditions. ...

    • Simplified and representative bacterial community of maize roots 

      Niu, Ben; Paulson, Joseph Nathaniel; Zheng, Xiaoqi; Kolter, Roberto (National Academy of Sciences, 2017)
      Plant-associated microbes are important for the growth and health of their hosts. As a result of numerous prior studies, we know that host genotypes and abiotic factors influence the composition of plant microbiomes. ...

    • A Simplified Method for Analysis of Polyunsaturated Fatty Acids 

      Kang, Jing Xuan; Wang, Jingping (BioMed Central, 2005)
      Background: Analysis of fatty acid composition of biological materials is a common task in lipid research. Conventionally, preparation of samples for fatty acid analysis by gas chromatography involves two separate procedures: ...

    • Simplified Negative Pressure Wound Therapy Device for Application in Low-Resource Settings 

      Zurovcik, Danielle R.; Mody, Gita Natwar; Riviello, Robert; Slocum, Alex (Ovid Technologies (Wolters Kluwer Health), 2015)
      Negative pressure wound therapy (NPWT) provides proven wound healing benefits and is often a desirable wound treatment. Unfortunately, NPWT devices are not widely available in low-resource settings (LRSs). In order to ...

    • A Simplified Score to Quantify Comorbidity in COPD 

      Putcha, Nirupama; Puhan, Milo A.; Drummond, M. Bradley; Han, MeiLan K.; Regan, Elizabeth A.; Hanania, Nicola A.; Martinez, Carlos H.; Foreman, Marilyn; Bhatt, Surya P.; Make, Barry; Ramsdell, Joe; DeMeo, Dawn L.; Barr, R. Graham; Rennard, Stephen I.; Martinez, Fernando; Silverman, Edwin K.; Crapo, James; Wise, Robert A.; Hansel, Nadia N. (Public Library of Science, 2014)
      Importance Comorbidities are common in COPD, but quantifying their burden is difficult. Currently there is a COPD-specific comorbidity index to predict mortality and another to predict general quality of life. We sought ...

    • Simplified Syntheses of Complex Multifunctional Nanomaterials 

      Garanger, Elisabeth; Aikawa, Elena; Reynolds, Fred; Weissleder, Ralph; Josephson, Lee (Royal Society of Chemistry, 2008)
      Multifunctional probes are synthesized in a single step using peptide scaffold-based multifunctional single-attachment-point (MSAP) reagents.

    • Simplifying cardiovascular magnetic resonance pulse sequence terminology 

      Friedrich, Matthias G; Bucciarelli-Ducci, Chiara; White, James A; Plein, Sven; Moon, James C; Almeida, Ana G; Kramer, Christopher M; Neubauer, Stefan; Pennell, Dudley J; Petersen, Steffen E; Kwong, Raymond Y; Ferrari, Victor A; Schulz-Menger, Jeanette; Sakuma, Hajime; Schelbert, Erik B; Larose, Éric; Eitel, Ingo; Carbone, Iacopo; Taylor, Andrew J; Young, Alistair; de Roos, Albert; Nagel, Eike (BioMed Central, 2014)
      We propose a set of simplified terms to describe applied Cardiovascular Magnetic Resonance (CMR) pulse sequence techniques in clinical reports, scientific articles and societal guidelines or recommendations. Rather than ...

    • Simplifying clinical use of the genetic risk prediction model BRCAPRO 

      Biswas, Swati; Atienza, Philamer; Chipman, Jonathan; Hughes, Kevin S.; Barrera, Angelica M. Gutierrez; Amos, Christopher I.; Arun, Banu; Parmigiani, Giovanni (Springer Nature, 2013)
      Purpose: Health care providers need simple tools to identify patients at genetic risk of breast and ovarian cancers. Genetic risk prediction models such as BRCAPRO could fill this gap if incorporated into Electronic Medical ...

    • Simplifying the Evaluation of Children With New Onset Diabetes: Utility of Pancreatic Autoantibodies for Diabetes Type Classification and Use of Serum Bicarbonate to Diagnose and Classify Diabetic Ketoacidosis. 

      Von Oettingen, Julia Elisabeth (2015-05-20)
      Objectives: To assess whether routinely measuring pancreatic autoantibodies (PAA) in pediatric new onset diabetes (NODM) is necessary, and to evaluate serum bicarbonate (HCO3) as a substitute for venous pH (vpH) in the ...

