Browsing Harvard Medical School by Title
Now showing items 5641-5660 of 18428
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Endoneurial pathology of the needlestick-nerve-injury model of Complex Regional Pain Syndrome, including rats with and without pain behaviors
(Wiley-Blackwell, 2012)Current rodent models of neuropathic pain produce pain hypersensitivity in almost all lesioned animals and not all identified experimental effects are pain specific. 18G needlestick-nerve-injury (NNI) to one tibial nerve ... -
Endopeptidase-Mediated Beta Lactam Tolerance
(Public Library of Science, 2015)In many bacteria, inhibition of cell wall synthesis leads to cell death and lysis. The pathways and enzymes that mediate cell lysis after exposure to cell wall-acting antibiotics (e.g. beta lactams) are incompletely ... -
Endophenotype Network Models: Common Core of Complex Diseases
(Nature Publishing Group, 2016)Historically, human diseases have been differentiated and categorized based on the organ system in which they primarily manifest. Recently, an alternative view is emerging that emphasizes that different diseases often have ... -
Endophthalmitis
(Blackwell Publishing Ltd, 2013)Endophthalmitis means bacterial or fungal infection inside the eye involving the vitreous and/or aqueous humors. Most cases are exogenous and occur after eye surgery, after penetrating ocular trauma, or as an extension of ... -
The endoplasmic reticulum: structure, function and response to cellular signaling
(Springer International Publishing, 2015)The endoplasmic reticulum (ER) is a large, dynamic structure that serves many roles in the cell including calcium storage, protein synthesis and lipid metabolism. The diverse functions of the ER are performed by distinct ... -
Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut
(National Academy of Sciences, 2014)Given mounting evidence of the importance of gut-microbiota/immune-cell interactions in immune homeostasis and responsiveness, surprisingly little is known about leukocyte movements to, and especially from, the gut. We ... -
Endoscopic Surveillance of Patients With Hereditary Diffuse Gastric Cancer: Biopsy Recommendations After Topographic Distribution of Cancer Foci in a Series of 10 CDH1-mutated Gastrectomies
(Ovid Technologies (Wolters Kluwer Health), 2012)The management of hereditary diffuse-type gastric cancer revolves around surveillance biopsies and the timing of prophylactic gastrectomy. In the absence of a validated surveillance biopsy protocol, we modeled bioptic ... -
Endoscopic Ultrasound-Guided Pancreatobiliary Endoscopy in Surgically Altered Anatomy
(Korean Society of Gastrointestinal Endoscopy, 2016)Endoscopic retrograde cholangiopancreatography (ERCP) has become the mainstay of therapy for pancreatobiliary diseases. While ERCP is safe and highly effective in the general population, the procedure remains challenging ... -
Endoscopic ultrasound-guided techniques for diagnosing pancreatic mass lesions: Can we do better?
(Baishideng Publishing Group Inc, 2016)The diagnostic approach to a possible pancreatic mass lesion relies first upon various non-invasive imaging modalities, including computed tomography, ultrasound, and magnetic resonance imaging techniques. Once a suspect ... -
Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
(2014)The PTH receptor is one of the first GPCR found to sustain cAMP signaling after internalization of the ligand–receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR ... -
Endothelial cell mitogens derived from retina and hypothalamus: biochemical and biological similarities
(Rockefeller University Press, 1984)Bovine retina and hypothalamus contain anionic endothelial cell mitogens that display unusual affinities for the negatively charged glycosaminoglycan heparin. Both growth factor activities are acidic polypeptides (pl's of ... -
Endothelial Differentiation Gene-1, a New Downstream Gene Is Involved in RTEF-1 Induced Angiogenesis in Endothelial Cells
(Public Library of Science, 2014)Related Transcriptional Enhancer Factor-1 (RTEF-1) has been suggested to induce angiogenesis through regulating target genes. Whether RTEF-1 has a direct role in angiogenesis and what specific genes are involved in RTEF-1 ... -
Endothelial glycocalyx conditions influence nanoparticle uptake for passive targeting
(Dove Medical Press, 2016)Cardiovascular diseases are facilitated by endothelial cell (EC) dysfunction and coincide with EC glycocalyx coat shedding. These diseases may be prevented by delivering medications to affected vascular regions using ... -
Endothelial Sirt1 Is Required for PGC1α-Induced Angiogenesis in Skeletal Muscle Tissue
(2017-05-12)It is believed that the health benefits of exercise are mediated in part by exercise-induced adaptations of skeletal muscle tissue. The mechanisms whereby alterations in cellular energy state are sensed and how these signals ... -
Endothelial, platelet, and macrophage microparticle levels do not change acutely following transcatheter aortic valve replacement
(BioMed Central, 2016)Background: Patients with severe aortic stenosis have increased levels of prothrombotic and proinflammatory microparticles (MP), and MPs actively regulate pathological processes that lead to atherothrombotic cardiovascular ... -
Endothelin A Receptor Antagonist, Atrasentan, Attenuates Renal and Cardiac Dysfunction in Dahl Salt-Hypertensive Rats in a Blood Pressure Independent Manner
(Public Library of Science, 2015)Proteinuria is a hallmark of chronic kidney disease (CKD) and cardiovascular disease (CVD), and a good predictor of clinical outcome. Selective endothelin A (ETA) receptor antagonist used with renin-angiotensin system (RAS) ... -
Endothelin-1 and Endothelin Receptor mRNA Expression in Normal and Atherosclerotic Human Arteries
(Elsevier BV, 1993)Endothelin-1 (ET-1) is a potent vasoconstrictor peptide implicated in a number of human diseases including atherosclerosis. ET-1 binds to two distinct G protein-coupled receptors, known as the ETA and ETB receptor subtypes. ... -
Engaging older patients in cardiovascular research: observational analysis of the ICON-1 study
(BMJ Publishing Group, 2016)Background: As a consequence of population ageing, the number of older patients presenting with acute coronary syndrome (ACS) is increasing. The historical underrepresentation of older patients in many pivotal ACS clinical ...