Browsing Harvard Medical School by Title
Now showing items 3501-3520 of 18424
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Contribution of Distinct Homeodomain DNA Binding Specificities to Drosophila Embryonic Mesodermal Cell-Specific Gene Expression Programs
(Public Library of Science, 2013)Homeodomain (HD) proteins are a large family of evolutionarily conserved transcription factors (TFs) having diverse developmental functions, often acting within the same cell types, yet many members of this family paradoxically ... -
Contribution of estradiol levels and hormonal contraceptives to sex differences within the fear network during fear conditioning and extinction
(BioMed Central, 2015)Background: Findings about sex differences in the field of fear conditioning and fear extinction have been mixed. At the psychophysiological level, sex differences emerge only when taking estradiol levels of women into ... -
Contribution of Gelatinase, Serine Protease, and fsr to the Pathogenesis of Enterococcus faecalis Endophthalmitis
(American Society for Microbiology, 2004)Gelatinase and serine protease were found to contribute in concert to pathogenesis in a rabbit model of endophthalmitis. However, a mutant defective in the fsr regulator was observed to be more attenuated than a mutant ... -
The Contribution of GWAS Loci in Familial Dyslipidemias
(Public Library of Science, 2016)Familial combined hyperlipidemia (FCH) is a complex and common familial dyslipidemia characterized by elevated total cholesterol and/or triglyceride levels with over five-fold risk of coronary heart disease. The genetic ... -
Contribution of H. pylori and Smoking Trends to US Incidence of Intestinal-Type Noncardia Gastric Adenocarcinoma: A Microsimulation Model
(Public Library of Science, 2013)Background: Although gastric cancer has declined dramatically in the US, the disease remains the second leading cause of cancer mortality worldwide. A better understanding of reasons for the decline can provide important ... -
Contribution of High Plasma Triglycerides and Low High-Density Lipoprotein Cholesterol to Residual Risk of Coronary Heart Disease After Establishment of Low-Density Lipoprotein Cholesterol Control
(Elsevier BV, 2010)To determine the relative contributions of triglycerides (TGs) and high-density lipoprotein (HDL) cholesterol in the residual risk of coronary heart disease (CHD) after the reduction of low-density lipoprotein (LDL) ... -
Contribution of Preventable Acute Care Spending to Total Spending for High-cost Medicare Patients
(2013)Importance A small proportion of patients account for the majority of US health care spending, and understanding patterns of spending among this cohort is critical to reducing health care costs. The degree to which preventable ... -
The contribution of sleep problems to academic and psychosocial functioning
(Wiley, 2014-01-28)The current study examined the concurrent and longitudinal relations among sleep problems with academic and psychosocial functioning in a prospective cohort study, the Tucson Children’s Assessment of Sleep Apnea study ... -
The Contribution of Spatial and Temporal Molecular Networks in the Induction of Long-term Memory and Its Underlying Synaptic Plasticity
(2016)The ability to form long-lasting memories is critical to survival and thus is highly conserved across the animal kingdom. By virtue of its complexity, this same ability is vulnerable to disruption by a wide variety of ... -
Contributions of BCL3 to Humoral Immunity
(2021-07-19)The inhibitors of NF-B (IB) are regulators of NF-B signaling that typically sequester NF-B subunits in the cytosol, thereby restraining the inflammatory response. Unlike other IB proteins, the atypical IB proteins, ... -
Contributions of integrin-linked kinase to breast cancer metastasis and tumourigenesis
(Blackwell Publishing Ltd, 2008)Abstract Metastasis contributes to more than 90% of mortality in breast cancer. Critical stages in the development of aggressive breast cancer include growth of the primary tumours, and their abilities to spread to distant ... -
Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys
(Public Library of Science, 2010)CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 ... -
Contributions of the mother–infant relationship to dissociative, borderline, and conduct symptoms in young adulthood
(Wiley, 2008)Recent high-risk longitudinal studies have documented a unique contribution of the quality of the early mother–child relationship to diverse forms of psychopathology in young adulthood, even with family economic status, ... -
Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression
(2014)We have previously identified a tyrosine kinase-independent, guanine nucleotide exchange factor (GEF) activity that is contained within the region of p210 BCR/ABL that distinguishes it from p190 BCR/ABL. In the current ... -
Contributors to Contrast Between Glioma and Brain Tissue in Chemical Exchange Saturation Transfer Sensitive Imaging at 3Tesla
(Elsevier BV, 2014-10-01)Off-resonance saturation transfer images have shown intriguing differences in intensity in glioma compared to normal brain tissues. Interpretation of these differences is complicated, however, by the presence of multiple ... -
Control and Manipulation of Pathogens with an Optical Trap for Live Cell Imaging of Intercellular Interactions
(Public Library of Science, 2010)The application of live cell imaging allows direct visualization of the dynamic interactions between cells of the immune system. Some preliminary observations challenge long-held beliefs about immune responses to microorganisms; ... -
Control Capacity and A Random Sampling Method in Exploring Controllability of Complex Networks
(Nature Publishing Group, 2013)Controlling complex systems is a fundamental challenge of network science. Recent advances indicate that control over the system can be achieved through a minimum driver node set (MDS). The existence of multiple MDS's ... -
Control Centrality and Hierarchical Structure in Complex Networks
(Public Library of Science, 2012)We introduce the concept of control centrality to quantify the ability of a single node to control a directed weighted network. We calculate the distribution of control centrality for several real networks and find that ... -
Control of androgen receptor action by a novel nuclear receptor binding motif in Bag-1L
(BioMed Central, 2013) -
Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes
(Public Library of Science, 2008)Osteocytes, former osteoblasts buried within bone, are thought to orchestrate skeletal adaptation to mechanical stimuli. However, it remains unknown whether hormones control skeletal homeostasis through actions on osteocytes. ...