Now showing items 4979-4998 of 18424

    • Dynamic Magnetic Fields Remote-Control Apoptosis via Nanoparticle Rotation 

      Zhang, Enming; Kircher, Moritz F.; Koch, Martin; Eliasson, Lena; Goldberg, S. Nahum; Renström, Erik (American Chemical Society, 2014)
      The ability to control the movement of nanoparticles remotely and with high precision would have far-reaching implications in many areas of nanotechnology. We have designed a unique dynamic magnetic field (DMF) generator ...
    • Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow 

      Calibasi Kocal, Gizem; Güven, Sinan; Foygel, Kira; Goldman, Aaron; Chen, Pu; Sengupta, Shiladitya; Paulmurugan, Ramasamy; Baskin, Yasemin; Demirci, Utkan (Nature Publishing Group, 2016)
      Cancer microenvironment is a remarkably heterogeneous composition of cellular and non-cellular components, regulated by both external and intrinsic physical and chemical stimuli. Physical alterations driven by increased ...
    • Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein 

      McKee, Christopher J.; Kessl, Jacques J.; Shkriabai, Nikolozi; Dar, Mohd Jamal; Engelman, Alan; Kvaratskhelia, Mamuka (American Society for Biochemistry and Molecular Biology, 2008)
      The mandatory integration of the reverse-transcribed HIV-1 genome into host chromatin is catalyzed by the viral protein integrase (IN), and IN activity can be regulated by numerous viral and cellular proteins. Among these, ...
    • Dynamic oscillatory processes governing cued orienting and allocation of auditory attention 

      Ahveninen, Jyrki; Huang, Samantha; Belliveau, John; Chang, Wei-Tang; Matti Hämäläinen (Massachusetts Institute of Technology Press (MIT Press), 2013)
      In everyday listening situations, we need to constantly switch between alternative sound sources and engage attention according to cues that match our goals and expectations. The exact neuronal bases of these processes are ...
    • Dynamic Parameters of Balance Which Correlate to Elderly Persons with a History of Falls 

      Muir, Jesse W.; Kiel, Douglas P.; Hannan, Marian; Magaziner, Jay; Rubin, Clinton T. (Public Library of Science, 2013)
      Poor balance in older persons contributes to a rise in fall risk and serious injury, yet no consensus has developed on which measures of postural sway can identify those at greatest risk of falling. Postural sway was ...
    • Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe 

      Zhu, Lei; Guo, Ning; Li, Quanzheng; Ma, Ying; Jacboson, Orit; Lee, Seulki; Choi, Hak Soo; Mansfield, James R.; Niu, Gang; Chen, Xiaoyuan (Ivyspring International Publisher, 2012)
      Purpose: The aim of this study is to determine if dynamic optical imaging could provide comparable kinetic parameters to that of dynamic PET imaging by a near-infrared dye/64Cu dual-labeled cyclic RGD peptide. Methods: The ...
    • Dynamic Population Coding of Category Information in Inferior Temporal and Prefrontal Cortex 

      Meyers, E. M.; Freedman, D. J.; Kreiman, Gabriel; Miller, E. K.; Poggio, T. (American Physiological Society, 2008)
      Most electrophysiology studies analyze the activity of each neuron separately. While such studies have given much insight into properties of the visual system, they have also potentially overlooked important aspects of ...
    • Dynamic regulatory elements in single-cell multimodal data implicate key immune cell states enriched for autoimmune disease heritability 

      Gupta, Anika; Weinand, Kathryn; Nathan, Aparna; Sakaue, Saori; Donlin, Laura; Wei, Kevin; Price, Alkes L; Amariuta, Tiffany; Raychaudhuri, Soumya (Springer Science and Business Media LLC, 2023-11-30)
      In autoimmune diseases such as rheumatoid arthritis (RA), the immune system attacks host tissues1-3. Developing a precise understanding of the fine-grained cell states that mediate the genetics of autoimmunity is critical ...
    • Dynamic regulatory network controlling Th17 cell differentiation 

      Yosef, Nir; Shalek, Alex K.; Gaublomme, Jellert T.; Jin, Hulin; Lee, Youjin; Awasthi, Amit; Wu, Chuan; Karwacz, Katarzyna; Xiao, Sheng; Jorgolli, Marsela; Gennert, David; Satija, Rahul; Shakya, Arvind; Lu, Diana Y.; Trombetta, John J.; Pillai, Meenu R.; Ratcliffe, Peter J.; Coleman, Mathew L.; Bix, Mark; Tantin, Dean; Park, Hongkun; Kuchroo, Vijay K.; Regev, Aviv (2013)
      Despite their importance, the molecular circuits that control the differentiation of naïve T cells remain largely unknown. Recent studies that reconstructed regulatory networks in mammalian cells have focused on short-term ...
    • Dynamic Support Culture of Murine Skeletal Muscle-Derived Stem Cells Improves Their Cardiogenic Potential In Vitro 

      Neef, Klaus; Treskes, Philipp; Xu, Guoxing; Drey, Florian; Srinivasan, Sureshkumar Perumal; Saric, Tomo; Nembo, Erastus; Semmler, Judith; Nguemo, Filomain; Stamm, Christof; Cowan, Douglas B.; Deppe, Antje-Christin; Scherner, Maximilian; Wittwer, Thorsten; Hescheler, Jürgen; Wahlers, Thorsten; Choi, Yeong-Hoon (Hindawi Publishing Corporation, 2015)
      Ischemic heart disease is the main cause of death in western countries and its burden is increasing worldwide. It typically involves irreversible degeneration and loss of myocardial tissue leading to poor prognosis and ...
    • Dynamic Switch of Negative Feedback Regulation in Drosophila Akt–TOR Signaling 

