Browsing Harvard Medical School by Title
Now showing items 16434-16453 of 18424
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Substitutes of Structural and Non-Structural Autologous Bone Grafts in Hindfoot Arthrodeses and Osteotomies: A Systematic Review
(BioMed Central, 2013)Background: Structural and non-structural substitutes of autologous bone grafts are frequently used in hindfoot arthrodeses and osteotomies. However, their efficacy is unclear. The primary goal of this systematic review ... -
Substrate Docking to γ-Secretase Allows Access of γ-Secretase Modulators to an Allosteric Site
(Nature Publishing Group, 2010)γ-Secretase generates the peptides of Alzheimer's disease, \(Aβ_{40}\) and \(Aβ_{42}\), by cleaving the amyloid precursor protein within its transmembrane domain. γ-Secretase also cleaves numerous other substrates, raising ... -
Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility
(The Rockefeller University Press, 2012)The mechanical microenvironment is known to influence single-cell migration; however, the extent to which mechanical cues affect collective migration of adherent cells is not well understood. We measured the effects of ... -
Substrate stress relaxation regulates cell spreading
(Nature Publishing Group, 2015)Studies of cellular mechanotransduction have converged upon the idea that cells sense extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on the ECM. However, these studies typically ... -
A substrate-driven allosteric switch that enhances PDI catalytic activity
(Nature Publishing Group, 2016)Protein disulfide isomerase (PDI) is an oxidoreductase essential for folding proteins in the endoplasmic reticulum. The domain structure of PDI is a–b–b′–x–a′, wherein the thioredoxin-like a and a′ domains mediate disulfide ... -
Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network
(Nature Publishing Group, 2015)Subthreshold depression (StD) is a prevalent condition associated with social morbidity and increased service utilization, as well as a high risk of developing into a major depressive disorder (MDD). The lack of well-defined ... -
Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer
(BioMed Central, 2016)Background: Zinc (Zn) hyper-accumulates in breast tumors and malignant cell lines compared to normal mammary epithelium. The mechanisms responsible for Zn accumulation and the consequence of Zn dysregulation are poorly ... -
Subunit Composition of Neurotransmitter Receptors in the Immature and in the Epileptic Brain
(Hindawi Publishing Corporation, 2014)Neuronal activity is critical for synaptogenesis and the development of neuronal networks. In the immature brain excitation predominates over inhibition facilitating the development of normal brain circuits, but also ... -
Subunit interactions in bovine papillomavirus
(National Academy of Sciences, 2010)Papillomaviruses, members of a group of dsDNA viruses associated with epithelial growths and tumors, have compact capsids assembled from 72 pentamers of the protein L1. We have determined the structure of bovine papillomavirus ... -
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer
(2012)The trimeric human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) spike is a molecular machine that mediates virus entry into host cells and is the sole target for virus-neutralizing antibodies. The ... -
Subunit-specific Protein Footprinting Reveals Significant Structural Rearrangements and a Role for N-terminal Lys-14 of HIV-1 Integrase during Viral DNA Binding
(American Society for Biochemistry and Molecular Biology, 2008) -
Succesful Radiofrequency Ablation of Atrial Tachycardia Arising From Within the Coronary Venous Sinus
(Indian Heart Rhythm Society, 2010)Focal atrial tachycardia (AT) though a relatively uncommon cause of supraventricular tachycardia is difficult to control with antiarrythmic drugs. With the advent of radiofrequency ablation (RFA), this form of tachycardia ... -
Success and Efficiency of Phase 2/3 Adjunctive Trials for MDD Funded by Industry: A Systematic Review
(2020-01-27)To review the success rate and efficiency of industry-sponsored phase 2/3 clinical trials for adjunctive therapies for antidepressant partial- and non-responders with major depressive disorder (MDD), a systematic search ... -
Success and failure rates of tumor genotyping techniques in routine pathological samples with non-small-cell lung cancer
(Elsevier BV, 2014)Introduction—Identification of some somatic molecular alterations in non-small-cell lung cancer (NSCLC) has become evidence-based practice. The success and failure rate of using commercially-available tumor genotyping ... -
The Successful Aging After Elective Surgery Study: Cohort Description and Data Quality Procedures
(Wiley-Blackwell, 2015)Background/Objectives Delirium is the most common complication of major elective surgery in older patients. The Successful Aging after Elective Surgery (SAGES) study was designed to examine novel risk factors and long-term ... -
Successful cryopreservation of human ovarian cortex tissues using supercooling
(Nature Publishing Group, 2012)The development of new method to cryopreserve human ovarian cortex tissues without damage is needed for the improvement of quality of life (QOL) of female cancer patients. Here we show novel cryopreservation method of human ... -
Successful MRI-Guided Focused Ultrasound Uterine Fibroid Treatment Despite an Ostomy and Significant Abdominal Wall Scarring
(International Scholarly Research Network, 2010)We present a case of successful magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) of a uterine fibroid in a patient with extensive anterior abdominal wall surgical scars from two longitudinal laparotomies, ... -
Successful Supercooled Liver Storage for 4 Days
(2014)The realization of long–term human organ preservation will have groundbreaking effects on the current practice of transplantation. Herein we present a novel technique based on sub–zero non–freezing tissue preservation and ... -
A Successful US Academic Collaborative Supporting Medical Education in a Postconflict Setting
(SAGE Publications, 2014)This article describes a model employed by the Academic Collaborative to Support Medical Education in Liberia to augment medical education in a postconflict setting where the health and educational structures and funding ... -
Sudden Cardiac Death in Patients With Atrial Fibrillation: Insights From the ENGAGE AF‐TIMI 48 Trial
(John Wiley and Sons Inc., 2016)Background: Recent findings suggest that atrial fibrillation is associated with sudden cardiac death (SCD). We examined the incidence, characteristics, and factors associated with SCD in patients with atrial fibrillation. ...