Browsing Harvard Medical School by Title

Now showing items 3840-3859 of 18428

    • Current Progress of Aptamer-Based Molecular Imaging 

      Wang, Andrew Z.; Farokhzad, Omid (Society of Nuclear Medicine, 2014-03-01)
      Aptamers, single-stranded oligonucleotides, are an important class of molecular targeting ligand. Since their discovery, aptamers have been rapidly translated into clinical practice. They have been approved as therapeutics ...

    • A Current Review of Targeted Therapeutics for Ovarian Cancer 

      Campos, Susana Maria; Ghosh, Sue (Hindawi Publishing Corporation, 2010)
      Difficult to detect, ovarian cancer typically presents at an advanced stage. Significant progress has been achieved in the treatment of ovarian cancer with therapeutics focused on DNA replication or cell division. However, ...

    • Current State of Acute Stroke Imaging 

      Gonzalez, Ramon Gilberto (Ovid Technologies (Wolters Kluwer Health), 2013)
      Acute ischemic stroke is common and often treatable. Imaging by computed tomography (CT) and MRI is valuable for stroke treatment, in addition, for diagnosis, and for identification of the pathogenesis. But how they are ...

    • Current state-of-the-art of device therapy for advanced heart failure 

      Lee, Lawrence S.; Shekar, Prem S. (Croatian Medical Schools, 2014)
      Heart failure remains one of the most common causes of morbidity and mortality worldwide. The advent of mechanical circulatory support devices has allowed significant improvements in patient survival and quality of life ...

    • Current Status and Evolution of Preclinical Drug Development Models of Epithelial Ovarian Cancer 

      Konstantinopoulos, Panagiotis A.; Matulonis, Ursula A. (Frontiers Media S.A., 2013)
      Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and the fifth most common cause of female cancer death in the United States. Although important advances in surgical and chemotherapeutic strategies ...

    • Current status and recommendations for biomarkers and biobanking in neurofibromatosis 

      Hanemann, C. Oliver; Blakeley, Jaishri O.; Nunes, Fabio; Robertson, Kent; Stemmer-Rachamimov, Anat; Mautner, Victor; Kurtz, Andreas; Ferguson, Michael Andrew; Widemann, Brigitte C.; Evans, D. Gareth; Ferner, Rosalie; Carroll, Steven L.; Korf, Bruce; Wolkenstein, Pierre; Knight, Pamela; Plotkin, Scott Randall (Ovid Technologies (Wolters Kluwer Health), 2016)
      Objective: Clinically validated biomarkers for neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and schwannomatosis (SWN) have not been identified to date. The biomarker working group’s goals are to (1) define ...

    • Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer 

      Barth, Rolf F; H Vicente, M Graca; Harling, Otto K; Kiger, WS; Riley, Kent J; Binns, Peter J; Wagner, Franz M; Suzuki, Minoru; Aihara, Teruhito; Kato, Itsuro; Kawabata, Shinji (BioMed Central, 2012)
      Boron neutron capture therapy (BNCT) is a biochemically targeted radiotherapy based on the nuclear capture and fission reactions that occur when non-radioactive boron-10, which is a constituent of natural elemental boron, ...

    • Current status of vascularized composite tissue allotransplantation 

      Edtinger, Karoline; Yang, Xiaoyong; Uehara, Hanae; Tullius, Stefan G. (BioMed Central, 2014)
      Vascularized composite tissue allotransplantation (VCA) offers treatment options of complex functional deficiencies that cannot be repaired with conventional reconstructive methods. VCAs consist of blocks of functional ...

    • Current status of xenotransplantation and prospects for clinical application 

      Pierson, Richard N.; Dorling, Anthony; Ayares, David; Rees, Michael Kenneth; Seebach, Jörg D.; Fishman, Jay Alan; Hering, Bernhard J.; Cooper, David K. C. (Wiley-Blackwell, 2009)
      Xenotransplantation is one promising approach to bridge the gap between available human cells, tissues, and organs and the needs of patients with diabetes or end-stage organ failure. Based on recent progress using ...

    • Current update on retinopathy of prematurity: screening and treatment 

      Chen, Jing; Stahl, Andreas; Hellstrom, Ann; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2011)
      PURPOSE OF REVIEW: Despite current treatments, retinopathy of prematurity (ROP) remains a major cause of blindness in premature infants and the incidence is increasing with increased survival of infants born at very early ...

    • Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2 

      Medina, Igor; Friedel, Perrine; Rivera, Claudio; Kahle, Kristopher T.; Kourdougli, Nazim; Uvarov, Pavel; Pellegrino, Christophe (Frontiers Media S.A., 2014)
      In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl−)-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl− concentration ([Cl−]i). Lowering [Cl−]i ...

