Browsing Harvard Medical School by Title

Now showing items 3416-3435 of 18428

    • Consensus on guidelines for stereotactic neurosurgery for psychiatric disorders 

      Nuttin, Bart; Wu, Hemmings; Mayberg, Helen; Hariz, Marwan; Gabriëls, Loes; Galert, Thorsten; Merkel, Reinhard; Kubu, Cynthia; Vilela-Filho, Osvaldo; Matthews, Keith; Taira, Takaomi; Lozano, Andres M; Schechtmann, Gastón; Doshi, Paresh; Broggi, Giovanni; Régis, Jean; Alkhani, Ahmed; Sun, Bomin; Eljamel, Sam; Schulder, Michael; Kaplitt, Michael; Eskandar, Emad; Rezai, Ali; Krauss, Joachim K; Hilven, Paulien; Schuurman, Rick; Ruiz, Pedro; Chang, Jin Woo; Cosyns, Paul; Lipsman, Nir; Voges, Juergen; Cosgrove, Rees; Li, Yongjie; Schlaepfer, Thomas (BMJ Publishing Group, 2014)
      Background: For patients with psychiatric illnesses remaining refractory to ‘standard’ therapies, neurosurgical procedures may be considered. Guidelines for safe and ethical conduct of such procedures have previously and ...

    • Consensus Paper: The Role of the Cerebellum in Perceptual Processes 

      Baumann, Oliver; Borra, Ronald J.; Bower, James M.; Cullen, Kathleen E.; Habas, Christophe; Ivry, Richard B.; Leggio, Maria; Mattingley, Jason B.; Molinari, Marco; Moulton, Eric A.; Paulin, Michael G.; Pavlova, Marina A.; Schmahmann, Jeremy D.; Sokolov, Arseny A. (Springer US, 2014)
      Various lines of evidence accumulated over the past 30 years indicate that the cerebellum, long recognized as essential for motor control, also has considerable influence on perceptual processes. In this paper, we bring ...

    • Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression 

      McClintock, Shawn M.; Reti, Irving M.; Carpenter, Linda L.; McDonald, William M.; Dubin, Marc; Taylor, Stephan F.; Cook, Ian A.; O’Reardon, John; Husain, Mustafa M.; Wall, Christopher; Krystal, Andrew D.; Sampson, Shirlene M.; Morales, Oscar; Nelson, Brent G.; Latoussakis, Vassilios; George, Mark S.; Lisanby, Sarah H. (Physicians Postgraduate Press, Inc, 2018-02-21)
      Objective: To provide expert recommendations for the safe and effective application of repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depressive disorder (MDD). Participants: Participants ...

    • Consensus Statement on Electronic Health Predictive Analytics: A Guiding Framework to Address Challenges 

      Amarasingham, Ruben; Audet, Anne-Marie J.; Bates, David W.; Glenn Cohen, I.; Entwistle, Martin; Escobar, G. J.; Liu, Vincent; Etheredge, Lynn; Lo, Bernard; Ohno-Machado, Lucila; Ram, Sudha; Saria, Suchi; Schilling, Lisa M.; Shahi, Anand; Stewart, Walter F.; Steyerberg, Ewout W.; Xie, Bin (AcademyHealth, 2016)
      Context: The recent explosion in available electronic health record (EHR) data is motivating a rapid expansion of electronic health care predictive analytic (e-HPA) applications, defined as the use of electronic algorithms ...

    • Consensus Statement on Research Definitions for Drug-Resistant Tuberculosis in Children 

      Seddon, James A.; Perez-Velez, Carlos M.; Schaaf, H. Simon; Furin, Jennifer J.; Marais, Ben J.; Tebruegge, Marc; Detjen, Anne; Hesseling, Anneke C.; Shah, Sarita; Adams, Lisa V.; Starke, Jeffrey R.; Swaminathan, Soumya; Becerra, Mercedes C. (Oxford University Press, 2013)
      Few children with drug-resistant (DR) tuberculosis (TB) are identified, diagnosed, and given an appropriate treatment. The few studies that have described this vulnerable population have used inconsistent definitions. The ...