      Kockel, Lutz; Kerr, Kimberly Sayer; Melnick, Michael; Brückner, Katja; Hebrok, Matthias; Perrimon, Norbert (Public Library of Science, 2010)
      Akt represents a nodal point between the Insulin receptor and TOR signaling, and its activation by phosphorylation controls cell proliferation, cell size, and metabolism. The activity of Akt must be carefully balanced, as ...
    • Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratinocyte Differentiation 

      Cavazza, Alessia; Miccio, Annarita; Romano, Oriana; Petiti, Luca; Malagoli Tagliazucchi, Guidantonio; Peano, Clelia; Severgnini, Marco; Rizzi, Ermanno; De Bellis, Gianluca; Bicciato, Silvio; Mavilio, Fulvio (Elsevier, 2016)
      Summary Human skin is maintained by the differentiation and maturation of interfollicular stem and progenitors cells. We used DeepCAGE, genome-wide profiling of histone modifications and retroviral integration analysis, ...
    • Dynamic Transcriptional Reprogramming Leads to Immunotherapeutic Vulnerabilities in Myeloma 

      Frede, Julia; Anand, Praveen; Sotudeh, Noori; Pinto, Ricardo A.; Nair, Monica S.; Stuart, Hannah; Yee, Andrew J.; Vijaykumar, Tushara; Waldschmidt, Johannes M.; Potdar, Sayalee; Kloeber, Jake A.; Kokkalis, Antonis; Dimitrova, Valeriya; Mann, Mason; Laubach, Jacob; Richardson, Paul; Anderson, Kenneth; Raje, Noopur; Knoechel, Birgit; Lohr, Jens (Springer Science and Business Media LLC, 2021-10-21)
    • DyNAMiC Workbench: an integrated development environment for dynamic DNA nanotechnology 

      Grun, Casey; Werfel, Justin; Zhang, David Yu; Yin, Peng (The Royal Society, 2015)
      Dynamic DNA nanotechnology provides a promising avenue for implementing sophisticated assembly processes, mechanical behaviours, sensing and computation at the nanoscale. However, design of these systems is complex and ...
    • Dynamical density delay maps: simple, new method for visualising the behaviour of complex systems 

      Burykin, Anton; Costa, Madalena D; Citi, Luca; Goldberger, Ary L (BioMed Central, 2014)
      Background: Physiologic signals, such as cardiac interbeat intervals, exhibit complex fluctuations. However, capturing important dynamical properties, including nonstationarities may not be feasible from conventional time ...
    • Dynamical features of the Plasmodium falciparum ribosome during translation 

      Sun, Ming; Li, Wen; Blomqvist, Karin; Das, Sanchaita; Hashem, Yaser; Dvorin, Jeffrey D.; Frank, Joachim (Oxford University Press, 2015)
      Plasmodium falciparum, the mosquito-transmitted Apicomplexan parasite, causes the most severe form of human malaria. In the asexual blood-stage, the parasite resides within erythrocytes where it proliferates, multiplies ...
    • Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming 

      Yamaguchi, Shinpei; Hong, Kwonho; Liu, Rui; Inoue, Azusa; Shen, Li; Zhang, Kun; Zhang, Yi (Nature Publishing Group, 2013)
      Previous studies have revealed that mouse primordial germ cells (PGCs) undergo genome-wide DNA methylation reprogramming to reset the epigenome for totipotency. However, the precise 5-methylcytosine (5mC) dynamics and its ...
    • Dynamics of Envelope Evolution in Clade C SHIV-Infected Pig-Tailed Macaques during Disease Progression Analyzed by Ultra-Deep Pyrosequencing 

      Tso, For Yue; Tully, Damien C; Gonzalez, Sandra; Quince, Christopher; Ho, On; Polacino, Patricia; Ruprecht, Ruth Margrit; Hu, Shiu-Lok; Wood, Charles (Public Library of Science, 2012)
      Understanding the evolution of the human immunodeficiency virus type 1 (HIV-1) envelope during disease progression can provide tremendous insights for vaccine development, and simian-human immunodeficiency virus (SHIV) ...
    • Dynamics of Immune Reconstitution and Activation Markers in HIV+ Treatment-Naïve Patients Treated with Raltegravir, Tenofovir Disoproxil Fumarate and Emtricitabine 

      Funderburg, Nicholas T.; Andrade, Adriana; Chan, Ellen S.; Rosenkranz, Susan L.; Lu, Darlene; Clagett, Brian; Pilch-Cooper, Heather A.; Rodriguez, Benigno; Feinberg, Judith; Daar, Eric; Mellors, John; Kuritzkes, Daniel; Jacobson, Jeffrey M.; Lederman, Michael M. (Public Library of Science, 2013)
      Background: The dynamics of CD4+ T cell reconstitution and changes in immune activation and inflammation in HIV-1 disease following initiation of antiretroviral therapy (ART) are incompletely defined and their underlying ...
    • Dynamics of Obesity and Chronic Health Conditions Among Children and Youth 

      Van Cleave, Jeanne; Gortmaker, Steven L.; Perrin, James Marc (American Medical Association (AMA), 2010)
      Context: Rates of obesity and other childhood chronic conditions have increased over recent decades. Patterns of how conditions change over time have not been widely examined. Objective: To evaluate change in prevalence ...