Browsing Harvard Medical School by Title

Now showing items 596-615 of 18428

    • Alignment of Angular Velocity Sensors for a Vestibular Prosthesis 

      DiGiovanna, Jack; Carpaneto, Jacopo; Micera, Silvestro; Merfeld, Daniel M. (BioMed Central, 2012)
      Vestibular prosthetics transmit angular velocities to the nervous system via electrical stimulation. Head-fixed gyroscopes measure angular motion, but the gyroscope coordinate system will not be coincident with the sensory ...

    • ALK-Positive Diffuse Large B-Cell Lymphoma: Report of Four Cases and Review of the Literature 

      Beltran, Brady; Castillo, Jorge; Salas, Renzo; Quiñones, Pilar; Morales, Domingo; Hurtado, Fernando; Riva, Luis; Winer, Eric (Springer Science and Business Media LLC, 2009-02-27)
      Background Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma (ALK-DLBCL) is a rare lymphoma with several clinicopathological differences from ALK-positive anaplastic large cell lymphoma (ALCL). The latest ...

    • Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass 

      Davidson, Jesse A.; Urban, Tracy; Tong, Suhong; Twite, Mark; Woodruff, Alan; Wischmeyer, Paul E.; Klawitter, Jelena (Public Library of Science, 2016)
      Rationale: Decreased alkaline phosphatase activity after infant cardiac surgery is associated with increased post-operative cardiovascular support requirements. In adults undergoing coronary artery bypass grafting, alkaline ...

    • All for One, and One for All: The Clonality of the Intestinal Stem Cell Niche 

      Karpowicz, Phillip Adam; Perrimon, Norbert (Faculty of 1000 Ltd, 2010)
      Intestinal epithelia are maintained by intestinal stem cells (ISCs) that divide to replace dying absorptive and secretory cells that make up this tissue. Lineage labeling studies, both in vertebrates and Drosophila, have ...

    • All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins 

      Hochbaum, Daniel R.; Zhao, Yongxin; Farhi, Samouil L.; Klapoetke, Nathan; Werley, Christopher A.; Kapoor, Vikrant; Zou, Peng; Kralj, Joel M.; Maclaurin, Dougal; Smedemark-Margulies, Niklas; Saulnier, Jessica L.; Boulting, Gabriella L.; Straub, Christoph; Cho, Yong Ku; Melkonian, Michael; Wong, Gane Ka-Shu; Harrison, D. Jed; Murthy, Venkatesh N.; Sabatini, Bernardo; Boyden, Edward S.; Campbell, Robert E.; Cohen, Adam E. (2014)
      All-optical electrophysiology—spatially resolved simultaneous optical perturbation and measurement of membrane voltage—would open new vistas in neuroscience research. We evolved two archaerhodopsin-based voltage indicators, ...

    • All-Trans Retinoic Acid Directs Urothelial Specification of Murine Embryonic Stem Cells via GATA4/6 Signaling Mechanisms 

      Mauney, Joshua Robert; Ramachandran, Aruna; Yu, Richard N.; Daley, George Quentin; Adam, Rosalyn Mare; Estrada, Carlos R. (Public Library of Science, 2010)
      The urinary bladder and associated tract are lined by the urothelium, a transitional epithelium that acts as a specialized permeability barrier that protects the underlying tissue from urine via expression of a highly ...

    • Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis 

      LaFramboise, Thomas; Weir, Barbara Ann; Zhao, Xiaojun; Beroukhim, Rameen; Li, Cheng; Harrington, David Paul; Sellers, William R; Meyerson, Matthew Langer (Public Library of Science, 2005)
      Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at increasingly high resolution. Similarly, ...

    • Allele-specific detection of single mRNA molecules in situ 

      Hansen, Clinton H.; van Oudenaarden, Alexander (2013)
      We describe a method for fluorescent in situ identification of individual mRNA molecules, allowing quantitative and accurate measurements of allele-specific transcripts that differ by only a few nucleotides, in single ...

    • Allele-specific expression in the human heart and its application to postoperative atrial fibrillation and myocardial ischemia 

      Sigurdsson, Martin I.; Saddic, Louis; Heydarpour, Mahyar; Chang, Tzuu-Wang; Shekar, Prem; Aranki, Sary; Couper, Gregory S.; Shernan, Stanton K.; Seidman, Jon G.; Body, Simon C.; Muehlschlegel, Jochen D. (BioMed Central, 2016)
      Background: Allele-specific expression (ASE) is differential expression of each of the two chromosomal alleles of an autosomal gene. We assessed ASE patterns in the human left atrium (LA, n = 62) and paired samples from ...

    • Allele-specific expression of mutated in colorectal cancer (MCC) gene and alternative susceptibility to colorectal cancer in schizophrenia 

      Wang, Yang; Cao, Yanfei; Huang, Xiaoye; Yu, Tao; Wei, Zhiyun; McGrath, John; Xu, Fei; Bi, Yan; Li, Xingwang; Yang, Fengping; Li, Weidong; Zou, Xia; Peng, Zhihai; Xiao, Yanzeng; Zhang, Yan; He, Lin; He, Guang (Nature Publishing Group, 2016)
      Evidence has indicated that the incidence of colorectal cancer (CRC) among schizophrenia is lower than normal. To explore this potential protective effect, we employed an innovative strategy combining association study ...