    • Simulated 50 % radiation dose reduction in coronary CT angiography using adaptive iterative dose reduction in three-dimensions (AIDR3D) 

      Chen, Marcus Y.; Steigner, Michael L.; Leung, Steve W.; Kumamaru, Kanako K.; Schultz, Kurt; Mather, Richard T.; Arai, Andrew E.; Rybicki, Frank J. (Springer Netherlands, 2013)
      To compare the image quality of coronary CT angiography (CTA) studies between standard filtered back projection (FBP) and adaptive iterative dose reduction in three-dimensions (AIDR3D) reconstruction using CT noise additional ...

    • Simulated Activity But Real Trauma: A Systematic Review on Nintendo Wii Injuries Based on a Case Report of an Acute Anterior Cruciate Ligament Rupture 

      Müller, Sebastian A.; Vavken, Patrick; Pagenstert, Geert (Wolters Kluwer Health, 2015)
      Abstract Video gaming injuries are classically regarded as eccentric accidents and novelty diagnoses. A case of an anterior cruciate ligament (ACL) tear sustained during Wii boxing spurned us to review the literature for ...

    • Simulated Anthrax Attacks and Syndromic Surveillance 

      Nordin, James D.; Goodman, Michael J.; Kulldorff, Martin; Ritzwoller, Debra P.; Abrams, Allyson M.; Kleinman, Ken Paul; Levitt, Mary Jeanne; Donahue, James; Platt, Richard (Centers for Disease Control and Prevention, 2005)
      We measured sensitivity and timeliness of a syndromic surveillance system to detect bioterrorism events. A hypothetical anthrax release was modeled by using zip code population data, mall customer surveys, and membership ...

    • Simulating Non-small Cell Lung Cancer with a Multiscale Agent-based Model 

      Wang, Zhihui; Zhang, Le; Sagotsky, Jonathan; Deisboeck, Thomas Steve (BioMed Central, 2007)
      Background: The epidermal growth factor receptor (EGFR) is frequently overexpressed in many cancers, including non-small cell lung cancer (NSCLC). In silico modeling is considered to be an increasingly promising tool to ...

    • Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis 

      Krueger, Andrew S.; Munck, Christian; Dantas, Gautam; Church, George M.; Galagan, James; Lehár, Joseph; Sommer, Morten O. A. (Public Library of Science, 2016)
      Flux balance analysis (FBA) is an increasingly useful approach for modeling the behavior of metabolic systems. However, standard FBA modeling of genetic knockouts cannot predict drug combination synergies observed between ...

    • Simulation in Pre-departure Training for Residents Planning Clinical Work in a Low-Income Country 

      Schwartz, Kevin R.; Prentiss, Kimball A. (Department of Emergency Medicine, University of California, Irvine School of Medicine, 2015)
      Introduction: Increasingly, pediatric and emergency medicine (EM) residents are pursuing clinical rotations in low-income countries. Optimal pre-departure preparation for such rotations has not yet been established. ...

    • Simulation of thalamic prosthetic vision: reading accuracy, speed, and acuity in sighted humans 

      Vurro, Milena; Crowell, Anne Marie; Pezaris, John S. (Frontiers Media S.A., 2014)
      The psychophysics of reading with artificial sight has received increasing attention as visual prostheses are becoming a real possibility to restore useful function to the blind through the coarse, pseudo-pixelized vision ...

    • A Simulation Platform to Examine Heterogeneity Influence on Treatment 

      Chi, Chih-Lin; Fusaro, Vincent Alfred; Patil, Prasad; Crawford, Matthew A.; Content, Charles F.; Tonellato, Peter J. (American Medical Informatics Association, 2012)
      Although a protocol aims to guide treatment management and optimize overall outcomes, the benefits and harms for each individual vary due to heterogeneity. Some protocols integrate clinical and genetic variation to provide ...

    • Simulations of phase transitions in Rb2ZnCl4 

      Lu, Hsiao-ming; Hardy, J. (American Physical Society (APS), 1992)
      Structural relaxations, molecular-dynamics simulations, and lattice-dynamics calculations were performed to study the phase transitions in Rb2ZnCl4, using intermolecular and intramolecular potentials generated from ab ...

    • Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound 

      Lee, Wonhye; Chung, Yong An; Jung, Yujin; Song, In-Uk; Yoo, Seung-Schik (BioMed Central, 2016)
      Background: Transcranial focused ultrasound (FUS) is gaining momentum as a novel non-invasive brain stimulation method, with promising potential for superior spatial resolution and depth penetration compared to transcranial ...