Browsing Harvard Medical School by Title

Now showing items 4483-4502 of 18428

    • Diffusion and Perfusion: The Keys to Fat Grafting 

      Khouri, Roger K.; Khouri, Raoul-Emil R.; Lujan-Hernandez, Jorge R.; Khouri, Khalil R.; Lancerotto, Luca; Orgill, Dennis P. (Wolters Kluwer Health, 2014)
      Background: Fat grafting is now widely used in plastic surgery. Long-term graft retention can be unpredictable. Fat grafts must obtain oxygen via diffusion until neovascularization occurs, so oxygen delivery may be the ...

    • Diffusion imaging of mild traumatic brain injury in the impact accelerated rodent model: A pilot study 

      Kikinis, Zora; Pasternak, Ofer; Peled, Sharon; Bouix, Sylvain; Rathi, Yogesh; Muehlmann, Marc; Kulkarni, Praveen; Ferris, Craig; Koerte, Inga; Pieper, Steve; Yarmarkovich, Alexander; Porter, Caryn; Kristal, Bruce; Shenton, Martha (Informa UK Limited, 2017-06-19)
      PRIMARY OBJECTIVE: There is a need to understand pathologic processes of the brain following mild traumatic brain injury (mTBI). Previous studies report axonal injury and oedema in the first week after injury in a rodent ...

    • Diffusion MR Tractography of the Heart 

      Sosnovik, David E.; Wang, Ruopeng; Dai, Guangping; Reese, Timothy G.; Wedeen, Van Jay (BioMed Central, 2009)
      Histological studies have shown that the myocardium consists of an array of crossing helical fiber tracts. Changes in myocardial fiber architecture occur in ischemic heart disease and heart failure, and can be imaged ...

    • Diffusion MRI of Structural Brain Plasticity Induced by a Learning and Memory Task 

      Blumenfeld-Katzir, Tamar; Pasternak, Ofer; Dagan, Michael; Assaf, Yaniv (Public Library of Science, 2011)
      Background: Activity-induced structural remodeling of dendritic spines and glial cells was recently proposed as an important factor in neuroplasticity and suggested to accompany the induction of long-term potentiation ...

    • Diffusion MRI quality control and functional diffusion map results in ACRIN 6677/RTOG 0625: A multicenter, randomized, phase II trial of bevacizumab and chemotherapy in recurrent glioblastoma 

      ELLINGSON, BENJAMIN M.; KIM, EUNHEE; WOODWORTH, DAVIS C.; MARQUES, HELGA; BOXERMAN, JERROLD L.; SAFRIEL, YAIR; McKINSTRY, ROBERT C.; BOKSTEIN, FELIX; JAIN, RAJAN; CHI, T. LINDA; SORENSEN, A. GREGORY; GILBERT, MARK R.; BARBORIAK, DANIEL P. (D.A. Spandidos, 2015)
      Functional diffusion mapping (fDM) is a cancer imaging technique that quantifies voxelwise changes in apparent diffusion coefficient (ADC). Previous studies have shown value of fDMs in bevacizumab therapy for recurrent ...

    • Diffusion MRI Tractography of the Developing Human Fetal Heart 

      Mekkaoui, Choukri; Porayette, Prashob; Jackowski, Marcel P.; Kostis, William J.; Dai, Guangping; Sanders, Stephen; Sosnovik, David E. (Public Library of Science, 2013)
      Objective: Human myocardium has a complex and anisotropic 3D fiber pattern. It remains unknown, however, when in fetal life this anisotropic pattern develops and whether the human heart is structurally fully mature at ...

    • Diffusion MRI Tractography of the Human Heart \(In\) \(Vivo\) at End-Diastole and End-Systole 

      Mekkaoui, Choukri; Nielles-Vallespin, Sonia; Gatehouse, Peter D; Jackowski, Marcel P; Firmin, David N; Sosnovik, David E. (BioMed Central, 2012)
      Diffusion Tensor MRI (DTI) of the human heart \(in\) \(vivo\) has to date been performed in 2D and at a single phase of the cardiac cycle. Here we perform 3D tractography of the human heart \(in\) \(vivo\) at both end ...

    • Diffusion of Intraperitoneal Chemotherapy in Women with Advanced Ovarian Cancer in Community Settings 2003–2008: The Effect of the NCI Clinical Recommendation 

      Bowles, Erin J. Aiello; Wernli, Karen J.; Gray, Heidi J.; Bogart, Andy; Delate, Thomas; O’Keeffe-Rosetti, Maureen; Nekhlyudov, Larissa; Loggers, Elizabeth Trice (Frontiers Media S.A., 2014)
      Purpose: A 2006 National Cancer Institute clinical announcement recommended the use of combined intravenous (IV) and intraperitoneal (IP) chemotherapy over IV chemotherapy alone for women with International Federation of ...

    • Diffusion Spectrum Imaging Shows the Structural Basis of Functional Cerebellar Circuits in the Human Cerebellum In Vivo 

      Granziera, Cristina; Schmahmann, Jeremy Dan; Hadjikhani, Nouchine; Meyer, Heiko; Meuli, Reto; Wedeen, Van Jay; Krueger, Gunnar (Public Library of Science, 2009)
      Background: The cerebellum is a complex structure that can be affected by several congenital and acquired diseases leading to alteration of its function and neuronal circuits. Identifying the structural bases of cerebellar ...

