Now showing items 2110-2129 of 18423

    • Candida albicans Infection of Caenorhabditis elegans Induces Antifungal Immune Defenses 

      Pukkila-Worley, Read; Ausubel, Frederick M.; Mylonakis, Eleftherios; Levitz, Stuart M. (Public Library of Science, 2011)
      Candida albicans yeast cells are found in the intestine of most humans, yet this opportunist can invade host tissues and cause life-threatening infections in susceptible individuals. To better understand the host factors ...
    • Candida albicans Modulates Host Defense by Biosynthesizing the Pro-Resolving Mediator Resolvin E1 

      Haas-Stapleton, Eric J.; Lu, Yan; Hong, Song; Arita, Makoto; Favoreto, Silvio; Nigam, Santosh; Serhan, Charles Nicholas; Agabian, Nina (Public Library of Science, 2007)
      Candida albicans is an opportunistic fungal pathogen of humans that resides commensally on epithelial surfaces, but can cause inflammation when pathogenic. Resolvins are a class of anti-inflammatory lipids derived from ...
    • Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations 

      Nica, Alexandra C.; Montgomery, Stephen B.; Dimas, Antigone S.; Beazley, Claude; Barroso, Inês; Dermitzakis, Emmanouil T.; Gibson, Greg; Stranger, Barbara Elaine (Public Library of Science, 2010)
      The recent success of genome-wide association studies (GWAS) is now followed by the challenge to determine how the reported susceptibility variants mediate complex traits and diseases. Expression quantitative trait loci ...
    • Candidate genes of Waldenström’s macroglobulinemia: current evidence and research 

      Bianchi, Giada; Sacco, Antonio; Kumar, Shaji; Rossi, Giuseppe; Ghobrial, Irene; Roccaro, Aldo (Dove Medical Press, 2013)
      Waldenström’s macroglobulinemia (WM) is a relatively uncommon, indolent malignancy of immunoglobulin M-producing B cells. The World Health Organization classifies it as a lymphoplasmacytic lymphoma and patients typically ...
    • Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington’s disease motor onset 

      Ramos, Eliana Marisa; Latourelle, Jeanne C.; Gillis, Tammy; Mysore, Jayalakshmi S.; Squitieri, Ferdinando; Di Pardo, Alba; Di Donato, Stefano; Gellera, Cinzia; Hayden, Michael R.; Morrison, Patrick J.; Nance, Martha; Ross, Christopher A.; Margolis, Russell L.; Gomez-Tortosa, Estrella; Ayuso, Carmen; Suchowersky, Oksana; Trent, Ronald J.; McCusker, Elizabeth; Novelletto, Andrea; Frontali, Marina; Jones, Randi; Ashizawa, Tetsuo; Frank, Samuel; Saint-Hilaire, Marie-Helene; Hersch, Steven M.; Rosas, Herminia D.; Lucente, Diane; Harrison, Madaline B.; Zanko, Andrea; Abramson, Ruth K.; Marder, Karen; Gusella, James F.; Lee, Jong-Min; Alonso, Isabel; Sequeiros, Jorge; Myers, Richard H.; MacDonald, Marcy E. (Springer Berlin Heidelberg, 2013)
      Huntington’s disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and behavioral disturbances. It is caused by the expansion of the HTT CAG repeat, which is the major determinant of age at onset ...
    • Candidemia on presentation to the hospital: development and validation of a risk score 

      Shorr, Andrew F; Tabak, Ying P; Johannes, Richard Scott; Sun, Xiaowu; Spalding, James; Kollef, Marin H (BioMed Central, 2009)
      Introduction: Candidemia results in substantial morbidity and mortality, especially if initial antifungal therapy is delayed or is inappropriate; however, candidemia is difficult to diagnose because of its nonspecific ...
    • canEvolve: A Web Portal for Integrative Oncogenomics 

      Samur, Mehmet Kemal; Yan, Zhenyu; Wang, Xujun; Cao, Qingyi; Munshi, Nikhil C.; Li, Cheng; Shah, Parantu K. (Public Library of Science, 2013)
      Background & objective: Genome-wide profiles of tumors obtained using functional genomics platforms are being deposited to the public repositories at an astronomical scale, as a result of focused efforts by individual ...
    • Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic \(\beta\)-Cells 

