Browsing Harvard Medical School by Title
Now showing items 2010-2029 of 18428
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Buprenorphine Treatment for Opioid Addiction in the Primary Care Setting: Predictors of Treatment Success and Failure
(2015-06-08)Buprenorphine is a partial mu-opioid agonist with well-demonstrated efficacy in the medical treatment of opioid addiction. Little is known about which patients respond successfully to treatment with buprenorphine. To help ... -
Bupropion Reduces Some of the Symptoms of Marihuana Withdrawal in Chronic Marihuana Users: A Pilot Study
(Libertas Academica, 2012)Bupropion’s (Zyban® SR) effectiveness to treat symptoms experienced in marihuana withdrawal was tested in a double-blind, placebo-controlled study with chronic, heavy marihuana users. Participants maintained their usual ... -
Burden and predictors of hypertension in India: results of SEEK (Screening and Early Evaluation of Kidney Disease) study
(BioMed Central, 2014)Background: Hypertension (HTN) is one of the major causes of cardiovascular morbidity and mortality. The objective of the study was to investigate the burden and predictors of HTN in India. Methods: 6120 subjects participated ... -
Burden and Rates of Treatment and Control of Cardiovascular Disease Risk Factors in Obesity
(American Diabetes Association, 2008)OBJECTIVE—Obesity is associated with an increased risk for cardiovascular disease (CVD). We sought to determine rates of treatment and control of CVD risk factors among normal weight, overweight, and obese individuals in ... -
Burden of Changes in Pill Appearance for Patients Receiving Generic Cardiovascular Medications After Myocardial Infarction
(American College of Physicians, 2014)Background: Generic prescription drugs made by different manufacturers may vary in color or shape, and switching among these drug products may interrupt medication use. Objective: To determine whether nonpersistent use of ... -
The burden of clostridium difficile infection: estimates of the incidence of CDI from U.S. Administrative databases
(BioMed Central, 2016)Background: Many administrative data sources are available to study the epidemiology of infectious diseases, including Clostridium difficile infection (CDI), but few publications have compared CDI event rates across databases ... -
The burden of hypertension in sub-Saharan Africa: a four-country cross sectional study
(BioMed Central, 2015)Background: Hypertension, the leading single cause of morbidity and mortality worldwide, is a growing public health problem in sub-Saharan Africa (SSA). Few studies have estimated and compared the burden of hypertension ... -
Burden of illness score for elderly persons (BISEP): Risk adjustment incorporating the cumulative impact of diseases, physiologic abnormalities and functional impairments.
(Lippincott Williams & Wilkins, Inc., 2003)Background/Objectives. To develop and validate a new risk adjustment index-the Burden of Illness Score for Elderly Persons (BISEP)-which integrates multiple domains, including diseases, physiologic abnormalities, and ... -
The Burden of Inflammatory Bowel Disease: A Patient-Reported Qualitative Analysis and Development of a Conceptual Model
(Ovid Technologies (Wolters Kluwer Health), 2014)Background The aim of this study was to describe the impacts of inflammatory bowel disease (IBD) from the patients’ perspective, and to inform the development of a conceptual model. Methods Focus groups and ... -
Buried Barrett's Epithelium Following Photodynamic Therapy Shows Reduced Crypt Proliferation and Absence of DNA Content Abnormalities
(Springer Nature, 2008)OBJECTIVES: Photodynamic therapy (PDT) is increasingly used for the treatment of patients with Barrett's esophagus (BE) with dysplasia or early carcinoma. Post-PDT, some patients show residual BE either exposed to the ... -
Burkholderia spp. Alter Pseudomonas aeruginosa Physiology through Iron Sequestration
(American Society for Microbiology, 2004)Pseudomonas aeruginosa and members of the Burkholderia cepacia complex often coexist in both the soil and the lungs of cystic fibrosis patients. To gain an understanding of how these different species affect each other's ... -
Burn injury differentially alters whole-blood and organ glutathione synthesis rates: An experimental model
(BioMed Central, 2013)Previous studies from our laboratories revealed a reduced rate of whole-blood (WB) glutathione (GSH) synthesis in severely burned patients. To determine whether WB GSH metabolism is an indicator of the status of GSH ... -
Burn Injury Reduces Neutrophil Directional Migration Speed in Microfluidic Devices
(Public Library of Science, 2010)Thermal injury triggers a fulminant inflammatory cascade that heralds shock, end-organ failure, and ultimately sepsis and death. Emerging evidence points to a critical role for the innate immune system, and several studies ... -
Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation
(The Rockefeller University Press, 2009)Soon after its discovery ten years ago, the ion channel TRPA1 was proposed as a sensor of noxious cold. Evidence for its activation by painfully cold temperatures (below ~15° C) has been mixed, however. Some groups found ... -
The business of genomic testing: a survey of early adopters
(Nature Publishing Group, 2014)Purpose: The practice of “genomic” (or “personalized”) medicine requires the availability of appropriate diagnostic testing. Our study objective was to identify the reasons for health systems to bring next-generation ... -
Button-pressing affects P300 amplitude and scalp topography
(Elsevier BV, 2001)Background: Scant and equivocal research exists examining the effects of button-pressing on P300. Button-pressing may decrease P300 latency and amplitude. The melding of motor potentials and P300 may also confound studies ... -
Butyrylcholinesterase Predicts Cardiac Mortality in Young Patients with Acute Coronary Syndrome
(Public Library of Science, 2015)Background: The incidence of acute coronary syndrome (ACS) in young people (≤65 years) is continuously rising. While prognostic factors in ACS are well-investigated less attention has been paid to their age-dependent ... -
Bypass of a protein roadblock by a replicative DNA helicase
(2012)Replicative DNA helicases generally unwind DNA as a single hexamer that encircles and translocates along one strand of the duplex while excluding the complementary strand (“steric exclusion”). In contrast, large T antigen ... -
bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans
(National Academy of Sciences, 2010)Very little is known about how animals discriminate pathogens from innocuous microbes. To address this question, we examined infection-response gene induction in the nematode Caenorhabditis elegans. We focused on genes ... -
c-Abl Activation Regulates Induction of the SEK1/Stress-activated Protein Kinase Pathway in the Cellular Response to 1-β-D-Arabinofuranosylcytosine
(American Society for Biochemistry and Molecular Biology, 1995)