    • Allele-Specific Methylation Occurs at Genetic Variants Associated with Complex Disease 

      Hutchinson, John N.; Raj, Towfique; Fagerness, Jes; Stahl, Eli; Viloria, Fernando T.; Gimelbrant, Alexander; Seddon, Johanna; Daly, Mark; Chess, Andrew; Plenge, Robert (Public Library of Science, 2014)
      We hypothesize that the phenomenon of allele-specific methylation (ASM) may underlie the phenotypic effects of multiple variants identified by Genome-Wide Association studies (GWAS). We evaluate ASM in a human population ...

    • Allelic Expression of Deleterious Protein-Coding Variants across Human Tissues 

      Kukurba, Kimberly R.; Zhang, Rui; Li, Xin; Smith, Kevin S.; Knowles, David A.; How Tan, Meng; Piskol, Robert; Lek, Monkol; Snyder, Michael; MacArthur, Daniel G.; Li, Jin Billy; Montgomery, Stephen B. (Public Library of Science, 2014)
      Personal exome and genome sequencing provides access to loss-of-function and rare deleterious alleles whose interpretation is expected to provide insight into individual disease burden. However, for each allele, accurate ...

    • Allelic Selection of Amplicons in Glioblastoma Revealed by Combining Somatic and Germline Analysis 

      LaFramboise, Thomas; Dewal, Ninad; Wilkins, Katherine; Pe'er, Itsik; Freedman, Matthew Lawrence (Public Library of Science, 2010)
      Cancer is a disease driven by a combination of inherited risk alleles coupled with the acquisition of somatic mutations, including amplification and deletion of genomic DNA. Potential relationships between the inherited ...

    • Allergic Lung Inflammation Aggravates Angiotensin II–Induced Abdominal Aortic Aneurysms in Mice 

      Liu, Cong-Lin; Wang, Yi; Liao, Mengyang; Wemmelund, Holger; Ren, Jingyuan; Fernandes, Cleverson; Zhou, Yi; Sukhova, Galina K.; Lindholt, Jes S.; Johnsen, Søren P.; Zhang, Jin-Ying; Cheng, Xiang; Huang, Xiaozhu; Daugherty, Alan; Levy, Bruce David; Libby, Peter; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2015)

    • Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice 

      Liu, Cong-Lin; Wang, Yi; Liao, Mengyang; Santos, Marcela Malheiro; Fernandes, Cleverson; Sukhova, Galina K.; Zhang, Jin-Ying; Cheng, Xiang; Yang, Chongzhe; Huang, Xiaozhu; Levy, Bruce David; Libby, Peter; Wu, Gongxiong; Shi, Guo-Ping (Elsevier BV, 2016)
      Inflammation drives asthma and atherosclerosis. Clinical studies suggest that asthmatic patients have a high risk of atherosclerosis. Yet this hypothesis remains uncertain, given that Th2 imbalance causes asthma whereas ...

    • Allergic Non-Asthmatic Adults Have Regional Pulmonary Responses to Segmental Allergen Challenge 

      Kelly, Vanessa J.; Winkler, Tilo; Venegas, Jose G.; Kone, Mamary; Hamilos, Daniel L.; Afshar, Roshi; Cho, Josalyn L.; Luster, Andrew D.; Medoff, Benjamin D.; Harris, R. Scott (Public Library of Science, 2015)
      Background: Allergic non-asthmatic (ANA) adults experience upper airway symptoms of allergic disease such as rhinorrhea, congestion and sneezing without symptoms of asthma. The aim of this study was to utilize PET-CT ...

    • Alloimmunity and Tolerance in Corneal Transplantation 

      Amouzegar, Afsaneh; Chauhan, Sunil Kumar; Dana, Reza (The American Association of Immunologists, 2016)
      Corneal transplantation is one of the most prevalent and successful forms of solid tissue transplantation. Despite favorable outcomes, immune-mediated graft rejection still remains the major cause of corneal allograft ...

    • Allorecognition by T Lymphocytes and Allograft Rejection 

      Marino, Jose; Paster, Joshua; Benichou, Gilles (Frontiers Media S.A., 2016)
      Recognition of donor antigens by recipient T cells in secondary lymphoid organs initiates the adaptive inflammatory immune response leading to the rejection of allogeneic transplants. Allospecific T cells become activated ...

    • Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors 

      Singh, Parmit; Li, Wen; Bedwell, Gregory J.; Fadel, Hind J.; Poeschla, Eric M.; Engelman, Alan N. (MDPI, 2022-08)
      Allosteric integrase (IN) inhibitors (ALLINIs), which are promising preclinical compounds that engage the lens epithelium-derived growth factor (LEDGF)/p75 binding site on IN, can inhibit different aspects of human ...

    • Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation 

      Jurado, Kellie; Wang, Hao; Slaughter, Alison; Feng, Lei; Kessl, Jacques; Koh, Yasuhiro; Wang, Weifeng; Ballandras-Colas, Allison; Patel, Pratiq; Fuchs, James; Kvaratskhelia, Mamuka; Engelman, Alan (National Academy of Sciences, 2013)
      Integration is essential for HIV-1 replication, and the viral integrase (IN) protein is an important therapeutic target. Allosteric IN inhibitors (ALLINIs) that engage the IN dimer interface at the binding site for the ...