Browsing Harvard Medical School by Title
Now showing items 4297-4316 of 18424
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The developmental basis of adult arrhythmia: atrial fibrillation as a paradigm
(Frontiers Media S.A., 2013)Normal cardiac rhythm is one of the most fundamental physiologic phenomena, emerging early in the establishment of the vertebrate body plan. The developmental pathways underlying the patterning and maintenance of stable ... -
Developmental biology: Our fly cousins' gut
(Nature Research (part of Springer Nature), 2008) -
Developmental Controls are Re-Expressed during Induction of Neurogenesis in the Neocortex of Young Adult Mice
(Frontiers Research Foundation, 2012)Whether induction of low-level neurogenesis in normally non-neurogenic regions of the adult brain mimics aspects of developmental neurogenesis is currently unknown. Previously, we and others identified that biophysically ... -
Developmental correlates and predictors of emotional availability in mother–child interaction: A longitudinal study from infancy to middle childhood
(Cambridge University Press (CUP), 2012)In this investigation we examined the developmental correlates and predictors of maternal emotional availability in interactions with their 7-year-old children among a sample of families at psychosocial risk. We found ... -
Developmental Decrease of Neuronal Chloride Concentration Is Independent of Trauma in Thalamocortical Brain Slices
(Public Library of Science, 2016)The intraneuronal chloride concentration ([Cl-]i) is paramount for determining the polarity of signaling at GABAA synapses in the central nervous system. Sectioning hippocampal brain slices increases [Cl-]i in the superficial ... -
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
(National Academy of Sciences, 2003)SIRT1 is a mammalian homolog of the Saccharomyces cerevisiae chromatin silencing factor Sir2. Dominant-negative and overexpression studies have implicated a role for SIRT1 in deacetylating the p53 tumor suppressor protein ... -
Developmental delay in Rett syndrome: data from the natural history study
(BioMed Central, 2014)Background: Early development appears normal in Rett syndrome (OMIM #312750) and may be more apparent than real. A major purpose of the Rett Syndrome (RTT) Natural History Study (NHS) was to examine achievement of developmental ... -
Developmental interneuron subtype deficits after targeted loss of Arx
(BioMed Central, 2016)Background: Aristaless-related homeobox (ARX) is a paired-like homeodomain transcription factor that functions primarily as a transcriptional repressor and has been implicated in neocortical interneuron specification and ... -
Developmental regulation of myeloerythroid progenitor function by the Lin28b–let-7–Hmga2 axis
(The Rockefeller University Press, 2016)For appropriate development, tissue and organ system morphogenesis and maturation must occur in synchrony with the overall developmental requirements of the host. Mistiming of such developmental events often results in ... -
Developmental Self-Assembly of a DNA Tetrahedron
(American Chemical Society, 2014)Kinetically controlled isothermal growth is fundamental to biological development, yet it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed ... -
Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines
(American Society for Clinical Investigation, 2016)Hypertrophic cardiomyopathy is a common cause of mortality in congenital heart disease (CHD). Many gene abnormalities are associated with cardiac hypertrophy, but their function in cardiac development is not well understood. ... -
Developmental Trajectories of Resting EEG Power: An Endophenotype of Autism Spectrum Disorder
(Public Library of Science, 2012)Current research suggests that autism spectrum disorder (ASD) is characterized by asynchronous neural oscillations. However, it is unclear whether changes in neural oscillations represent an index of the disorder or are ... -
The Developmental Transcriptome of Drosophila Melanogaster
(Springer Science and Business Media LLC, 2011)Drosophila melanogaster is one of the most well studied genetic model organisms, nonetheless its genome still contains unannotated coding and non-coding genes, transcripts, exons, and RNA editing sites. Full discovery and ... -
Device for measuring bronchodilator delivery and response in resource-limited settings
(BioMed Central, 2013) -
Device-detected atrial fibrillation and risk for stroke: an analysis of >10 000 patients from the SOS AF project (Stroke preventiOn Strategies based on Atrial Fibrillation information from implanted devices)
(Oxford University Press, 2013)Objective: The aim of this study was to assess the association between maximum daily atrial fibrillation (AF) burden and risk of ischaemic stroke. Background: Cardiac implanted electronic devices (CIEDs) enhance detection ... -
Dexterity optimization by port placement in robot-assisted minimally invasive surgery
(SPIE, 2001)A computer-based algorithm has been developed which uses preoperative images to provide a surgeon with a list of feasible port triplets ranked according to tool dexterity and endoscopic view quality at each surgical site ... -
Dextran-Coated Iron Oxide Nanoparticles: a Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics and Therapy
(American Chemical Society, 2011)Advances in our understanding of the genetic basis of disease susceptibility coupled with prominent successes for molecular targeted therapies have resulted in an emerging strategy of personalized medicine. This approach ... -
Dextroamphetamine (but Not Atomoxetine) Induces Reanimation from General Anesthesia: Implications for the Roles of Dopamine and Norepinephrine in Active Emergence
(Public Library of Science, 2015)Methylphenidate induces reanimation (active emergence) from general anesthesia in rodents, and recent evidence suggests that dopaminergic neurotransmission is important in producing this effect. Dextroamphetamine causes ... -
The Deyo-Charlson and Elixhauser-van Walraven Comorbidity Indices as predictors of mortality in critically ill patients
(BMJ Publishing Group, 2015)Objectives: Our primary objective was to compare the utility of the Deyo-Charlson Comorbidity Index (DCCI) and Elixhauser-van Walraven Comorbidity Index (EVCI) to predict mortality in intensive care unit (ICU) patients. ... -
DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors
(American Chemical Society, 2014)Drug-resistance acquisition through kinase gate-keeper mutations is a major hurdle in the clinic. Here, we determined the first crystal structures of the human FGFR4 kinase domain (FGFR4K) alone and complexed with ponatinib, ...