Browsing Harvard Medical School by Title
Now showing items 2776-2795 of 18428
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Claudin-8 Expression in Madin-Darby Canine Kidney Cells Augments the Paracellular Barrier to Cation Permeation
(American Society for Biochemistry and Molecular Biology, 2003)Claudins are a family of integral membrane proteins of the tight junction that are thought to participate in the permeation of solutes across epithelia via the paracellular pathway. Claudin-8 is expressed in the distal ... -
ClC-3 Expression and Its Association with Hyperglycemia Induced HT22 Hippocampal Neuronal Cell Apoptosis
(Hindawi Publishing Corporation, 2016)Although apoptosis plays an important role in the development of Diabetic Encephalopathy (DE), the underlying molecular mechanisms remain unclear. With respect to this, the present work aims to study the variation in ... -
Clean Lighting Leads to Improved Health in Rural Africa: Field Study and Design of a Dirt-Powered Generator
(2014-07-07)Two billion people world-wide use kerosene-burning lamps for household lighting. These lamps produce large quantities of soot. In Chapter 2, I describe our field study examining 230 people in rural Uganda. I show that ... -
Clear Film Adhesion Barrier Use at Cesarean Section: A Retrospective Analysis
(2015-06-08)Objective: To evaluate the use of a carboxymethylcellulose-hyaluronate adhesion barrier (Seprafilm) at the time of Cesarean section. Design: Retrospective cohort study. Setting: A tertiary care center in Boston, MA, ... -
Clearance of Hepatic Sphingomyelin by Olipudase Alfa Is Associated With Improvement in Lipid Profiles in Acid Sphingomyelinase Deficiency
(Wolters Kluwer Health, Inc, 2016)Acid sphingomyelinase deficiency (ASMD; Niemann-Pick disease type A and B) is a lysosomal storage disorder characterized by abnormal intracellular sphingomyelin (SM) accumulation. Prominent liver involvement results in ... -
Clearance of persistent hepatitis C virus infection using a claudin-1-targeting monoclonal antibody
(2015)Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and cancer1. Cell entry of HCV2 and other pathogens3-5 is mediated by tight junction (TJ) proteins, but successful therapeutic targeting of TJ proteins ... -
Cleavage of the Anaplastic Lymphoma Kinase in Neuroblastoma
(2016-05-17)Neuroblastoma, a tumor of the sympathetic nervous system, is responsible for 15% of all childhood cancer deaths. Genetic aberrations in the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase have been implicated as ... -
The cleavage site of the restriction endonuclease Ava II
(Oxford University Press (OUP), 1978)We have determined that the type II restriction enzyme Ava II, isolated from Anabaena variabilis, recognizes and cuts the sequence (formula: see article). The eight Ava II sites of pBR322 have been mapped, as well as a ... -
The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture
(2014)In lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of FRCs is their propensity to contract ... -
Climate Change and Health – What’s the Problem?
(BioMed Central, 2013)The scientific consensus is that global warming is occurring and is largely the result of greenhouse gas emissions from human activity. This paper examines the health implications of global warming, the current socio-political ... -
Climate change, cash transfers and health
(World Health Organization, 2015)Abstract The forecast consequences of climate change on human health are profound, especially in low- and middle-income countries and among the most disadvantaged populations. Innovative policy tools are needed to address ... -
ClinGen Pathogenicity Calculator: a configurable system for assessing pathogenicity of genetic variants
(BioMed Central, 2017)Background: The success of the clinical use of sequencing based tests (from single gene to genomes) depends on the accuracy and consistency of variant interpretation. Aiming to improve the interpretation process through ... -
Clinic accessibility and clinic-level predictors of the geographic variation in 2009 pandemic influenza vaccine coverage in Montreal, Canada
(Blackwell Publishing Ltd, 2014)Background: Nineteen mass vaccination clinics were established in Montreal, Canada, as part of the 2009 influenza A/H1N1p vaccination campaign. Although approximately 50% of the population was vaccinated, there was a ... -
The Clinical and Economic Impact of Point-of-Care CD4 Testing in Mozambique and Other Resource-Limited Settings: A Cost-Effectiveness Analysis
(Public Library of Science, 2014)Background: Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to ... -
Clinical and Genetic Evaluation of Undervirilized Boys With Bifid Scrotum
(2016-05-18)Bifid scrotum and hypospadias suggest undervirilization, yet boys presenting with these findings often do not receive a genetic diagnosis. Some of these individuals fall on the spectrum toward genital ambiguity, which ... -
Clinical and molecular evaluations of siblings with “pure” 11q23.3-qter trisomy or reciprocal monosomy due to a familial translocation t (10;11) (q26;q23.3)
(BioMed Central, 2014)11qter trisomy is rare, mostly occurs in combination with partial monosomy of a terminal segment of another chromosome due to unbalanced segregation of parental translocations. Pure 11qter trisomy is rarer, only five cases ... -
Clinical and Neuroimaging Investigations in Neuropsychiatric Disorders
(2016-05-18)In this Master’s Program in Clinical and Translational Investigation Thesis Titled “Clinical and Neuroimaging Investigations in Neuropsychiatric Disorders” by Dr. David L. Perez, research activities related to two studies ... -
Clinical and pathological analysis of colonic Crohn's disease, including a subgroup with ulcerative colitis-like features
(Springer Nature, 2011)Little is known regarding the clinical and, in particular, pathological manifestations of patients with isolated colonic Crohn's disease. The purpose of this study was to evaluate the clinical and pathological features of ... -
Clinical and Polysomnographic Correlates of Subjective Sleepiness in Mild Obstructive Sleep Apnea
(Springer Science and Business Media LLC, 2019-06-19)Purpose: The decision to treat mild obstructive sleep apnea (OSA) often hinges on the presence of subjective daytime sleepiness. This study was done to identify clinical and polysomnographic features which correlate with ... -
Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases
(Versita, Warsaw, 2014)Background: The aim of the study was to evaluate the clinical and imaging features of extraskeletal myxoid chondrosarcoma (EMC) including initial presentation, recurrence, and metastases. Patients and methods. In this ...