Browsing Harvard Medical School by Title

Now showing items 4987-5006 of 18428

    • Dynamic regulatory network controlling Th17 cell differentiation 

      Yosef, Nir; Shalek, Alex K.; Gaublomme, Jellert T.; Jin, Hulin; Lee, Youjin; Awasthi, Amit; Wu, Chuan; Karwacz, Katarzyna; Xiao, Sheng; Jorgolli, Marsela; Gennert, David; Satija, Rahul; Shakya, Arvind; Lu, Diana Y.; Trombetta, John J.; Pillai, Meenu R.; Ratcliffe, Peter J.; Coleman, Mathew L.; Bix, Mark; Tantin, Dean; Park, Hongkun; Kuchroo, Vijay K.; Regev, Aviv (2013)
      Despite their importance, the molecular circuits that control the differentiation of naïve T cells remain largely unknown. Recent studies that reconstructed regulatory networks in mammalian cells have focused on short-term ...

    • Dynamic Support Culture of Murine Skeletal Muscle-Derived Stem Cells Improves Their Cardiogenic Potential In Vitro 

      Neef, Klaus; Treskes, Philipp; Xu, Guoxing; Drey, Florian; Srinivasan, Sureshkumar Perumal; Saric, Tomo; Nembo, Erastus; Semmler, Judith; Nguemo, Filomain; Stamm, Christof; Cowan, Douglas B.; Deppe, Antje-Christin; Scherner, Maximilian; Wittwer, Thorsten; Hescheler, Jürgen; Wahlers, Thorsten; Choi, Yeong-Hoon (Hindawi Publishing Corporation, 2015)
      Ischemic heart disease is the main cause of death in western countries and its burden is increasing worldwide. It typically involves irreversible degeneration and loss of myocardial tissue leading to poor prognosis and ...

    • Dynamic Switch of Negative Feedback Regulation in Drosophila Akt–TOR Signaling 

      Kockel, Lutz; Kerr, Kimberly Sayer; Melnick, Michael; Brückner, Katja; Hebrok, Matthias; Perrimon, Norbert (Public Library of Science, 2010)
      Akt represents a nodal point between the Insulin receptor and TOR signaling, and its activation by phosphorylation controls cell proliferation, cell size, and metabolism. The activity of Akt must be carefully balanced, as ...

    • Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratinocyte Differentiation 

      Cavazza, Alessia; Miccio, Annarita; Romano, Oriana; Petiti, Luca; Malagoli Tagliazucchi, Guidantonio; Peano, Clelia; Severgnini, Marco; Rizzi, Ermanno; De Bellis, Gianluca; Bicciato, Silvio; Mavilio, Fulvio (Elsevier, 2016)
      Summary Human skin is maintained by the differentiation and maturation of interfollicular stem and progenitors cells. We used DeepCAGE, genome-wide profiling of histone modifications and retroviral integration analysis, ...

    • Dynamic Transcriptional Reprogramming Leads to Immunotherapeutic Vulnerabilities in Myeloma 

      Frede, Julia; Anand, Praveen; Sotudeh, Noori; Pinto, Ricardo A.; Nair, Monica S.; Stuart, Hannah; Yee, Andrew J.; Vijaykumar, Tushara; Waldschmidt, Johannes M.; Potdar, Sayalee; Kloeber, Jake A.; Kokkalis, Antonis; Dimitrova, Valeriya; Mann, Mason; Laubach, Jacob; Richardson, Paul; Anderson, Kenneth; Raje, Noopur; Knoechel, Birgit; Lohr, Jens (Springer Science and Business Media LLC, 2021-10-21)

    • DyNAMiC Workbench: an integrated development environment for dynamic DNA nanotechnology 

      Grun, Casey; Werfel, Justin; Zhang, David Yu; Yin, Peng (The Royal Society, 2015)
      Dynamic DNA nanotechnology provides a promising avenue for implementing sophisticated assembly processes, mechanical behaviours, sensing and computation at the nanoscale. However, design of these systems is complex and ...

    • Dynamical density delay maps: simple, new method for visualising the behaviour of complex systems 

      Burykin, Anton; Costa, Madalena D; Citi, Luca; Goldberger, Ary L (BioMed Central, 2014)
      Background: Physiologic signals, such as cardiac interbeat intervals, exhibit complex fluctuations. However, capturing important dynamical properties, including nonstationarities may not be feasible from conventional time ...

    • Dynamical features of the Plasmodium falciparum ribosome during translation 

      Sun, Ming; Li, Wen; Blomqvist, Karin; Das, Sanchaita; Hashem, Yaser; Dvorin, Jeffrey D.; Frank, Joachim (Oxford University Press, 2015)
      Plasmodium falciparum, the mosquito-transmitted Apicomplexan parasite, causes the most severe form of human malaria. In the asexual blood-stage, the parasite resides within erythrocytes where it proliferates, multiplies ...

    • Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming 

      Yamaguchi, Shinpei; Hong, Kwonho; Liu, Rui; Inoue, Azusa; Shen, Li; Zhang, Kun; Zhang, Yi (Nature Publishing Group, 2013)
      Previous studies have revealed that mouse primordial germ cells (PGCs) undergo genome-wide DNA methylation reprogramming to reset the epigenome for totipotency. However, the precise 5-methylcytosine (5mC) dynamics and its ...

