Browsing Harvard Medical School by Title
Now showing items 50-69 of 18426
-
52-kDa Ro/SSA Epitopes Preferentially Recognized by Antibodies from Mothers of Children with Neonatal Lupus and Congenital Heart Block
(BioMed Central, 2005)Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with ... -
53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis
(National Academy of Sciences, 2006)p53-binding protein 1 (53BP1) participates in the cellular response to DNA double-stranded breaks where it associates with various DNA repair/cell cycle factors including the H2AX histone variant. Mice deficient for 53BP1 ... -
53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks
(Public Library of Science, 2016)DNA double-strand breaks (DSB) are very harmful lesions that can generate genome rearrangements. In this study, we used intrachromosomal reporters to compare both the efficiency and accuracy of end-joining occurring with ... -
5mC and 5hmC dynamics during PGC reprogramming and role of Tet1 in female meiosis
(BioMed Central, 2013) -
A 600 kb Deletion Syndrome at 16p11.2 Leads to Energy Imbalance and Neuropsychiatric Disorders
(BMJ Publishing Group, 2012)Background: The recurrent ∼600 kb 16p11.2 BP4-BP5 deletion is among the most frequent known genetic aetiologies of autism spectrum disorder (ASD) and related neurodevelopmental disorders. Objective: To define the medical, ... -
7T MRI of spinal cord injury
(Ovid Technologies (Wolters Kluwer Health), 2012)A man with 25 years of mild left neck, arm, and leg paresthesias had initial MRI in 1996 identifying a left C3-4 dorsal horn cavernous hemangioma. In 1997, hemorrhage (C3-7) and resection induced left arm > leg proprioceptive ... -
89 Zr-Labeled Dextran Nanoparticles Allow in Vivo Macrophage Imaging
(American Chemical Society, 2011)Tissue macrophages play a critical role both in normal physiology and in disease states. However, because of a lack of specific imaging agents, we continue to have a poor understanding of their absolute numbers, flux rates, ... -
The 8q24 Cancer Risk Variant Rs6983267 Shows Long-Range Interaction With MYC in Colorectal Cancer
(Springer Science and Business Media LLC, 2009-06-28)An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with ... -
The 8th Annual Computational and Systems Neuroscience (Cosyne) Meeting
(BioMed Central, 2011) -
8th international conference on management and rehabilitation of chronic respiratory failure: the long summaries – part 1
(BioMed Central, 2015)This paper summarizes the Part 1 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes the ... -
8th International conference on management and rehabilitation of chronic respiratory failure: the long summaries – part 2
(BioMed Central, 2015)This paper summarizes the Part 2 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes the ... -
8th International conference on management and rehabilitation of chronic respiratory failure: the long summaries – Part 3
(BioMed Central, 2015)This paper summarizes the Part 3 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes the ... -
A 12-Residue-long Polyleucine Tail Is Sufficient to Anchor Synaptobrevin to the Endoplasmic Reticulum Membrane
(American Society for Biochemistry and Molecular Biology, 1996) -
A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice
(National Academy of Sciences, 2005) -
A broad-spectrum antiviral targeting entry of enveloped viruses
(National Academy of Sciences, 2010)We describe an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1. In sharp ... -
A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance
(National Academy of Sciences, 2016)The bacterial cell wall is critical for maintenance of cell shape and survival. Following exposure to antibiotics that target enzymes required for cell wall synthesis, bacteria typically lyse. Although several cell envelope ... -
A Chimeric Protein of Simian Immunodeficiency Virus Envelope Glycoprotein gp140 and Escherichia coli Aspartate Transcarbamoylase
(American Society for Microbiology, 2004)The envelope glycoproteins of the human immunodeficiency virus and the related simian immunodeficiency virus (SIV) mediate viral entry into host cells by fusing viral and target cell membranes. We have reported expression, ... -
A Cholera Toxin B-subunit Variant That Binds Ganglioside G M1 but Fails to Induce Toxicity
(American Society for Biochemistry and Molecular Biology, 2001) -
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
(National Academy of Sciences, 2010)Many proteins that respond to DNA damage are recruited to DNA lesions. We used a proteomics approach that coupled isotopic labeling with chromatin fractionation and mass spectrometry to uncover proteins that associate with ... -
A Clinician-administered Severity Rating Scale for Illness Anxiety: Development, Reliability, and Validity of the H-ybocs-m
(2012)Background Clinician-administered measures to assess severity of illness anxiety and response to treatment are few. The authors evaluated a modified version of the hypochondriasis-Y-BOCS (H-YBOCS-M), a 19-item, semistructured, ...