Browsing Harvard Medical School by Title
Now showing items 2128-2147 of 18428
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Capturing sequence diversity in metagenomes with comprehensive and scalable probe design
(Springer Science and Business Media LLC, 2019-02)Metagenomic sequencing has the potential to transform microbial detection and characterization, but new tools are needed to improve its sensitivity. Here we present CATCH, a computational method to enhance nucleic-acid ... -
CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells
(Nature Publishing Group, 2015)Glioblastoma (GB) remains the most aggressive primary brain malignancy. Adoptive transfer of chimeric antigen receptor (CAR)-modified immune cells has emerged as a promising anti-cancer approach, yet the potential utility ... -
Carbon Monoxide Abrogates Ischemic Insult to Neuronal Cells via the Soluble Guanylate Cyclase-cGMP Pathway
(Public Library of Science, 2013)Purpose Carbon monoxide (CO) is an accepted cytoprotective molecule. The extent and mechanisms of protection in neuronal systems have not been well studied. We hypothesized that delivery of CO via a novel releasing molecule ... -
Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators*
(Lippincott Williams & Wilkins, 2016)Objectives: Mesenchymal stromal cells are being investigated as a cell-based therapy for a number of disease processes, with promising results in animal models of systemic inflammation and sepsis. Studies are ongoing to ... -
Carbon Monoxide Modulates the Innate Immune Response to Bacterial Lung Infection
(2018-05-16)Carbon monoxide (CO) is generated endogenously in all mammalian cells by the enzyme Heme Oxygenase-1 (HO-1). HO-1 is primarily responsible for heme metabolism but is also vital for the host’s ability to appropriately respond ... -
Carbon Monoxide Protects against Hepatic Ischemia/Reperfusion Injury via ROS-Dependent Akt Signaling and Inhibition of Glycogen Synthase Kinase 3β
(Hindawi Publishing Corporation, 2013)Carbon monoxide (CO) may exert important roles in physiological and pathophysiological states through the regulation of cellular signaling pathways. CO can protect organ tissues from ischemia/reperfusion (I/R) injury by ... -
Carbon Monoxide: Present and Future Indications for a Medical Gas
(The Korean Association of Internal Medicine, 2013)Gaseous molecules continue to hold new promise in molecular medicine as experimental and clinical therapeutics. The low molecular weight gas carbon monoxide (CO), and similar gaseous molecules (e.g., \(H_2S\), nitric oxide) ... -
Carbon-Nanotube Optoacoustic Lens for Focused Ultrasound Generation and High-Precision Targeted Therapy
(Nature Publishing Group, 2012)We demonstrate a new optical approach to generate high-frequency (>15 MHz) and high-amplitude focused ultrasound, which can be used for non-invasive ultrasound therapy. A nano-composite film of carbon nanotubes (CNTs) and ... -
Carboplatin-Induced Gene Expression Changes In Vitro are Prognostic of Survival in Epithelial Ovarian Cancer
(BioMed Central, 2008)Background: We performed a time-course microarray experiment to define the transcriptional response to carboplatin in vitro, and to correlate this with clinical outcome in epithelial ovarian cancer (EOC). RNA was isolated ... -
Carboxamide SIRT1 Inhibitors Block DBC1 Binding via an Acetylation-Independent Mechanism
(Landes Bioscience, 2013)SIRT1 is an NAD+-dependent deacetylase that counteracts multiple disease states associated with aging and may underlie some of the health benefits of calorie restriction. Understanding how SIRT1 is regulated in vivo could ... -
Carboxyl-Proximal Regions of Reovirus Nonstructural Protein μNS Necessary and Sufficient for Forming Factory-Like Inclusions
(American Society for Microbiology, 2005)Mammalian orthoreoviruses are believed to replicate in distinctive, cytoplasmic inclusion bodies, commonly called viral factories or viroplasms. The viral nonstructural protein mu NS has been implicated in forming the ... -
Carboxyl-terminal Vesicular Stomatitis Virus G Protein-tagged Intestinal Na-dependent Glucose Cotransporter (sglt1). Maintenance of Surface Expression and Global Transport Function with Selective Perturbation of Transport Kinetics and Polarized Expression
(American Society for Biochemistry and Molecular Biology, 1996) -
Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications
(Wiley, 2010)Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non-cross-linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under varying temperatures, pH, and ionic strengths. The polymer-coated ... -
Carcinoma and Multiple Lymphomas in One Patient: Establishing the Diagnoses and Analyzing Risk Factors
(Springer-Verlag, 2009)Multiple malignancies may occur in the same patient, and a few reports describe cases with multiple hematologic and non-hematologic neoplasms. We report the case of a patient who showed the sequential occurrence of four ... -
Carcinoma of the gastroesophageal junction in Chinese patients
(Baishideng Publishing Group, 2012)Carcinoma of the gastroesophageal junction (GEJ) is defined as carcinoma that crosses the GEJ line, irrespective of where the tumor epicenter is located. This group of cancer is rare but controversial. Based on study results ... -
Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation
(BioMed Central, 2015)Background: Thoracic and cardiac irradiation increases the risk of pulmonary and cardiovascular disease. In addition, radiation, often in combination with chemotherapy, can cause treatment-related pneumonitis. Previously, ... -
Cardiac Angiogenic Imbalance Leads to Peripartum Cardiomyopathy
(Nature Publishing Group, 2012)Peripartum cardiomyopathy (PPCM) is an often fatal disease that affects pregnant women who are near delivery, and it occurs more frequently in women with pre-eclampsia and/or multiple gestation. The aetiology of PPCM, and ... -
Cardiac Autoimmunity as a Novel Biomarker, Mediator, and Therapeutic Target of Heart Disease in Type 1 Diabetes
(Springer US, 2015)Patients with type 1 diabetes (T1D) suffer excess mortality from cardiovascular disease (CVD) that has persisted despite substantial reductions in microvascular complications. Although T1D and type 2 diabetes (T2D) are ... -
Cardiac Autonomic Dysfunction: Particulate Air Pollution Effects Are Modulated by Epigenetic Immunoregulation of Toll‐like Receptor 2 and Dietary Flavonoid Intake
(Blackwell Publishing Ltd, 2015)Background: Short‐term fine particles (PM2.5) exposure is associated with reduced heart rate variability, a strong predictor of cardiac mortality among older people. Identifying modifiable factors that confer susceptibility ... -
Cardiac Hypertrophy Involves both Myocyte Hypertrophy and Hyperplasia in Anemic Zebrafish
(Public Library of Science, 2009)Background: An adult zebrafish heart possesses a high capacity of regeneration. However, it has been unclear whether and how myocyte hyperplasia contributes to cardiac remodeling in response to biomechanical stress and ...