Browsing Harvard Medical School by Title
Now showing items 1584-1603 of 18423
-
BAL1 and Its Partner E3 Ligase, BBAP, Link Poly(ADP-Ribose) Activation, Ubiquitylation, and Double-Strand DNA Repair Independent of ATM, MDC1, and RNF8
(American Society for Microbiology, 2013)The BAL1 macrodomain-containing protein and its partner E3 ligase, BBAP, are overexpressed in chemotherapy-resistant lymphomas. BBAP selectively ubiquitylates histone H4 and indirectly promotes early 53BP1 recruitment to ... -
Balancing Antiplatelet and Anticoagulant Therapies in Patients with Cardiovascular Disease
(Springer Healthcare, 2013)Anticoagulation is needed for stroke prevention in patients with atrial fibrillation. Antiplatelet therapy is essential for the prevention of stent thrombosis and the reduction of cardiovascular events in patients who ... -
Balancing Education and Service in Graduate Medical Education: Data From Pediatric Trainees and Program Directors
(Published for the Association of American Medical Colleges by Lippincott Williams & Wilkins, 2014)Purpose To measure pediatric program directors’ (PDs’) and trainees’ perceptions of and expectations for the balance of service and education in their training programs. Method In fall 2011, an electronic survey was sent ... -
Balancing Image Quality and Compression Factor for Special Stains Whole Slide Images
(IOS Press, 2012)The objective is to find a practical balance between quality and performance for daily high volume whole slide imaging. We evaluated whole slide images created by various scanners at different compression factors to determine ... -
Balancing Selection on a Regulatory Region Exhibiting Ancient Variation That Predates Human–Neandertal Divergence
(Public Library of Science, 2013)Ancient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of the structure of modern human genomes. We identified a ∼36-kb ... -
Balancing speed and accuracy of polyclonal T cell activation: A role for extracellular feedback
(BioMed Central, 2012)Background: Extracellular feedback is an abundant module of intercellular communication networks, yet a detailed understanding of its role is still lacking. Here, we study interactions between polyclonal activated T cells ... -
Barcoding Bias in High-Throughput Multiplex Sequencing of miRNA
(Cold Spring Harbor Laboratory, 2011-09)Second-generation sequencing is gradually becoming the method of choice for miRNA detection and expression profiling. Given the relatively small number of miRNAs and improvements in DNA sequencing technology, studying miRNA ... -
Barcoding cells using cell-surface programmable DNA-binding domains
(2013)We develop here a novel approach to barcode large numbers of cells through cell-surface expression of programmable zinc-finger DNA-binding domains (sZFs). We show sZFs enable double-stranded DNA to sequence-specifically ... -
Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials
(BMJ Publishing Group Ltd., 2013)Objective: To quantify the overall effects of bariatric surgery compared with non-surgical treatment for obesity. Design: Systematic review and meta-analysis based on a random effects model. Data sources Searches of Medline, ... -
Barrier-to-Autointegration Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate-Early Gene Promoters
(American Society of Microbiology, 2015)ABSTRACT We have shown previously that A-type lamins and intranuclear localization of the herpes simplex virus (HSV) genome are critical for the formation of the VP16 activator complex on HSV immediate-early (IE) gene ... -
Barriers and Facilitators to Implementing Delirium Rounds in a Clinical Trial Across Three Diverse Hospital Settings
(SAGE Publications, 2013)Delirium occurs in more than half of hospitalized older adults with dementia, substantially worsening outcomes. The use of multiple strategies and a local opinion leader, unit champion, has cumulative and lasting effects ... -
Barriers in household access to medicines for chronic conditions in three Latin American countries
(BioMed Central, 2015)Background: Access to medicines is one of the major challenges in health policy. The high out-of-pocket expenditures on medicines in the Latin American and Caribbean (LAC) region represents important barrier to affordable ... -
Barriers to a cure for HIV in women
(International AIDS Society, 2016)Introduction: Distinct biological factors exist that affect the natural history of HIV and the host immune response between women and men. These differences must be addressed to permit the optimal design of effective HIV ... -
Barriers to colorectal cancer screening in community health centers: A qualitative study
(BioMed Central, 2008)Background: Colorectal cancer screening rates are low among disadvantaged patients; few studies have explored barriers to screening in community health centers. The purpose of this study was to describe barriers to/facilitators ... -
Barriers to HPV immunization among blacks and latinos: a qualitative analysis of caregivers, adolescents, and providers
(BioMed Central, 2016)Background: Despite recommendations that 11–12-year-olds receive the full three-shot Human papillomavirus (HPV) vaccine series, national HPV immunization coverage rates remain low. Disparities exist, with Blacks and Latinos ... -
Barriers to Self-monitoring of Blood Glucose Among Adults with Diabetes in an HMO: A Cross Sectional Study
(BioMed Central, 2003)Background: Recent studies suggest that patients at greatest risk for diabetes complications are least likely to self-monitor blood glucose. However, these studies rely on self-reports of monitoring, an unreliable measure ... -
Barriers to Specialty Care and Specialty Referral Completion in the Community Health Center Setting
(Elsevier BV, 2013)Objective To assess the frequency of barriers to specialty care and to assess which barriers are associated with an incomplete specialty referral (not attending a specialty visit when referred by a primary care provider) ... -
Barriers, Benefits, and Beliefs of Brain Training Smartphone Apps: An Internet Survey of Younger US Consumers
(Frontiers Media SA, 2016)Background: While clinical evidence for the efficacy of brain training remains in question, numerous smartphone applications (apps) already offer brain training directly to consumers. Little is known about why consumers ... -
Barx1-Mediated Inhibition of Wnt Signaling in the Mouse Thoracic Foregut Controls Tracheo-Esophageal Septation and Epithelial Differentiation
(Public Library of Science (PLoS), 2011-07-22)Mesenchymal cells underlying the definitive endoderm in vertebrate animals play a vital role in digestive and respiratory organogenesis. Although several signaling pathways are implicated in foregut patterning and ... -
Basal forebrain control of wakefulness and cortical rhythms
(Nature Pub. Group, 2015)Wakefulness, along with fast cortical rhythms and associated cognition, depend on the basal forebrain (BF). BF cholinergic cell loss in dementia and the sedative effect of anti-cholinergic drugs have long implicated these ...