Browsing Harvard Medical School by Title
Now showing items 3913-3932 of 18428
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D3 Phosphoinositides and Outside-in integrin Signaling by Glycoprotein IIb-IIIa Mediate Platelet Actin Assembly and Filopodial Extension Induced by Phorbol 12-Myristate 13-Acetate
(American Society for Biochemistry and Molecular Biology, 1996)Phorbol 12-myristate 13-acetate (PMA) uncaps a small number of the fast-growing (barbed) ends of actin filaments, thereby eliciting slow actin assembly and extension of filopodia in human blood platelets, These reactions, ... -
Daily Step Count Predicts Acute Exacerbations in a US Cohort with COPD
(Public Library of Science, 2013)Background: COPD is characterized by variability in exercise capacity and physical activity (PA), and acute exacerbations (AEs). Little is known about the relationship between daily step count, a direct measure of PA, and ... -
Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis
(BioMed Central, 2014)Background: The relation between consumption of different types of dairy and risk of type 2 diabetes (T2D) remains uncertain. Therefore, we aimed to evaluate the association between total dairy and individual types of dairy ... -
Daptomycin Versus Vancomycin Plus Gentamicin for Treatment of Bacteraemia and Endocarditis Due to Staphylococcus aureus: Subset Analysis of Patients Infected with Methicillin-resistant Isolates
(Oxford University Press, 2008)Objectives: In a prospective, randomized trial, daptomycin was non-inferior to standard therapy for Staphylococcus aureus bacteraemia and right-sided endocarditis. Since rates of infection due to methicillin-resistant S. ... -
Dark microglia: A new phenotype predominantly associated with pathological states
(John Wiley and Sons Inc., 2016)The past decade has witnessed a revolution in our understanding of microglia. These immune cells were shown to actively remodel neuronal circuits, leading to propose new pathogenic mechanisms. To study microglial implication ... -
Data describing the effects of dietary bioactive agents on colonic stem cell microRNA and mRNA expression
(Elsevier, 2015)With the identification of Lgr5 as a definitive marker for intestinal stem cells, we used the highly novel, recently described, Lgr5-EGFP-IRES-cre ERT2knock in mouse model. Mice were injected with azoxymethane (AOM, a colon ... -
Data Extraction and Management in Networks of Observational Health Care Databases for Scientific Research: A Comparison of EU-ADR, OMOP, Mini-Sentinel and MATRICE Strategies
(AcademyHealth, 2016)Introduction: We see increased use of existing observational data in order to achieve fast and transparent production of empirical evidence in health care research. Multiple databases are often used to increase power, to ... -
Data for Genetic Analysis Workshop (GAW) 15 Problem 2, Genetic Causes of Rheumatoid Arthritis and Associated Traits
(BioMed Central, 2007)For Genetic Analysis Workshop 15 Problem 2, we organized data from several ongoing studies designed to identify genetic and environmental risk factors for rheumatoid arthritis. Data were derived from the North American ... -
Data for Genetic Analysis Workshop 16 Problem 1, Association Analysis of Rheumatoid Arthritis Data
(BioMed Central, 2009)For Genetic Analysis Workshop 16 Problem 1, we provided data for genome-wide association analysis of rheumatoid arthritis. Single-nucleotide polymorphism (SNP) genotype data were provided for 868 cases and 1194 controls ... -
Data in Crisis — Rethinking Disaster Preparedness in the United States
(Massachusetts Medical Society, 2021-10-14)To protect our most vulnerable communities from increasingly frequent climate-related extreme weather events, public health agencies and hospitals need to know — before, during, and after a disaster — who and where these ... -
Data on Medicare eligibility and cancer screening utilization
(Elsevier, 2016)Health insurance is associated with increased utilization of cancer screening services. Data on breast, prostate and colorectal cancer screening were abstracted from the 2012 Behavioral Risk Factor and Surveillance System. ... -
Data publication with the structural biology data grid supports live analysis
(Nature Publishing Group, 2016)Access to experimental X-ray diffraction image data is fundamental for validation and reproduction of macromolecular models and indispensable for development of structural biology processing methods. Here, we established ... -
Data Quality Challenges in Systemic Lupus Erythematosus Trials: How Can This Be Optimized?
(Current Science Inc., 2012)Major scientific advances in basic science, pharmacology, and translational medicine have allowed the discovery of new molecular targets whose manipulation by new chemical entities has led to treatments for inflammatory ... -
Data Sharing In Neuroimaging Research
(Frontiers Research Foundation, 2012)Significant resources around the world have been invested in neuroimaging studies of brain function and disease. Easier access to this large body of work should have profound impact on research in cognitive neuroscience ... -
Data-Driven Subtypes of Major Depressive Disorder: A Systematic Review
(BioMed Central, 2012)Background: According to current classification systems, patients with major depressive disorder (MDD) may have very different combinations of symptoms. This symptomatic diversity hinders the progress of research into the ... -
Data-efficient and weakly supervised computational pathology on whole-slide images
(Springer Science and Business Media LLC, 2021-03-01)Deep-learning methods for computational pathology typically suffer from poor domain adaptation, interpretability or visualization, and require either manual annotation of gigapixel whole slide images (WSIs) or large datasets ... -
A database of human exposomes and phenomes from the US National Health and Nutrition Examination Survey
(Nature Publishing Group, 2016)The National Health and Nutrition Examination Survey (NHANES) is a population survey implemented by the Centers for Disease Control and Prevention (CDC) to monitor the health of the United States whose data is publicly ... -
Dataset for Reporting of Malignant Mesothelioma of the Pleura or Peritoneum: Recommendations From the International Collaboration on Cancer Reporting (ICCR)
(Archives of Pathology and Laboratory Medicine, 2016-10)Context The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, ... -
The Date of Interbreeding between Neandertals and Modern Humans
(Public Library of Science, 2012)Comparisons of DNA sequences between Neandertals and present-day humans have shown that Neandertals share more genetic variants with non-Africans than with Africans. This could be due to interbreeding between Neandertals ... -
Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity
(2014)Summary Interventions that delay ageing mobilize mechanisms that protect and repair cellular components1–3, but it is unknown how these interventions might slow the functional decline of extracellular matrices4,5, which ...