    • Diffusion tensor and volumetric magnetic resonance imaging using an MR-compatible hand-induced robotic device suggests training-induced neuroplasticity in patients with chronic stroke 

      LAZARIDOU, ASIMINA; ASTRAKAS, LOUKAS; MINTZOPOULOS, DIONYSSIOS; KHANICHEH, AZADEH; SINGHAL, ANEESH B.; MOSKOWITZ, MICHAEL A.; ROSEN, BRUCE; TZIKA, ARIA A. (D.A. Spandidos, 2013)
      Stroke is the third leading cause of mortality and a frequent cause of long-term adult impairment. Improved strategies to enhance motor function in individuals with chronic disability from stroke are thus required. Post-stroke ...

    • Diffusion Tensor Imaging and Its Application to Neuropsychiatric Disorders 

      Kubicki, Marek R.; Westin, Carl-Fredrik; Maier, Stephan Ernst; Mamata, Hatsuho; Frumin, Melissa; Ersner-Hershfield, Hal; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Ovid Technologies (Wolters Kluwer Health), 2002)
      Magnetic resonance diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue; it is particularly useful for evaluating white matter abnormalities. ...

    • Diffusion tensor imaging in acute-to-subacute traumatic brain injury: a longitudinal analysis 

      Edlow, Brian L.; Copen, William A.; Izzy, Saef; Bakhadirov, Khamid; van der Kouwe, Andre; Glenn, Mel B.; Greenberg, Steven M.; Greer, David M.; Wu, Ona (BioMed Central, 2016)
      Background: Diffusion tensor imaging (DTI) may have prognostic utility in patients with traumatic brain injury (TBI), but the optimal timing of DTI data acquisition is unknown because of dynamic changes in white matter ...

    • Diffusion Tensor Imaging in Patients with Glioblastoma Multiforme Using the Supertoroidal Model 

      Mekkaoui, Choukri; Metellus, Philippe; Kostis, William J.; Martuzzi, Roberto; Pereira, Fabricio R.; Beregi, Jean-Paul; Reese, Timothy G.; Constable, Todd R.; Jackowski, Marcel P. (Public Library of Science, 2016)
      Purpose Diffusion Tensor Imaging (DTI) is a powerful imaging technique that has led to improvements in the diagnosis and prognosis of cerebral lesions and neurosurgical guidance for tumor resection. Traditional tensor ...

    • A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia 

      Levitt, James Jonathan; Kubicki, Marek R.; Nestor, Paul Gerard; Ersner-Hershfield, Hal; Westin, C-F; Alvarado, Jorge L.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2010)
      Introduction—Frontal-subcortical cognitive and limbic feedback loops modulate higher cognitive functioning. The final step in these feedback loops is the thalamo-cortical projection through the anterior limb of the internal ...

    • Diffusion Tensor Imaging, Structural Connectivity, and Schizophrenia 

      Whitford, Thomas; Kubicki, Marek R.; Shenton, Martha E. (Hindawi Publishing Corporation, 2011)
      A fundamental tenet of the “disconnectivity” theories of schizophrenia is that the disorder is ultimately caused by abnormal communication between spatially disparate brain structures. Given that the white matter fasciculi ...

    • Diffusion tractography of the fornix in schizophrenia 

      Fitzsimmons, Jennifer J; Kubicki, Marek R.; Smith, K.; Bushell, G.; Estepar, R. San Jose; Westin, Carl-Fredrik; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; Kikinis, Ron; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2009)
      Background: White matter fiber tracts, especially those interconnecting the frontal and temporal lobes, are likely implicated in pathophysiology of schizophrenia. Very few studies, however, have focused on the fornix, a ...

    • Diffusion-informed spatial smoothing of fMRI data in white matter using spectral graph filters 

      Abramian, David; Larsson, Martin; Eklund, Anders; Aganj, Iman; Westin, Carl-Fredrik; Behjat, Hamid (Elsevier BV, 2021-08-15)
      Brain activation mapping using functional magnetic resonance imaging (fMRI) has been extensively studied in brain gray matter (GM), whereas in large disregarded for probing white matter (WM). This unbalanced treatment has ...

    • Digital Connectedness in the Framingham Heart Study 

      Fox, Caroline S.; Hwang, Shih‐Jen; Nieto, Kenneth; Valentino, Maureen; Mutalik, Karen; Massaro, Joseph M.; Benjamin, Emelia J.; Murabito, Joanne M. (John Wiley and Sons Inc., 2016)
      Background: New avenues of data collection such as eHealth and mobile technology have the potential to revolutionize the way large populations can be assessed and managed outside of standard research and clinical settings. ...

    • Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone 

      Im, Hyungsoon; Castro, Cesar M.; Shao, Huilin; Liong, Monty; Song, Jun; Pathania, Divya; Fexon, Lioubov; Min, Changwook; Avila-Wallace, Maria; Zurkiya, Omar; Rho, Junsung; Magaoay, Brady; Tambouret, Rosemary H.; Pivovarov, Misha; Weissleder, Ralph; Lee, Hakho (National Academy of Sciences, 2015)
      The widespread distribution of smartphones, with their integrated sensors and communication capabilities, makes them an ideal platform for point-of-care (POC) diagnosis, especially in resource-limited settings. Molecular ...

    • Digital diffraction detection of protein markers for avian influenza 

      Im, Hyungsoon; Park, Yong Il; Pathania, Divya; Castro, Cesar; Weissleder, Ralph; Lee, Hakho (Royal Society of Chemistry, 2016)
      Rapid pathogen testing is expected to play a critical role in infection control and in limiting epidemics. Smartphones equipped with state-of-the-art computing and imaging technologies have emerged as new point-of-use (POU) ...