Browsing Harvard Medical School by Title

Now showing items 3541-3560 of 18428

    • A controlled study of Hostile-Helpless states of mind among borderline and dysthymic women 

      Lyons-Ruth, Karlen; Melnick, Sharon; Patrick, Matthew; Hobson, R. Peter (Informa UK Limited, 2007)
      The aim of this study was to determine whether women with borderline personality disorder (BPD) are more likely than those with dysthymia to manifest contradictory Hostile-Helpless (HH) states of mind. A reliable rater ...

    • A Controlled Trial of Educational Outreach to Improve Blood Transfusion Practice 

      Soumerai, Stephen Bertram; Salem-Schatz, Susanne; Avorn, Jerry Lewis (American Medical Association (AMA), 1993)
      Objective. —To determine whether brief, face-to-face educational outreach visits can improve the appropriateness of blood product utilization. Design. —Randomized, controlled multicenter trial with 6-month ...

    • A controlled trial of Partners in Dementia Care: veteran outcomes after six and twelve months 

      Bass, David M; Judge, Katherine S; Snow, A Lynn; Wilson, Nancy L; Morgan, Robert O; Maslow, Katie; Randazzo, Ronda; Moye, Jennifer A; Odenheimer, Germaine L; Archambault, Elizabeth; Elbein, Richard; Pirraglia, Paul; Teasdale, Thomas A; McCarthy, Catherine A; Looman, Wendy J; Kunik, Mark E (BioMed Central, 2014)
      Introduction: “Partners in Dementia Care” (PDC) tested the effectiveness of a care-coordination program integrating healthcare and community services and supporting veterans with dementia and their caregivers. Delivered ...

    • A Controlled Trial of Value-based Insurance Design – The MHealthy: Focus on Diabetes (FOD) Trial 

      Spaulding, Alicen; Fendrick, A Mark; Herman, William H; Stevenson, James G; Smith, Dean G; Chernew, Michael Esman; Parsons, Dawn M; Bruhnsen, Keith; Rosen, Allison B. (BioMed Central, 2009)
      Background: Diabetes affects over 20 million Americans, resulting in substantial morbidity, mortality, and costs. While medications are the cornerstone of secondary prevention, many evidence-based therapies are underutilized, ...

    • Controlled Ultrasound-Induced Blood-Brain Barrier Disruption Using Passive Acoustic Emissions Monitoring 

      Arvanitis, Costas D.; Livingstone, Margaret Stratford; Vykhodtseva, Natalia I.; McDannold, Nathan Judson (Public Library of Science, 2012)
      The ability of ultrasonically-induced oscillations of circulating microbubbles to permeabilize vascular barriers such as the blood-brain barrier (BBB) holds great promise for noninvasive targeted drug delivery. A major ...

    • The Controlled-Environment Chamber: A New Mouse Model of Dry Eye 

      Barabino, Stefano; Shen, LinLing; Chen, Lu; Rashid, Saadia; Rolando, Maurizio; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2005)
      purpose. To develop a controlled-environment chamber (CEC) for mice and verify the effects of a low-humidity setting on ocular surface signs in normal mice. methods. Eight- to 12-week-old BALB/c mice were used in a ...

    • The conundrum of the young colon cancer patient 

      Amri, Ramzi; Bordeianou, Liliana Grigorievna; Berger, David Lawrence (Elsevier BV, 2015)
      BACKGROUND:Colonoscopy has had a major impact on the incidence and survival of colon cancer for patients who are screened, usually beginning at the age of 50. Meanwhile, the incidence rate of colon cancer is actually ...

    • Convection and Retro-Convection Enhanced Delivery: Some Theoretical Considerations Related to Drug Targeting 

      Motion, J. P. Michael; Huynh, Grace H.; Szoka, Francis C.; Siegel, Ronald D. (Springer Verlag, 2010)
      Delivery of drugs and macromolecules into the brain is a challenging problem, due in part to the blood–brain barrier. In this article, we focus on the possibilities and limitations of two infusion techniques devised to ...

    • Convergence of coronary artery disease genes onto endothelial cell programs 

      Schnitzler, Gavin R.; Kang, Helen; Fang, Shi; Angom, Ramcharan S.; Lee-Kim, Vivian S.; Ma, X. Rosa; Zhou, Ronghao; Zeng, Tony; Guo, Katherine; Taylor, Martin S.; Vellarikkal, Shamsudheen K.; Barry, Aurelie E.; Sias-Garcia, Oscar; Bloemendal, Alex; Munson, Glen; Guckelberger, Philine; Nguyen, Tung H.; Bergman, Drew T.; Hinshaw, Stephen; Cheng, Nathan; Cleary, Brian; Aragam, Krishna; Lander, Eric S.; Finucane, Hilary K.; Mukhopadhyay, Debabrata; Gupta, Rajat; Engreitz, Jesse M. (Springer Science and Business Media LLC, 2024-02-07)
      Linking variants from genome-wide association studies (GWAS) to underlying mechanisms of disease remains a challenge1,4,6. For some diseases, a successful strategy has been to look for cases where multiple GWAS loci contain ...