    • Dynamics of Envelope Evolution in Clade C SHIV-Infected Pig-Tailed Macaques during Disease Progression Analyzed by Ultra-Deep Pyrosequencing 

      Tso, For Yue; Tully, Damien C; Gonzalez, Sandra; Quince, Christopher; Ho, On; Polacino, Patricia; Ruprecht, Ruth Margrit; Hu, Shiu-Lok; Wood, Charles (Public Library of Science, 2012)
      Understanding the evolution of the human immunodeficiency virus type 1 (HIV-1) envelope during disease progression can provide tremendous insights for vaccine development, and simian-human immunodeficiency virus (SHIV) ...

    • Dynamics of Immune Reconstitution and Activation Markers in HIV+ Treatment-Naïve Patients Treated with Raltegravir, Tenofovir Disoproxil Fumarate and Emtricitabine 

      Funderburg, Nicholas T.; Andrade, Adriana; Chan, Ellen S.; Rosenkranz, Susan L.; Lu, Darlene; Clagett, Brian; Pilch-Cooper, Heather A.; Rodriguez, Benigno; Feinberg, Judith; Daar, Eric; Mellors, John; Kuritzkes, Daniel; Jacobson, Jeffrey M.; Lederman, Michael M. (Public Library of Science, 2013)
      Background: The dynamics of CD4+ T cell reconstitution and changes in immune activation and inflammation in HIV-1 disease following initiation of antiretroviral therapy (ART) are incompletely defined and their underlying ...

    • Dynamics of Obesity and Chronic Health Conditions Among Children and Youth 

      Van Cleave, Jeanne; Gortmaker, Steven L.; Perrin, James Marc (American Medical Association (AMA), 2010)
      Context: Rates of obesity and other childhood chronic conditions have increased over recent decades. Patterns of how conditions change over time have not been widely examined. Objective: To evaluate change in prevalence ...

    • The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation 

      Lee, Semin; Bolanos-Garcia, Victor M. (Frontiers Media S.A., 2014)
      The control of chromosome segregation relies on the spindle assembly checkpoint (SAC), a complex regulatory system that ensures the high fidelity of chromosome segregation in higher organisms by delaying the onset of ...

    • Dynamics of the Microbiota in Response to Host Infection 

      Belzer, Clara; Gerber, Georg K.; Roeselers, Guus; Delaney, Mary; DuBois, Andrea; Liu, Qing; Belavusava, Vera; Yeliseyev, Vladimir; Houseman, Andres; Onderdonk, Andrew; Cavanaugh, Colleen; Bry, Lynn (Public Library of Science, 2014)
      Longitudinal studies of the microbiota are important for discovering changes in microbial communities that affect the host. The complexity of these ecosystems requires rigorous integrated experimental and computational ...

    • Dynamics of Ubiquitin Conjugation during Erythroid Differentiation in Vitro 

      Haldeman, Margaret T.; Finley, Daniel; Pickart, Cecile M. (American Society for Biochemistry and Molecular Biology, 1995)

    • Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts 

      Shin, Nah-Young; Choi, Hyewon; Neff, Lynn; Wu, Yumei; Saito, Hiroaki; Ferguson, Shawn M.; De Camilli, Pietro; Baron, Roland (The Rockefeller University Press, 2014)
      Cell–cell fusion is an evolutionarily conserved process that leads to the formation of multinucleated myofibers, syncytiotrophoblasts and osteoclasts, allowing their respective functions. Although cell–cell fusion requires ...

    • Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit 

      Cocucci, Emanuele; Gaudin, Raphaël; Kirchhausen, Tom (The American Society for Cell Biology, 2014)
      Dynamin, the GTPase required for clathrin-mediated endocytosis, is recruited to clathrin-coated pits in two sequential phases. The first is associated with coated pit maturation; the second, with fission of the membrane ...

    • The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae 

      Anwar, Kamran; Klemm, Robin; Condon, Amanda; Severin, Katharina N.; Zhang, Miaoxing; Ghirlando, Rodolfo; Hu, Junjie; Rapoport, Tom A.; Prinz, William A. (The Rockefeller University Press, 2012)
      The endoplasmic reticulum (ER) forms a network of tubules and sheets that requires homotypic membrane fusion to be maintained. In metazoans, this process is mediated by dynamin-like guanosine triphosphatases (GTPases) ...

    • Dynorphin Activates Quorum Sensing Quinolone Signaling in Pseudomonas aeruginosa 

      Zaborina, Olga; Lepine, Francois; Xiao, Gaoping; Valuckaite, Vesta; Chen, Yimei; Li, Terry; Ciancio, Mae; Zaborin, Alex; Petroff, Elaine; Turner, Jerrold R; Chang, Eugene; Alverdy, John C; Rahme, Laurence G. (Public Library of Science, 2007)
      There is now substantial evidence that compounds released during host stress directly activate the virulence of certain opportunistic pathogens. Here, we considered that endogenous opioids might function as such compounds, ...

    • Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease 

      Shaw, Kelly A.; Bertha, Madeline; Hofmekler, Tatyana; Chopra, Pankaj; Vatanen, Tommi; Srivatsa, Abhiram; Prince, Jarod; Kumar, Archana; Sauer, Cary; Zwick, Michael E.; Satten, Glen A.; Kostic, Aleksandar D.; Mulle, Jennifer G.; Xavier, Ramnik J.; Kugathasan, Subra (BioMed Central, 2016)
      Background: Gut microbiome dysbiosis has been demonstrated in subjects with newly diagnosed and chronic inflammatory bowel disease (IBD). In this study we sought to explore longitudinal changes in dysbiosis and ascertain ...