    • Customized Care 2020: How Medical Sequencing and Network Biology Will Enable Personalized Medicine 

      Boguski, Mark S.; Arnaout, Ramy; Hill, Colin (Biology Reports Ltd, 2009)
      Applications of next-generation nucleic acid sequencing technologies will lead to the development of precision diagnostics that will, in turn, be a major technology enabler of precision medicine. Terabyte-scale, multidimensional ...

    • Customized Prediction of Short Length of Stay Following Elective Cardiac Surgery in Elderly Patients Using a Genetic Algorithm 

      Lee, Joon; Govindan, Sapna; Celi, Leo A.; Khabbaz, Kamal R.; Subramaniam, Balachundhar (2013)
      Objective: To develop a customized short LOS (<6 days) prediction model for geriatric patients receiving cardiac surgery, using local data and a computational feature selection algorithm. Design: Utilization of a machine ...

    • Cutpoints for Low Appendicular Lean Mass That Identify Older Adults With Clinically Significant Weakness 

      Cawthon, Peggy M.; Peters, Katherine W.; Shardell, Michelle D.; McLean, Robert R.; Dam, Thuy-Tien L.; Kenny, Anne M.; Fragala, Maren S.; Harris, Tamara B.; Kiel, Douglas P.; Guralnik, Jack M.; Ferrucci, Luigi; Kritchevsky, Stephen B.; Vassileva, Maria T.; Studenski, Stephanie A.; Alley, Dawn E. (Oxford University Press, 2014)
      Background. Low lean mass is potentially clinically important in older persons, but criteria have not been empirically validated. As part of the FNIH (Foundation for the National Institutes of Health) Sarcopenia Project, ...

    • Cuz1/Ynl155w, a Zinc-dependent Ubiquitin-binding Protein, Protects Cells from Metalloid-induced Proteotoxicity 

      Hanna, John; Waterman, David; Isasa, Marta; Elsasser, Suzanne; Shi, Yuan; Gygi, Steven; Finley, Daniel (American Society for Biochemistry and Molecular Biology, 2014)
      Background: Protein misfolding, a universal threat to cells, is dealt with by the ubiquitin-proteasome system. Results: Ynl155w is a zinc-dependent ubiquitin-binding protein, interacts with proteasome and Cdc48, and is ...

    • CX3CR1: Re-Defining Exhausted CD8+ T Cell Populations 

      ElJalby, Mahmoud (2017-06-07)
      Persistent infections result in dysfunctional state of CD8+ T cells associated with the expression of multiple inhibitory receptors. Recent studies have attempted to elucidate T cell subsets in chronic infections1–5. ...

    • CXCR3 Controls T-Cell Accumulation in Fat Inflammation 

      Rocha, V. Z.; Folco, Eduardo; Ozdemir, Cafer; Sheikine, Y.; Christen, T.; Sukhova, Galina K.; Tang, E. H. C.; Bittencourt, M. S.; Santos, R. D.; Luster, Andrew David; Cohen, David E; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2014)
      Objective—Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism of T-cell recruitment remains unknown. This study tested the hypothesis that the chemokine ...

    • A Cyberday in the Life 

      Bates, David (American Medical Association (AMA), 1996-03-13)
      At 9 PM Sunday, February 5,2006, Dr Susan Scott returned home from a weekend of cross-country skiing, tucked her chil¬ dren in bed, sank down on the couch in front of her large-screen three-dimensional information center ...

    • Cyclic AMP Responsive Element Binding Proteins Are Involved in ‘Emergency’ Granulopoiesis through the Upregulation of CCAAT/Enhancer Binding Protein β 

      Hirai, Hideyo; Kamio, Naoka; Huang, Gang; Matsusue, Akiko; Ogino, Shinpei; Kimura, Nobuhiko; Satake, Sakiko; Ashihara, Eishi; Imanishi, Jiro; Tenen, Daniel Geoffrey; Maekawa, Taira (Public Library of Science, 2013)
      In contrast to the definitive role of the transcription factor, CCAAT/Enhancer binding protein α (C/EBPα), in steady-state granulopoiesis, previous findings have suggested that granulopoiesis during emergency situations, ...

    • A Cyclic-di-GMP Receptor Required for Bacterial Exopolysaccharide Production 

      Lee, Vincent T.; Matewish, Jody M; Kessler, Jennifer L; Hyodo, Mamoru; Hayakawa, Yoshihiro; Lory, Stephen (Blackwell Publishing Ltd, 2007)
      Bis-(3′,5′)-cyclic-dimeric-guanosine monophosphate (c-di-GMP) has been shown to be a global regulatory molecule that modulates the reciprocal responses of bacteria to activate either virulence pathways or biofilm formation. ...