Browsing Harvard Medical School by Title
Now showing items 2190-2209 of 18428
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Cartilage Oligomeric Matrix Protein Is a Calcium-binding Protein, and a Mutation in Its Type 3 Repeats Causes Conformational Changes
(American Society for Biochemistry and Molecular Biology, 2000)Mutations in residues in the type 3 calcium-binding repeats and COOH-terminal globular region of cartilage oligomeric matrix protein (COMP) lead to two skeletal dysplasias, pseudoachondroplasia and multiple epiphyseal ... -
Cartilage Oligomeric Matrix Protein/Thrombospondin 5 Supports Chondrocyte Attachment through Interaction with Integrins
(American Society for Biochemistry and Molecular Biology, 2005)Cartilage oligomeric matrix protein/ thrombospondin 5 ( COMP/ TSP5) is a major component of the extracellular matrix of the musculoskeletal system. Although COMP/ TSP5 abnormalities are associated with several pathological ... -
Cas9 as a Versatile Tool for Engineering Biology
(Springer Science and Business Media LLC, 2013-10)RNA-guided Cas9 nucleases derived from clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems have dramatically transformed our ability to edit the genomes of diverse organisms. We believe tools and ... -
Cas9 Functionally Opens Chromatin
(Public Library of Science, 2016)Using a nuclease-dead Cas9 mutant, we show that Cas9 reproducibly induces chromatin accessibility at previously inaccessible genomic loci. Cas9 chromatin opening is sufficient to enable adjacent binding and transcriptional ... -
Cas9 gRNA Engineering for Genome Editing, Activation and Repression
(Springer Science and Business Media LLC, 2015-11)We demonstrate that by altering the length of Cas9-associated guide RNA(gRNA) we were able to control Cas9 nuclease activity and simultaneously perform genome editing and transcriptional regulation with a single Cas9 ... -
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
(2013)Prokaryotic type II CRISPR-Cas systems can be adapted to enable targeted genome modifications across a range of eukaryotes.1–7. Here we engineer this system to enable RNA-guided genome regulation in human cells by tethering ... -
Cascade of neural processing orchestrates cognitive control in human frontal cortex
(eLife Sciences Publications, Ltd, 2016)Rapid and flexible interpretation of conflicting sensory inputs in the context of current goals is a critical component of cognitive control that is orchestrated by frontal cortex. The relative roles of distinct subregions ... -
Case 10-2009: A 23-Year-Old Woman With an Abnormal Papanicolaou Smear
(Massachusetts Medical Society, 2009-03-26) -
Case 14-2013 — A 70-Year-Old Woman With Vaginal Bleeding
(Massachusetts Medical Society, 2013-05-09) -
Case 16-2004
(New England Journal of Medicine (NEJM/MMS), 2004) -
Case 32-2003 — a 37-Year-Old Woman With Atypical Squamous Cells on a Papanicolaou Smear
(Massachusetts Medical Society, 2003-10-16)Presentation of Case: A 37-year-old woman was referred to the colposcopy clinic because of two Papanicolaou smears showing atypical squamous cells of undetermined significance (ASC-US). One and two years previously, the ... -
Case 40-2010 — A 68-Year-Old Woman with Chest Pain during an Airplane Flight
(New England Journal of Medicine (NEJM/MMS), 2010)A 68-year-old woman was transferred to this hospital because of substernal chest pain. An ECG showed evidence of MI. Coronary angiography was performed, with stenting of an occluded coronary artery. On the fourth hospital ... -
Case 8-2010 — A 22-Year-Old Woman with Hypercalcemia and a Pelvic Mass
(Massachusetts Medical Society, 2010-03-18)A 22-year-old woman was admitted to this hospital because of hypercalcemia and a pelvic mass. One month before admission, abdominal pain developed, followed by abdominal fullness, anorexia, nausea, vomiting, polydipsia, ... -
The Case for Reforming Drug Naming: Should Brand Name Trademark Protections Expire upon Generic Entry?
(Public Library of Science, 2016)Ameet Sarpatwari and Aaron Kesselheim explore whether stripping branded drugs of trademark protection would improve the efficiency and fairness of health care. -
A Case of Carotid Aneurysm in Familial Retinal Arterial Tortuosity
(The Korean Ophthalmological Society, 2009)A 44-year-old woman who showed recurrent vitreous hemorrhages with vascular tortuosity received CT angiography which revealed an internal carotid artery aneurysm. A case of internal carotid aneurysm was associated with a ... -
A Case of Complete and Durable Molecular Remission of Chronic Lymphocytic Leukemia Following Treatment with Epigallocatechin-3-gallate, an Extract of Green Tea
(Cureus, 2015)We report the case of a 48-year-old man who achieved a complete molecular remission 20 years after a diagnosis of chronic lymphocytic leukemia while using epigallicatechin-3-gallate, an extract of green tea. The patient ... -
A Case of Lower Extremity Venous Thrombosis in the Pediatric Emergency Department
(Ovid Technologies (Wolters Kluwer Health), 2011)Unilateral calf swelling and pain is not a common complaint in the pediatric emergency department. We present a case of a 17-year-old male with no past medical history who presented with left leg swelling and pain while ... -
A Case of Radiation-Induced Multifocal Laryngeal Angiosarcoma Presenting as a Diagnostic Dilemma
(Hindawi Publishing Corporation, 2012)Head and neck sarcomas are relatively rare tumors, with angiosarcomas representing a small subset. Angiosarcoma is a malignant endothelial neoplasm characterized by atypical, multilayered, or solid endothelial proliferation ... -
A case report in cardiovascular magnetic resonance: the contrast agent matters in amyloid
(BioMed Central, 2017)Background: Cardiac amyloidosis is a progressive but underdiagnosed and underappreciated cause of heart failure. In the last few years, cardiovascular magnetic resonance (CMR) has become the gold standard for non invasive ... -
Case Report of a Child after Hematopoietic Cell Transplantation with Acute Aspergillus Tracheobronchitis as a Cause for Respiratory Failure
(Hindawi Publishing Corporation, 2016)Rapid respiratory failure due to invasive mycosis of the airways is an uncommon presentation of Aspergillus infection, even in immunocompromised patients, and very few pediatric cases have been reported. Patients with ...