    • Convergence of Mortality Rates among Patients on Antiretroviral Therapy in South Africa and North America 

      Binagwaho, Agnes; Nutt, Cameron T.; Mugwaneza, Placidie; Wagner, Claire M.; Nsanzimana, Sabin (Public Library of Science, 2014)
      Agnes Binagwaho and colleagues explore the narrowing gap between South African and North American cohorts in survival on HIV treatment, described in the study by Andrew Boulle and colleagues. Please see later in the article ...

    • Convergence of Obesity and High Glycemic Diet on Compounding Diabetes and Cardiovascular Risks in Modernizing China: An Emerging Public Health Dilemma 

      Ding, Eric L.; Malik, Vasanti (BioMed Central, 2008)
      As China is undergoing dramatic development, it is also experiencing major societal changes, including an emerging obesity epidemic, with the prevalence of overweight and obesity doubling in the past decade. However, the ...

    • Convergent evolution of marine mammals is associated with distinct substitutions in common genes 

      Zhou, Xuming; Seim, Inge; Gladyshev, Vadim N. (Nature Publishing Group, 2015)
      Phenotypic convergence is thought to be driven by parallel substitutions coupled with natural selection at the sequence level. Multiple independent evolutionary transitions of mammals to an aquatic environment offer an ...

    • Conversion of a yeast prion protein to an infectious form in bacteria 

      Garrity, Sean J.; Sivanathan, Viknesh; Dong, Jijun; Lindquist, Susan; Hochschild, Ann (National Academy of Sciences, 2010)
      Prions are infectious, self-propagating protein aggregates that have been identified in evolutionarily divergent members of the eukaryotic domain of life. Nevertheless, it is not yet known whether prokaryotes can support ...

    • Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells 

      Spijker, H. Siebe; Ravelli, Raimond B.G.; Mommaas-Kienhuis, A. Mieke; van Apeldoorn, Aart A.; Engelse, Marten A.; Zaldumbide, Arnaud; Bonner-Weir, Susan; Rabelink, Ton J.; Hoeben, Rob C.; Clevers, Hans; Mummery, Christine L.; Carlotti, Françoise; de Koning, Eelco J.P. (American Diabetes Association, 2013)
      Conversion of one terminally differentiated cell type into another (or transdifferentiation) usually requires the forced expression of key transcription factors. We examined the plasticity of human insulin-producing β-cells ...

    • Conversion to aflibercept for diabetic macular edema unresponsive to ranibizumab or bevacizumab 

      Lim, Laurence S; Ng, Wei Yan; Mathur, Ranjana; Wong, Doric; Wong, Edmund YM; Yeo, Ian; Cheung, Chui Ming Gemmy; Lee, Shu Yen; Wong, Tien Yin; Papakostas, Thanos D; Kim, Leo A (Dove Medical Press, 2015)
      Background: The purpose of this study was to determine if eyes with diabetic macular edema (DME) unresponsive to ranibizumab or bevacizumab would benefit from conversion to aflibercept. Methods: This study was conducted ...

    • Converting a Sulfenic Acid Reductase into a Disulfide Bond Isomerase 

      Chatelle, Claire; Kraemer, Stéphanie; Ren, Guoping; Chmura, Hannah; Marechal, Nils; Boyd, Dana; Roggemans, Caroline; Ke, Na; Riggs, Paul; Bardwell, James; Berkmen, Mehmet (Mary Ann Liebert, Inc., 2015)
      Abstract Aims: Posttranslational formation of disulfide bonds is essential for the folding of many secreted proteins. Formation of disulfide bonds in a protein with more than two cysteines is inherently fraught with error ...

    • Convolutional neural network for earthquake detection and location 

      Perol, Thibaut; Gharbi, Michaël; Denolle, Marine (American Association for the Advancement of Science (AAAS), 2018-02-02)
      <jats:p>ConvNetQuake is the first neural network for detection and location of earthquakes from seismograms.</jats:p>

    • Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia 

      Laidlaw, Kamilla M.E.; Berhan, Samuel; Liu, Suhu; Silvestri, Giovannino; Holyoake, Tessa L.; Frank, David A.; Aggarwal, Bharat; Bonner, Michael Y.; Perrotti, Danilo; Jørgensen, Heather G.; Arbiser, Jack L. (Impact Journals LLC, 2016)
      The use of tyrosine kinase inhibitors (TKI), including nilotinib, has revolutionized the treatment of chronic myeloid leukemia (CML). However current unmet clinical needs include combating activation of additional survival ...

    • Cooperative behavior cascades in human social networks 

      Fowler, J. H.; Christakis, N (Proceedings of the National Academy of Sciences, 2010)
      Theoretical models suggest that social networks influence the evolution of cooperation, but to date there have been few experimental studies. Observational data suggest that a wide variety of behaviors may spread in human ...

    • Cooperative benefit for the combination of rapamycin and imatinib in tuberous sclerosis complex neoplasia 

      Govindarajan, Baskaran; Willoughby, Laura; Band, Hamid; Curatolo, Adam S; Veledar, Emir; Chen, Suephy; Bonner, Michael Y.; Abel, Martin-Garrido; Moses, Marsha; Arbiser, Jack L (BioMed Central, 2012)
      Tuberous sclerosis (TS) is a common autosomal-dominant disorder characterized by tumors of the skin, lung, brain, and kidneys. Monotherapy with rapamycin however resulted in partial regression of tumors, implying the ...