      Doyle, Máire E.; Liu, Zhuo; Lao, Qizong; Shin, Yu-Kyong; Carlson, Olga D.; Thomas, Sam; Napora, Joshua K.; Moaddel, Ruin; Maudsley, Stuart; Martin, Bronwen; Egan, Josephine M.; Kim, Wookhyun; Kim, Hee Seung; Lee, Eun-Kyung; Wang, Yan; Kulkarni, Rohit Narayan (American Diabetes Association, 2011)
      Objective: Optimal glucose homeostasis requires exquisitely precise adaptation of the number of insulin-secreting \(\beta\)-cells in the islets of Langerhans. Insulin itself positively regulates \(\beta\)-cell proliferation ...
    • CANOES: detecting rare copy number variants from whole exome sequencing data 

      Backenroth, Daniel; Homsy, Jason; Murillo, Laura R.; Glessner, Joe; Lin, Edwin; Brueckner, Martina; Lifton, Richard; Goldmuntz, Elizabeth; Chung, Wendy K.; Shen, Yufeng (Oxford University Press, 2014)
      We present CANOES, an algorithm for the detection of rare copy number variants from exome sequencing data. CANOES models read counts using a negative binomial distribution and estimates variance of the read counts using a ...
    • Canonical and Atypical E2Fs Regulate the Mammalian Endocycle 

      Chen, Hui-Zi; Ouseph, Madhu M.; Li, Jing; Pécot, Thierry; Chokshi, Veda; Kent, Lindsey; Bae, Sooin; Byrne, Morgan; Duran, Camille; Comstock, Grant; Trikha, Prashant; Mair, Markus; Senapati, Shantibhusan; Martin, Chelsea K.; Gandhi, Sagar; Wilson, Nicholas; Liu, Bin; Huang, Yi-Wen; Thompson, John C.; Raman, Sundaresan; Singh, Shantanu; Leone, Marcelo; Machiraju, Raghu; Huang, Kun; Mo, Xiaokui; Fernandez, Soledad; Kalaszczynska, Ilona; Wolgemuth, Debra J.; Sicinski, Piotr; Huang, Tim; Jin, Victor; Leone, Gustavo (2012)
      SUMMARY The endocycle is a variant cell cycle consisting of successive DNA synthesis and Gap phases that yield highly polyploid cells. Although essential for metazoan development, relatively little is known about its control ...
    • Canonical Genetic Signatures of the Adult Human Brain 

      Hawrylycz, Michael; Miller, Jeremy A.; Menon, Vilas; Feng, David; Dolbeare, Tim; Guillozet-Bongaarts, Angela L.; Jegga, Anil G.; Aronow, Bruce J.; Lee, Chang-Kyu; Bernard, Amy; Glasser, Matthew F.; Dierker, Donna L.; Menche, Jörge; Szafer, Aaron; Collman, Forrest; Grange, Pascal; Berman, Kenneth A.; Mihalas, Stefan; Yao, Zizhen; Stewart, Lance; Barabási, Albert-László; Schulkin, Jay; Phillips, John; Ng, Lydia; Dang, Chinh; Haynor, David R.; Jones, Allan; Van Essen, David C.; Koch, Christof; Lein, Ed (2015)
      The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure, and function. We applied a correlation-based metric of ...
    • CanWalk: study protocol for a randomized feasibility trial of a walking intervention for people with recurrent or metastatic cancer 

      Harris, Jenny; Tsianakas, Vicki; Ream, Emma; Van Hemelrijck, Mieke; Purushotham, Arnie; Mucci, Lorelei; Green, James SA; Robb, Karen; Fewster, Jacquetta; Armes, Jo (BioMed Central, 2015)
      Background: Increasing numbers of people in the UK are living with recurrent or metastatic cancer, many of whom experience reduced quality of life resulting from the physical and psychosocial consequences of cancer and its ...
    • Capacity Building in Global Mental Health: Professional Training 

      Fricchione, Gregory Lewis; Borba, Christina; Alem, Atalay; Shibre, Teshome; Carney, Julia R; Henderson, David Carlton (Informa Healthcare, 2012)
      We suggest that the optimal approach to building capacity in global mental health care will require partnerships between professional resources in high-income countries and promising health-related institutions in low- and ...
    • Capacity Building in Urban Mongolia: Evaluating Optimal Strategies to Improve Pediatric Medical Training From Abroad 

      Neumann, Natalie (2015-06-08)
      This paper, a needs assessment, represents the first-order objective of larger project to enhance post-graduate education and patient outcomes at the National Center for Maternal and Child Health in Ulaanbaatar, Mongolia ...
    • Capsid Protein VP4 of Human Rhinovirus Induces Membrane Permeability by the Formation of a Size-Selective Multimeric Pore 