    • Consensus Statement on the Immunohistochemical Detection of Ocular Lymphatic Vessels 

      Schroedl, Falk; Kaser-Eichberger, Alexandra; Schlereth, Simona L.; Bock, Felix; Regenfuss, Birgit; Reitsamer, Herbert A.; Lutty, Gerard A.; Maruyama, Kazuichi; Chen, Lu; Lütjen-Drecoll, Elke; Dana, Reza; Kerjaschki, Dontscho; Alitalo, Kari; De Stefano, Maria Egle; Junghans, Barbara M.; Heindl, Ludwig M.; Cursiefen, Claus (Association for Research in Vision and Ophthalmology (ARVO), 2014)
      There is currently considerable controversy about existence and classification of “lymphatic vessels” in the eye. Some of the confusion is certainly caused by inappropriate use (or nonuse) of the correct immunohistochemical ...

    • Consensus Statement on the Pathology of IgG4-Related Disease 

      Deshpande, Vikram; Zen, Yoh; Chan, John KC; Yi, Eunhee E; Sato, Yasuharu; Yoshino, Tadashi; Klöppel, Günter; Heathcote, J Godfrey; Khosroshahi, Arezou; Ferry, Judith Ann; Aalberse, Rob C; Bloch, Donald Bendit; Brugge, William Robert; Bateman, Adrian C; Carruthers, Mollie Nicole; Chari, Suresh T; Cheuk, Wah; Cornell, Lynn D; Fernandez-Del Castillo, Carlos F.; Forcione, David G.; Hamilos, Daniel L.; Kamisawa, Terumi; Kasashima, Satomi; Kawa, Shigeyuki; Kawano, Mitsuhiro; Lauwers, Gregory Y.; Masaki, Yasufumi; Nakanuma, Yasuni; Notohara, Kenji; Okazaki, Kazuichi; Ryu, Ji Kon; Saeki, Takako; Sahani, Dushyant V.; Smyrk, Thomas C; Stone, James Robert; Takahira, Masayuki; Webster, George J; Yamamoto, Motohisa; Zamboni, Giuseppe; Umehara, Hisanori; Stone, John H (Nature Publishing Group, 2012)
      IgG4-related disease is a newly recognized fibro-inflammatory condition characterized by several features: a tendency to form tumefactive lesions in multiple sites; a characteristic histopathological appearance; and—often ...

    • Consequences of Cold-Ischemia Time on Primary Nonfunction and Patient and Graft Survival in Liver Transplantation: A Meta-Analysis 

      Stahl, James E.; Kreke, Jennifer E.; Malek, Fawaz Ali Abdul; Schaefer, Andrew J.; Vacanti, Joseph Philip (Public Library of Science, 2008)
      Introduction: The ability to preserve organs prior to transplant is essential to the organ allocation process. Objective: The purpose of this study is to describe the functional relationship between cold-ischemia time (CIT) ...

    • The Consequences of Obesity on Trauma, Emergency Surgery, and Surgical Critical Care 

      Brown, Carlos V. R.; Velmahos, George (BioMed Central, 2006)
      The era of the acute care surgeon has arrived and this "new" specialty will be expected to provide trauma care, emergency surgery, and surgical critical care to a variety of patients arriving at their institution. With the ...

    • Conservation Analysis of Dengue Virus T-cell Epitope-Based Vaccine Candidates Using Peptide Block Entropy 

      Olsen, Lars Rønn; Zhang, Guang Lan; Keskin, Derin Benerci; Reinherz, Ellis Leonard; Brusic, Vladimir (Frontiers Research Foundation, 2011)
      Broad coverage of the pathogen population is particularly important when designing CD8+ T-cell epitope vaccines against viral pathogens. Traditional approaches are based on combinations of highly conserved T-cell epitopes. ...

    • Conservation of DNA Regulatory Motifs and Discovery of New Motifs in Microbial Genomes 

      McGuire, Abigail Manson; Hughes, Jason D.; Church, George (Cold Spring Harbor Laboratory, 2000-06-01)
      Regulatory motifs can be found by local multiple alignment of upstream regions from coregulated sets of genes, or regulons. We searched for regulatory motifs using the program AlignACE together with a set of filters that ...

    • Conservation of transcription factor binding events predicts gene expression across species 

      Hemberg, Martin; Kreiman, Gabriel (Oxford University Press (OUP), 2011)
      Recent technological advances have made it possible to determine the genome-wide binding sites of transcription factors (TFs). Comparisons across species have suggested a relatively low degree of evolutionary conservation ...

