Browsing Harvard Medical School by Title
Now showing items 4754-4773 of 18428
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DNA-Binding and -Bending Activities of SAP30L and SAP30 Are Mediated by a Zinc-Dependent Module and Monophosphoinositides
(American Society for Microbiology, 2009)Deacetylation of histones is carried out by a corepressor complex in which Sin3A is an essential scaffold protein. Two proteins in this complex, the Sin3A-associated proteins SAP30L and SAP30, have previously been suggested ... -
DNA-loop extruding SMC complexes can traverse one another in vivo
(Research Square Platform LLC, 2021-01-06)Chromosome organization by structural maintenance of chromosomes (SMC) complexes is vital to living organisms. SMC complexes were recently found to be motors that extrude DNA loops. However, it remains unclear what happens ... -
DNA-Protein Interactions in High Definition
(BioMed Central, 2012)An elegant, genome-wide approach to define the precise DNA sequences bound by transcription factors has been developed by Rhee and Pugh. -
DNAvisualization.org: A Serverless Web Tool for DNA Sequence Visualization
(Oxford University Press, 2019-07-02)Raw DNA sequences contain an immense amount of meaningful biological information. However, these sequences are hard for humans to intuitively interpret. To solve this problem, a number of methods have been proposed to ... -
DNMT1-interacting RNAs block gene specific DNA methylation
(2013)Summary DNA methylation was described almost a century ago. However, the rules governing its establishment and maintenance remain elusive. Here, we present data demonstrating that active transcription regulates levels of ... -
Do Ask, Do Tell: High Levels of Acceptability by Patients of Routine Collection of Sexual Orientation and Gender Identity Data in Four Diverse American Community Health Centers
(Public Library of Science, 2014)Background: The Institute of Medicine and The Joint Commission have recommended asking sexual orientation and gender identity (SOGI) questions in clinical settings and including such data in Electronic Health Records (EHRs). ... -
Do Atypical Antipsychotics Have Antisuicidal Effects? A Hypothesis-Generating Overview
(MDPI, 2016)Modern antipsychotic drugs are employed increasingly in the treatment of mood disorders as well as psychoses, stimulating interest in their possible contributions to altering suicidal risk. Clozapine remains the only ... -
Do biologic markers predict cardiovascular end points in diabetic end-stage renal disease? A prospective longitudinal study
(Oxford University Press, 2013)Background: Diabetic patients on hemodialysis are at high risk of death from cardiovascular disease, and research has suggested that various biologic markers of inflammation, oxidative stress and hemostasis may give added ... -
Do Cyclosporine A, an IL-1 Receptor Antagonist, Uridine Triphosphate, Rebamipide, and/or Bimatoprost Regulate Human Meibomian Gland Epithelial Cells?
(The Association for Research in Vision and Ophthalmology, 2016)Purpose Researchers have hypothesized that treatment with cyclosporine A (CyA), interleukin-1 receptor antagonists (IL-1RA; e.g., anakinra), P2Y2 receptor agonists (e.g., uridine triphosphate; UTP), and rebamipide may ... -
Do design variations in the artificial disc influence cervical spine biomechanics? A finite element investigation
(Springer-Verlag, 2009)Various ball and socket-type designs of cervical artificial discs are in use or under investigation. Many artificial disc designs claim to restore the normal kinematics of the cervical spine. What differentiates one type ... -
Do Diabetic Patients with Acute Coronary Syndromes Have a Higher Threshold for Ischemic Pain?
(Sociedade Brasileira de Cardiologia, 2014)Background: Data from over 4 decades have reported a higher incidence of silent infarction among patients with diabetes mellitus (DM), but recent publications have shown conflicting results regarding the correlation between ... -
Do Differences in Hospital and Surgeon Quality Explain Racial Disparities in Lower-extremity Vascular Amputations?
(2009)Objective: To understand whether racial disparities in surgery for lower-extremity arterial disease are minimized by high-quality providers, or instead, differential treatment of otherwise similar patients pervades all ... -
Do DSM-5 Eating Disorder Criteria Overpathologize Normative Eating Patterns among Individuals with Obesity?
(Hindawi Publishing Corporation, 2014)Background. DSM-5 revisions have been criticized in the popular press for overpathologizing normative eating patterns—particularly among individuals with obesity. To evaluate the evidence for this and other DSM-5 critiques, ... -
Do heads of government age more quickly? Observational study comparing mortality between elected leaders and runners-up in national elections of 17 countries
(BMJ Publishing Group Ltd., 2015)Objectives: To determine whether being elected to head of government is associated with accelerated mortality by studying survival differences between people elected to office and unelected runner-up candidates who never ... -
Do healthier foods and diet patterns cost more than less healthy options? A systematic review and meta-analysis
(BMJ Publishing Group, 2013)Objective: To conduct a systematic review and meta-analysis of prices of healthier versus less healthy foods/diet patterns while accounting for key sources of heterogeneity. Data sources MEDLINE (2000–2011), supplemented ... -
Do immature platelet levels in chest pain patients presenting to the emergency department aid in the diagnosis of acute coronary syndrome?
(Wiley-Blackwell, 2014)INTRODUCTION: Early and accurate identification of acute coronary syndrome (ACS) vs. noncardiac chest pain in patients presenting to the emergency department (ED) is problematic and new diagnostic markers are needed. ... -
Do Instructional Videos on Sputum Submission Result in Increased Tuberculosis Case Detection? A Randomized Controlled Trial
(Public Library of Science (PLoS), 2015-09-29)Objective We examined the effect of an instructional video about the production of diagnostic sputum on case detection of tuberculosis (TB), and evaluated the acceptance of the video. Trial Design Randomized controlled ... -
Do March-in Rights Ensure Low-Cost Access to Medical Products Arising From Federally-Funded Research? A Qualitative Study
(2016-05-17)The high cost of new prescription drugs and other medical products is one of the most important health policy issues of the decade. Yet the expense of new medical technology has become controversial when the government ... -
Do Medical Models of Mental Illness Relate to Increased or Decreased Stigmatization of Mental Illness Among Orthodox Jews?
(Ovid Technologies (Wolters Kluwer Health), 2010)Research suggests that attributing mental illness to moral causes and perceiving it as dangerous relates to greater stigma, whereas belief in biomedical factors is associated with less. Within the family-centric Orthodox ... -
Do Moderate‐Intensity and Vigorous‐Intensity Physical Activities Reduce Mortality Rates to the Same Extent?
(Blackwell Publishing Ltd, 2014)Background: Limited data exist directly comparing the relative benefits of moderate‐ and vigorous‐intensity activities with all‐cause and cardiovascular (CV) disease mortality rates when controlling for physical activity ...