      Panjwani, Anusha; Strauss, Mike; Gold, Sarah; Wenham, Hannah; Jackson, Terry; Chou, James J.; Rowlands, David J.; Stonehouse, Nicola J.; Hogle, James M.; Tuthill, Tobias J. (Public Library of Science, 2014)
      Non-enveloped viruses must deliver their viral genome across a cell membrane without the advantage of membrane fusion. The mechanisms used to achieve this remain poorly understood. Human rhinovirus, a frequent cause of the ...
    • The capsular polysaccharide of Enterococcus faecalis and its relationship to other polysaccharides in the cell wall 

      Hancock, L. E.; Gilmore, Michael S. (Proceedings of the National Academy of Sciences, 2002)
      With the goal of identifying and characterizing traits of Enterococcus faecalis that play key roles in human disease, we identified an operon specifying synthesis of a capsular carbohydrate of the type most commonly expressed ...
    • Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling 

      Lal, Ashish; Thomas, Marshall P.; Altschuler, Gabriel; Navarro, Francisco; O'Day, Elizabeth; Li, Xiao Ling; Concepcion, Carla; Han, Yoon-Chi; Thiery, Jerome; Rajani, Danielle K.; Deutsch, Aaron; Hofmann, Oliver; Ventura, Andrea; Hide, Winston; Lieberman, Judy; McManus, Michael T. (Public Library of Science, 2011)
      A simple biochemical method to isolate mRNAs pulled down with a transfected, biotinylated microRNA was used to identify direct target genes of miR-34a, a tumor suppressor gene. The method reidentified most of the known ...
    • Capturing Pain in the Cortex during General Anesthesia: Near Infrared Spectroscopy Measures in Patients Undergoing Catheter Ablation of Arrhythmias 

      Kussman, Barry D.; Aasted, Christopher M.; Yücel, Meryem A.; Steele, Sarah C.; Alexander, Mark E.; Boas, David A.; Borsook, David; Becerra, Lino (Public Library of Science, 2016)
      The predictability of pain makes surgery an ideal model for the study of pain and the development of strategies for analgesia and reduction of perioperative pain. As functional near-infrared spectroscopy reproduces the ...
    • Capturing sequence diversity in metagenomes with comprehensive and scalable probe design 

      Metsky, Hayden C.; Siddle, Katherine J.; Gladden-Young, Adrianne; Qu, James; Yang, David K.; Brehio, Patrick; Goldfarb, Andrew; Piantadosi, Anne; Wohl, Shirlee; Carter, Amber; Lin, Aaron E.; Barnes, Kayla G.; Tully, Damien C.; Corleis, Bjӧrn; Hennigan, Scott; Barbosa-Lima, Giselle; Vieira, Yasmine R.; Paul, Lauren M.; Tan, Amanda L.; Garcia, Kimberly F.; Parham, Leda A.; Odia, Ikponmwosa; Eromon, Philomena; Folarin, Onikepe A.; Goba, Augustine; Simon-Lorière, Etienne; Hensley, Lisa; Balmaseda, Angel; Harris, Eva; Kwon, Douglas S.; Allen, Todd M.; Runstadler, Jonathan A.; Smole, Sandra; Bozza, Fernando A.; Souza, Thiago M. L.; Isern, Sharon; Michael, Scott F.; Lorenzana, Ivette; Gehrke, Lee; Bosch, Irene; Ebel, Gregory; Grant, Donald S.; Happi, Christian T.; Park, Daniel J.; Gnirke, Andreas; Sabeti, Pardis; Matranga, Christian B. (Springer Science and Business Media LLC, 2019-02)
      Metagenomic sequencing has the potential to transform microbial detection and characterization, but new tools are needed to improve its sensitivity. Here we present CATCH, a computational method to enhance nucleic-acid ...
    • CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells 

      Han, Jianfeng; Chu, Jianhong; Keung Chan, Wing; Zhang, Jianying; Wang, Youwei; Cohen, Justus B.; Victor, Aaron; Meisen, Walter H.; Kim, Sung-hak; Grandi, Paola; Wang, Qi-En; He, Xiaoming; Nakano, Ichiro; Chiocca, E. Antonio; Glorioso III, Joseph C.; Kaur, Balveen; Caligiuri, Michael A.; Yu, Jianhua (Nature Publishing Group, 2015)
      Glioblastoma (GB) remains the most aggressive primary brain malignancy. Adoptive transfer of chimeric antigen receptor (CAR)-modified immune cells has emerged as a promising anti-cancer approach, yet the potential utility ...