    • A Conserved CCCH-type Zinc Finger Protein Regulates mRNA Nuclear Adenylation and Export 

      Hurt, Jessica A.; Obar, Robert Alan; Zhai, Bo; Farny, Natalie G.; Gygi, Steven P.; Silver, Pamela A. (The Rockefeller University Press, 2009)
      Coupling of messenger RNA (mRNA) nuclear export with prior processing steps aids in the fidelity and efficiency of mRNA transport to the cytoplasm. In this study, we show that the processes of export and polyadenylation ...

    • A Conserved CXXC Motif in CD3ε Is Critical for T Cell Development and TCR Signaling 

      Wang, Yingbing; Becker, Dean; Vass, Tibor; White, Janice; Marrack, Philippa; Kappler, John W. (Public Library of Science, 2009)
      Virtually all T cell development and functions depend on its antigen receptor. The T cell receptor (TCR) is a multi-protein complex, comprised of a ligand binding module and a signal transmission module. The signal ...

    • Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease 

      Gjoneska, Elizabeta; Pfenning, Andreas R.; Mathys, Hansruedi; Quon, Gerald; Kundaje, Anshul; Tsai, Li-Huei; Kellis, Manolis (2015)
      Alzheimer’s disease (AD) is a severe1 age-related neurodegenerative disorder characterized by accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several ...

    • Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects 

      Dimitriadi, Maria; Sleigh, James N.; Chang, Howard C.; Kalloo, Geetika; Harris, Jevede; Barsby, Tom; Walsh, Melissa B.; Satterlee, John S.; Li, Chris; Hart, Anne C.; Walker, Amy K.; Sen, Anindya Kumar; Van Vactor, David L.; Artavanis-Tsakonas, Spiro (Public Library of Science, 2010)
      Spinal Muscular Atrophy (SMA) is caused by diminished function of the Survival of Motor Neuron (SMN) protein, but the molecular pathways critical for SMA pathology remain elusive. We have used genetic approaches in ...

    • A conserved human T cell population targets mycobacterial antigens presented by CD1b 

      Van Rhijn, Ildiko; Kasmar, Anne; de Jong, Annemieke; Gras, Stephanie; Bhati, Mugdha; Doorenspleet, Marieke E.; de Vries, Niek; Godfrey, Dale I.; Altman, John; de Jager, Wilco; Rossjohn, Jamie; Moody, D. Branch (2013)
      T cell receptors (TCRs) pair in millions of combinations to create complex and personally unique T cell repertoires. Using tetramers to analyze CD1b-reactive TCRs, we detected T cells with highly stereotyped TCR α chains ...

    • A Conserved Hydrophobic Patch on V\(\beta\) Domains Revealed by TCR\(\beta\) Chain Crystal Structures: Implications for Pre-TCR Dimerization 

      Zhou, Bo; Chen, Qiang; Mallis, Robert J.; Zhang, Hongmin; Liu, Jin-Huan; Reinherz, Ellis Leonard; Wang, Jiahuai (Frontiers Research Foundation, 2011)
      The \(\alpha\beta\) T cell receptor (TCR) is a multimeric complex whose \(\beta\) chain plays a crucial role in thymocyte development as well as antigen recognition by mature T lymphocytes. We report here crystal structures ...

    • A Conserved Pattern of Primer-Dependent Transcription Initiation in Escherichia coli and Vibrio cholerae Revealed by 5′ RNA-seq 

      Druzhinin, Sergey Y.; Tran, Ngat T.; Skalenko, Kyle S.; Goldman, Seth R.; Knoblauch, Jared G.; Dove, Simon L.; Nickels, Bryce E. (Public Library of Science, 2015)
      Transcription initiation that involves the use of a 2- to ~4-nt oligoribonucleotide primer, “primer-dependent initiation,” (PDI) has been shown to be widely prevalent at promoters of genes expressed during the stationary ...

    • Conserved phosphorylation hotspots in eukaryotic protein domain families 

      Strumillo, Marta J.; Oplová, Michaela; Viéitez, Cristina; Ochoa, David; Shahraz, Mohammed; Busby, Bede P.; Sopko, Richelle; Studer, Romain A.; Perrimon, Norbert; Panse, Vikram G.; Beltrao, Pedro (Springer Science and Business Media LLC, 2019-04-29)
      Protein phosphorylation is the best characterized post-translational modification that regulates almost all cellular processes through diverse mechanisms such as changing protein conformations, interactions, and localization. ...